CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dihydrochalcone
Accession: CHEBI:71231
browse the term
Definition: A member of the class of dihydrochalcones that is acetophenone in which one of the hydrogens of the methyl group is replaced by a benzyl group.
Synonyms: exact_synonym: 1,3-diphenylpropan-1-one
related_synonym: 1,3-Diphenyl-1-oxopropane; Formula=C15H14O; Hydrochalcone; Hydrocinnamophenone; InChI=1S/C15H14O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-10H,11-12H2; InChIKey=QGGZBXOADPVUPN-UHFFFAOYSA-N; SMILES=O=C(CCc1ccccc1)c1ccccc1; benzyl acetophenone; beta-phenylpropiophenone
xref: CAS:1083-30-3; Reaxys:1910661; Wikipedia:Dihydrochalcone
G
Ache
acetylcholinesterase
multiple interactions
ISO
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased activity of ACHE protein; [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]; Phloretin inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]
CTD
PMID:33410021 PMID:35547012
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of ADIPOQ mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of ADIPOQ mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of ADIPOQ mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in decreased secretion of ADIPOQ protein]]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of ADIPOQ mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of ADIPOQ mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of ADIPOQ mRNA; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in decreased secretion of ADIPOQ protein]
CTD
PMID:32408695
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Afp
alpha-fetoprotein
affects binding
EXP
Phloretin binds to AFP protein
CTD
PMID:23013281 PMID:25349334
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO EXP
[Ruthenium binds to Phloretin] which results in decreased expression of AKT1 protein Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of AKT1 mRNA]
CTD
PMID:34037972 PMID:34896434
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Angptl4
angiopoietin-like 4
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of ANGPTL4 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of ANGPTL4 mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of ANGPTL4 mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of ANGPTL4 mRNA
CTD
PMID:32408695
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Aqp9
aquaporin 9
multiple interactions decreases activity
EXP ISO
Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid] Phloretin results in decreased activity of AQP9 protein
CTD
PMID:9733774 PMID:12606488 PMID:21259319 PMID:28798983
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
G
Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BAD protein]]; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BAD protein]
CTD
PMID:32408695
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]
CTD
PMID:34037972 PMID:34896434
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bche
butyrylcholinesterase
multiple interactions
ISO
[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; Phloretin inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; Phloretin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of BCHE protein]
CTD
PMID:33410021 PMID:35547012
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]
CTD
PMID:34037972 PMID:34896434
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of BCL2L1 protein]]; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of BCL2L1 protein]
CTD
PMID:32408695
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
G
Bcl2l11
Bcl2-like 11
multiple interactions
ISO
Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BCL2L11 protein]
CTD
PMID:32408695
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
G
Casp3
caspase 3
multiple interactions
ISO
[Ruthenium binds to Phloretin] which results in increased cleavage of CASP3 protein; Phloretin inhibits the reaction [SYT1 protein inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]]
CTD
PMID:34896434 PMID:39059605
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions
ISO
[Ruthenium binds to Phloretin] which results in decreased expression of and results in increased cleavage of CASP9 protein
CTD
PMID:34896434
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
EXP
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAT protein]
CTD
PMID:34896434
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Cav3
caveolin 3
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAV3 mRNA]
CTD
PMID:34037972
NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO EXP
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of CCL2 protein] 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of CCL2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of CCL2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of CCL2 mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of CCL2 mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of CCL2 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of CCL2 mRNA
CTD
PMID:24707119 PMID:32408695 PMID:34037972
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]
CTD
PMID:24707119
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[Ruthenium binds to Phloretin] which results in increased expression of CDKN1A protein
CTD
PMID:34896434
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cftr
CF transmembrane conductance regulator
multiple interactions
EXP
Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]
CTD
PMID:12606488
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Csf3
colony stimulating factor 3
multiple interactions
ISO
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]
CTD
PMID:24707119
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
CTD
PMID:17177569
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Des
desmin
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of DES mRNA]
CTD
PMID:34037972
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
[Ruthenium binds to Phloretin] which results in decreased expression of EGFR protein
CTD
PMID:34896434
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Phloretin binds to and results in increased activity of ESR1 protein
CTD
PMID:9751507
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions affects binding
ISO
Phloretin binds to and results in increased activity of ESR2 protein Phloretin binds to ESR2 protein
CTD
PMID:9751507 PMID:12224631
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Phloretin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD
PMID:30287234
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gsk3b
glycogen synthase kinase 3 beta
decreases activity
ISO
Phloretin results in decreased activity of GSK3B protein
CTD
PMID:16968061
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of HIF1A mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of HIF1A mRNA
CTD
PMID:32408695
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Ifng
interferon gamma
multiple interactions
ISO EXP
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG protein]
CTD
PMID:24707119 PMID:34037972
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of IGF1 mRNA]
CTD
PMID:34037972
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il10
interleukin 10
multiple interactions
ISO EXP
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of IL10 protein]
CTD
PMID:24707119 PMID:34037972
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]
CTD
PMID:24707119
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL1B mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of IL1B mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of IL1B mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL1B mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of IL1B mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of IL1B mRNA
CTD
PMID:21051542 PMID:32408695
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
multiple interactions
ISO
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]
CTD
PMID:24707119
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il2
interleukin 2
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of IL2 protein]
CTD
PMID:34037972
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il6
interleukin 6
multiple interactions
ISO EXP
Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein] 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL6 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of IL6 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of IL6 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of IL6 mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of IL6 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of IL6 mRNA; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]
