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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hexacyclic triterpenoid
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Accession:CHEBI:70994 term browser browse the term
Definition:A triterpenoid that consists of a hexacyclic ring system.
Synonyms:related_synonym: hexacyclic triterpenoids


show annotations for term's descendants           Sort by:
dioscin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] CTD PMID:27317372 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP 		dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein CTD PMID:24680847 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:27317372 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] CTD PMID:24146112 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] CTD PMID:24146112 NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:24146112 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] CTD PMID:24146112 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] CTD PMID:24146112 NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] CTD PMID:35481609 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression 		ISO dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein] 		CTD PMID:25111127 PMID:29990575 PMID:35481609 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] CTD PMID:24146112 NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO dioscin results in decreased expression of APAF1 mRNA CTD PMID:33359023 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] CTD PMID:24146112 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO dioscin results in increased expression of BAD mRNA CTD PMID:33359023 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression 		ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein 		CTD PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein 		CTD PMID:22334414 PMID:22939915 PMID:33359023 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein CTD PMID:29990575 PMID:33359023 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression 		ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein
dioscin results in increased expression of BCL2 protein 		CTD PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression 		ISO [Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein 		CTD PMID:22334414 PMID:22939915 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO dioscin results in increased expression of BIRC5 mRNA CTD PMID:29990575 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
decreases expression 		EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in increased activity of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein 		CTD PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases expression ISO dioscin results in increased expression of CASP7 mRNA CTD PMID:29990575 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 increases activity
increases expression
decreases expression
multiple interactions 		ISO dioscin results in increased activity of CASP8 protein
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein 		CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression 		EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein 		CTD PMID:24146112 PMID:29990575 PMID:33359023 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein CTD PMID:33359023 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein CTD PMID:29990575 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression 		ISO dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein 		CTD PMID:29990575 PMID:33359023 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein CTD PMID:33359023 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein CTD PMID:29990575 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein CTD PMID:33359023 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO dioscin results in decreased expression of CDK4 mRNA CTD PMID:33359023 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein CTD PMID:33359023 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein CTD PMID:29990575 PMID:33359023 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein CTD PMID:33359023 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein CTD PMID:33359023 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:24146112 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions 		ISO dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA] 		CTD PMID:24742230 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO dioscin results in increased expression of CYCS mRNA CTD PMID:33359023 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] CTD PMID:24146112 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] CTD PMID:24146112 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO dioscin results in increased expression of DIABLO mRNA CTD PMID:29990575 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions 		ISO dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein] 		CTD PMID:24742230 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression 		ISO fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] CTD PMID:24742230 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein CTD PMID:22334414 PMID:33359023 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand increases expression ISO dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein CTD PMID:22334414 PMID:29990575 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO dioscin results in increased expression of FOXO1 mRNA CTD PMID:33359023 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] CTD PMID:27317372 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] CTD PMID:24146112 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver] 		CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver] 		CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:24146112 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] CTD PMID:35481609 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver] 		CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] CTD PMID:35481609 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] CTD PMID:35481609 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver] 		CTD
RGD		 PMID:24146112 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO
EXP 		dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions
increases expression 		ISO fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] CTD PMID:24742230 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] 		CTD PMID:24146112 PMID:25111127 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] 		CTD PMID:24146112 PMID:25111127 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO dioscin results in increased expression of MAPK8 mRNA CTD PMID:29990575 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO dioscin results in increased expression of MAPK9 mRNA CTD PMID:29990575 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] CTD PMID:22939915 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO dioscin results in decreased expression of MTOR mRNA CTD PMID:29990575 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] CTD PMID:35481609 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver] 		CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO dioscin results in decreased degradation of NFKBIA protein CTD PMID:24680847 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression 		EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA 		CTD PMID:27317372 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver] 		CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
