Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:muscimol
go back to main search page
Accession:CHEBI:7035 term browser browse the term
Definition:A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Synonyms:exact_synonym: 5-(aminomethyl)-1,2-oxazol-3(2H)-one
 related_synonym: 5-(aminomethyl)-3(2H)-isoxazolone;   Formula=C4H6N2O2;   InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7);   InChIKey=ZJQHPWUVQPJPQT-UHFFFAOYSA-N;   SMILES=NCc1cc(=O)[nH]o1
 xref: CAS:2763-96-4;   KEGG:C08311;   KNApSAcK:C00001423
 xref_mesh: MESH:D009118
 xref: PMID:18599311;   PMID:21427702;   PMID:21751026;   PMID:2181052;   PMID:22049436;   PMID:24259680;   PMID:24316475;   PMID:24473816;   Reaxys:774694;   Wikipedia:Muscimol


show annotations for term's descendants           Sort by:
muscimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Muscimol inhibits the reaction [decamethrin results in increased expression of BDNF exon] CTD PMID:22079160 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein] CTD PMID:29044621 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit multiple interactions ISO Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] CTD PMID:8388298 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions ISO Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] CTD PMID:8388298 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased phosphorylation of ERN1 protein] CTD PMID:29044621 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Muscimol inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:16930414 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression		 EXP Muscimol inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]
Muscimol results in decreased expression of FSHB protein		 CTD PMID:29774754 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding		 ISO GABRA1 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]		 CTD PMID:12490572 PMID:22029276 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 affects binding EXP Muscimol binds to GABRB1 protein CTD PMID:9661255 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions
affects binding		 ISO
EXP		 GABRB2 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
alphaxalone promotes the reaction [Muscimol binds to GABRB2 protein]; Pentobarbital affects the reaction [GABRB2 protein binds to Muscimol]; Pentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]
GABRB2 protein binds to Muscimol; Muscimol binds to GABRB2 protein		 CTD PMID:8397295 PMID:10591412 PMID:12490572 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding		 EXP
ISO		 alphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]; Pentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]		 CTD PMID:8397295 PMID:22029276 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding		 ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:22029276 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 increases activity EXP Muscimol results in increased activity of GABRR3 protein CTD PMID:10635063 NCBI chr11:40,902,812...40,955,263
Ensembl chr11:40,902,812...40,955,263 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Muscimol affects the reaction [bisphenol A affects the secretion of GNRH1 protein] CTD PMID:26950200 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:29044621 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Muscimol results in decreased expression of LHB protein CTD PMID:29774754 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased expression of MAP3K5 protein] CTD PMID:29044621 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK1 protein] CTD PMID:19344668 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK3 protein] CTD PMID:19344668 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased expression of MAPK8 protein] CTD PMID:29044621 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases expression		 EXP Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]
Muscimol results in decreased expression of POMC mRNA		 CTD PMID:7937335 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Syn1 synapsin I decreases expression EXP Muscimol results in decreased expression of SYN1 protein CTD PMID:21920406 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            alkaloid 8016
              muscimol 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  heteroarene 17151
                                    monocyclic heteroarene 14980
                                      azole 14503
                                        oxazole 3646
                                          isoxazoles 3119
                                            muscimol 22
paths to the root