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Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antidote to curare poisoning
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Accession:CHEBI:74530 term browser browse the term
Definition:A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare.
Synonyms:related_synonym: antidote to curare;   antidote to tubocurarine;   antidote to tubocurarine poisoning;   antidotes to curare;   antidotes to curare poisoning;   antidotes to tubocurarine;   antidotes to tubocurarine poisoning;   curare antidote;   curare antidotes;   curare poisoning antidote;   curare poisoning antidotes;   tubocurarine antidote;   tubocurarine antidotes
 xref: pubmed:13358565;   pubmed:13386996;   pubmed:14128111;   pubmed:1579914;   pubmed:3896015;   pubmed:5333582;   pubmed:5352084;   pubmed:7720787



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(R)-pantothenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh8 atonal bHLH transcription factor 8 increases expression ISO Pantothenic Acid results in increased expression of ATOH8 mRNA CTD PMID:19397697 NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA CTD PMID:34323617 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid] CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Pantothenic Acid results in increased expression of CYP1B1 mRNA CTD PMID:19397697 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Pantothenic Acid results in increased expression of FAM43A mRNA CTD PMID:19397697 NCBI chr11:83,633,165...83,636,313
Ensembl chr11:83,633,154...83,695,297
JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Pantothenic Acid results in decreased expression of FUT7 mRNA CTD PMID:19397697 NCBI chr 3:28,635,913...28,640,407
Ensembl chr 3:28,637,107...28,641,388
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein CTD PMID:19397697 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hspb7 heat shock protein family B (small) member 7 increases expression ISO Pantothenic Acid results in increased expression of HSPB7 mRNA CTD PMID:19397697 NCBI chr 5:159,010,759...159,014,245
Ensembl chr 5:159,010,629...159,014,243
JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO Pantothenic Acid results in increased expression of ID1 mRNA CTD PMID:19397697 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Pantothenic Acid results in increased expression of ID3 mRNA CTD PMID:19397697 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Pantothenic Acid
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]
CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248
JBrowse link
G Il6 interleukin 6 increases expression ISO Pantothenic Acid results in increased expression of IL6 mRNA CTD PMID:19397697 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Marchf2 membrane associated ring-CH-type finger 2 increases expression ISO Pantothenic Acid results in increased expression of MARCHF2 mRNA CTD PMID:19397697 NCBI chr 7:15,183,931...15,209,988
Ensembl chr 7:15,183,925...15,202,002
JBrowse link
G Mtres1 mitochondrial transcription rescue factor 1 increases expression ISO Pantothenic Acid results in increased expression of MTRES1 mRNA CTD PMID:19397697 NCBI chr20:48,604,479...48,622,364
Ensembl chr20:48,604,372...48,622,014
JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein] CTD PMID:16112698 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor increases expression ISO Pantothenic Acid results in increased expression of MYCN mRNA CTD PMID:19397697 NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:41,446,684...41,452,508
JBrowse link
G Nhlrc1 NHL repeat containing E3 ubiquitin protein ligase 1 increases expression ISO Pantothenic Acid results in increased expression of NHLRC1 mRNA CTD PMID:19397697 NCBI chr17:17,880,570...17,883,411
Ensembl chr17:17,880,365...17,883,620
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Pantothenic Acid results in increased expression of NREP mRNA CTD PMID:19397697 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein] CTD PMID:16112698 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764
JBrowse link
G Pou3f4 POU class 3 homeobox 4 increases expression ISO Pantothenic Acid results in increased expression of POU3F4 mRNA CTD PMID:19397697 NCBI chr  X:79,974,808...79,976,085
Ensembl chr  X:79,974,627...79,987,326
JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein increases expression ISO Pantothenic Acid results in increased expression of PTPRCAP mRNA CTD PMID:19397697 NCBI chr 1:210,878,593...210,880,752
Ensembl chr 1:210,878,573...210,881,753
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein CTD PMID:34323617 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121
JBrowse link
G Slc51b SLC51 subunit beta increases expression ISO Pantothenic Acid results in increased expression of SLC51B mRNA CTD PMID:19397697 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109
JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions
EXP
ISO
SLC5A6 results in increased transport of Pantothenic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Pantothenic Acid results in decreased expression of SOX2 mRNA CTD PMID:19397697 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350
JBrowse link
G Tf transferrin multiple interactions ISO [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tmem18 transmembrane protein 18 increases expression ISO Pantothenic Acid results in increased expression of TMEM18 mRNA CTD PMID:19397697 NCBI chr 6:52,934,419...52,941,868
Ensembl chr 6:52,934,419...52,941,866
JBrowse link
G Zfp575 zinc finger protein 575 decreases expression ISO Pantothenic Acid results in decreased expression of ZNF575 mRNA CTD PMID:19397697 NCBI chr 1:89,302,927...89,305,087
Ensembl chr 1:89,302,904...89,305,187
JBrowse link
galanthamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
EXP
ISO
Galantamine results in decreased activity of ACHE protein
Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
CTD PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon
galanthamine inhibits the reaction [ethanol increases expression of RAGE protein in basal forebrain cholinergic neurons]
RGD PMID:29572553 PMID:33716687 RGD:152995414, RGD:597538457 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein] CTD PMID:27346436 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO
