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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dabrafenib
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Accession:CHEBI:75045 term browser browse the term
Definition:An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Synonyms:exact_synonym: N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
 related_synonym: Formula=C23H20F3N5O2S2;   InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29);   InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
 xref: CAS:1195765-45-7;   Drug_Central:4801;   KEGG:D10064;   LINCS:LSM-6303
 xref_mesh: MESH:C561627
 xref: PMID:22981500;   PMID:23237741;   PMID:23249624;   PMID:23276366;   PMID:23290787;   PMID:23317446;   PMID:23403819;   PMID:23463215;   PMID:23470635;   PMID:23515890;   PMID:23537694;   PMID:23552670;   PMID:23608920;   PMID:23617957;   PMID:23621583;   PMID:23656699;   PMID:23709751;   PMID:23714462;   PMID:23795808;   PMID:23807941;   PMID:23833299;   PMID:23844038;   PMID:23846776;   PMID:23870055;   PMID:23881668;   Patent:WO2011047238;   Reaxys:19689971;   Wikipedia:Dabrafenib


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dabrafenib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO dabrafenib results in increased expression of ABCC1 mRNA CTD PMID:34780725 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO dabrafenib results in increased expression of ABCG2 mRNA CTD PMID:34780725 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions
decreases activity
increases response to substance
affects response to substance		 ISO [BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]
dabrafenib results in decreased activity of BRAF protein; dabrafenib results in decreased activity of BRAF protein mutant form		 CTD PMID:20823850 PMID:23237741 PMID:26978007 PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib] CTD PMID:26978007 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO dabrafenib results in decreased activity of CYP1A2 protein CTD PMID:34780725 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO dabrafenib results in decreased activity of CYP2C19 protein CTD PMID:34780725 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO dabrafenib results in decreased activity of CYP2C8 protein CTD PMID:34780725
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions		 ISO dabrafenib results in increased expression of CYP3A4 mRNA
dabrafenib results in decreased activity of CYP3A4 protein
dabrafenib inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]		 CTD PMID:34780725 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity ISO dabrafenib results in decreased activity of CYP3A5 protein CTD PMID:34780725 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO dabrafenib inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of EGFR protein] CTD PMID:38641160 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of GPT protein] CTD PMID:27458080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased secretion of IL6 protein] CTD PMID:27458080 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb5 integrin subunit beta 5 multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance
multiple interactions		 ISO KRAS protein affects the susceptibility to dabrafenib
[KRAS protein affects the susceptibility to dabrafenib] which affects the expression of TNFRSF10B protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein		 CTD PMID:27222248 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation
multiple interactions		 ISO dabrafenib results in decreased phosphorylation of MAP2K1 protein
decabromobiphenyl ether inhibits the reaction [dabrafenib results in decreased phosphorylation of MAP2K1 protein]		 CTD PMID:38641160 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions
decreases phosphorylation		 ISO decabromobiphenyl ether inhibits the reaction [dabrafenib results in decreased phosphorylation of MAP2K2 protein] CTD PMID:38641160 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK1 protein]; decabromobiphenyl ether inhibits the reaction [dabrafenib results in decreased phosphorylation of MAPK1 protein]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK1 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 PMID:38641160 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK3 protein]; decabromobiphenyl ether inhibits the reaction [dabrafenib results in decreased phosphorylation of MAPK3 protein]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK3 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 PMID:38641160 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO dabrafenib inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of RAF1 protein] CTD PMID:38641160 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased activity of RELA protein] CTD PMID:27458080 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein] CTD PMID:27458080 PMID:29042256 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions		 ISO dabrafenib results in decreased cleavage of SREBF1 protein
[BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein		 CTD PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with dabrafenib] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177 		JBrowse link
G Tgfbi transforming growth factor, beta induced multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]; dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:29042256 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of TNF protein] CTD PMID:27458080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        antimicrobial agent 18260
          antiviral agent 11341
            anticoronaviral agent 10036
              dabrafenib 28
                dabrafenib mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  azane 17886
                                    ammonia 17885
                                      organic amino compound 17885
                                        aromatic amine 15498
                                          aminopyrimidine 2024
                                            dabrafenib 28
                                              dabrafenib mesylate 0
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