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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lumiracoxib
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Accession:CHEBI:73044 term browser browse the term
Definition:An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Synonyms:exact_synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
 related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid;   COX 189;   COX189;   Formula=C15H13ClFNO2;   InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20);   InChIKey=KHPKQFYUPIUARC-UHFFFAOYSA-N;   Prexige;   SMILES=Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1;   lumiracoxibum
 xref: CAS:220991-20-8;   DrugBank:DB01283;   Drug_Central:1618;   HMDB:HMDB0015403;   KEGG:D03714
 xref_mesh: MESH:C473384
 xref: PDBeChem:LUR;   PMID:14965322;   PMID:15311562;   PMID:15456339;   PMID:17380211;   PMID:19800190;   PMID:21688392;   PMID:22069133;   PMID:22142375;   PMID:22621454;   PMID:22732767;   Reaxys:9784107;   Wikipedia:Lumiracoxib


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lumiracoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO lumiracoxib results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO lumiracoxib inhibits the reaction [Crotoxin results in increased expression of CKM protein] CTD PMID:36702313 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Ereg epiregulin increases expression ISO lumiracoxib results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO lumiracoxib results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il24 interleukin 24 increases expression ISO lumiracoxib results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO lumiracoxib results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Myog myogenin multiple interactions ISO lumiracoxib promotes the reaction [Crotoxin results in increased expression of MYOG protein] CTD PMID:36702313 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO lumiracoxib affects the reaction [Crotoxin results in increased expression of PAX6 protein] CTD PMID:36702313 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lumiracoxib results in decreased activity of PTGS2 protein CTD PMID:17164136 PMID:17661736 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G RT1-Ba RT1 class II, locus Ba affects response to substance ISO HLA-DQA1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects response to substance ISO HLA-DQB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects response to substance ISO HLA-DRB1 gene SNP affects the susceptibility to lumiracoxib CTD PMID:20639878 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO lumiracoxib results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO lumiracoxib results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lumiracoxib promotes the reaction [Crotoxin results in increased expression of TNF protein] CTD PMID:36702313 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          anti-inflammatory drug 15100
            non-steroidal anti-inflammatory drug 14404
              lumiracoxib 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        secondary amino compound 8181
                                          lumiracoxib 16
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