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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ortho ester
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Accession:CHEBI:71989 term browser browse the term
Definition:Any organooxygen compound that has the general formula RC(OR(1))(OR(2))(OR(3)), where R(1), R(2), R(3) =/= H.
Synonyms:related_synonym: Formula=CO3R4;   SMILES=[*]C(O[*])(O[*])O[*];   ortho-esters;   orthoester;   orthoesters
 xref: Wikipedia:Orthoester


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resiniferatoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions
decreases expression		 ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of CALCA protein]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of CALCA protein] CTD PMID:17291600 PMID:18219259 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]
resiniferatoxin promotes the reaction [Bee Venoms results in increased expression of FOS protein]		 CTD PMID:15217452 PMID:15601931 PMID:16621078 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ifng interferon gamma multiple interactions ISO resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; resiniferatoxin inhibits the reaction [IFNG results in increased activity of STAT1 protein]; resiniferatoxin inhibits the reaction [IFNG results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression EXP resiniferatoxin results in increased expression of IL10 mRNA; resiniferatoxin results in increased expression of IL10 protein CTD PMID:18460982 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resiniferatoxin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:17291600 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein] CTD PMID:14530214 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein] CTD PMID:14530214 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO resiniferatoxin results in increased activity of MAPK8 protein CTD PMID:9580328 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases activity ISO resiniferatoxin results in increased activity of MAPK9 protein CTD PMID:9580328 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Sst somatostatin multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein] CTD PMID:17291600 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO resiniferatoxin inhibits the reaction [IFNG results in increased activity of STAT1 protein] CTD PMID:14530214 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
decreases expression		 ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 protein]
resiniferatoxin results in decreased expression of TAC1 protein		 CTD PMID:17291600 PMID:18219259 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP resiniferatoxin results in decreased expression of TNF mRNA CTD PMID:18460982 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; phenyl-N-tert-butylnitrone inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein] CTD PMID:19531269 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases expression EXP resiniferatoxin results in decreased expression of TRPA1 mRNA CTD PMID:25077949 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects binding
increases activity
decreases expression		 ISO
EXP		 [resiniferatoxin binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium; Cannabidiol inhibits the reaction [[resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium]; Cannabidiol inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; resiniferatoxin binds to and results in increased activity of TRPV1 protein
resiniferatoxin results in increased activity of TRPV1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]; resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased abundance of Reactive Oxygen Species]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]
capsazepine inhibits the reaction [resiniferatoxin promotes the reaction [TRPV1 protein binds to TRPV1 protein]]; Cyclosporine affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Docosahexaenoic Acids inhibits the reaction [resiniferatoxin binds to and results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [resiniferatoxin binds to and results in increased activity of TRPV1 protein]; Ionomycin inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; JYL 1421 inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; KJM 429 inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin binds to and results in increased activity of TRPV1 protein; resiniferatoxin promotes the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [TRPV1 protein binds to TRPV1 protein]; Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [resiniferatoxin binds to TRPV1 protein]
resiniferatoxin results in decreased expression of TRPV1 mRNA		 CTD PMID:11358970 PMID:11606325 PMID:12237342 PMID:15363968 PMID:16597917 More... NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
decreases expression		 ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein] CTD PMID:18219259 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          oxygen atom 19587
            oxygen molecular entity 19587
              organooxygen compound 19205
                ortho ester 18
                  2-[2-(2-methoxyethoxy)ethoxy]-1,3-dioxolane 0
                  4-O-phosphohygromycin B 0
                  7''-O-phosphohygromycin B 0
                  Oxirapentyn D 0
                  Spiromentin B 0
                  avilamycin A 0
                  avilamycin A precursor 0
                  curamycin A 0
                  daphnetoxin 0
                  erythromycin E 0
                  fumigatonoid C 0
                  hygromycin B + 0
                  novofumigatonin 0
                  rediocide A 0
                  rediocide C 0
                  rediocide E 0
                  rediocide F 0
                  rediocide G 0
                  resiniferatoxin 18
                  tinyatoxin 0
                  trigoheterin E, (rel)- 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  ortho ester 18
                                    2-[2-(2-methoxyethoxy)ethoxy]-1,3-dioxolane 0
                                    4-O-phosphohygromycin B 0
                                    7''-O-phosphohygromycin B 0
                                    Oxirapentyn D 0
                                    Spiromentin B 0
                                    avilamycin A 0
                                    avilamycin A precursor 0
                                    curamycin A 0
                                    daphnetoxin 0
                                    erythromycin E 0
                                    fumigatonoid C 0
                                    hygromycin B + 0
                                    novofumigatonin 0
                                    rediocide A 0
                                    rediocide C 0
                                    rediocide E 0
                                    rediocide F 0
                                    rediocide G 0
                                    resiniferatoxin 18
                                    tinyatoxin 0
                                    trigoheterin E, (rel)- 0
paths to the root