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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrithiamine
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Accession:CHEBI:72290 term browser browse the term
Definition:A pyridinium ion that is 3-(2-hydroxyethyl)-2-methylpyridine substituted at position 1 by a (4-amino-2-methylpyrimidin-5-yl)methyl group.
Synonyms:related_synonym: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium;   1-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-(2-HYDROXYETHYL)-2-METHYLPYRIDINIUM;   Formula=C14H19N4O;   InChI=1S/C14H19N4O/c1-10-12(5-7-19)4-3-6-18(10)9-13-8-16-11(2)17-14(13)15/h3-4,6,8,19H,5,7,9H2,1-2H3,(H2,15,16,17)/q+1;   InChIKey=PZWYDZMWPANLMB-UHFFFAOYSA-N;   SMILES=Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1;   pyrithiamine cation
 alt_id: CHEBI:39662
 xref_mesh: MESH:D011745
 xref: PDBeChem:218;   Reaxys:3913157


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pyrithiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Nicardipine inhibits the reaction [Pyrithiamine results in increased expression of FOS mRNA] CTD PMID:8229066 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Pyrithiamine results in increased expression of GFAP protein CTD PMID:27984051 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Pyrithiamine results in increased expression of ITGAM protein CTD PMID:27984051 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression EXP Pyrithiamine results in decreased expression of SLC2A1 protein CTD PMID:27984051 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      molecular entity 19897
        ion 17101
          organic ion 11455
            organic cation 8962
              pyridinium ion 2445
                pyrithiamine 4
                  1-(4-amino-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide 0
                  pyrithiamine pyrophosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      p-block molecular entity 19835
                        carbon group molecular entity 19776
                          organic molecular entity 19772
                            organic ion 11455
                              organic cation 8962
                                pyridinium ion 2445
                                  pyrithiamine 4
                                    1-(4-amino-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide 0
                                    pyrithiamine pyrophosphate 0
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