CTD
PMID:24707119 PMID:32408695 PMID:34037972
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ins2
insulin 2
multiple interactions
ISO
Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]
CTD
PMID:17965850
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Kcnma1
potassium calcium-activated channel subfamily M alpha 1
affects response to substance
EXP
KCNMA1 mRNA affects the susceptibility to Phloretin
CTD
PMID:19247476
NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
G
Lep
leptin
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of LEP mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of LEP mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of LEP mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of LEP mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of LEP mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] affects the expression of LEP mRNA; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of LEP protein]
CTD
PMID:32408695
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Ltf
lactotransferrin
increases expression
EXP
Phloretin results in increased expression of LTF protein
CTD
PMID:24487097
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAPK1 mRNA]
CTD
PMID:34037972
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAPK3 mRNA]
CTD
PMID:34037972
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of MAPK8 mRNA]
CTD
PMID:34037972
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mki67
marker of proliferation Ki-67
multiple interactions
EXP
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MKI67 protein]
CTD
PMID:34896434
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP9 protein]
CTD
PMID:34896434
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
[Ruthenium binds to Phloretin] which results in decreased expression of MTOR protein
CTD
PMID:34896434
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of NFATC1 mRNA]; Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of NFATC1 protein]
CTD
PMID:34037972
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased expression of NFE2L2 mRNA
CTD
PMID:33410021
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of NFKB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of NFKB1 mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of NFKB1 mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of NFKB1 mRNA
CTD
PMID:32408695
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nos3
nitric oxide synthase 3
decreases expression multiple interactions
ISO
Phloretin results in decreased expression of NOS3 mRNA Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]
CTD
PMID:20021702
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of PPARG mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of PPARG mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of PPARG mRNA
CTD
PMID:32408695
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of PPP3CA protein]
CTD
PMID:34037972
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
EXP
Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAF1 mRNA]
CTD
PMID:34037972
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein]]; Phloretin inhibits the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein] Phloretin inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]
CTD
PMID:32408695 PMID:34037972
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Shbg
sex hormone binding globulin
affects binding
ISO
Phloretin binds to SHBG protein
CTD
PMID:25349334
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
G
Slc14a1
solute carrier family 14 member 1 (Kidd blood group)
multiple interactions
EXP
Phloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea]
CTD
PMID:8982255
NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
G
Slc14a2
solute carrier family 14 member 2
multiple interactions
EXP
Phloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea]
CTD
PMID:11181411
NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
G
Slc16a1
solute carrier family 16 member 1
multiple interactions
EXP
[[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate; [Phloretin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
CTD
PMID:17108059
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Slc16a2
solute carrier family 16 member 2
multiple interactions
ISO
Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]
CTD
PMID:28119167
NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
G
Slc2a1
solute carrier family 2 member 1
multiple interactions decreases activity
ISO
Phloretin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] Phloretin results in decreased activity of SLC2A1 protein
CTD
PMID:14642735
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
G
Slc2a2
solute carrier family 2 member 2
multiple interactions decreases expression
ISO EXP
Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose] Phloretin results in decreased expression of SLC2A2 protein Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
CTD
PMID:15986457 PMID:17272349 PMID:26616219
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
G
Slc2a9
solute carrier family 2 member 9
multiple interactions
ISO
Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]
CTD
PMID:19587147
NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
G
Slc9a1
solute carrier family 9 member A1
multiple interactions decreases activity
ISO
Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]] Phloretin results in decreased activity of SLC9A1 protein; Phloretin results in decreased activity of SLC9A1 protein alternative form
CTD
PMID:12765964
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
G
Slc9b2
solute carrier family 9 member B2
decreases activity
ISO
Phloretin results in decreased activity of SLC9B2 protein
CTD
PMID:18000046
NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225
G
Syt1
synaptotagmin 1
multiple interactions
ISO
Phloretin inhibits the reaction [SYT1 protein inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]]; Phloretin inhibits the reaction [SYT1 protein results in increased export of Paraquat]
CTD
PMID:39059605
NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of TNF mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of TNF mRNA Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]
CTD
PMID:32408695 PMID:34037972
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
multiple interactions
EXP ISO
[Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TP53 protein] [Ruthenium binds to Phloretin] which results in increased expression of TP53 protein
CTD
PMID:34896434
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
decreases activity
ISO
Phloretin results in decreased activity of UGT1A1 protein
CTD
PMID:35868516
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
decreases activity
ISO
Phloretin results in decreased activity of UGT1A3 protein
CTD
PMID:35868516
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases activity
ISO
Phloretin results in decreased activity of UGT1A6 protein
CTD
PMID:35868516
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
decreases activity
ISO
Phloretin results in decreased activity of UGT1A9 protein
CTD
PMID:35868516
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
decreases activity
ISO
Phloretin results in decreased activity of UGT2B17 protein
CTD
PMID:35868516
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Ugt2b7
UDP glucuronosyltransferase family 2 member B7
decreases activity
ISO
Phloretin results in decreased activity of UGT2B7 protein
CTD
PMID:35868516
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of VEGFA mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of VEGFA mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of VEGFA protein]]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of VEGFA mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of VEGFA mRNA; Phloretin promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of VEGFA protein] [Ruthenium binds to Phloretin] which results in decreased expression of VEGFA protein
CTD
PMID:32408695 PMID:34896434
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Abat
4-aminobutyrate aminotransferase
decreases expression
ISO
Phlorhizin results in decreased expression of ABAT mRNA
CTD
PMID:22538082
NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
G
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
