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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazoloquinoline
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Accession:CHEBI:74147 term browser browse the term
Definition:Any organic heterotricyclic compound that consists of a pyrazole ring ortho-fused to a quinoline.
Synonyms:related_synonym: pyrazoloquinolines


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quinpirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 EXP Quinpirole results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]		 CTD PMID:9111066 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
increases activity
increases expression		 EXP Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]
Quinpirole results in increased expression of ABCB1B mRNA		 CTD PMID:9111066 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Adcy5 adenylate cyclase 5 multiple interactions ISO ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Cfl1 cofilin 1 multiple interactions
increases phosphorylation		 ISO DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein] CTD PMID:27717053 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases response to substance
affects response to substance
increases activity		 ISO
EXP		 [Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; [Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein; DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]; Quinpirole binds to and results in increased activity of DRD2 protein; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]; DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]
DRD2 results in increased susceptibility to Quinpirole
DRD2 protein affects the susceptibility to Quinpirole
[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine; cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]; estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]; Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]; Quinpirole binds to and results in increased activity of DRD2 protein; tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]
DRD2 protein results in increased susceptibility to Quinpirole
Quinpirole results in increased activity of DRD2 protein		 CTD PMID:1724532 PMID:8032591 PMID:9547254 PMID:10936494 PMID:11124974 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO
EXP		 Quinpirole binds to and results in increased activity of DRD3 protein
mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]		 CTD PMID:10683862 PMID:12523492 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 affects binding EXP quinpirole binds to Drd4 protein RGD PMID:17314300 RGD:1625010 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA] CTD PMID:9729266 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
multiple interactions		 EXP Quinpirole results in decreased expression of FOS mRNA; Quinpirole results in decreased expression of FOS protein
Quinpirole results in increased expression of FOS protein
8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein; [SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein]; Quinpirole inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]		 CTD PMID:7845612 PMID:7914358 PMID:8102797 PMID:8577368 PMID:8864302 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Quinpirole inhibits the reaction [Ovalbumin results in increased expression of GRIA1 protein modified form] CTD PMID:34624383 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Quinpirole inhibits the reaction [Ovalbumin results in increased expression of GRIA2 protein modified form] CTD PMID:34624383 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein] CTD PMID:12122080 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK1 protein CTD PMID:27717053 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK3 protein CTD PMID:27717053 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO Quinpirole results in decreased secretion of MMP9 protein CTD PMID:27920206 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] CTD PMID:12183048 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Quinpirole results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions		 ISO Quinpirole results in decreased expression of POU5F1 mRNA
DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]		 CTD PMID:27920206 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Quinpirole CTD PMID:15728856 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein CTD PMID:27717053 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects response to substance ISO SLC18A2 protein affects the susceptibility to Quinpirole CTD PMID:12716422 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression
affects localization		 EXP
ISO		 Quinpirole results in increased expression of SLC6A3 mRNA
Quinpirole affects the localization of SLC6A3 protein		 CTD PMID:20875051 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA CTD PMID:9751140 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Quinpirole results in increased expression of TREX1 mRNA CTD PMID:20298760 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pyrazoloquinoline 26
                    2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                    SCH51344 0
                    quinpirole 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      pyrazoloquinoline 26
                                        2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                                        SCH51344 0
                                        quinpirole 26
paths to the root