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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pasireotide
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Accession:CHEBI:72312 term browser browse the term
Definition:A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.
Synonyms:exact_synonym: cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl]
 related_synonym: Formula=C58H66N10O9;   InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1;   InChIKey=VMZMNAABQBOLAK-DBILLSOUSA-N;   SMILES=NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1;   SOM 230;   SOM230;   cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-);   pasireotida;   pasireotidum
 alt_id: MESH:C517782
 xref: CAS:396091-73-9;   KEGG:D10147
 xref_mesh: MESH:C517782
 xref: PMID:20643121;   PMID:20970474;   PMID:21264796;   PMID:21330405;   PMID:21493671;   PMID:21506098;   PMID:21525729;   PMID:21532334;   PMID:21673137;   PMID:21732759;   PMID:22170729;   PMID:22282526;   PMID:22383336;   PMID:22573933;   PMID:22634958;   PMID:22713526;   PMID:22736724;   PMID:22745760;   PMID:22807497;   PMID:22960304;   PMID:22965070;   PMID:23102680;   PMID:23137853;   PMID:23345100;   Reaxys:9469122;   Wikipedia:Pasireotide
 cyclic_relationship: is_conjugate_base_of CHEBI:72315


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pasireotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]] CTD PMID:23137853 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA] CTD PMID:23137853 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]		 CTD PMID:23137853 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]] CTD PMID:23137853 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions EXP pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA] CTD PMID:23137853 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Id1 inhibitor of DNA binding 1 multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Smad6 SMAD family member 6 decreases expression EXP pasireotide results in decreased expression of SMAD6 mRNA CTD PMID:23137853 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP pasireotide results in decreased expression of SMAD7 mRNA CTD PMID:23137853 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sstr1 somatostatin receptor 1 affects binding ISO pasireotide binds to SSTR1 protein CTD PMID:16625840 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
G Sstr2 somatostatin receptor 2 affects binding ISO pasireotide binds to SSTR2 protein CTD PMID:16625840 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351 		JBrowse link
G Sstr3 somatostatin receptor 3 affects binding ISO pasireotide binds to SSTR3 protein CTD PMID:16625840 NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769 		JBrowse link
G Sstr4 somatostatin receptor 4 affects binding ISO pasireotide binds to SSTR4 protein CTD PMID:16625840 NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689 		JBrowse link
G Sstr5 somatostatin receptor 5 affects binding ISO pasireotide binds to SSTR5 protein CTD PMID:16625840 NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        molecular messenger 18665
          hormone 18495
            peptide hormone 151
              pasireotide 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              peptide 11442
                                                cyclic peptide 8925
                                                  homodetic cyclic peptide 8404
                                                    pasireotide 18
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