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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazine-2-carboxylic acid
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Accession:CHEBI:71311 term browser browse the term
Definition:The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Synonyms:related_synonym: 2-Carboxypyrazine;   2-Pyrazinecarboxylic acid;   Formula=C5H4N2O2;   InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9);   InChIKey=NIPZZXUFJPQHNH-UHFFFAOYSA-N;   Paradiazinecarboxylic acid;   Pyrazinemonocarboxylic acid;   Pyrazinic acid;   Pyrazinoic acid;   SMILES=OC(=O)c1cnccn1;   pyrazinecarboxylic acid
 xref: CAS:98-97-5;   KEGG:C19915
 xref_mesh: MESH:C005296
 xref: MetaCyc:PYRAZINOIC-ACID;   PDBeChem:VGL;   PMID:19298694;   PMID:19963078;   PMID:20099263;   PMID:20382083;   PMID:20429806;   PMID:20879713;   PMID:21283666;   PMID:21775138;   PMID:21835980;   PMID:21876062;   PMID:22004792;   PMID:22074423;   PMID:22236853;   PMID:22372927;   PMID:22613684;   PMID:23101013;   PMID:28166217;   Reaxys:112305;   Wikipedia:Pyrazinoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:71266



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pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:39,200,412...39,245,954 JBrowse link
G Cat catalase decreases expression EXP pyrazinoic acid results in decreased expression of CAT protein CTD PMID:28425350 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP pyrazinoic acid results in increased activity of GPT protein CTD PMID:28425350 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
ISO
pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:203,845,039...203,852,496 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179 JBrowse link

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  CHEBI ontology 19898
    role 19869
      biological role 19867
        antimicrobial agent 18275
          antibacterial agent 16391
            antibacterial drug 7401
              antimycobacterial drug 1043
                antitubercular agent 605
                  pyrazine-2-carboxylic acid 5
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organic heteromonocyclic compound 17821
                                    diazines 13238
                                      pyrazines 1094
                                        pyrazinecarboxylic acid 43
                                          pyrazine-2-carboxylic acid 5
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