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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perampanel
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Accession:CHEBI:71013 term browser browse the term
Definition:A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Synonyms:exact_synonym: 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
 related_synonym: 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;   E 2007;   E2007;   ER-155055-90;   Formula=C23H15N3O;   Fycompa;   InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H;   InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N;   SMILES=O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N;   perampanelum
 xref: CAS:380917-97-5;   Drug_Central:4684;   KEGG:D08964
 xref_mesh: MESH:C551441
 xref: PMID:21635236;   PMID:21686307;   PMID:21883097;   PMID:22161845;   PMID:22222634;   PMID:22433907;   PMID:22517103;   PMID:22650169;   PMID:22776828;   PMID:22788917;   PMID:22843280;   PMID:22905857;   PMID:22905878;   PMID:22913800;   PMID:23093905;   PMID:23114872;   Patent:EP1875912;   Patent:US2008108603;   Patent:US2009088574;   Patent:WO2006107859;   Patent:WO2008111590;   Reaxys:11343244;   Wikipedia:Perampanel


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perampanel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of perampanel CTD PMID:35200000 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:36669621 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein] CTD PMID:36669621 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      group 19831
        pseudohalo group 4581
          cyano group 4581
            nitrile 4581
              perampanel 4
                perampanel hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      benzonitrile 7
                                        perampanel 4
                                          perampanel hydrate 0
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