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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naproxen
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Accession:CHEBI:7476 term browser browse the term
Definition:A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Synonyms:exact_synonym: (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
 related_synonym: (+)-2-(Methoxy-2-naphthyl)-propionic acid;   (+)-2-(Methoxy-2-naphthyl)-propionsaeure;   (S)-2-(6-Methoxy-2-naphthyl)propanoic acid;   (S)-2-(6-Methoxy-2-naphthyl)propionic acid;   (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid;   (S)-Naproxen;   2-(6-Methoxy-2-naphthyl)propionic acid;   Formula=C14H14O3;   InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1;   InChIKey=CMWTZPSULFXXJA-VIFPVBQESA-N;   SMILES=COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O;   naproxene;   naproxeno;   naproxenum
 alt_id: CHEBI:603695
 xref: Beilstein:3591067;   CAS:22204-53-1;   DrugBank:DB00788;   Drug_Central:1883;   HMDB:HMDB0001923;   KEGG:D00118;   LINCS:LSM-5689
 xref_mesh: MESH:D009288
 xref: PMID:18044350;   PMID:24478225;   PMID:9784154;   Patent:US3904682;   Patent:US4009197;   Wikipedia:Naproxen
 cyclic_relationship: is_conjugate_acid_of CHEBI:59527


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naproxen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Naproxen inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Naproxen results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression ISO Naproxen affects the expression of ABCB1 mRNA CTD PMID:18581209 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects expression
affects activity		 ISO Naproxen affects the expression of ABCG2 protein
Naproxen affects the activity of ABCG2 protein		 CTD PMID:18581209 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Naproxen results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Naproxen results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Naproxen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Naproxen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Naproxen results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin affects binding ISO
EXP		 [Naproxen binds to Cobalt] which binds to ALB protein; Naproxen binds to ALB protein CTD PMID:9353694 PMID:22178666 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bace1 beta-secretase 1 decreases expression ISO Naproxen results in decreased expression of BACE1 mRNA CTD PMID:16407166 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of BDNF protein] CTD PMID:22150557 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase decreases expression EXP Naproxen results in decreased expression of CAT protein CTD PMID:25034942 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL2 protein] CTD PMID:22150557 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL20 protein] CTD PMID:22150557 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL22 protein] CTD PMID:22150557 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL3 protein] CTD PMID:22150557 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15489888 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCR4 protein] CTD PMID:22150557 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP [Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Naproxen affects the reaction [Capsaicin results in increased expression of CD80 protein] CTD PMID:22150557 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cilk1 ciliogenesis associated kinase 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CILK1 protein] CTD PMID:22150557 NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTF protein] CTD PMID:22150557 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Cntfr ciliary neurotrophic factor receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTFR protein] CTD PMID:22150557 NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:56,823,965...56,841,392 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CSF2 protein] CTD PMID:22150557 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein] CTD PMID:22150557 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein] CTD PMID:22150557 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein] CTD PMID:22150557 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein] CTD PMID:22150557 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein] CTD PMID:22150557 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein] CTD PMID:22150557 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein] CTD PMID:22150557 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein] CTD PMID:22150557 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FAS protein] CTD PMID:22150557 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FASLG protein] CTD PMID:22150557 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein] CTD PMID:22150557 NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496 		JBrowse link
G Fgl1 fibrinogen-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FGL1 protein] CTD PMID:22150557 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093 		JBrowse link
G Fstl1 follistatin-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein] CTD PMID:22150557 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Naproxen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Naproxen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA1 protein] CTD PMID:22150557 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gfra2 GDNF family receptor alpha 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA2 protein] CTD PMID:22150557 NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein] CTD PMID:22150557 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GHR protein] CTD PMID:22150557 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of HCRT protein] CTD PMID:22150557 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Ide insulin degrading enzyme multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IDE protein] CTD PMID:22150557 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IFNG protein] CTD PMID:22150557 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL10 protein] CTD PMID:22150557 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein] CTD PMID:22150557 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IL1A protein] CTD PMID:22150557 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL1B protein]		 CTD PMID:14762100 PMID:15705740 PMID:22150557 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL2 protein] CTD PMID:22150557 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il3 interleukin 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein] CTD PMID:22150557 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL4 protein] CTD PMID:22150557 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL5 protein] CTD PMID:22150557 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:22150557 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions EXP Naproxen inhibits the reaction [Capsaicin results in increased expression of INHBA protein] CTD PMID:22150557 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Ins1 insulin 1 increases expression