decreases expression 		ISO
EXP 		dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in increased expression of PARP1 mRNA
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein 		CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases expression ISO dioscin results in decreased expression of PIK3CB mRNA CTD PMID:29990575 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] CTD PMID:22939915 NCBI chr15:26,644,147...26,651,808
Ensembl chr15:26,643,858...26,678,162 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO 		dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:24146112 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] CTD PMID:22939915 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO dioscin results in increased expression of PRKAB1 mRNA CTD PMID:29990575 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] CTD PMID:25111127 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] CTD PMID:28082111 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rgn regucalcin multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] CTD PMID:22939915 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dioscin results in decreased expression of RPS6KB1 mRNA CTD PMID:29990575 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:27317372 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 increases expression
multiple interactions 		EXP dioscin results in increased expression of SLCO1A1 mRNA
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A1 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A1 protein] 		CTD PMID:27317372 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP dioscin results in increased expression of SLCO1A2 mRNA CTD PMID:27317372 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases expression 		EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA 		CTD PMID:27317372 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Suox sulfite oxidase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] CTD PMID:22939915 NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,687,666...1,690,235 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] 		CTD PMID:35481609 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver] 		CTD
RGD		 PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More... RGD:15090820 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions 		ISO dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA] 		CTD PMID:24742230 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO dioscin results in increased expression of TNFRSF25 mRNA CTD PMID:29990575 PMID:33359023 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions 		ISO dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] 		CTD PMID:24742230 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO
EXP 		dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein 		CTD PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO dioscin results in increased expression of TRADD mRNA CTD PMID:29990575 PMID:33359023 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO dioscin results in increased expression of TRAF1 protein CTD PMID:22334414 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO dioscin results in increased expression of WEE1 mRNA CTD PMID:29990575 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449 		JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression 		EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA
Diosgenin results in increased expression of ABCC2 mRNA 		CTD PMID:16105132 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions 		EXP Diosgenin results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA 		CTD PMID:16105132 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions 		EXP
ISO 		Diosgenin results in increased expression of ABCG5 mRNA
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA
Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol] 		CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression
multiple interactions 		EXP
ISO 		Diosgenin results in increased expression of ABCG8 mRNA
[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA
Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol] 		CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Diosgenin results in decreased expression of ACACA mRNA CTD PMID:32347045 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:16331273 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]] 		CTD PMID:39059093 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 protein] CTD PMID:35305976 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] CTD PMID:16331273 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:35149085 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:28106847 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO
EXP 		Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Diosgenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
Diosgenin results in decreased expression of BCL2 protein 		CTD PMID:16331273 PMID:28106847 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]
Diosgenin results in decreased expression of BCL2A1 protein 		CTD PMID:16331273 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of BCL2L1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] 		CTD PMID:16331273 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Diosgenin results in decreased expression of BIRC2 protein 		CTD PMID:16331273 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP3 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein] 		CTD PMID:28106847 PMID:35149085 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased expression of CASP9 protein] CTD PMID:35149085 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of CCL2 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA] 		CTD PMID:26408789 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:16331273 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh5 cadherin 5 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]] 		CTD PMID:39059093 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions EXP Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 protein] CTD PMID:33383043 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of CFLAR protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein] 		CTD PMID:16331273 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of COL1A1 mRNA] CTD PMID:39059093 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of COL3A1 mRNA] CTD PMID:39059093 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Diosgenin results in decreased expression of CTNNB1 mRNA CTD PMID:26408789 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA] CTD PMID:33383043 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein] CTD PMID:12963437 PMID:33383043 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO
EXP 		Diosgenin affects the reaction [alpha-Chlorohydrin affects the localization of DNM1L protein]
Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of DNM1L protein] 		CTD PMID:35149085 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:35149085 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression 		ISO Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of ESR2 protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]
