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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:G-protein-coupled receptor agonist
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Accession:CHEBI:70998 term browser browse the term
Definition:An agonist that binds to and activates G-protein-coupled receptors
Synonyms:related_synonym: G-protein-coupled receptor agonists;   GPCR agonist;   GPCR agonists
 xref: Wikipedia:G_protein-coupled_receptor



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3-iodothyronamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhcg Rh family, C glycoprotein affects uptake ISO RHCG mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:133,531,704...133,555,902
Ensembl chr 1:133,531,716...133,555,876
JBrowse link
G Slc16a7 solute carrier family 16 member 7 affects uptake ISO SLC16A7 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994
JBrowse link
G Slc17a5 solute carrier family 17 member 5 affects uptake ISO SLC17A5 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 8:79,394,416...79,429,387 JBrowse link
G Slc26a11 solute carrier family 26 member 11 affects uptake ISO SLC26A11 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970
JBrowse link
G Slc27a1 solute carrier family 27 member 1 affects uptake ISO SLC27A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
JBrowse link
G Slc28a3 solute carrier family 28 member 3 affects uptake ISO SLC28A3 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr17:6,062,563...6,112,965
Ensembl chr17:6,062,549...6,114,038
JBrowse link
G Slc29a2 solute carrier family 29 member 2 affects uptake ISO SLC29A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
JBrowse link
G Slc30a10 solute carrier family 30, member 10 affects uptake ISO SLC30A10 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Slc30a8 solute carrier family 30 member 8 affects uptake ISO SLC30A8 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305
JBrowse link
G Slc31a1 solute carrier family 31 member 1 affects uptake ISO SLC31A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc35c2 solute carrier family 35 member C2 affects uptake ISO SLC35C2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:154,012,416...154,023,488
JBrowse link
G Slc35d2 solute carrier family 35 member D2 affects uptake ISO SLC35D2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr17:987,899...1,019,747
Ensembl chr17:988,157...1,019,743
JBrowse link
G Slc37a1 solute carrier family 37 member 1 affects uptake ISO SLC37A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892
JBrowse link
G Slc43a3 solute carrier family 43, member 3 affects uptake ISO SLC43A3 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749
JBrowse link
G Slc45a2 solute carrier family 45, member 2 affects uptake ISO SLC45A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317
JBrowse link
G Slc45a4 solute carrier family 45, member 4 affects uptake ISO SLC45A4 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:105,478,886...105,550,160
Ensembl chr 7:105,481,792...105,550,170
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects uptake ISO SLC46A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc6a18 solute carrier family 6 member 18 affects uptake ISO SLC6A18 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925
JBrowse link
G Slc7a1 solute carrier family 7 member 1 affects uptake ISO SLC7A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slc7a14 solute carrier family 7, member 14 affects uptake ISO SLC7A14 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 2:112,065,286...112,171,319
Ensembl chr 2:112,065,286...112,171,313
JBrowse link
G Slc7a2 solute carrier family 7 member 2 affects uptake ISO SLC7A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
JBrowse link
G Slc9a4 solute carrier family 9 member A4 affects uptake ISO SLC9A4 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:42,825,334...42,879,729
Ensembl chr 9:42,825,064...42,879,422
JBrowse link
G Slc9a5 solute carrier family 9 member A5 affects uptake ISO SLC9A5 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr19:33,225,481...33,246,913
Ensembl chr19:33,226,816...33,246,903
JBrowse link
G Slc9a6 solute carrier family 9 member A6 affects uptake ISO SLC9A6 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375
JBrowse link
G Slc9a7 solute carrier family 9 member A7 affects uptake ISO SLC9A7 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012
JBrowse link
G Slc9a8 solute carrier family 9 member A8 affects uptake ISO SLC9A8 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471
JBrowse link
G Slc9a9 solute carrier family 9 member A9 affects uptake ISO SLC9A9 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake ISO SLCO1A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 affects uptake ISO SLCO3A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 affects uptake ISO SLCO4A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 affects uptake ISO SLCO4C1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715
JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 affects uptake ISO SLCO5A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 5:6,228,938...6,358,124
Ensembl chr 5:6,228,973...6,352,913
JBrowse link
G Slco6b1 solute carrier organic anion transporter family member 6B1 affects uptake ISO SLCO6A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:97,266,655...97,347,336
Ensembl chr 9:97,271,334...97,347,336
JBrowse link
3-methoxycatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3-methoxycatechol CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 3-methoxycatechol results in increased expression of NFE2L2 mRNA CTD PMID:26862668 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
kynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid] CTD PMID:30639138 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein
Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein
CTD PMID:20106948 PMID:27020609 PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]
Kynurenic Acid results in increased activity of CYP1A1 protein
Kynurenic Acid results in increased expression of CYP1A1 mRNA
CTD PMID:20106948 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Kynurenic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO Kynurenic Acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
CTD PMID:20106948 PMID:35123988 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] CTD PMID:20106948 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid CTD PMID:30151725 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein] CTD PMID:35123988 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] CTD PMID:35123988 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ocln occludin multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of OCLN protein] CTD PMID:35123988 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Kynurenic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein] CTD PMID:35123988 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of TJP1 protein] CTD PMID:35123988 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:35123988 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