Galantamine results in decreased activity of BCHE protein CTD PMID:19345205 PMID:29886234 PMID:31125207 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon
Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
CTD
RGD
PMID:27346436 PMID:29572553 RGD:152995414 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein] CTD PMID:27346436 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions EXP Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:27346436 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Galantamine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Galantamine results in decreased expression of CHRM1 protein CTD PMID:28837785 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein] CTD PMID:27346436 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein] CTD PMID:27346436 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
neostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Neostigmine results in decreased activity of ACHE protein CTD PMID:623676 PMID:19105816 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Avp arginine vasopressin increases abundance EXP Neostigmine increases abundance of Avp protein in plasma RGD PMID:19515985 RGD:596920310 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Bche butyrylcholinesterase affects response to substance ISO BCHE affects the susceptibility to Neostigmine CTD PMID:18399847 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Il10 interleukin 10 increases expression EXP Neostigmine results in increased expression of IL10 protein CTD PMID:17872965 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Pygl glycogen phosphorylase L increases activity
multiple interactions
EXP Neostigmine results in increased activity of PYGL protein modified form
Phentolamine inhibits the reaction [Neostigmine results in increased activity of PYGL protein modified form]
CTD PMID:1350317 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Neostigmine results in decreased expression of TNF protein CTD PMID:17872965 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
physostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525
JBrowse link
G Ache acetylcholinesterase decreases activity
affects expression
multiple interactions
increases expression
ISO
EXP
Physostigmine results in decreased activity of ACHE protein
Physostigmine affects the expression of ACHE mRNA
[Corticosterone co-treated with Physostigmine] results in decreased activity of ACHE protein; Physostigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]] which results in decreased carbamoylation of ACHE protein; ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
asoxime chloride affects the reaction [Physostigmine results in decreased activity of ACHE protein]; asoxime chloride promotes the reaction [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Physostigmine affects the expression of and affects the activity of ACHE protein; Physostigmine affects the reaction [Sarin affects the expression of ACHE mRNA]; Physostigmine affects the reaction [Sarin affects the expression of and affects the activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine results in increased expression of ACHE protein
CTD PMID:4859365 PMID:11740913 PMID:14644616 PMID:15586889 PMID:19283689 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G App amyloid beta precursor protein increases secretion EXP Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915 PMID:8624119 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP
ISO
Physostigmine results in decreased activity of BCHE protein
Physostigmine inhibits the reaction [Sarin results in decreased activity of BCHE protein]
CTD PMID:19283689 PMID:32795450 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Physostigmine inhibits the reaction [Corticosterone results in decreased expression of CCL2 mRNA] CTD PMID:28500787 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Physostigmine results in decreased activity of CES2 protein CTD PMID:9169443 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Chat choline O-acetyltransferase decreases expression
increases expression
EXP Physostigmine results in decreased expression of CHAT protein
Physostigmine results in increased expression of CHAT protein
CTD PMID:22640809 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of FOS mRNA] CTD PMID:11337201 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein] CTD PMID:28499986 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Physostigmine affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Physostigmine affects the reaction [Corticosterone affects the expression of IL1B mRNA] CTD PMID:28500787 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in decreased expression of IL6 mRNA CTD PMID:28500787 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of JUN mRNA] CTD PMID:11337201 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in decreased expression of LIF mRNA CTD PMID:28500787 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein] CTD PMID:28499986 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Osm oncostatin M multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in increased expression of OSM mRNA CTD PMID:28500787 PMID:29846716 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827
JBrowse link
G Slc18a3 solute carrier family 18 member A3 increases expression EXP Physostigmine results in increased expression of SLC18A3 protein CTD PMID:22640809 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:28499986 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Physostigmine results in decreased phosphorylation of STAT3 protein CTD PMID:28500787 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Syp synaptophysin multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:28499986 NCBI chr  X:17,521,348...17,536,449
Ensembl chr  X:17,521,348...17,536,984
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in increased expression of TNF mRNA CTD PMID:28500787 PMID:29846716 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link

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  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            protective agent 18433
              antidote 10106
                antidote to curare poisoning 74
                  (R)-pantothenic acid + 32
                  galanthamine 22
                  neostigmine + 6
                  physostigmine + 27
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