increases expression
ISO
Phlorhizin results in increased expression of ACAA1 mRNA
CTD
PMID:22538082
NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
G
Acaa2
acetyl-CoA acyltransferase 2
decreases expression
ISO
Phlorhizin results in decreased expression of ACAA2 mRNA
CTD
PMID:22538082
NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
G
Acad8
acyl-CoA dehydrogenase family, member 8
decreases expression
ISO
Phlorhizin results in decreased expression of ACAD8 mRNA
CTD
PMID:22538082
NCBI chr 8:25,382,271...25,406,404
Ensembl chr 8:25,382,273...25,406,414
G
Acad9
acyl-CoA dehydrogenase family, member 9
decreases expression
ISO
Phlorhizin results in decreased expression of ACAD9 mRNA
CTD
PMID:22538082
NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
G
Acadl
acyl-CoA dehydrogenase, long chain
decreases expression
ISO
Phlorhizin results in decreased expression of ACADL mRNA
CTD
PMID:22538082
NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
G
Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
ISO
Phlorhizin results in decreased expression of ACADM mRNA
CTD
PMID:22538082
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
G
Acat1
acetyl-CoA acetyltransferase 1
decreases expression
ISO
Phlorhizin results in decreased expression of ACAT1 mRNA
CTD
PMID:22538082
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
G
Aco1
aconitase 1
decreases expression
ISO
Phlorhizin results in decreased expression of ACO1 mRNA
CTD
PMID:22538082
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
G
Acox1
acyl-CoA oxidase 1
decreases expression
ISO
Phlorhizin results in decreased expression of ACOX1 mRNA
CTD
PMID:22538082
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
G
Acox2
acyl-CoA oxidase 2
decreases expression
ISO
Phlorhizin results in decreased expression of ACOX2 mRNA
CTD
PMID:22538082
NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
G
Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
ISO
Phlorhizin results in decreased expression of ACSL1 mRNA
CTD
PMID:22538082
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
G
Actb
actin, beta
increases expression
ISO
Phlorhizin results in increased expression of ACTB mRNA
CTD
PMID:22538082
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
decreases expression
ISO
Phlorhizin results in decreased expression of ADH5 mRNA
CTD
PMID:22538082
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
G
Adhfe1
alcohol dehydrogenase, iron containing, 1
decreases expression
ISO
Phlorhizin results in decreased expression of ADHFE1 mRNA
CTD
PMID:22538082
NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of ADIPOQ mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of ADIPOQ mRNA]; [cobaltous chloride co-treated with Phlorhizin] affects the expression of ADIPOQ mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of ADIPOQ mRNA
CTD
PMID:32408695
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Akr1a1
aldo-keto reductase family 1 member A1
decreases expression
ISO
Phlorhizin results in decreased expression of AKR1A1 mRNA
CTD
PMID:22538082
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr7a2
aldo-keto reductase family 7, member A2
increases expression
ISO
Phlorhizin results in increased expression of AKR7A2 mRNA
CTD
PMID:22538082
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
G
Alb
albumin
multiple interactions
ISO
Phlorhizin inhibits the reaction [Glucose results in decreased uptake of ALB protein]
CTD
PMID:16313995
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Aldh2
aldehyde dehydrogenase 2 family member
decreases expression increases expression
ISO
Phlorhizin results in decreased expression of ALDH2 mRNA Phlorhizin results in increased expression of ALDH2 mRNA
CTD
PMID:22538082
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Aldh3a2
aldehyde dehydrogenase 3 family, member A2
decreases expression
ISO
Phlorhizin results in decreased expression of ALDH3A2 mRNA
CTD
PMID:22538082
NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
G
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
decreases expression
ISO
Phlorhizin results in decreased expression of ALDH4A1 mRNA
CTD
PMID:22538082
NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
G
Aldh6a1
aldehyde dehydrogenase 6 family, member A1
decreases expression
ISO
Phlorhizin results in decreased expression of ALDH6A1 mRNA
CTD
PMID:22538082
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
G
Aldh7a1
aldehyde dehydrogenase 7 family, member A1
decreases expression
ISO
Phlorhizin results in decreased expression of ALDH7A1 mRNA
CTD
PMID:22538082
NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
G
Anapc2
anaphase promoting complex subunit 2
decreases expression
ISO
Phlorhizin results in decreased expression of ANAPC2 mRNA
CTD
PMID:22538082
NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
G
Anapc5
anaphase-promoting complex subunit 5
decreases expression
ISO
Phlorhizin results in decreased expression of ANAPC5 mRNA
CTD
PMID:22538082
NCBI chr12:33,748,709...33,781,709
Ensembl chr12:33,748,735...33,781,781
G
Aox1
aldehyde oxidase 1
decreases expression
ISO
Phlorhizin results in decreased expression of AOX1 mRNA
CTD
PMID:22538082
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
G
Aph1b
aph-1 homolog B, gamma secretase subunit
increases expression
ISO
Phlorhizin results in increased expression of APH1B mRNA
CTD
PMID:22538082
NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
G
App
amyloid beta precursor protein
decreases expression
ISO
Phlorhizin results in decreased expression of APP mRNA
CTD
PMID:22538082
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Atf3
activating transcription factor 3
decreases expression
ISO
Phlorhizin results in decreased expression of ATF3 mRNA
CTD
PMID:16123366
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
increases expression
ISO
Phlorhizin results in increased expression of ATP2A2 mRNA
CTD
PMID:16123366
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
G
Atp5f1a
ATP synthase F1 subunit alpha
decreases expression
ISO
Phlorhizin results in decreased expression of ATP5F1A mRNA
CTD
PMID:22538082
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
G
Atp5f1c
ATP synthase F1 subunit gamma
increases expression
ISO
Phlorhizin results in increased expression of ATP5F1C mRNA
CTD
PMID:22538082
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
G
Auh
AU RNA binding methylglutaconyl-CoA hydratase
decreases expression
ISO
Phlorhizin results in decreased expression of AUH mRNA
CTD
PMID:22538082
NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896
G
B2m
beta-2 microglobulin
increases expression
ISO
Phlorhizin results in increased expression of B2M mRNA
CTD
PMID:22538082
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
G
Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Phlorhizin] promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BAD protein]
CTD
PMID:32408695
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bag1
BAG cochaperone 1
decreases expression
ISO
Phlorhizin results in decreased expression of BAG1 mRNA
CTD
PMID:22538082
NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
G
Bckdhb
branched chain keto acid dehydrogenase E1 subunit beta
decreases expression
ISO
Phlorhizin results in decreased expression of BCKDHB mRNA
CTD
PMID:22538082
NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
G
Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Phlorhizin] promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of BCL2L1 protein]
CTD
PMID:32408695
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
G
Birc6
baculoviral IAP repeat-containing 6
increases expression
ISO
Phlorhizin results in increased expression of BIRC6 mRNA
CTD
PMID:22538082
NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
G
Cat
catalase
increases expression
ISO
Phlorhizin results in increased expression of CAT mRNA
CTD
PMID:22538082
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of CCL2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of CCL2 mRNA]; [cobaltous chloride co-treated with Phlorhizin] affects the expression of CCL2 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of CCL2 mRNA
CTD
PMID:32408695
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cct7
chaperonin containing TCP1 subunit 7
decreases expression
ISO
Phlorhizin results in decreased expression of CCT7 mRNA
CTD
PMID:22538082
NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
EXP
Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]
CTD
PMID:18715473
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Clybl
