CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: GR 113808
Accession: CHEBI:73380
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Definition: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Synonyms: exact_synonym: (1-{2-[(methylsulfonyl)amino]ethyl}piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate
related_synonym: Formula=C19H27N3O4S; GR113808; InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3; InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N; SMILES=Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
xref: CAS:144625-51-4; LINCS:LSM-3098
xref_mesh: MESH:C082871
xref: PMID:23597562; Patent:EP501322; Reaxys:7778599; Wikipedia:GR-113\,808
G
Htr4
5-hydroxytryptamine receptor 4
multiple interactions affects binding
ISO EXP
GR 113808 binds to and results in decreased activity of HTR4 protein GR 113808 binds to HTR4 protein
CTD
PMID:11020291 PMID:12736770 PMID:15236628
NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
G
Il1b
interleukin 1 beta
multiple interactions
ISO
GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
CTD
PMID:30611738
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD
PMID:30611738
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mpo
myeloperoxidase
multiple interactions
ISO
GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]
CTD
PMID:30611738
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Napepld
N-acyl phosphatidylethanolamine phospholipase D
multiple interactions
ISO
GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]
CTD
PMID:30611738
NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
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