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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aurones
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Accession:CHEBI:72576 term browser browse the term
Definition:Any member of the class of 1-benzofurans with an arylmethylidene substituent at position 2. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.
Synonyms:related_synonym: Formula=C15O2R10;   SMILES=[*]c1c([*])c([*])c(c([*])c1[*])C(\\[*])=C1/Oc2c([*])c([*])c([*])c([*])c2C1=O



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aureusidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP aureusidin results in increased phosphorylation of AKT1 protein CTD PMID:31790703 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]
aureusidin results in increased expression of HMOX1 mRNA; aureusidin results in increased expression of HMOX1 protein
CTD PMID:31790703 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:31790703 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP aureusidin results in decreased expression of KEAP1 mRNA; aureusidin results in decreased expression of KEAP1 protein CTD PMID:31790703 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP aureusidin results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]
CTD PMID:31790703 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP aureusidin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK3 protein]
CTD PMID:31790703 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein] CTD PMID:31790703 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; aureusidin results in increased expression of and affects the localization of NFE2L2 protein; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]
aureusidin results in increased expression of NFE2L2 mRNA
CTD PMID:31790703 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31790703 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:31790703 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP aureusidin results in increased expression of NQO1 mRNA CTD PMID:31790703 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31790703 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of and affects the localization of RELA protein] CTD PMID:31790703 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31790703 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    chemical entity 19913
      atom 19895
        nonmetal atom 19817
          oxygen atom 19555
            oxygen molecular entity 19574
              flavonoids 11632
                aurones 14
                  (-)-2-((3,5-Dihydroxy-4-methoxyphenyl)methyl)-2,4,6-trihydroxy-3(2H)-benzofuranone 0
                  (Z)-4',6-dihydroxyaurone 6-glucoside 0
                  (Z)-7,4'-dimethoxy-6-hydroxyl-auraone-4-O-beta-glucopyranoside 0
                  2,3',6-Trihydroxy-4'-methoxybenzylcoumaranone 0
                  2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-3-oxo-2,3-dihydro-1-benzofuran-4-yl hexopyranoside 0
                  3',4'-Methylenedioxyfurano[2'',3'':6,7]aurone 0
                  4,6,3',4'-Tetrahydroxy-5-methylaurone 0
                  4,6,4'-Trihydroxy-7-methylaurone 4-rhamnoside 0
                  4,6,4'-Trihydroxyaurone 0
                  4,6-dihydroxy-2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-3-benzofuranone 0
                  4-Methoxyfurano[2'',3'':6,7]aurone 0
                  5-Hydroxy-4,4',6-trimethoxyaurone 0
                  6,4'-Dihydroxy-7-methylaurone 6-rhamnoside 0
                  6-Hydroxy-2-(4'-hydroxy-3'-methoxybenzylidene)benzofuran-3(2h)-one 0
                  6-Hydroxy-5-methyl-3',4',5'-trimethoxyaurone-4-O-alpha-L-rhamnopyranoside 0
                  Amaronol A 0
                  Antiarone A 0
                  Bractein 0
                  Castillene A 0
                  Dalmaisione D 0
                  Hovetrichoside C 0
                  Leptosin 0
                  Maesopsin 0
                  Maesopsin 6-beta-D-glucopyranoside 0
                  Maesopsin 6-glucoside 0
                  Maritimetin 6-(6''-acetylglucoside) 0
                  Nigrescin 0
                  Sulfurein 0
                  aurone + 14
                  furano[2'',3'':6,7]aurone 0
                  hydroxyaurone + 14
                  methoxyaurone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19722
                              organic cyclic compound 19529
                                organic heterocyclic compound 18893
                                  oxacycle 17920
                                    benzofurans 3289
                                      1-benzofurans 1426
                                        aurones 14
                                          (-)-2-((3,5-Dihydroxy-4-methoxyphenyl)methyl)-2,4,6-trihydroxy-3(2H)-benzofuranone 0
                                          (Z)-4',6-dihydroxyaurone 6-glucoside 0
                                          (Z)-7,4'-dimethoxy-6-hydroxyl-auraone-4-O-beta-glucopyranoside 0
                                          2,3',6-Trihydroxy-4'-methoxybenzylcoumaranone 0
                                          2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-3-oxo-2,3-dihydro-1-benzofuran-4-yl hexopyranoside 0
                                          3',4'-Methylenedioxyfurano[2'',3'':6,7]aurone 0
                                          4,6,3',4'-Tetrahydroxy-5-methylaurone 0
                                          4,6,4'-Trihydroxy-7-methylaurone 4-rhamnoside 0
                                          4,6,4'-Trihydroxyaurone 0
                                          4,6-dihydroxy-2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-3-benzofuranone 0
                                          4-Methoxyfurano[2'',3'':6,7]aurone 0
                                          5-Hydroxy-4,4',6-trimethoxyaurone 0
                                          6,4'-Dihydroxy-7-methylaurone 6-rhamnoside 0
                                          6-Hydroxy-2-(4'-hydroxy-3'-methoxybenzylidene)benzofuran-3(2h)-one 0
                                          6-Hydroxy-5-methyl-3',4',5'-trimethoxyaurone-4-O-alpha-L-rhamnopyranoside 0
                                          Amaronol A 0
                                          Antiarone A 0
                                          Bractein 0
                                          Castillene A 0
                                          Dalmaisione D 0
                                          Hovetrichoside C 0
                                          Leptosin 0
                                          Maesopsin 0
                                          Maesopsin 6-beta-D-glucopyranoside 0
                                          Maesopsin 6-glucoside 0
                                          Maritimetin 6-(6''-acetylglucoside) 0
                                          Nigrescin 0
                                          Sulfurein 0
                                          aurone + 14
                                          furano[2'',3'':6,7]aurone 0
                                          hydroxyaurone + 14
                                          methoxyaurone + 0
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