Diosgenin results in increased expression of ESR2 protein 		CTD PMID:26408789 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of FABP4 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA] 		CTD PMID:26408789 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Diosgenin results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FASN protein] 		CTD PMID:39536891 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA] CTD PMID:33383043 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:35149085 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:39536891 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of HIF1A mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of HIF1A protein] 		CTD PMID:39536891 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Diosgenin co-treated with Ecdysterone] results in increased expression of IGF1 mRNA CTD PMID:39395682 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]; Diosgenin inhibits the reaction [MTOR protein promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]] 		CTD PMID:35305976 PMID:39536891 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]]
Diosgenin results in decreased expression of IL6 mRNA 		CTD PMID:26408789 PMID:35305976 PMID:39059093 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:24001619 PMID:35305976 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of LDHA protein] CTD PMID:39059093 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lipc lipase C, hepatic type increases activity EXP Diosgenin results in increased activity of LIPC protein CTD PMID:20149787 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases lipidation 		EXP
ISO 		[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]
3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; [alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased lipidation of MAP1LC3B protein] 		CTD PMID:35149085 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 decreases expression ISO Diosgenin results in decreased expression of MESP1 mRNA; Diosgenin results in decreased expression of MESP1 protein CTD PMID:34806916 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:143,147,671...143,149,189 		JBrowse link
G Mest mesoderm specific transcript multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
Diosgenin results in decreased expression of MEST mRNA 		CTD PMID:26408789 NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:60,316,102...60,333,509 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN1 protein] CTD PMID:35149085 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein] CTD PMID:35149085 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression 		EXP Diosgenin results in increased activity of MMP2 protein
Diosgenin results in increased expression of MMP2 mRNA 		CTD PMID:21814480 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity 		ISO
EXP 		Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
Diosgenin results in decreased expression of MMP9 mRNA
Diosgenin results in decreased activity of MMP9 protein 		CTD PMID:16331273 PMID:21814480 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO
EXP 		3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of MTOR mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased phosphorylation of MTOR protein]; Diosgenin inhibits the reaction [MTOR protein promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MTOR mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased phosphorylation of MTOR protein] 		CTD PMID:35149085 PMID:39536891 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:16331273 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:16331273 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16331273 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 protein] CTD PMID:33383043 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diosgenin results in increased activity of NR1I2 protein CTD PMID:15611112 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in increased degradation of NR3C1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]]
Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of NR3C1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]] 		CTD PMID:39059093 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]] CTD PMID:39059093 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions 		ISO Diosgenin results in increased expression of PIK3R1 mRNA
[Diosgenin co-treated with Ecdysterone] results in increased expression of PIK3R1 mRNA 		CTD PMID:39395682 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases response to substance
decreases expression
multiple interactions 		ISO Diosgenin results in increased expression of PPARG protein
Diosgenin results in increased expression of PPARG mRNA
PPARG protein results in decreased susceptibility to Diosgenin
Diosgenin results in decreased expression of PPARG mRNA
[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA] 		CTD PMID:24001619 PMID:26408789 PMID:32347045 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:16331273 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of RELA protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA] 		CTD PMID:16331273 PMID:35305976 PMID:39536891 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 multiple interactions EXP Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 protein] CTD PMID:35305976 NCBI chr10:102,331,991...102,359,117
Ensembl chr10:102,331,991...102,359,117 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:35149085 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein] CTD PMID:26408789 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein] CTD PMID:33383043 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased phosphorylation of STK11 protein] CTD PMID:35149085 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Tagln transgelin multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]] 		CTD PMID:39059093 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity 		ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Diosgenin results in decreased activity of TNF protein 		CTD PMID:16331273 PMID:35305976 PMID:39536891 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases activity 		ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
Diosgenin results in decreased activity of TNFSF11 protein 		CTD PMID:16331273 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein CTD PMID:35149085 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] 		CTD PMID:16331273 PMID:39536891 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO Diosgenin results in decreased expression of WNT10B mRNA CTD PMID:26408789 NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:131,801,046...131,806,850 		JBrowse link
limonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions 		ISO limonin results in decreased expression of ALDH1A1 mRNA
