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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:patulin
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Accession:CHEBI:74926 term browser browse the term
Definition:A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.
Synonyms:exact_synonym: 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
 related_synonym: (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone;   4,6-dihydro-4-hydroxy-2H-furo(3,2-c)pyran-2-one;   Formula=C7H6O4;   InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2;   InChIKey=ZRWPUFFVAOMMNM-UHFFFAOYSA-N;   PAT;   SMILES=OC1OCC=C2OC(=O)C=C12;   clavacin;   clavatin;   claviform;   claviformin;   expansin;   expansine;   mycoin C3;   mycoine C3;   patuline
 xref: CAS:149-29-1;   HMDB:HMDB0034299;   KEGG:C16748;   KNApSAcK:C00024000
 xref_mesh: MESH:D010365
 xref: PMID:21656641;   PMID:22410236;   PMID:22988003;   PMID:23192667;   PMID:23384314;   PMID:23416552;   PMID:23729413;   PMID:23813870;   PMID:23870868;   Patent:US2417584;   Reaxys:149675;   Wikipedia:Patulin


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patulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Patulin results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein]		 CTD PMID:29604266 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Patulin results in increased expression of ATF3 mRNA CTD PMID:21844328 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 protein affects the reaction [Patulin results in increased expression of and results in increased cleavage of GSDMD protein]; ATG5 protein affects the reaction [Patulin results in increased expression of IL1B protein] CTD PMID:33217525 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Patulin results in increased expression of BAX protein CTD PMID:19000704 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Patulin results in increased expression of BCL2L11 mRNA CTD PMID:21844328 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Becn1 beclin 1 increases phosphorylation
multiple interactions		 ISO Patulin results in increased phosphorylation of BECN1 protein
Patulin promotes the reaction [BECN1 protein modified form binds to SLC7A11 protein]		 CTD PMID:35772596 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO Patulin results in increased expression of BID mRNA CTD PMID:21844328 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [Patulin results in increased expression of CASP1 protein]; CA 074 methyl ester inhibits the reaction [Patulin results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Patulin results in increased expression of CASP1 protein] CTD PMID:33217525 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Patulin results in increased activity of CASP3 protein
diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP3 protein]		 CTD PMID:19000704 PMID:25577197 PMID:26095701 PMID:33577942 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO Patulin results in increased activity of CASP8 protein
diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP8 protein]		 CTD PMID:33577942 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Patulin results in increased activity of CASP9 protein
diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP9 protein]		 CTD PMID:33577942 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases response to substance
increases activity		 ISO Patulin results in decreased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Patulin results in decreased activity of CAT protein]
CAT protein results in decreased susceptibility to Patulin
diphenyleneiodonium inhibits the reaction [Patulin results in decreased activity of CAT protein]		 CTD PMID:17090621 PMID:21964610 PMID:26095701 PMID:26584762 PMID:33577942 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases degradation ISO Patulin results in decreased degradation of CCNB1 protein CTD PMID:34718031 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdh1 cadherin 1 decreases expression EXP Patulin results in decreased expression of CDH1 protein CTD PMID:34896196 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 increases expression EXP Patulin results in increased expression of CDH2 protein CTD PMID:34896196 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Patulin results in increased expression of CDKN1A protein CTD PMID:19000704 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cldn1 claudin 1 affects localization ISO Patulin affects the localization of CLDN1 protein CTD PMID:19013514 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn3 claudin 3 affects localization ISO Patulin affects the localization of CLDN3 protein CTD PMID:19013514 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Cldn4 claudin 4 affects localization ISO Patulin affects the localization of CLDN4 protein CTD PMID:19013514 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Clk1 CDC-like kinase 1 decreases expression ISO Patulin results in decreased expression of CLK1 mRNA CTD PMID:27913847 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Clu clusterin increases expression EXP Patulin results in increased expression of CLU protein CTD PMID:34896196 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Ctsb cathepsin B increases secretion
multiple interactions		 ISO Patulin results in increased secretion of CTSB protein
3-methyladenine inhibits the reaction [Patulin results in increased secretion of CTSB protein]; CA 074 methyl ester inhibits the reaction [Patulin results in increased secretion of CTSB protein]		 CTD PMID:33217525 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Patulin results in increased expression of CYBB mRNA; Patulin results in increased expression of CYBB protein CTD PMID:33577942 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Patulin results in increased expression of DDIT3 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Patulin results in increased expression of FOS protein
