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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorquinaldol
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Accession:CHEBI:74500 term browser browse the term
Definition:A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.
Synonyms:exact_synonym: 5,7-dichloro-2-methylquinolin-8-ol
 related_synonym: 2-methyl-5,7-dichloro-8-hydroxyquinoline;   5,7-dichloro-2-methyl-8-quinolinol;   5,7-dichloro-8-hydroxy-2-methylquinoline;   5,7-dichloro-8-hydroxyquinaldine;   5,7-dichloro-8-quinaldinol;   Formula=C10H7Cl2NO;   InChI=1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3;   InChIKey=GPTXWRGISTZRIO-UHFFFAOYSA-N;   SMILES=Cc1ccc2c(Cl)cc(Cl)c(O)c2n1;   chlorquinaldolum;   clorquinaldol
 xref: CAS:72-80-0;   Drug_Central:3095;   KEGG:D07208
 xref_mesh: MESH:D002750
 xref: PMID:13307049;   PMID:478062;   PMID:6228382;   Patent:US2411670;   Reaxys:156683;   Wikipedia:Chlorquinaldol


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chlorquinaldol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of CASP1 protein] CTD PMID:36002070 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein] CTD PMID:36002070 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein] CTD PMID:36002070 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Chlorquinaldol inhibits the reaction [NLRP3 protein binds to PYCARD protein] CTD PMID:36002070 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Chlorquinaldol inhibits the reaction [NLRP3 protein binds to PYCARD protein] CTD PMID:36002070 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          antimicrobial drug 11254
            antiprotozoal drug 7466
              chlorquinaldol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  organonitrogen heterocyclic compound 18546
                                    quinolines 2684
                                      hydroxyquinoline 331
                                        monohydroxyquinoline 328
                                          chlorquinaldol 5
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