multiple interactions		 ISO
EXP		 Naproxen results in increased expression of INS1 protein
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of INS1 protein]		 CTD PMID:22150557 PMID:23784744 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lep leptin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein] CTD PMID:22150557 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein] CTD PMID:22150557 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP2 protein] CTD PMID:22150557 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Naproxen CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Musk muscle associated receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MUSK protein] CTD PMID:22150557 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:22150557 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor increases expression
multiple interactions		 ISO
EXP		 Naproxen results in increased expression of NGFR protein
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein]		 CTD PMID:17409433 PMID:22150557 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Naproxen results in increased expression of NOS2 mRNA CTD PMID:16944022 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NRP1 protein] CTD PMID:22150557 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PDGFA protein] CTD PMID:22150557 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Plin2 perilipin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of PLIN2 protein] CTD PMID:22150557 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein] CTD PMID:22150557 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Naproxen results in increased activity of PPARA protein CTD PMID:11755111 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity EXP Naproxen results in increased activity of PPARG protein CTD PMID:11755111 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein] CTD PMID:22150557 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prlr prolactin receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRLR protein] CTD PMID:22150557 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prok1 prokineticin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PROK1 protein] CTD PMID:22150557 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP		 Naproxen results in decreased activity of PTGS1 protein CTD PMID:9258749 PMID:17164136 PMID:25034942 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
increases expression		 ISO
EXP		 Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
Naproxen results in decreased activity of PTGS2 protein
Naproxen results in increased expression of PTGS2		 CTD PMID:9258749 PMID:11840453 PMID:15489888 PMID:15705740 PMID:17164136 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15489888 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin decreases activity ISO Naproxen results in decreased activity of REN protein CTD PMID:2203262 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Retn resistin multiple interactions
decreases expression		 EXP
ISO		 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETN protein]
Naproxen results in decreased expression of RETN protein		 CTD PMID:22150557 PMID:23784744 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Retnlb resistin like beta multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETNLB protein] CTD PMID:22150557 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Naproxen affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G Sele selectin E multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELE protein] CTD PMID:22150557 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELL protein] CTD PMID:22150557 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Naproxen results in decreased activity of SLC22A2 protein CTD PMID:12388633 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Naproxen results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Naproxen results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Naproxen results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TAL1 protein] CTD PMID:22150557 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein] CTD PMID:22150557 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein] CTD PMID:22150557 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein] CTD PMID:22150557 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein] CTD PMID:22150557 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein] CTD PMID:22150557 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein] CTD PMID:22150557 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein] CTD PMID:22150557 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNF protein]		 CTD PMID:15489888 PMID:22150557 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein] CTD PMID:22150557 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein] CTD PMID:22150557 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
increases glucuronidation		 ISO Naproxen results in decreased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Naproxen		 CTD PMID:15593333 PMID:15843492 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Naproxen CTD PMID:15535975 PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Naproxen CTD PMID:15843492 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Naproxen CTD PMID:15535975 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Naproxen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation		 ISO Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Naproxen; UGT2B7 protein results in increased glucuronidation of Naproxen		 CTD PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein] CTD PMID:22150557 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VEGFA protein] CTD PMID:22150557 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        xenobiotic 18732
          naproxen 110
            desmethylnaproxen sulfate 0
            naproxcinod 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                carbocyclic compound 18607
                                  carbopolycyclic compound 17189
                                    carbobicyclic compound 5885
                                      naphthalenes 3849
                                        alkyloxynaphthalene 114
                                          methoxynaphthalene 114
                                            naproxen 110
                                              desmethylnaproxen sulfate 0
                                              naproxcinod 0
paths to the root