Patulin promotes the reaction [FOS protein binds to TGFB1 promoter]; pyrazolanthrone inhibits the reaction [Patulin results in increased expression of FOS protein]		 CTD PMID:21964610 PMID:34896196 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Patulin results in increased expression of GPT protein CTD PMID:33217525 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO ATG5 protein affects the reaction [Patulin results in increased expression of and results in increased cleavage of GSDMD protein]; N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone inhibits the reaction [Patulin results in increased expression of and results in increased cleavage of GSDMD protein]; Patulin results in increased expression of and results in increased cleavage of GSDMD protein CTD PMID:33217525 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 ISO Patulin results in decreased activity of GSR protein
diphenyleneiodonium inhibits the reaction [Patulin results in decreased activity of GSR protein]		 CTD PMID:21964610 PMID:33577942 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Patulin results in increased expression of HAVCR1 protein CTD PMID:34896196 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Patulin results in increased expression of HSPA5 protein CTD PMID:25577197 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
decreases expression		 ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein
Patulin results in decreased secretion of IFNG protein
Patulin results in decreased expression of IFNG mRNA		 CTD PMID:12112629 PMID:18214930 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein CTD PMID:18214930 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein CTD PMID:18214930 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO 3-methyladenine inhibits the reaction [Patulin results in increased expression of IL18 protein] CTD PMID:33217525 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [Patulin results in increased expression of IL1B protein]; ATG5 protein affects the reaction [Patulin results in increased expression of IL1B protein]; CA 074 methyl ester inhibits the reaction [Patulin results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Patulin results in increased expression of IL1B protein]; N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone inhibits the reaction [Patulin results in increased expression of IL1B protein]; Patulin inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] CTD PMID:18308354 PMID:33217525 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il20 interleukin 20 increases expression ISO Patulin results in increased expression of IL20 protein CTD PMID:33217525 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Il4 interleukin 4 affects secretion
increases expression
multiple interactions		 ISO Patulin affects the secretion of IL4 protein
Patulin results in increased expression of IL4 mRNA
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein		 CTD PMID:12112629 PMID:18214930 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Patulin results in increased expression of JUN protein
Patulin promotes the reaction [JUN protein binds to TGFB1 promoter]; pyrazolanthrone inhibits the reaction [Patulin results in increased expression of JUN protein]		 CTD PMID:21964610 PMID:34896196 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO
EXP		 Patulin results in increased phosphorylation of MAPK1 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:17090621 PMID:21964610 PMID:34896196 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO
EXP		 Patulin results in increased phosphorylation of MAPK3 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:17090621 PMID:21964610 PMID:34896196 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Patulin results in increased phosphorylation of MAPK8 protein CTD PMID:34896196 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of MTOR protein] CTD PMID:29604266 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Patulin results in increased expression of NCF1 mRNA; Patulin results in increased expression of NCF1 protein CTD PMID:33577942 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 affects response to substance
increases expression
multiple interactions		 ISO NFE2L1 protein affects the susceptibility to Patulin
Patulin results in increased expression of NFE2L1 protein
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA2 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA5 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA7 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA8 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMC1 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD2 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD3 mRNA]; NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD4 mRNA]		 CTD PMID:35367319 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [Patulin results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Patulin results in increased expression of NLRP3 protein] CTD PMID:33217525 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Ocln occludin increases degradation
multiple interactions		 ISO Patulin results in increased degradation of OCLN protein