limonin results in decreased expression of and results in decreased activity of ALDH1A1 protein 		CTD PMID:30738134 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein] CTD PMID:34423886 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases activity ISO limonin results in increased activity of CASP3 protein CTD PMID:31702096 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases activity ISO limonin results in increased activity of CASP9 protein CTD PMID:31702096 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] CTD PMID:31702096 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein] CTD PMID:34423886 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO limonin results in decreased expression of CCN2 mRNA CTD PMID:30738134 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein] CTD PMID:34423886 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO limonin results in increased expression of CDH1 mRNA; limonin results in increased expression of CDH1 protein CTD PMID:30738134 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO limonin results in decreased activity of CYP3A4 protein CTD PMID:22001672 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO limonin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein] CTD PMID:31702096 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein] CTD PMID:34423886 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]; limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein] CTD PMID:31702096 PMID:34423886 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein] CTD PMID:34423886 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein] CTD PMID:34423886 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO limonin results in decreased expression of NANOG mRNA; limonin results in decreased expression of NANOG protein CTD PMID:30738134 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein] CTD PMID:34423886 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]; limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein] CTD PMID:31702096 PMID:34423886 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vim vimentin decreases expression ISO limonin results in decreased expression of VIM mRNA; limonin results in decreased expression of VIM protein CTD PMID:30738134 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization ISO limonin affects the localization of YAP1 protein CTD PMID:30738134 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        polyatomic entity 20745
          molecule 20540
            cyclic compound 20415
              polycyclic compound 19205
                organic polycyclic compound 17588
                  hexacyclic triterpenoid 166
                    (16alpha,20R,22S,23S)-16,23:22,25-diepoxy-2,20,22,23-tetrahydroxycucurbita-1,5-diene-3,11-dione 2-O-beta-D-glucopyranoside 0
                    (16alpha,20S,22S,23S)-16,23:22,25-diepoxy-2,22,23-trihydroxycucurbita-1,5-diene-3,11-dione 2-O-beta-D-glucopyranoside 0
                    (3beta,16alpha)-13,28-epoxyoleanane-3,16,30-triol 0
                    (3beta,16alpha)-13,28-epoxyoleanane-3,16-diol 0
                    (3beta,16alpha)-16-hydroxy-13,28-epoxyoleanan-3-yl alpha-L-Rhap-(1->2)-beta-D-Glcp-(1->4)-[beta-D-Glcp-(1->2)]-alpha-L-arabinopyranoside 0
                    26-desglucoavenacoside A 0
                    26-desglucoavenacoside B 0
                    3alpha-hydroxyolean-11-en-28,13beta-olide 0
                    3beta-[(alpha-L-arabinopyranosyl)oxy]-20beta-hydroxyursan-28-oic acid delta-lactone 0
                    anagalligenin A 0
                    ardisianoside A 0
                    ardisianoside B 0
                    ardisianoside C 0
                    ardisianoside D 0
                    ardisianoside E 0
                    ardisimamiloside E 0
                    avenacoside A 0
                    avenacoside B 0
                    capilliposide B 0
                    celastolide 0
                    clethroidoside C 0
                    clethroidoside D 0
                    clethroidoside E 0
                    clethroidoside F 0
                    dioscin 108
                    diosgenin 73
                    diosgenin 3-O-beta-D-glucoside 0
                    fatsicarpain G 0
                    hyperinol A 0
                    hyperinol B 0
                    kadlongilactone A 0
                    kadlongilactone B 0
                    limonin 21
                    lysikokianoside 1 0
                    maytenfolone A 0
                    nolinospiroside F 0
                    oblonganoside A 0
                    orthosphenic acid 0
                    rotundifolioside A 0
                    rotundifolioside H 0
                    rotundifolioside I 0
                    rotundifolioside J 0
                    rubriflordilactone B 0
                    saikogenin E 0
                    saikosaponin C 0
                    salaspermic acid 0
                    tigogenin 3-O-beta-D-glucopyranoside 0
                    triptocallic acid C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            lipid 17852
                              isoprenoid 14136
                                terpenoid 13837
                                  triterpenoid 1286
                                    hexacyclic triterpenoid 166
                                      (16alpha,20R,22S,23S)-16,23:22,25-diepoxy-2,20,22,23-tetrahydroxycucurbita-1,5-diene-3,11-dione 2-O-beta-D-glucopyranoside 0
                                      (16alpha,20S,22S,23S)-16,23:22,25-diepoxy-2,22,23-trihydroxycucurbita-1,5-diene-3,11-dione 2-O-beta-D-glucopyranoside 0
                                      (3beta,16alpha)-13,28-epoxyoleanane-3,16,30-triol 0
                                      (3beta,16alpha)-13,28-epoxyoleanane-3,16-diol 0
                                      (3beta,16alpha)-16-hydroxy-13,28-epoxyoleanan-3-yl alpha-L-Rhap-(1->2)-beta-D-Glcp-(1->4)-[beta-D-Glcp-(1->2)]-alpha-L-arabinopyranoside 0
                                      26-desglucoavenacoside A 0
                                      26-desglucoavenacoside B 0
                                      3alpha-hydroxyolean-11-en-28,13beta-olide 0
                                      3beta-[(alpha-L-arabinopyranosyl)oxy]-20beta-hydroxyursan-28-oic acid delta-lactone 0
                                      anagalligenin A 0
                                      ardisianoside A 0
                                      ardisianoside B 0
                                      ardisianoside C 0
                                      ardisianoside D 0
                                      ardisianoside E 0
                                      ardisimamiloside E 0
                                      avenacoside A 0
                                      avenacoside B 0
                                      capilliposide B 0
                                      celastolide 0
                                      clethroidoside C 0
                                      clethroidoside D 0
                                      clethroidoside E 0
                                      clethroidoside F 0
                                      dioscin 108
                                      diosgenin 73
                                      diosgenin 3-O-beta-D-glucoside 0
                                      fatsicarpain G 0
                                      hyperinol A 0
                                      hyperinol B 0
                                      kadlongilactone A 0
                                      kadlongilactone B 0
                                      limonin 21
                                      lysikokianoside 1 0
                                      maytenfolone A 0
                                      nolinospiroside F 0
                                      oblonganoside A 0
                                      orthosphenic acid 0
                                      rotundifolioside A 0
                                      rotundifolioside H 0
                                      rotundifolioside I 0
                                      rotundifolioside J 0
                                      rubriflordilactone B 0
                                      saikogenin E 0
                                      saikosaponin C 0
                                      salaspermic acid 0
                                      tigogenin 3-O-beta-D-glucopyranoside 0
                                      triptocallic acid C 0
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