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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saxagliptin
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Accession:CHEBI:71272 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Synonyms:exact_synonym: (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
 related_synonym: (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile;   BMS 477118;   Formula=C18H25N3O2;   InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1;   InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N;   SMILES=[H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
 xref: CAS:361442-04-8;   DrugBank:DB06335;   Drug_Central:4114;   HMDB:HMDB0015634;   KEGG:D08996
 xref_mesh: MESH:C502994
 xref: PMID:22001114;   PMID:22066527;   PMID:22081481;   PMID:22098472;   PMID:22132773;   PMID:22149373;   PMID:22192246;   PMID:22221000;   PMID:22232748;   PMID:22248301;   PMID:22292415;   PMID:22313154;   PMID:22313172;   PMID:22334441;   PMID:22349123;   PMID:22475049;   PMID:22496391;   PMID:22564773;   PMID:22668067;   PMID:22776778;   PMID:22823746;   PMID:22828124;   PMID:22932707;   PMID:22943617;   PMID:23137182;   Patent:US2005222242;   Patent:US2007172525;   Patent:WO2007078726;   Patent:WO2009022009;   Patent:WO2011125011;   Reaxys:10201614;   Wikipedia:Saxagliptin


show annotations for term's descendants           Sort by:
saxagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:25446674 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:25446674 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CASP3 protein] CTD PMID:25446674 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CYCS protein] CTD PMID:25446674 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity
decreases expression
multiple interactions		 ISO
EXP		 saxagliptin results in decreased activity of DPP4 protein
saxagliptin results in decreased expression of DPP4 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]		 CTD PMID:21186796 PMID:21388136 PMID:25446674 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein] CTD PMID:31629700 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein] CTD PMID:31629700 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of ICAM1 protein] CTD PMID:25446674 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:31629700 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein] CTD PMID:31629700 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of MPO protein] CTD PMID:25446674 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] CTD PMID:31629700 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 EXP saxagliptin results in increased expression of NFE2L2 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of NFE2L2 protein]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]		 CTD PMID:25446674 PMID:31629700 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of NOS2 protein] CTD PMID:25446674 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:31629700 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of RELA protein] CTD PMID:25446674 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of TNF protein] CTD PMID:25446674 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19901
    chemical entity 19899
      group 19852
        pseudohalo group 4590
          cyano group 4590
            nitrile 4590
              saxagliptin 18
                saxagliptin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19901
    subatomic particle 19899
      composite particle 19899
        hadron 19899
          baryon 19899
            nucleon 19899
              atomic nucleus 19899
                atom 19899
                  main group element atom 19838
                    p-block element atom 19838
                      carbon group element atom 19778
                        carbon atom 19775
                          organic molecular entity 19775
                            heteroorganic entity 19534
                              organochalcogen compound 19295
                                organooxygen compound 19211
                                  carbon oxoacid 18679
                                    carboxylic acid 18676
                                      carboacyl group 17718
                                        univalent carboacyl group 17718
                                          carbamoyl group 17569
                                            carboxamide 17569
                                              monocarboxylic acid amide 15745
                                                saxagliptin 18
                                                  saxagliptin hydrate 0
paths to the root