citramalyl-CoA lyase
decreases expression
ISO
Phlorhizin results in decreased expression of CLYBL mRNA
CTD
PMID:22538082
NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695
G
Cox15
cytochrome c oxidase assembly homolog COX15
decreases expression
ISO
Phlorhizin results in decreased expression of COX15 mRNA
CTD
PMID:22538082
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
G
Cox17
cytochrome c oxidase copper chaperone COX17
decreases expression
ISO
Phlorhizin results in decreased expression of COX17 mRNA
CTD
PMID:22538082
NCBI chr11:62,400,733...62,406,507
G
Cox7c
cytochrome c oxidase subunit 7C
increases expression
ISO
Phlorhizin results in increased expression of COX7C mRNA
CTD
PMID:22538082
NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
G
Cox8a
cytochrome c oxidase subunit 8A
decreases expression
ISO
Phlorhizin results in decreased expression of COX8A mRNA
CTD
PMID:22538082
NCBI chr 1:204,402,118...204,404,439
G
Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
ISO
Phlorhizin results in decreased expression of CPT1A mRNA
CTD
PMID:16123366 PMID:22538082
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Cpt2
carnitine palmitoyltransferase 2
decreases expression
ISO
Phlorhizin results in decreased expression of CPT2 mRNA
CTD
PMID:22538082
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
G
Crebbp
CREB binding protein
decreases expression
ISO
Phlorhizin results in decreased expression of CREBBP mRNA
CTD
PMID:22538082
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
G
Cs
citrate synthase
decreases expression
ISO
Phlorhizin results in decreased expression of CS mRNA
CTD
PMID:22538082
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
G
Cul1
cullin 1
decreases expression
ISO
Phlorhizin results in decreased expression of CUL1 mRNA
CTD
PMID:22538082
NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
G
Cyb5r3
cytochrome b5 reductase 3
decreases expression
ISO
Phlorhizin results in decreased expression of CYB5R3 mRNA
CTD
PMID:22538082
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases expression
ISO
Phlorhizin results in decreased expression of CYP1A2 mRNA
CTD
PMID:22538082
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression
ISO
Phlorhizin results in decreased expression of CYP2B6 mRNA
CTD
PMID:22538082
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases expression
ISO
Phlorhizin results in increased expression of CYP2D6 mRNA
CTD
PMID:22538082
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
decreases expression
ISO
Phlorhizin results in decreased expression of CYP4F12 mRNA
CTD
PMID:22538082
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
G
Dhrs4
dehydrogenase/reductase 4
decreases expression
ISO
Phlorhizin results in decreased expression of DHRS4 mRNA
CTD
PMID:22538082
NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
G
Dld
dihydrolipoamide dehydrogenase
decreases expression
ISO
Phlorhizin results in decreased expression of DLD mRNA
CTD
PMID:22538082
NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
G
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJA2 mRNA
CTD
PMID:22538082
NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
G
Dnaja3
DnaJ heat shock protein family (Hsp40) member A3
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJA3 mRNA
CTD
PMID:22538082
NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
G
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
decreases expression increases expression
ISO
Phlorhizin results in decreased expression of DNAJB1 mRNA Phlorhizin results in increased expression of DNAJB1 mRNA
CTD
PMID:22538082
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJB4 mRNA
CTD
PMID:22538082
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
G
Dnajb6
DnaJ heat shock protein family (Hsp40) member B6
increases expression
ISO
Phlorhizin results in increased expression of DNAJB6 mRNA
CTD
PMID:22538082
NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
G
Dnajc1
DnaJ heat shock protein family (Hsp40) member C1
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJC1 mRNA
CTD
PMID:22538082
NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988
G
Dnajc13
DnaJ heat shock protein family (Hsp40) member C13
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJC13 mRNA
CTD
PMID:22538082
NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317
G
Dnajc14
DnaJ heat shock protein family (Hsp40) member C14
increases expression
ISO
Phlorhizin results in increased expression of DNAJC14 mRNA
CTD
PMID:22538082
NCBI chr 7:1,233,856...1,247,349
Ensembl chr 7:1,235,162...1,248,645
G
Dnajc19
DnaJ heat shock protein family (Hsp40) member C19
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJC19 mRNA
CTD
PMID:22538082
NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264
G
Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJC3 mRNA
CTD
PMID:22538082
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
G
Dnajc4
DnaJ heat shock protein family (Hsp40) member C4
increases expression
ISO
Phlorhizin results in increased expression of DNAJC4 mRNA
CTD
PMID:22538082
NCBI chr 1:204,178,189...204,182,412
Ensembl chr 1:204,178,191...204,182,387
G
Dnajc5
DnaJ heat shock protein family (Hsp40) member C5
decreases expression
ISO
Phlorhizin results in decreased expression of DNAJC5 mRNA
CTD
PMID:22538082
NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
G
Echs1
enoyl-CoA hydratase, short chain 1
decreases expression
ISO
Phlorhizin results in decreased expression of ECHS1 mRNA
CTD
PMID:22538082
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
G
Ep300
E1A binding protein p300
decreases expression
ISO
Phlorhizin results in decreased expression of EP300 mRNA
CTD
PMID:22538082
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Ephx1
epoxide hydrolase 1
decreases expression
ISO
Phlorhizin results in decreased expression of EPHX1 mRNA
CTD
PMID:22538082
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Fas
Fas cell surface death receptor
decreases expression
ISO
Phlorhizin results in decreased expression of FAS mRNA
CTD
PMID:16123366
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fbxw7
F-box and WD repeat domain containing 7
decreases expression
ISO
Phlorhizin results in decreased expression of FBXW7 mRNA
CTD
PMID:22538082
NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
G
Fh
fumarate hydratase
decreases expression
ISO
Phlorhizin results in decreased expression of FH mRNA
CTD
PMID:22538082
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
G
Fis1
fission, mitochondrial 1
increases expression
ISO
Phlorhizin results in increased expression of FIS1 mRNA
CTD
PMID:22538082
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
G
Fkbp5
FKBP prolyl isomerase 5
decreases expression
ISO
Phlorhizin results in decreased expression of FKBP5 mRNA
CTD
PMID:22538082
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
ISO
Phlorhizin results in decreased expression of FMO1 mRNA
CTD
PMID:22538082
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions
EXP
Phlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC1 mRNA]
CTD
PMID:12446591
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
ISO
Phlorhizin results in decreased expression of GCLC mRNA
CTD
PMID:22538082
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases expression
ISO
Phlorhizin results in decreased expression of GCLM mRNA
CTD
PMID:22538082
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Glrx2
glutaredoxin 2
decreases expression
ISO
Phlorhizin results in decreased expression of GLRX2 mRNA
CTD
PMID:22538082
NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
increases expression decreases expression
ISO
Phlorhizin results in increased expression of GPD2 mRNA Phlorhizin results in decreased expression of GPD2 mRNA
CTD
PMID:16123366 PMID:22538082
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
G
Gpx1
glutathione peroxidase 1
decreases expression
ISO
Phlorhizin results in decreased expression of GPX1 mRNA
CTD
PMID:16123366
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx7
glutathione peroxidase 7
increases expression
ISO
Phlorhizin results in increased expression of GPX7 mRNA
CTD
PMID:22538082
NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004
G
Gsta5
glutathione S-transferase alpha 5
decreases expression
ISO
Phlorhizin results in decreased expression of GSTA5 mRNA
CTD
PMID:22538082
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
G
Gstk1
glutathione S-transferase kappa 1
decreases expression
ISO
Phlorhizin results in decreased expression of GSTK1 mRNA
