Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium-glucose transport protein subtype 2 inhibitor
go back to main search page
Accession:CHEBI:73273 term browser browse the term
Definition:Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.
Synonyms:related_synonym: SGLT2 inhibitor;   SGLT2 inhibitors;   sodium glucose co-transporter 2 inhibitor;   sodium glucose co-transporter 2 inhibitors;   sodium-glucose transport protein subtype 2 inhibitors;   sodium/glucose cotransporter 2 inhibitor;   sodium/glucose cotransporter 2 inhibitors
 xref: Wikipedia:Sodium/glucose_cotransporter_2


show annotations for term's descendants           Sort by:
bexagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO bexagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21215314 PMID:36867399 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of bexagliflozin CTD PMID:36867399 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
canagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Canagliflozin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:27566243 PMID:28837785 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression
multiple interactions		 EXP Canagliflozin results in decreased expression of CHRM1 protein
Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]		 CTD PMID:28837785 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Canagliflozin results in increased expression of HAVCR1 CTD PMID:25130857 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Canagliflozin results in increased expression of LHB protein CTD PMID:25289773 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Pth parathyroid hormone decreases expression EXP Canagliflozin results in decreased expression of PTH protein CTD PMID:25289773 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Canagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306 		JBrowse link
dapagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ACTA2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] CTD PMID:30551545 PMID:34939712 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 multiple interactions EXP [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein] CTD PMID:37741535 NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33412153 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein] CTD PMID:28807765 PMID:32259528 PMID:34391751 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ATF4 mRNA] CTD PMID:37741535 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein] CTD PMID:34939712 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [Thapsigargin co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [Vildagliptin co-treated with dapagliflozin] inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:28807765 PMID:33412153 PMID:35438302 PMID:37741535 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] CTD PMID:28807765 PMID:32259528 PMID:33412153 PMID:35438302 PMID:37352119 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions EXP dapagliflozin affects the reaction [Streptozocin results in decreased expression of BECN1 mRNA]; dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]; dapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BECN1 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]] CTD PMID:33412153 PMID:33882723 PMID:37352119 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein] CTD PMID:34939712 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; SRT1460 promotes the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]] CTD PMID:33412153 PMID:33882723 PMID:35438302 PMID:37741535 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] CTD PMID:30551545 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase multiple interactions EXP dapagliflozin inhibits the reaction [Streptozocin results in decreased expression of CAT protein] CTD PMID:37352119 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein] CTD PMID:30551545 PMID:34939712 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein] CTD PMID:32259528 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein] CTD PMID:34939712 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]; [taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased expression of CYCS protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of CYCS protein] CTD PMID:32259528 PMID:33882723 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 protein] CTD PMID:37741535 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2A mRNA] CTD PMID:37741535 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]] CTD PMID:37741535 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Epo erythropoietin multiple interactions EXP dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of EPO protein] CTD PMID:34391751 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein] CTD PMID:32259528 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Atorvastatin promotes the reaction [dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein]]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein] CTD PMID:34939712 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [Streptozocin results in increased expression of GPT protein] CTD PMID:32259528 PMID:37352119 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]] CTD PMID:33882723 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of HMOX1 protein] CTD PMID:32259528 PMID:33412153 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP dapagliflozin inhibits the reaction [IL1B protein results in increased expression of HSPA5 mRNA] CTD PMID:37741535 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein] CTD PMID:33412153 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il15 interleukin 15 multiple interactions EXP dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]] CTD PMID:33882723 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of IL1B protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; [Thapsigargin co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of ATF4 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of DDIT3 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2A mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of HSPA5 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; SRT1460 promotes the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]] CTD PMID:34939712 PMID:37741535 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; dapagliflozin promotes the reaction [Vildagliptin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]] CTD PMID:28807765 PMID:34939712 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor multiple interactions EXP [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; dapagliflozin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein] CTD PMID:28807765 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of JAK2 protein] CTD PMID:34391751 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 PMID:32259528 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased lipidation of MAP1LC3B protein]; dapagliflozin inhibits the reaction [Streptozocin results in decreased expression of MAP1LC3B mRNA] CTD PMID:34939712 PMID:37352119 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP dapagliflozin inhibits the reaction [Colistin results in increased activity of MAPK8 protein] CTD PMID:33882723 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mir192 microRNA 192 multiple interactions EXP dapagliflozin inhibits the reaction [Streptozocin results in increased expression of MIR192 mRNA] CTD PMID:37352119 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mir21 microRNA 21 multiple interactions EXP dapagliflozin inhibits the reaction [Streptozocin results in increased expression of MIR21 mRNA] CTD PMID:37352119 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [SRT1460 co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]] CTD PMID:37741535 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP dapagliflozin inhibits the reaction [Streptozocin results in increased expression of MMP2 mRNA] CTD PMID:37352119 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:33412153 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of and results in increased phosphorylation of MTOR protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of MTOR protein] CTD PMID:33412153 PMID:34939712 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]; dapagliflozin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid affects the expression of NFE2L2 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]] CTD PMID:32259528 PMID:33412153 PMID:33882723 PMID:37352119 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]] CTD PMID:33882723 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein] CTD PMID:34939712 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Oga O-GlcNAcase multiple interactions EXP [taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased activity of OGA protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; dapagliflozin inhibits the reaction [Colistin results in increased activity of OGA protein] CTD PMID:30551545 PMID:33882723 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G Plin2 perilipin 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PLIN2 protein] CTD PMID:34939712 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein] CTD PMID:32259528 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein] CTD PMID:32259528 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein] CTD PMID:32259528 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcz protein kinase C, zeta multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein] CTD PMID:32259528 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PTGS2 protein] CTD PMID:34939712 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of RELA protein]; [dapagliflozin co-treated with Vildagliptin] inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]; dapagliflozin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]] CTD PMID:28807765 PMID:33412153 PMID:33882723 PMID:34939712 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]; dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]] CTD PMID:34939712 PMID:37741535 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO dapagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of SQSTM1 protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SQSTM1 protein] CTD PMID:33412153 PMID:34939712 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein] CTD PMID:32259528 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 EXP dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of STAT3 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]]
dapagliflozin results in increased expression of STAT3 protein		 CTD PMID:33882723 PMID:35438302 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]; dapagliflozin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]] CTD PMID:30551545 PMID:33882723 PMID:37352119 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]] CTD PMID:33882723 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]] CTD PMID:30551545 PMID:33412153 PMID:33882723 PMID:34391751 PMID:34939712 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TP53 protein] CTD PMID:34391751 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VIM protein] CTD PMID:34939712 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vnn1 vanin 1 multiple interactions EXP dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] CTD PMID:30551545 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions EXP [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of WT1 protein] CTD PMID:34939712 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
empagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein] CTD PMID:35654124 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Cat catalase multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:35654124 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA] CTD PMID:35654124 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35654124 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in decreased expression of ELF2 mRNA] CTD PMID:35654124 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of HSPA5 protein] CTD PMID:35654124 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of IL1B protein] CTD PMID:35654124 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mir211 microRNA 211 multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of MIR211 mRNA] CTD PMID:35654124 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644 		JBrowse link
G Snca synuclein alpha multiple interactions EXP empagliflozin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:35654124 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          sodium-glucose transport protein subtype 2 inhibitor 75
            Synjardy 0
            TA-1887 0
            bexagliflozin 2
            canagliflozin + 6
            canagliflozin hydrate 0
            dapagliflozin + 67
            dapagliflozin propanediol monohydrate 0
            empagliflozin + 9
            sotagliflozin 0
paths to the root