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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trifluridine
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Accession:CHEBI:75179 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.
Synonyms:exact_synonym: 2'-deoxy-5-(trifluoromethyl)uridine
 related_synonym: 5-(Trifluoromethyl)deoxyuridine;   5-Trifluoromethyl-2-deoxyuridine;   Formula=C10H11F3N2O5;   InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1;   InChIKey=VSQQQLOSPVPRAZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F;   Trifluoromethyldeoxyuridine;   Trifluorothymidine;   Viroptic;   trifluorothymine deoxyriboside;   trifluridina;   trifluridinum
 alt_id: CHEBI:9713
 xref: CAS:70-00-8;   DrugBank:DB00432;   Drug_Central:2743;   HMDB:HMDB0014576;   KEGG:D00391;   LINCS:LSM-5217
 xref_mesh: MESH:D014271
 xref: PMID:19816940;   PMID:19886911;   PMID:20861476;   PMID:21278209;   PMID:21491084;   PMID:22076553;   PMID:22607463;   PMID:22662200;   PMID:22735906;   PMID:22977515;   PMID:23343513;   PMID:23386782;   PMID:23521072;   PMID:23919755;   Reaxys:568095;   Wikipedia:Trifluridine


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trifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19816940 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Trifluridine results in increased cleavage of CASP9 protein CTD PMID:19816940 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ctsb cathepsin B increases cleavage
multiple interactions		 ISO Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]		 CTD PMID:19816940 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Trifluridine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Trifluridine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          antimetabolite 10285
            trifluridine 12
              Lonsurf 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      carbohydrate derivative 14305
                                        glycosyl compound 13067
                                          N-glycosyl compound 5873
                                            nucleoside 5731
                                              deoxyribonucleoside 2889
                                                2'-deoxyribonucleoside 2246
                                                  pyrimidine 2'-deoxyribonucleoside 353
                                                    trifluridine 12
                                                      Lonsurf 0
paths to the root