Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Mitotane
go back to main search page
Accession:CHEBI:6954 term browser browse the term
Synonyms:related_synonym: Formula=C14H10Cl4;   InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H;   InChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N;   Lysodren (TN);   SMILES=C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl;   chloditan;   chlodithane;   lysodren;   mitotan;   opeprim
 alt_id: CHEBI:91626
 xref: CAS:53-19-0;   Drug_Central:1820;   HMDB:HMDB0014786;   KEGG:D00420;   LINCS:LSM-1451
 xref_mesh: MESH:D008939


show annotations for term's descendants           Sort by:
Mitotane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
increases expression		 ISO Mitotane inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]
Mitotane results in decreased activity of ABCB1 protein
Mitotane results in increased expression of ABCB1 mRNA		 CTD PMID:1675220 PMID:9815696 PMID:12015757 PMID:31312845 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Mitotane results in increased expression of ALDH1L2 mRNA CTD PMID:22966885 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding		 ISO
EXP		 Mitotane binds to and results in decreased activity of AR protein; Mitotane inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Mitotane inhibits the reaction [Dihydrotestosterone binds to AR protein]
Mitotane binds to AR protein		 CTD PMID:9705896 PMID:14565775 PMID:14579009 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Aven apoptosis and caspase activation inhibitor increases expression EXP Mitotane analog results in increased expression of AVEN mRNA; Mitotane results in increased expression of AVEN mRNA CTD PMID:23485034 NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634 		JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP Mitotane results in increased expression of BAG1 mRNA CTD PMID:23485034 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP Mitotane results in increased expression of BAK1 mRNA CTD PMID:23485034 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Mitotane analog results in increased expression of BAX mRNA; Mitotane results in increased expression of BAX mRNA
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein		 CTD PMID:9815696 PMID:23485034 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Mitotane results in increased expression of BCL2 mRNA
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein		 CTD PMID:9815696 PMID:23485034 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression EXP Mitotane results in increased expression of BCL2A1 mRNA CTD PMID:23485034 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression EXP Mitotane results in increased expression of BCL2L11 mRNA CTD PMID:23485034 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression EXP Mitotane results in increased expression of BCL2L2 mRNA CTD PMID:23485034 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bdkrb1 bradykinin receptor B1 increases activity EXP Mitotane results in increased activity of BDKRB1 protein CTD PMID:11159707 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Mitotane analog results in increased expression of BID mRNA; Mitotane results in increased expression of BID mRNA CTD PMID:23485034 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Mitotane results in increased expression of BIRC3 mRNA CTD PMID:23485034 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Mitotane analog results in increased expression of BNIP3 mRNA; Mitotane results in increased expression of BNIP3 mRNA CTD PMID:23485034 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Casp1 caspase 1 increases expression EXP Mitotane results in increased expression of CASP1 mRNA CTD PMID:23485034 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 increases expression EXP Mitotane analog results in increased expression of CASP12 mRNA; Mitotane results in increased expression of CASP12 mRNA CTD PMID:23485034 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp2 caspase 2 increases expression EXP Mitotane results in increased expression of CASP2 mRNA CTD PMID:23485034 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity		 EXP
ISO		 Mitotane results in increased expression of CASP3 mRNA
Mitotane results in increased activity of CASP3 protein		 CTD PMID:23254310 PMID:23485034 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression EXP Mitotane analog results in increased expression of CASP4 mRNA; Mitotane results in increased expression of CASP4 mRNA CTD PMID:23485034 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 increases activity
increases expression		 ISO
EXP		 Mitotane results in increased activity of CASP7 protein
Mitotane results in increased expression of CASP7 mRNA		 CTD PMID:23254310 PMID:23485034 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression EXP Mitotane analog results in increased expression of CASP8AP2 mRNA; Mitotane results in increased expression of CASP8AP2 mRNA CTD PMID:23485034 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Mitotane results in increased expression of and results in increased localization of CCNB1 protein CTD PMID:18509009 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression EXP Mitotane analog results in increased expression of CFLAR mRNA CTD PMID:23485034 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression
increases expression		 EXP Mitotane analog results in decreased expression of CIDEB mRNA
Mitotane analog results in increased expression of CIDEB mRNA		 CTD PMID:23485034 NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression ISO Mitotane results in decreased expression of COX4I1 mRNA CTD PMID:23696597 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity ISO Mitotane results in increased activity of CREB1 protein CTD PMID:18791200 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebbp CREB binding protein increases activity ISO Mitotane results in increased activity of CREBBP protein CTD PMID:22609851 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