CTD
PMID:22538082
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
G
Gstm1
glutathione S-transferase mu 1
decreases expression
ISO
Phlorhizin results in decreased expression of GSTM1 mRNA
CTD
PMID:22538082
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
increases expression decreases expression
ISO
Phlorhizin results in increased expression of GSTM2 mRNA; Phlorhizin results in increased expression of GSTM5 mRNA Phlorhizin results in decreased expression of GSTM5 mRNA
CTD
PMID:22538082
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm4
glutathione S-transferase mu 4
increases expression
ISO
Phlorhizin results in increased expression of GSTM4 mRNA
CTD
PMID:22538082
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstp1
glutathione S-transferase pi 1
increases expression
ISO
Phlorhizin results in increased expression of GSTP1 mRNA
CTD
PMID:22538082
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt1
glutathione S-transferase theta 1
decreases expression increases expression
ISO
Phlorhizin results in decreased expression of GSTT1 mRNA Phlorhizin results in increased expression of GSTT1 mRNA
CTD
PMID:22538082
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
decreases expression
ISO
Phlorhizin results in decreased expression of HACD3 mRNA
CTD
PMID:22538082
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
ISO
Phlorhizin results in increased expression of HADHB mRNA
CTD
PMID:22538082
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Herpud1
homocysteine inducible ER protein with ubiquitin like domain 1
decreases expression
ISO
Phlorhizin results in decreased expression of HERPUD1 mRNA
CTD
PMID:22538082
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
G
Hibadh
3-hydroxyisobutyrate dehydrogenase
decreases expression
ISO
Phlorhizin results in decreased expression of HIBADH mRNA
CTD
PMID:22538082
NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
Phlorhizin results in decreased expression of HMGCS1 mRNA
CTD
PMID:22538082
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hmox1
heme oxygenase 1
decreases expression
ISO
Phlorhizin results in decreased expression of HMOX1 mRNA
CTD
PMID:16123366
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hras
HRas proto-oncogene, GTPase
increases expression
ISO
Phlorhizin results in increased expression of HRAS mRNA
CTD
PMID:22538082
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
decreases expression
ISO
Phlorhizin results in decreased expression of HSD17B10 mRNA
CTD
PMID:22538082
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
ISO
Phlorhizin results in decreased expression of HSD17B4 mRNA
CTD
PMID:22538082
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
decreases expression
ISO
Phlorhizin results in decreased expression of HSP90AA1 mRNA
CTD
PMID:22538082
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
decreases expression
ISO
Phlorhizin results in decreased expression of HSP90AB1 mRNA
CTD
PMID:22538082
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
G
Hspa13
heat shock protein family A (Hsp70) member 13
decreases expression
ISO
Phlorhizin results in decreased expression of HSPA13 mRNA
CTD
PMID:22538082
NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Phlorhizin results in increased expression of HSPA5 mRNA
CTD
PMID:22538082
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
increases expression
ISO
Phlorhizin results in increased expression of HSPA8 mRNA
CTD
PMID:22538082
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspa9
heat shock protein family A (Hsp70) member 9
decreases expression
ISO
Phlorhizin results in decreased expression of HSPA9 mRNA
CTD
PMID:22538082
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
G
Hspb1
heat shock protein family B (small) member 1
increases expression
ISO
Phlorhizin results in increased expression of HSPB1 mRNA
CTD
PMID:22538082
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
G
Hspb8
heat shock protein family B (small) member 8
decreases expression
ISO
Phlorhizin results in decreased expression of HSPB8 mRNA
CTD
PMID:22538082
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
G
Hspd1
heat shock protein family D (Hsp60) member 1
decreases expression
ISO
Phlorhizin results in decreased expression of HSPD1 mRNA
CTD
PMID:22538082
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Hspe1
heat shock protein family E (Hsp10) member 1
decreases expression
ISO
Phlorhizin results in decreased expression of HSPE1 mRNA
CTD
PMID:22538082
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
G
Htra2
HtrA serine peptidase 2
decreases expression
ISO
Phlorhizin results in decreased expression of HTRA2 mRNA
CTD
PMID:22538082
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
G
Id1
inhibitor of DNA binding 1
decreases expression
ISO
Phlorhizin results in decreased expression of ID1 mRNA
CTD
PMID:16123366
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
increases expression
ISO
Phlorhizin results in increased expression of IDH2 mRNA
CTD
PMID:22538082
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
G
Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
decreases expression
ISO
Phlorhizin results in decreased expression of IDH3A mRNA
CTD
PMID:22538082
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
G
Idh3b
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
decreases expression
ISO
Phlorhizin results in decreased expression of IDH3B mRNA
CTD
PMID:22538082
NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
G
Idh3g
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
decreases expression
ISO
Phlorhizin results in decreased expression of IDH3G mRNA
CTD
PMID:22538082
NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171
G
Il1b
interleukin 1 beta
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of IL1B mRNA]; [cobaltous chloride co-treated with Phlorhizin] affects the expression of IL1B mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of IL1B mRNA
CTD
PMID:32408695
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of IL6 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of IL6 mRNA]; [cobaltous chloride co-treated with Phlorhizin] affects the expression of IL6 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of IL6 mRNA
CTD
PMID:32408695
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ivd
isovaleryl-CoA dehydrogenase
decreases expression
ISO
Phlorhizin results in decreased expression of IVD mRNA
CTD
PMID:22538082
NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Phlorhizin results in decreased expression of JUNB mRNA
CTD
PMID:22538082
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Phlorhizin results in increased expression of JUND mRNA
CTD
PMID:22538082
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
G
Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
increases expression
ISO
Phlorhizin results in increased expression of KCNJ11 mRNA
CTD
PMID:16123366
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
G
Keap1
Kelch-like ECH-associated protein 1
increases expression
ISO
Phlorhizin results in increased expression of KEAP1 mRNA
CTD
PMID:22538082
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
G
Kras
KRAS proto-oncogene, GTPase
decreases expression
ISO
Phlorhizin results in decreased expression of KRAS mRNA
CTD
PMID:22538082
NCBI chr 4:178,185,418...178,218,484
G
Lep
leptin
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of LEP mRNA]; [2,2-bis(4-glycidyloxyphenyl)propane co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] affects the expression of LEP mRNA; [cobaltous chloride co-treated with Phlorhizin] affects the expression of LEP mRNA
CTD
PMID:32408695
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Maf
MAF bZIP transcription factor
decreases expression
ISO
Phlorhizin results in decreased expression of MAF mRNA
CTD
PMID:22538082
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
G
Mafg
MAF bZIP transcription factor G
decreases expression
ISO
Phlorhizin results in decreased expression of MAFG mRNA
CTD
PMID:22538082
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
G
Maob
monoamine oxidase B
decreases expression
ISO
Phlorhizin results in decreased expression of MAOB mRNA
CTD
PMID:22538082
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
G
Map2k2
mitogen activated protein kinase kinase 2
increases expression
ISO
Phlorhizin results in increased expression of MAP2K2 mRNA
CTD
PMID:22538082
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Map2k6
mitogen-activated protein kinase kinase 6
increases expression