1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein]; Zinc Sulfate inhibits the reaction [Patulin results in increased degradation of OCLN protein]		 CTD PMID:19013514 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Patulin results in increased activity of ODC1 protein CTD PMID:19000704 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Patulin results in increased expression of PMAIP1 mRNA CTD PMID:21844328 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Patulin results in increased expression of PPP1R15A mRNA; Patulin results in increased expression of PPP1R15A protein CTD PMID:21844328 PMID:25577197 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMA2 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA2 mRNA]		 CTD PMID:35367319 NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMA5 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA5 mRNA]		 CTD PMID:35367319 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions
increases expression		 ISO NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA7 mRNA] CTD PMID:35367319 NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672 		JBrowse link
G Psma8 proteasome 20S subunit alpha 8 multiple interactions
increases expression		 ISO NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMA8 mRNA] CTD PMID:35367319 NCBI chr18:5,863,594...5,928,226
Ensembl chr18:5,863,608...5,928,226 		JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMC1 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMC1 mRNA]		 CTD PMID:35367319 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMD2 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD2 mRNA]		 CTD PMID:35367319 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Psmd3 proteasome 26S subunit, non-ATPase 3 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMD3 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD3 mRNA]		 CTD PMID:35367319 NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618 		JBrowse link
G Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 increases expression
multiple interactions		 ISO Patulin results in increased expression of PSMD4 mRNA
NFE2L1 protein affects the reaction [Patulin results in increased expression of PSMD4 mRNA]		 CTD PMID:35367319 NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions		 ISO Patulin results in increased expression of SLC7A11 protein
Patulin promotes the reaction [BECN1 protein modified form binds to SLC7A11 protein]		 CTD PMID:35772596 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation EXP Patulin results in increased phosphorylation of SMAD2 protein CTD PMID:34896196 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation EXP Patulin results in increased phosphorylation of SMAD3 protein CTD PMID:34896196 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 increases expression EXP Patulin results in increased expression of SMAD4 protein CTD PMID:34896196 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions		 EXP Patulin results in increased expression of SNAI1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Patulin results in increased expression of SNAI1 protein]		 CTD PMID:34896196 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression EXP Patulin results in increased expression of SNAI2 protein CTD PMID:34896196 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod1 superoxide dismutase 1 decreases response to substance ISO SOD1 protein results in decreased susceptibility to Patulin CTD PMID:17090621 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 ISO Patulin results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [Patulin results in decreased expression of SQSTM1 protein]		 CTD PMID:29604266 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 EXP Patulin results in increased expression of TGFB1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Patulin results in increased expression of TGFB1 protein]; Patulin promotes the reaction [FOS protein binds to TGFB1 promoter]; Patulin promotes the reaction [JUN protein binds to TGFB1 promoter]; Patulin results in increased expression of and results in increased secretion of TGFB1 protein; pyrazolanthrone inhibits the reaction [Patulin results in increased expression of TGFB1 protein]		 CTD PMID:34896196 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Patulin results in increased expression of TGFBR1 protein CTD PMID:34896196 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Patulin results in increased expression of TGFBR2 protein CTD PMID:34896196 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Patulin results in increased expression of TIMP1 protein CTD PMID:34896196 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Patulin results in decreased expression of TJP1 protein CTD PMID:19013514 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Patulin results in increased expression of TRP53; Patulin results in increased expression of TRP53 protein
Patulin results in increased expression of TP53 protein		 CTD PMID:19000704 PMID:19744505 PMID:26095701 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Patulin results in increased expression of VEGFA protein CTD PMID:34896196 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression
multiple interactions		 EXP Patulin results in increased expression of VIM protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Patulin results in increased expression of VIM protein]		 CTD PMID:34896196 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Patulin results in increased splicing of XBP1 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        antimicrobial agent 18274
          patulin 74
            patulin-4-bromothiophenol adduct 0
            patulin-4-bromothiophenol hapten 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  ester 17480
                                    carboxylic ester 16763
                                      lactone 13305
                                        gamma-lactone 6862
                                          patulin 74
                                            patulin-4-bromothiophenol adduct 0
                                            patulin-4-bromothiophenol hapten 0
paths to the root