liraglutide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] CTD PMID:32898504 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adam33 ADAM metallopeptidase domain 33 decreases methylation
increases expression
ISO Liraglutide results in decreased methylation of ADAM33 promoter
Liraglutide results in increased expression of ADAM33 mRNA; Liraglutide results in increased expression of ADAM33 protein
CTD PMID:34534549 NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein] CTD PMID:32898504 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]] CTD PMID:31173752 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]
Liraglutide inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD PMID:31173752 PMID:31362085 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]
Liraglutide inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
CTD PMID:31173752 PMID:31362085 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]
Liraglutide inhibits the reaction [Methotrexate results in increased expression of and results in increased activity of CASP3 protein]
CTD PMID:31173752 PMID:31362085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdh1 cadherin 1 increases expression
decreases methylation
ISO Liraglutide results in increased expression of CDH1 mRNA; Liraglutide results in increased expression of CDH1 protein
Liraglutide results in decreased methylation of CDH1 promoter
CTD PMID:34534549 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein] CTD PMID:32898504 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in decreased phosphorylation of CREB1 protein] CTD PMID:31362085 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] CTD PMID:35985417 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBB mRNA] CTD PMID:35985417 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein] CTD PMID:32898504 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Liraglutide results in increased expression of ESR1 mRNA; Liraglutide results in increased expression of ESR1 protein CTD PMID:34534549 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions
increases activity
increases expression
EXP
ISO
Liraglutide inhibits the reaction [nitrofen results in decreased expression of GLP1R mRNA]
Liraglutide results in increased activity of GLP1R protein
Liraglutide binds to and results in increased activity of GLP1R protein
Liraglutide results in increased expression of GLP1R mRNA
CTD PMID:23354098 PMID:23471186 PMID:35985417 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:31362085 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]] CTD PMID:31173752 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of HMOX1 protein] CTD PMID:31362085 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein]; Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] CTD PMID:32898504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:31362085 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]] CTD PMID:31173752 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] CTD PMID:31362085 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein] CTD PMID:32898504 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein] CTD PMID:32898504 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein] CTD PMID:31362085 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of RELA protein] CTD PMID:31362085 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions
EXP Liraglutide results in increased expression of SFTPA1 mRNA
Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA]; Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 protein]
CTD PMID:23354098 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpb surfactant protein B increases expression EXP Liraglutide results in increased expression of SFTPB mRNA CTD PMID:23354098 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:31362085 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tsc1 TSC complex subunit 1 multiple interactions EXP Liraglutide reverses the reaction [palmitate fatty acid decreases expression of tsc1 protein in hepatocytes] RGD PMID:31787541 RGD:25823196 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of XDH mRNA] CTD PMID:35985417 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
lixisenatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein] CTD PMID:38229325 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:38229325 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]] CTD PMID:38229325 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]]; NFE2L2 protein affects the reaction [lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]] CTD PMID:38229325 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:38229325 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in decreased expression of RELA mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in decreased expression of RELA protein]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:38229325 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lixisenatide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lixisenatide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:38229325 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
semaglutide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:36075570 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein] CTD PMID:36075570 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP
ISO
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]
CTD PMID:36075570 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:36075570 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:36075570 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:36075570 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:36075570 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
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  CHEBI ontology 19899
    role 19869
      biological role 19867
        pharmacological role 19101
          agonist 18630
            G-protein-coupled receptor agonist 83
              3-methoxycatechol 2
              G-1 0
              GRI977143 0
              MEDICA 16 0
              SAG hydrochloride 0
              dibenziodolium chloride 0
              gastric inhibitory polypeptide receptor agonist + 0
              glucagon-like peptide-1 receptor agonist + 35
              kynurenic acid + 19
              protease-activated receptor-1 agonist 0
              somatostatin receptor agonist + 0
              trace amine-associated receptor 1 agonist + 33
paths to the root