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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antimutagen
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Accession:CHEBI:73190 term browser browse the term
Definition:An agent that reduces or interferes with the mutagenic actions or effects of a substance.
Synonyms:related_synonym: antimutagenic agent;   antimutagenic agents;   antimutagens


show annotations for term's descendants           Sort by:
anthraflavic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Alb albumin affects binding ISO 2,6-dihydroxyanthraquinone binds to ALB protein CTD PMID:16404478 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA CTD PMID:11502733 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA CTD PMID:11502733 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:12756209 PMID:14557274 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
dibenzoylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO dibenzoylmethane results in increased expression of ABCG2 protein CTD PMID:17077187 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		ISO dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforaphane] results in decreased phosphorylation of AKT1 protein 		CTD PMID:17942926 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression 		ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein] CTD PMID:21523861 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO dibenzoylmethane results in increased expression of BAX protein CTD PMID:17942926 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:16051634 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein] CTD PMID:21523861 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions 		ISO dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA 		CTD PMID:17942926 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dibenzoylmethane results in decreased expression of CCND1 protein CTD PMID:17942926 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO dibenzoylmethane results in decreased expression of CDKN1A protein CTD PMID:17942926 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Clu clusterin decreases expression
multiple interactions 		ISO dibenzoylmethane results in decreased expression of CLU mRNA
[sulforaphane co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA 		CTD PMID:17942926 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity
multiple interactions
increases expression 		ISO dibenzoylmethane results in increased activity of EPHX1 protein
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA 		CTD PMID:3621371 PMID:17942926 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer] CTD PMID:16051634 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions 		ISO dibenzoylmethane results in increased expression of GCLC mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA 		CTD PMID:17942926 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions 		ISO dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA 		CTD PMID:17942926 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression 		ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA 		CTD PMID:17942926 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA] CTD PMID:16051634 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer] CTD PMID:16051634 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases response to substance 		ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane 		CTD PMID:21523861 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA CTD PMID:17942926 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dibenzoylmethane results in decreased expression of PTGS2 protein CTD PMID:17942926 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA] CTD PMID:16051634 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
oltipraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO oltipraz results in decreased expression of ABCB11 mRNA CTD PMID:16837569 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP 		oltipraz results in increased expression of ABCB1 mRNA
oltipraz results in increased expression of ABCB1A mRNA 		CTD PMID:16837569 PMID:18418891 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP oltipraz results in increased expression of ABCB1B mRNA CTD PMID:18418891 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein CTD PMID:18032408 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression 		ISO
EXP 		[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA
oltipraz results in increased expression of ABCC2 mRNA; oltipraz results in increased expression of ABCC2 protein 		CTD PMID:12920174 PMID:15833929 PMID:16837569 PMID:18032408 PMID:25752797 More... NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions 		ISO
EXP 		oltipraz results in increased expression of ABCC3 mRNA
oltipraz results in increased expression of ABCC3 mRNA; oltipraz results in increased expression of ABCC3 protein
[oltipraz results in increased expression of ABCC3 protein] which affects the export of Acetaminophen metabolite
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA] 		CTD PMID:12920174 PMID:15833929 PMID:16837569 PMID:18418891 PMID:22496397 More... NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression 		ISO
EXP 		[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]
oltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]
oltipraz results in increased expression of ABCC4 mRNA; oltipraz results in increased expression of ABCC4 protein 		CTD PMID:15833929 PMID:18032408 PMID:18418891 PMID:20395535 PMID:22496397 More... NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression 		ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
oltipraz results in increased expression of ABCC5 mRNA 		CTD PMID:15833929 PMID:18032408 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases expression 		ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA
oltipraz results in increased expression of ABCC6 mRNA 		CTD PMID:15833929 NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
increases expression 		ISO oltipraz promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite]
oltipraz results in increased activity of ABCG2 protein
oltipraz results in increased expression of ABCG2 mRNA 		CTD PMID:15917307 PMID:16837569 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA CTD PMID:22496397 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO
EXP 		oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of ACE mRNA]] 		CTD PMID:29211853 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP
ISO 		oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]] 		CTD PMID:29211853 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO 		oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of AGT mRNA]]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]] 		CTD PMID:29211853 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity 		ISO [oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]
oltipraz results in increased activity of AHR protein 		CTD PMID:11959854 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity EXP oltipraz results in increased activity of AKR7A3 protein CTD PMID:9328168 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153 		JBrowse link