ISO
Phlorhizin results in increased expression of MAP2K6 mRNA
CTD
PMID:22538082
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
G
Map2k7
mitogen activated protein kinase kinase 7
increases expression
ISO
Phlorhizin results in increased expression of MAP2K7 mRNA
CTD
PMID:22538082
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
G
Map3k7
mitogen activated protein kinase kinase kinase 7
decreases expression
ISO
Phlorhizin results in decreased expression of MAP3K7 mRNA
CTD
PMID:22538082
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
G
Mapk3
mitogen activated protein kinase 3
increases expression
ISO
Phlorhizin results in increased expression of MAPK3 mRNA
CTD
PMID:22538082
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk9
mitogen-activated protein kinase 9
decreases expression
ISO
Phlorhizin results in decreased expression of MAPK9 mRNA
CTD
PMID:22538082
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Mccc2
methylcrotonyl-CoA carboxylase subunit 2
decreases expression
ISO
Phlorhizin results in decreased expression of MCCC2 mRNA
CTD
PMID:22538082
NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
G
Mdm2
MDM2 proto-oncogene
decreases expression
ISO
Phlorhizin results in decreased expression of MDM2 mRNA
CTD
PMID:22538082
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Med20
mediator complex subunit 20
decreases expression
ISO
Phlorhizin results in decreased expression of MED20 mRNA
CTD
PMID:22538082
NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
G
Mgst1
microsomal glutathione S-transferase 1
increases expression
ISO
Phlorhizin results in increased expression of MGST1 mRNA
CTD
PMID:22538082
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
G
Mmut
methylmalonyl-CoA mutase
decreases expression
ISO
Phlorhizin results in decreased expression of MMUT mRNA
CTD
PMID:22538082
NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
G
Myl9
myosin light chain 9
decreases phosphorylation
EXP
Phlorhizin results in decreased phosphorylation of MYL9 protein
CTD
PMID:17272349
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
G
Ndufa12
NADH:ubiquinone oxidoreductase subunit A12
increases expression
ISO
Phlorhizin results in increased expression of NDUFA12 mRNA
CTD
PMID:22538082
NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
G
Ndufa2
NADH:ubiquinone oxidoreductase subunit A2
increases expression
ISO
Phlorhizin results in increased expression of NDUFA2 mRNA
CTD
PMID:22538082
NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
G
Ndufa3
NADH:ubiquinone oxidoreductase subunit A3
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFA3 mRNA
CTD
PMID:22538082
NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235
G
Ndufa7
NADH:ubiquinone oxidoreductase subunit A7
increases expression
ISO
Phlorhizin results in increased expression of NDUFA7 mRNA
CTD
PMID:22538082
NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
G
Ndufab1
NADH:ubiquinone oxidoreductase subunit AB1
increases expression
ISO
Phlorhizin results in increased expression of NDUFAB1 mRNA
CTD
PMID:22538082
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
G
Ndufaf1
NADH:ubiquinone oxidoreductase complex assembly factor 1
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFAF1 mRNA
CTD
PMID:22538082
NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212
G
Ndufb6
NADH:ubiquinone oxidoreductase subunit B6
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFB6 mRNA
CTD
PMID:22538082
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
G
Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFS1 mRNA
CTD
PMID:22538082
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
G
Ndufs4
NADH:ubiquinone oxidoreductase subunit S4
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFS4 mRNA
CTD
PMID:22538082
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
G
Ndufs5
NADH:ubiquinone oxidoreductase subunit S5
decreases expression
ISO
Phlorhizin results in decreased expression of NDUFS5 mRNA
CTD
PMID:22538082
NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603 Ensembl chr14:135,974,034...135,979,603 Ensembl chr 2:135,974,034...135,979,603
G
Ndufs8
NADH:ubiquinone oxidoreductase core subunit S8
increases expression
ISO
Phlorhizin results in increased expression of NDUFS8 mRNA
CTD
PMID:22538082
NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
G
Nedd4
NEDD4 E3 ubiquitin protein ligase
decreases expression
ISO
Phlorhizin results in decreased expression of NEDD4 mRNA
CTD
PMID:22538082
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
G
Neurod1
neuronal differentiation 1
increases expression
ISO
Phlorhizin results in increased expression of NEUROD1 mRNA
CTD
PMID:16123366
NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
G
Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression
ISO
Phlorhizin results in decreased expression of NFE2L2 mRNA
CTD
PMID:22538082
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[Phlorhizin co-treated with 2,2-bis(4-glycidyloxyphenyl)propane co-treated with cobaltous chloride] affects the expression of NFKB1 mRNA
CTD
PMID:32408695
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nkx6-1
NK6 homeobox 1
increases expression
ISO
Phlorhizin results in increased expression of NKX6-1 mRNA
CTD
PMID:16123366
NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
G
Nos3
nitric oxide synthase 3
multiple interactions decreases expression
ISO
Phlorhizin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA] Phlorhizin results in decreased expression of NOS3 mRNA
CTD
PMID:20021702
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nras
NRAS proto-oncogene, GTPase
decreases expression
ISO
Phlorhizin results in decreased expression of NRAS mRNA
CTD
PMID:22538082
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
G
Ogdh
oxoglutarate dehydrogenase
decreases expression
ISO
Phlorhizin results in decreased expression of OGDH mRNA
CTD
PMID:22538082
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
G
Park7
Parkinsonism associated deglycase
increases expression
ISO
Phlorhizin results in increased expression of PARK7 mRNA
CTD
PMID:22538082
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Pc
pyruvate carboxylase
increases expression decreases expression
ISO
Phlorhizin results in increased expression of PCX mRNA Phlorhizin results in decreased expression of PC mRNA
CTD
PMID:16123366 PMID:22538082
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
G
Pcca
propionyl-CoA carboxylase subunit alpha
decreases expression
ISO
Phlorhizin results in decreased expression of PCCA mRNA
CTD
PMID:22538082
NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266
G
Pck1
phosphoenolpyruvate carboxykinase 1
decreases expression
ISO
Phlorhizin results in decreased expression of PCK1 mRNA
CTD
PMID:22538082
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
G
Pecr
peroxisomal trans-2-enoyl-CoA reductase
increases expression decreases expression
ISO
Phlorhizin results in increased expression of PECR mRNA Phlorhizin results in decreased expression of PECR mRNA
CTD
PMID:22538082
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
G
Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
decreases expression
ISO
Phlorhizin results in decreased expression of PIK3C2A mRNA
CTD
PMID:22538082
NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
G
Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
decreases expression
ISO
Phlorhizin results in decreased expression of PIK3C3 mRNA
CTD
PMID:22538082
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
G
Pink1
PTEN induced kinase 1
increases expression
ISO
Phlorhizin results in increased expression of PINK1 mRNA
CTD
PMID:22538082
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
G
Prdx1
peroxiredoxin 1
increases expression
ISO
Phlorhizin results in increased expression of PRDX1 mRNA
CTD
PMID:22538082
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
G
Prdx5
peroxiredoxin 5
decreases expression
ISO
Phlorhizin results in decreased expression of PRDX5 mRNA
CTD
PMID:22538082
NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
G
Prkch
protein kinase C, eta
increases expression
ISO
Phlorhizin results in increased expression of PRKCH mRNA
CTD
PMID:22538082
NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
G
Prkci
protein kinase C, iota
decreases expression
ISO
Phlorhizin results in decreased expression of PRKCI mRNA
CTD
PMID:22538082
NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
G
Prkd3
protein kinase D3
decreases expression
ISO
Phlorhizin results in decreased expression of PRKD3 mRNA
