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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dihydrocorynantheine
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Accession:CHEBI:70074 term browser browse the term
Definition:An alkaloid that has formula C22H28N2O3.
Synonyms:related_synonym: 18,19-Dihydrocorynantheine;   Formula=C22H28N2O3;   InChI=1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17-,20-/m0/s1;   InChIKey=NMLUOJBSAYAYEM-XPOGPMDLSA-N;   SMILES=[H][C@@]1(C[C@]2([H])N(CCc3c2[nH]c2ccccc32)C[C@@H]1CC)C(=C/OC)\\C(=O)OC;   hirsutine;   methyl(E)-2-[(2S,3R,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
 xref: CAS:50439-68-4;   CAS:7729-23-9;   ChemIDplus:0050439684;   KEGG:C16953;   KEGG:C16972
 xref_mesh: MESH:C038369
 xref: PMID:21070010


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Dihydrocorynantheine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D decreases activity
multiple interactions 		ISO hirsutine results in decreased activity of CES1 protein
[hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir 		CTD PMID:37716419 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO hirsutine results in decreased activity of CYP2D6 protein CTD PMID:31707106 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions EXP hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA] CTD PMID:25551766 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA] CTD PMID:25551766 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      biological role 20829
        biochemical role 20275
          metabolite 20256
            Dihydrocorynantheine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            heteroorganic entity 20226
                              organonitrogen compound 19404
                                alkaloid 8071
                                  Dihydrocorynantheine 4
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