G Alb albumin decreases expression EXP oltipraz results in decreased expression of ALB mRNA CTD PMID:9395210 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression 		ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA] CTD PMID:17998271 PMID:22496397 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA
oltipraz inhibits the reaction [Acetaminophen results in increased expression of BAX protein] 		CTD PMID:19433268 PMID:33959992 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA CTD PMID:19433268 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein] CTD PMID:33959992 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Dexamethasone co-treated with oltipraz] results in increased activity of CEBPB protein; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]; oltipraz results in increased localization of and results in increased activity of CEBPB protein CTD PMID:12509401 PMID:15319326 PMID:15870285 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Ces1d carboxylesterase 1D increases expression
multiple interactions 		ISO oltipraz results in increased expression of CES1 mRNA
NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA] 		CTD PMID:30114225 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Ces2c carboxylesterase 2C increases expression
multiple interactions 		ISO oltipraz results in increased expression of CES2C mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA] 		CTD PMID:22429928 NCBI chr 1:270,377,201...270,384,768
Ensembl chr 1:270,374,913...270,384,801 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects activity
decreases activity
increases expression
affects metabolic processing 		ISO
EXP 		1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [[oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA]; [oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; [oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; oltipraz results in increased expression of and results in increased activity of CYP1A1 protein; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]
oltipraz affects the activity of CYP1A1 protein
oltipraz metabolite results in decreased activity of CYP1A1 protein
oltipraz results in increased expression of CYP1A1 mRNA; oltipraz results in increased expression of CYP1A1 protein
CYP1A1 protein affects the metabolism of oltipraz 		CTD PMID:10775323 PMID:11959854 PMID:15831204 PMID:15890477 PMID:15920769 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
affects metabolic processing
multiple interactions
increases activity
increases expression 		ISO
EXP 		oltipraz metabolite results in decreased activity of CYP1A2 protein; oltipraz results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of oltipraz
oltipraz inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline]
oltipraz results in increased activity of CYP1A2 protein
oltipraz results in increased expression of CYP1A2 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA] 		CTD PMID:8625305 PMID:10775323 PMID:15831204 PMID:15920769 PMID:22496397 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
affects activity 		ISO oltipraz metabolite results in decreased activity of CYP1B1 protein
oltipraz results in increased expression of CYP1B1 mRNA
oltipraz affects the activity of CYP1B1 protein 		CTD PMID:10775323 PMID:15890477 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects metabolic processing
increases expression 		EXP CYP2B1 protein affects the metabolism of oltipraz
oltipraz results in increased expression of CYP2B1 mRNA; oltipraz results in increased expression of CYP2B1 protein 		CTD PMID:15831204 PMID:15920769 PMID:18418891 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects metabolic processing
increases expression 		EXP CYP2B2 protein affects the metabolism of oltipraz
oltipraz results in increased expression of CYP2B2 mRNA; oltipraz results in increased expression of CYP2B2 protein 		CTD PMID:15831204 PMID:15920769 PMID:18418891 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
increases expression 		ISO oltipraz results in decreased activity of CYP2B6 protein
oltipraz results in increased expression of CYP2B6 mRNA; oltipraz results in increased expression of CYP2B6 protein
oltipraz results in increased expression of CYP2B10 mRNA 		CTD PMID:17627975 PMID:19833192 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects metabolic processing EXP CYP2D1 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects activity ISO oltipraz affects the activity of CYP2E1 protein CTD PMID:10775323 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
affects activity
decreases activity 		EXP
ISO 		CYP3A2 protein affects the metabolism of oltipraz
oltipraz affects the activity of CYP3A4 protein
oltipraz metabolite results in decreased activity of CYP3A4 protein; oltipraz results in decreased activity of CYP3A4 protein 		CTD PMID:10775323 PMID:15831204 PMID:15920769 PMID:19833192 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing
increases expression 		EXP CYP3A23-3A1 protein affects the metabolism of oltipraz
oltipraz results in increased expression of CYP3A23-3A1 mRNA 		CTD PMID:15831204 PMID:15920769 PMID:18418891 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP oltipraz results in increased expression of EPHX1 mRNA CTD PMID:18418891 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in increased activity of GOT1 protein] CTD PMID:33959992 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:33959992 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in decreased activity of GPX3 protein] CTD PMID:33959992 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in decreased expression of and results in increased secretion of GSTA1 protein]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of GSTA1 mRNA]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of GSTA1 protein] CTD PMID:31385618 PMID:33959992 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
multiple interactions 		EXP
ISO 		oltipraz results in increased expression of GSTA2 mRNA; oltipraz results in increased expression of GSTA2 protein
2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]
oltipraz results in increased expression of GSTA1 mRNA; oltipraz results in increased expression of GSTA1 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA] 		CTD PMID:9203627 PMID:11309284 PMID:12242683 PMID:12509401 PMID:15155840 More... NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP oltipraz results in increased expression of GSTA3 mRNA; oltipraz results in increased expression of GSTA3 protein CTD PMID:9203627 PMID:9794803 NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression
multiple interactions 		ISO oltipraz results in increased expression of GSTA4 mRNA; oltipraz results in increased expression of GSTA4 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA4 mRNA] 		CTD PMID:11309284 PMID:18723825 PMID:22496397 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity
increases expression 		EXP oltipraz results in increased activity of GSTA5 protein