decreases activity		 ISO Mitotane results in decreased expression of CYP11A1 mRNA; Mitotane results in decreased expression of CYP11A1 protein
Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]
Mitotane results in decreased activity of CYP11A1 protein		 CTD PMID:6094274 PMID:22546480 PMID:23254310 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression
multiple interactions
decreases expression		 ISO Mitotane results in increased expression of CYP11B1 mRNA
Mitotane affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA]
Mitotane results in decreased expression of CYP11B1 protein		 CTD PMID:19900470 PMID:22546480 PMID:23696597 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression ISO Mitotane results in decreased expression of CYP11B2 protein CTD PMID:23696597 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions		 ISO Mitotane results in decreased expression of CYP17A1 mRNA
Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]		 CTD PMID:22546480 PMID:23254310 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Mitotane results in increased expression of CYP2B2 mRNA CTD PMID:10036216 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects abundance
increases expression
multiple interactions		 ISO CYP2B6 gene polymorphism affects the abundance of Mitotane; CYP2B6 protein affects the abundance of Mitotane
Mitotane results in increased expression of CYP2B6 mRNA
[Mitotane co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [Mitotane co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA		 CTD PMID:23524664 PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases activity		 ISO [Mitotane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Mitotane promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Mitotane results in increased expression of CYP3A4 mRNA]
Mitotane results in increased activity of CYP3A4 protein		 CTD PMID:23179081 PMID:31312845 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dapk1 death associated protein kinase 1 increases expression EXP Mitotane results in increased expression of DAPK1 mRNA CTD PMID:23485034 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression EXP Mitotane results in increased expression of DFFA mRNA CTD PMID:23485034 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dffb DNA fragmentation factor subunit beta increases expression EXP Mitotane results in increased expression of DFFB mRNA CTD PMID:23485034 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases activity ISO Mitotane results in increased activity of ELK1 protein CTD PMID:18791200 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
affects binding
multiple interactions		 ISO
EXP		 Mitotane results in increased activity of ESR1 protein
Mitotane binds to ESR1 protein
ESR1 protein promotes the reaction [Mitotane results in increased expression of SERPINA6 protein]; ESR1 protein promotes the reaction [Mitotane results in increased expression of SHBG protein]; Mitotane binds to and results in increased activity of ESR1 protein; Mitotane inhibits the reaction [Estradiol binds to ESR1 protein]
Mitotane inhibits the reaction [Estradiol binds to ESR1 protein]; Mitotane inhibits the reaction [Estradiol results in increased activity of ESR1 protein]		 CTD PMID:8930550 PMID:10580743 PMID:14579009 PMID:16551731 PMID:26139245 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions		 ISO Mitotane results in increased activity of ESR2 protein
Mitotane binds to and results in increased activity of ESR2 protein		 CTD PMID:26139245 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Faslg Fas ligand increases expression EXP Mitotane results in increased expression of FASLG mRNA CTD PMID:23485034 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO Mitotane results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Mitotane results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Mitotane analog results in increased expression of GADD45A mRNA; Mitotane results in increased expression of GADD45A mRNA CTD PMID:23485034 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Mitotane results in increased expression of GDF15 mRNA CTD PMID:22966885 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Mitotane analog results in increased expression of GPX2 mRNA; Mitotane results in increased expression of GPX2 mRNA CTD PMID:23485034 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Mitotane analog results in increased expression of GSTA2 mRNA CTD PMID:23485034 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Mitotane inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Mitotane results in decreased expression of HSD3B1 mRNA CTD PMID:22966885 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression
multiple interactions		 ISO Mitotane results in decreased expression of HSD3B2 mRNA
Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B2 mRNA]		 CTD PMID:19900470 PMID:22546480 PMID:22966885 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Mitotane analog results in increased expression of HSP90AA1 mRNA; Mitotane results in increased expression of HSP90AA1 mRNA CTD PMID:23485034 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Mitotane analog results in increased expression of HSPA4 mRNA CTD PMID:23485034 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Mitotane results in increased expression of HSPD1 mRNA CTD PMID:23485034 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifnb1 interferon beta 1 increases response to substance
multiple interactions		 ISO IFNB1 protein results in increased susceptibility to Mitotane
