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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazine-2-carboxylic acid
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Accession:CHEBI:71311 term browser browse the term
Definition:The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Synonyms:related_synonym: 2-Carboxypyrazine;   2-Pyrazinecarboxylic acid;   Formula=C5H4N2O2;   InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9);   InChIKey=NIPZZXUFJPQHNH-UHFFFAOYSA-N;   Paradiazinecarboxylic acid;   Pyrazinemonocarboxylic acid;   Pyrazinic acid;   Pyrazinoic acid;   SMILES=OC(=O)c1cnccn1;   pyrazinecarboxylic acid
 xref: CAS:98-97-5;   KEGG:C19915
 xref_mesh: MESH:C005296
 xref: MetaCyc:PYRAZINOIC-ACID;   PDBeChem:VGL;   PMID:19298694;   PMID:19963078;   PMID:20099263;   PMID:20382083;   PMID:20429806;   PMID:20879713;   PMID:21283666;   PMID:21775138;   PMID:21835980;   PMID:21876062;   PMID:22004792;   PMID:22074423;   PMID:22236853;   PMID:22372927;   PMID:22613684;   PMID:23101013;   PMID:28166217;   Reaxys:112305;   Wikipedia:Pyrazinoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:71266


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pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Cat catalase decreases expression EXP pyrazinoic acid results in decreased expression of CAT protein CTD PMID:28425350 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP pyrazinoic acid results in increased activity of GPT protein CTD PMID:28425350 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
ISO		 pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        antimicrobial agent 18269
          antibacterial agent 16385
            antibacterial drug 7406
              antimycobacterial drug 1044
                antitubercular agent 605
                  pyrazine-2-carboxylic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteromonocyclic compound 17817
                                    diazines 13247
                                      pyrazines 1092
                                        pyrazinecarboxylic acid 43
                                          pyrazine-2-carboxylic acid 5
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