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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nabumetone
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Accession:CHEBI:7443 term browser browse the term
Definition:A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Synonyms:related_synonym: 4-(6-Methoxy-2-naphthalenyl)-2-butanone;   4-(6-Methoxy-2-naphthyl)-2-butanone;   Formula=C15H16O2;   InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3;   InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N;   Relafen;   SMILES=COc1ccc2cc(CCC(C)=O)ccc2c1;   nabumetona;   nabumetonum
 xref: CAS:42924-53-8;   DrugBank:DB00461;   Drug_Central:1863;   HMDB:HMDB0014604;   KEGG:D00425;   LINCS:LSM-3453
 xref_mesh: MESH:C035605
 xref: PDBeChem:NBO;   PMID:21532165;   PMID:21650014;   PMID:21674107;   PMID:21898684;   PMID:22028826;   PMID:22298755;   PMID:22381180;   PMID:22605805;   PMID:22977877;   PMID:23020786;   PMID:23129452;   PMID:23132511;   PMID:23225308;   PMID:23584048;   PMID:23781467;   PMID:23781476;   PMID:23806470;   PMID:24074034;   PMID:24083957;   Reaxys:2103472;   Wikipedia:Nabumetone


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nabumetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nabumetone results in decreased expression of BCL2 protein CTD PMID:16019514 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO nabumetone results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO nabumetone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS1 protein CTD PMID:9258749 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS2 protein CTD PMID:9258749 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sell selectin L affects expression ISO nabumetone affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Utrn utrophin increases expression ISO nabumetone results in increased expression of UTRN mRNA; nabumetone results in increased expression of UTRN protein CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pro-agent 11549
          prodrug 11293
            nabumetone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                carbocyclic compound 18579
                                  carbopolycyclic compound 17179
                                    carbobicyclic compound 5884
                                      naphthalenes 3849
                                        alkyloxynaphthalene 113
                                          methoxynaphthalene 113
                                            nabumetone 7
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