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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procarbazine
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Accession:CHEBI:71417 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Synonyms:related_synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine;   2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine;   4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide;   Formula=C12H19N3O;   InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);   InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N;   N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide;   N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine;   N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide;   N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide;   N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide;   Procarbazin;   SMILES=CNNCc1ccc(cc1)C(=O)NC(C)C;   p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide;   procarbazina;   procarbazinum
 alt_id: CHEBI:8432
 xref: CAS:671-16-9;   DrugBank:DB01168;   Drug_Central:2272;   HMDB:HMDB0015299;   KEGG:C07402;   KEGG:D08423;   LINCS:LSM-2272
 xref_mesh: MESH:D011344
 xref: PMID:21420247;   PMID:21703849;   PMID:21740300;   PMID:21870118;   PMID:22423248;   PMID:22708037;   PMID:22744756;   PMID:22851558;   PMID:22913972;   PMID:23071237;   Patent:BE618638;   Patent:US2007122414;   Patent:US2008107661;   Patent:US3520926;   Patent:US3830840;   Reaxys:958270;   Wikipedia:Procarbazine
 cyclic_relationship: is_conjugate_base_of CHEBI:71431


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procarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases activity EXP Procarbazine results in decreased activity of AOC3 protein CTD PMID:8583353 NCBI chr10:86,773,018...86,780,961 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Procarbazine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:255,838,129...255,849,680 		JBrowse link
G Ldha lactate dehydrogenase A increases mutagenesis ISO Procarbazine results in increased mutagenesis of LDHA gene CTD PMID:7534515 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Maoa monoamine oxidase A increases activity EXP Procarbazine results in increased activity of MAOA protein CTD PMID:8583353 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]; MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:16033832 PMID:16936459 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Prm1 protamine 1 decreases expression EXP Procarbazine results in decreased expression of PRM1 mRNA CTD PMID:8226304 NCBI chr10:5,378,740...5,379,235 JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO Procarbazine results in increased mutagenesis of TK1 gene CTD PMID:3288842 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        pharmaceutical 20416
          drug 20416
            antineoplastic agent 18072
              procarbazine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      carboacyl group 18089
                                        univalent carboacyl group 18071
                                          carbamoyl group 17906
                                            carboxamide 17925
                                              monocarboxylic acid amide 15956
                                                arenecarboxamide 8280
                                                  benzamides 8285
                                                    procarbazine 8
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