CTD
PMID:22538082
NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443
G
Psma4
proteasome 20S subunit alpha 4
decreases expression
ISO
Phlorhizin results in decreased expression of PSMA4 mRNA
CTD
PMID:22538082
NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890
G
Psmb1
proteasome 20S subunit beta 1
increases expression
ISO
Phlorhizin results in increased expression of PSMB1 mRNA
CTD
PMID:22538082
NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
G
Psmb2
proteasome 20S subunit beta 2
decreases expression
ISO
Phlorhizin results in decreased expression of PSMB2 mRNA
CTD
PMID:22538082
NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
G
Psmc1
proteasome 26S subunit, ATPase 1
decreases expression
ISO
Phlorhizin results in decreased expression of PSMC1 mRNA
CTD
PMID:22538082
NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
G
Psmc4
proteasome 26S subunit, ATPase 4
increases expression decreases expression
ISO
Phlorhizin results in increased expression of PSMC4 mRNA Phlorhizin results in decreased expression of PSMC4 mRNA
CTD
PMID:22538082
NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
G
Psmc6
proteasome 26S subunit, ATPase 6
decreases expression
ISO
Phlorhizin results in decreased expression of PSMC6 mRNA
CTD
PMID:22538082
NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
G
Psmd10
proteasome 26S subunit, non-ATPase 10
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD10 mRNA
CTD
PMID:22538082
NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097
G
Psmd12
proteasome 26S subunit, non-ATPase 12
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD12 mRNA
CTD
PMID:22538082
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
G
Psmd14
proteasome 26S subunit, non-ATPase 14
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD14 mRNA
CTD
PMID:22538082
NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
G
Psmd4
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD4 mRNA
CTD
PMID:22538082
NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
G
Psmd6
proteasome 26S subunit, non-ATPase 6
increases expression
ISO
Phlorhizin results in increased expression of PSMD6 mRNA
CTD
PMID:22538082
NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620
G
Psmd7
proteasome 26S subunit, non-ATPase 7
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD7 mRNA
CTD
PMID:22538082
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
G
Psmd9
proteasome 26S subunit, non-ATPase 9
decreases expression
ISO
Phlorhizin results in decreased expression of PSMD9 mRNA
CTD
PMID:22538082
NCBI chr12:33,337,182...33,357,468
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
decreases expression
ISO
Phlorhizin results in decreased expression of RAF1 mRNA
CTD
PMID:22538082
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Rdh14
retinol dehydrogenase 14
increases expression
ISO
Phlorhizin results in increased expression of RDH14 mRNA
CTD
PMID:22538082
NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
G
S100a6
S100 calcium binding protein A6
decreases expression
ISO
Phlorhizin results in decreased expression of S100A6 mRNA
CTD
PMID:16123366
NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
G
Sdha
succinate dehydrogenase complex flavoprotein subunit A
decreases expression
ISO
Phlorhizin results in decreased expression of SDHA mRNA
CTD
PMID:22538082
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
G
Sdhb
succinate dehydrogenase complex iron sulfur subunit B
increases expression
ISO
Phlorhizin results in increased expression of SDHB mRNA
CTD
PMID:22538082
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
G
Sds
serine dehydratase
decreases expression
ISO
Phlorhizin results in decreased expression of SDS mRNA
CTD
PMID:22538082
NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
G
Slc2a2
solute carrier family 2 member 2
increases expression
ISO
Phlorhizin results in increased expression of SLC2A2 mRNA
CTD
PMID:16123366
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
G
Slc35a2
solute carrier family 35 member A2
increases expression
ISO
Phlorhizin results in increased expression of SLC35A2 mRNA
CTD
PMID:22538082
NCBI chr X:14,608,145...14,616,937
Ensembl chr X:14,608,055...14,616,678
G
Slc5a1
solute carrier family 5 member 1
multiple interactions affects binding decreases activity
ISO EXP
Phlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside]; Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] SLC5A1 protein binds to Phlorhizin Phlorhizin results in decreased activity of SLC5A1 protein [Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose [Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
CTD
PMID:12663055 PMID:12927799 PMID:16300400 PMID:17288452 PMID:17983207
NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
G
Slc5a2
solute carrier family 5 member 2
decreases activity
ISO
Phlorhizin results in decreased activity of SLC5A2 protein
CTD
PMID:21128592
NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
G
Sod1
superoxide dismutase 1
increases expression
ISO
Phlorhizin results in increased expression of SOD1 mRNA
CTD
PMID:22538082
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
decreases expression
ISO
Phlorhizin results in decreased expression of SOD2 mRNA
CTD
PMID:22538082
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Phlorhizin results in decreased expression of STIP1 mRNA
CTD
PMID:22538082
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
G
Sucla2
succinate-CoA ligase ADP-forming subunit beta
decreases expression
ISO
Phlorhizin results in decreased expression of SUCLA2 mRNA
CTD
PMID:22538082
NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
G
Suclg2
succinate-CoA ligase GDP-forming subunit beta
decreases expression
ISO
Phlorhizin results in decreased expression of SUCLG2 mRNA
CTD
PMID:22538082
NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
G
Sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
decreases expression
ISO
Phlorhizin results in decreased expression of SUGT1 mRNA
CTD
PMID:22538082
NCBI chr15:54,991,419...55,032,244
Ensembl chr15:54,990,672...55,069,150
G
Txn1
thioredoxin 1
decreases expression increases expression
ISO
Phlorhizin results in decreased expression of TXN mRNA Phlorhizin results in increased expression of TXN mRNA
CTD
PMID:22538082
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Txn2
thioredoxin 2
increases expression
ISO
Phlorhizin results in increased expression of TXN2 mRNA
CTD
PMID:22538082
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
G
Ubb
ubiquitin B
increases expression
ISO
Phlorhizin results in increased expression of UBB mRNA
CTD
PMID:22538082
NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
G
Ubc
ubiquitin C
decreases expression
ISO
Phlorhizin results in decreased expression of UBC mRNA
CTD
PMID:22538082
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
G
Ube2b
ubiquitin-conjugating enzyme E2B
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2B mRNA
CTD
PMID:22538082
NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
G
Ube2f
ubiquitin-conjugating enzyme E2F (putative)
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2F mRNA
CTD
PMID:22538082
NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594
G
Ube2h
ubiquitin-conjugating enzyme E2H
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2H mRNA
CTD
PMID:22538082
NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156
G
Ube2i
ubiquitin-conjugating enzyme E2I
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2I mRNA
CTD
PMID:22538082
NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443 Ensembl chr10:69,701,618...69,702,443
G
Ube2l3
ubiquitin-conjugating enzyme E2L 3
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2L3 mRNA
CTD
PMID:22538082
NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
G
Ube2m
ubiquitin-conjugating enzyme E2M
increases expression
ISO
Phlorhizin results in increased expression of UBE2M mRNA
CTD
PMID:22538082
NCBI chr 1:73,662,576...73,666,113
Ensembl chr 1:73,662,576...73,666,026
G
Ube2n
ubiquitin-conjugating enzyme E2N
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2N mRNA
CTD
PMID:22538082
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
G
Ube2q1
ubiquitin conjugating enzyme E2 Q1
increases expression
ISO
Phlorhizin results in increased expression of UBE2Q1 mRNA
CTD
PMID:22538082
NCBI chr 2:175,198,793...175,209,152
Ensembl chr 2:175,198,873...175,207,942
G
Ube2r2
ubiquitin-conjugating enzyme E2R 2
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2R2 mRNA
CTD
PMID:22538082
NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
G
Ube2v2
ubiquitin conjugating enzyme E2 V2
decreases expression
ISO
Phlorhizin results in decreased expression of UBE2V2 mRNA
CTD
PMID:22538082
NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
G
Ube4a
ubiquitination factor E4A
increases expression
ISO
Phlorhizin results in increased expression of UBE4A mRNA
CTD
PMID:22538082
NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038
G
Ubr2
ubiquitin protein ligase E3 component n-recognin 2
increases expression
ISO
Phlorhizin results in increased expression of UBR2 mRNA
CTD
PMID:22538082
NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
G
Uchl3
ubiquitin C-terminal hydrolase L3
decreases expression
ISO
Phlorhizin results in decreased expression of UCHL3 mRNA
CTD
PMID:22538082
NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355 Ensembl chr 3:78,485,315...78,527,355
G
Uchl5
ubiquitin C-terminal hydrolase L5
decreases expression
ISO
Phlorhizin results in decreased expression of UCHL5 mRNA
CTD
PMID:22538082
NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
decreases activity
ISO
Phlorhizin results in decreased activity of UGT1A1 protein
CTD
PMID:35868516
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
decreases activity
ISO
Phlorhizin results in decreased activity of UGT1A3 protein
CTD
PMID:35868516
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
decreases activity
ISO
Phlorhizin results in decreased activity of UGT1A9 protein
CTD
PMID:35868516
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
decreases activity
ISO
Phlorhizin results in decreased activity of UGT2B17 protein
CTD
PMID:35868516
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Ugt2b7
UDP glucuronosyltransferase family 2 member B7
decreases activity
ISO
Phlorhizin results in decreased activity of UGT2B7 protein
CTD
PMID:35868516
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
G
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
decreases expression
ISO
Phlorhizin results in decreased expression of UQCRC2 mRNA
CTD
PMID:22538082
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
G
Usp1
ubiquitin specific peptidase 1
increases expression
ISO
Phlorhizin results in increased expression of USP1 mRNA
CTD
PMID:22538082
NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932
G
Usp14
ubiquitin specific peptidase 14
decreases expression
ISO
Phlorhizin results in decreased expression of USP14 mRNA
CTD
PMID:22538082
NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519
G
Usp19
ubiquitin specific peptidase 19
increases expression
ISO
Phlorhizin results in increased expression of USP19 mRNA
CTD
PMID:22538082
NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741
G
Usp24
ubiquitin specific peptidase 24
decreases expression
ISO
Phlorhizin results in decreased expression of USP24 mRNA
CTD
PMID:22538082
NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311
G
Usp33
ubiquitin specific peptidase 33
decreases expression
ISO
Phlorhizin results in decreased expression of USP33 mRNA
CTD
PMID:22538082
NCBI chr 2:241,283,209...241,328,479
Ensembl chr 2:241,292,985...241,328,479
G
Usp4
ubiquitin specific peptidase 4
increases expression
ISO
Phlorhizin results in increased expression of USP4 mRNA
CTD
PMID:22538082
NCBI chr 8:109,035,402...109,079,382
Ensembl chr 8:109,036,099...109,080,427
G
Usp45
ubiquitin specific peptidase 45
decreases expression
ISO
Phlorhizin results in decreased expression of USP45 mRNA
CTD
PMID:22538082
NCBI chr 5:35,318,621...35,392,090
Ensembl chr 5:35,318,635...35,389,420
G
Usp46
ubiquitin specific peptidase 46
decreases expression
ISO
Phlorhizin results in decreased expression of USP46 mRNA
CTD
PMID:22538082
NCBI chr14:34,150,055...34,219,227
Ensembl chr14:34,150,004...34,219,227
G
Usp7
ubiquitin specific peptidase 7
decreases expression
ISO
Phlorhizin results in decreased expression of USP7 mRNA
CTD
PMID:22538082
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
G
Usp9x
ubiquitin specific peptidase 9, X-linked
decreases expression
ISO
Phlorhizin results in decreased expression of USP9X mRNA
CTD
PMID:22538082
NCBI chr X:9,588,825...9,726,993
Ensembl chr X:9,588,825...9,696,711
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] results in increased expression of VEGFA mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of VEGFA mRNA]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phlorhizin] results in increased expression of VEGFA mRNA; [cobaltous chloride co-treated with Phlorhizin] affects the expression of VEGFA mRNA
CTD
PMID:32408695
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
Phlorhizin results in decreased expression of XIAP mRNA
CTD
PMID:22538082
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]
CTD
PMID:30104959
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
CTD
PMID:30104959
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cat
catalase
multiple interactions
ISO
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]
CTD
PMID:32663520
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Esrra
estrogen related receptor, alpha
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein]
CTD
PMID:30104959
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
G
Foxo3
forkhead box O3
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein]
CTD
PMID:30104959
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Gpx1
glutathione peroxidase 1
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]
CTD
PMID:30104959
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Hmox1
heme oxygenase 1
multiple interactions
ISO EXP
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein] trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD
PMID:30104959 PMID:32663520
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein]
CTD
PMID:30104959
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
G
Il1b
interleukin 1 beta
multiple interactions
ISO
trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:25053100
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:25053100
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Keap1
Kelch-like ECH-associated protein 1
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]
CTD
PMID:30104959
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
G
Mt-atp6
mitochondrially encoded ATP synthase membrane subunit 6
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP6 mRNA]
CTD
PMID:30104959
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
G
Mt-co1
mitochondrially encoded cytochrome c oxidase I
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX1 mRNA]
CTD
PMID:30104959
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
G
Mt-cyb
mitochondrially encoded cytochrome b
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CYTB mRNA]
CTD
PMID:30104959
NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
G
Mt-nd2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND2 mRNA]
CTD
PMID:30104959
NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
G
Mt-nd5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND5 mRNA]
CTD
PMID:30104959
NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP ISO
trilobatin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein] NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
CTD
PMID:30104959 PMID:32663520
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
trilobatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
CTD
PMID:25053100
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP ISO
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein] trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
CTD
PMID:30104959 PMID:32663520
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein]
CTD
PMID:30104959
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
trilobatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD
PMID:25053100
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sirt3
sirtuin 3
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein]
CTD
PMID:30104959
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
G
Sod2
superoxide dismutase 2
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein]
CTD
PMID:30104959
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Tnf
tumor necrosis factor
multiple interactions
ISO
trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:25053100
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Ucp2
uncoupling protein 2
multiple interactions
EXP
trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein]
CTD
PMID:30104959
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all