oltipraz results in increased expression of GSTA5 mRNA; oltipraz results in increased expression of GSTA5 protein 		CTD PMID:8051171 PMID:8625305 PMID:9203627 PMID:9328168 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression 		ISO
EXP 		[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA] CTD PMID:9203627 PMID:18723825 PMID:22496397 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression 		ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA] CTD PMID:18723825 PMID:22496397 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm4 glutathione S-transferase mu 4 multiple interactions
increases expression 		ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA] CTD PMID:18723825 PMID:22496397 NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression 		ISO
EXP 		[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]
oltipraz results in increased expression of GSTM3 protein 		CTD PMID:9794803 PMID:18723825 PMID:22496397 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions 		ISO
EXP 		oltipraz results in increased expression of GSTP1 mRNA
oltipraz results in increased expression of and results in increased activity of GSTP1 protein
oltipraz results in increased expression of GSTP1 protein 		CTD PMID:9794803 PMID:15374950 PMID:16950796 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects localization
increases expression 		EXP oltipraz affects the localization of GSTT1 protein
oltipraz results in increased expression of GSTT1 protein 		CTD PMID:9794803 PMID:9855024 PMID:10413528 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; oltipraz inhibits the reaction [Acetaminophen results in decreased expression of HNF1A protein] CTD PMID:31385618 PMID:33959992 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]] CTD PMID:29211853 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Ivl involucrin decreases expression ISO oltipraz results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of JUN protein] CTD PMID:33959992 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] CTD PMID:33959992 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO
EXP 		oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of MAS1 mRNA]] 		CTD PMID:29211853 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA CTD PMID:19433268 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression
multiple interactions 		ISO oltipraz results in increased expression of MGMT mRNA
oltipraz results in increased expression of and results in increased activity of MGMT protein 		CTD PMID:16950796 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions
increases expression 		ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA
oltipraz results in increased expression of MGST3 mRNA 		CTD PMID:18723825 PMID:22496397 NCBI chr13:82,059,480...82,080,418
Ensembl chr13:82,059,480...82,080,575 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects activity
affects response to substance
multiple interactions
increases activity 		ISO
EXP 		oltipraz affects the activity of NFE2L2 protein
NFE2L2 protein affects the susceptibility to oltipraz
[oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B35 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES1G mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of SULT3A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT1A6A mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B36 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz binds to and results in increased activity of NFE2L2 protein; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein]] 		CTD PMID:11309284 PMID:15833929 PMID:15919853 PMID:19150646 PMID:20086057 More... NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
increases expression 		ISO
EXP 		oltipraz results in increased activity of NQO1 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]
oltipraz metabolite results in increased expression of NQO1 protein; oltipraz results in increased expression of NQO1 mRNA; oltipraz results in increased expression of NQO1 protein
oltipraz promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] 		CTD PMID:11309284 PMID:12407167 PMID:15919853 PMID:17627975 PMID:18418891 More... NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein] CTD PMID:19433268 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO oltipraz results in decreased expression of SLC10A1 mRNA CTD PMID:16837569 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO oltipraz results in decreased expression of SLC22A7 mRNA CTD PMID:16837569 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO oltipraz results in decreased expression of SLCO1B3 mRNA CTD PMID:16837569 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO oltipraz results in increased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO oltipraz inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:33959992 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP oltipraz results in increased expression of SOD2 mRNA CTD PMID:9395210 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO oltipraz results in increased expression of TXNRD1 mRNA CTD PMID:16451816 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO oltipraz inhibits the reaction [Doxorubicin results in decreased expression of UCP2 protein] CTD PMID:29061315 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions 		ISO oltipraz results in increased expression of UGT1A1 mRNA
oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA] 		CTD PMID:15374950 PMID:19144771 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO oltipraz results in increased expression of UGT1A5 mRNA CTD PMID:19144771 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase family 1 member A6a increases expression
multiple interactions 		EXP
ISO 		oltipraz results in increased expression of UGT1A6 mRNA
oltipraz results in increased expression of UGT1A mRNA; oltipraz results in increased expression of UGT1A6A mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT1A6A mRNA]; oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A mRNA] 		CTD PMID:15374950 PMID:18418891 PMID:22496397 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO oltipraz results in decreased expression of UGT2A3 mRNA CTD PMID:22496397 NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,851,969...20,869,973 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression
multiple interactions
increases expression 		ISO
EXP 		oltipraz results in decreased expression of UGT2B1 mRNA
[oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA
oltipraz results in increased expression of UGT2B1 mRNA 		CTD PMID:18418891 PMID:19144771 PMID:22496397 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases expression
multiple interactions 		ISO oltipraz results in increased expression of UGT2B34 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA] 		CTD PMID:22496397 NCBI chr14:21,436,939...21,483,494
Ensembl chr14:21,462,841...21,483,494 		JBrowse link
ortho-vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        antimutagen 94
          4',5,6,7-tetramethoxyflavone 0
          4',6,7-trihydroxyisoflavone 0
          anthraflavic acid 6
          dibenzoylmethane 21
          garbanzol 0
          oltipraz 76
          ortho-vanillin 1
          pinobanksin 0
          zinolol 0
paths to the root