Mitotane promotes the reaction [IFNB1 protein results in decreased secretion of Hydrocortisone]		 CTD PMID:23507702 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression EXP Mitotane analog results in increased expression of MAPK8IP1 mRNA; Mitotane results in increased expression of MAPK8IP1 mRNA CTD PMID:23485034 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Mitotane results in decreased expression of COX2 mRNA CTD PMID:23696597 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Mitotane promotes the reaction [NCOA1 protein binds to NR1I2 protein]; Mitotane promotes the reaction [NCOA1 protein binds to NR1I3 protein] CTD PMID:23179081 PMID:31312845 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Mitotane promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nol3 nucleolar protein 3 increases expression EXP Mitotane results in increased expression of NOL3 mRNA CTD PMID:23485034 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Notch1 notch receptor 1 increases activity ISO Mitotane results in increased activity of NOTCH1 protein CTD PMID:18791200 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [Mitotane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Mitotane binds to and results in increased activity of NR1I2 protein; Mitotane promotes the reaction [NCOA1 protein binds to NR1I2 protein]; Mitotane promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Mitotane results in increased expression of CYP3A4 mRNA] CTD PMID:23179081 PMID:31312845 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
affects localization
multiple interactions
affects binding		 ISO Mitotane results in increased activity of NR1I3 protein
Mitotane affects the localization of NR1I3 protein mutant form
[Mitotane co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [Mitotane co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Mitotane binds to and results in increased activity of NR1I3 protein alternative form; Mitotane inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Mitotane promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Mitotane promotes the reaction [NCOA3 protein binds to NR1I3 protein]
Mitotane binds to NR1I3 protein		 CTD PMID:28927721 PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Mitotane results in decreased expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding		 ISO Mitotane inhibits the reaction [Progesterone binds to PGR protein]
Mitotane binds to PGR protein		 CTD PMID:14579009 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Mitotane binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO Mitotane results in decreased expression of PRKAR1A mRNA CTD PMID:23254310 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Mitotane results in increased expression of PTGS2 protein CTD PMID:23132776 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression EXP Mitotane results in increased expression of RIPK2 mRNA CTD PMID:23485034 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression
decreases response to substance		 ISO Mitotane results in increased expression of RRM1 mRNA
RRM1 protein results in decreased susceptibility to Mitotane		 CTD PMID:22547773 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Mitotane results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpina6 serpin family A member 6 increases expression
multiple interactions		 ISO Mitotane results in increased expression of SERPINA6 protein
ESR1 protein promotes the reaction [Mitotane results in increased expression of SERPINA6 protein]		 CTD PMID:16551731 NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349 		JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Mitotane results in increased expression of SERPINE2 mRNA CTD PMID:22966885 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Shbg sex hormone binding globulin increases expression
multiple interactions
affects binding		 ISO Mitotane results in increased expression of SHBG protein
ESR1 protein promotes the reaction [Mitotane results in increased expression of SHBG protein]
Mitotane binds to SHBG protein		 CTD PMID:16551731 PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Mitotane analog results in increased expression of SOD1 mRNA; Mitotane results in increased expression of SOD1 mRNA CTD PMID:23485034 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Mitotane analog results in increased expression of SOD2 mRNA CTD PMID:23485034 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression		 ISO Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]
Mitotane results in decreased expression of STAR mRNA; Mitotane results in decreased expression of STAR protein		 CTD PMID:22546480 PMID:23696597 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Mitotane results in decreased expression of TGFB1 mRNA CTD PMID:23254310 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO Mitotane results in decreased expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Mitotane results in increased expression of TNFRSF1A mRNA CTD PMID:23485034 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression EXP Mitotane analog results in increased expression of TNFRSF1B mRNA; Mitotane results in increased expression of TNFRSF1B mRNA CTD PMID:23485034 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tp53 tumor protein p53 affects expression
increases expression
multiple interactions		 EXP
ISO		 Mitotane analog affects the expression of TP53 protein
Mitotane analog results in increased expression of TP53 mRNA; Mitotane results in increased expression of TP53 mRNA; Mitotane results in increased expression of TP53 protein
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of TP53 protein		 CTD PMID:9815696 PMID:23485034 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 increases expression EXP Mitotane results in increased expression of TP53BP2 mRNA CTD PMID:23485034 NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression EXP Mitotane results in increased expression of TRAF2 mRNA CTD PMID:23485034 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf4 Tnf receptor associated factor 4 increases expression EXP Mitotane results in increased expression of TRAF4 mRNA CTD PMID:23485034 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Mitotane results in increased expression of TRIB3 mRNA CTD PMID:22966885 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Mitotane results in increased expression of UGT2B1 mRNA CTD PMID:10036216 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Mitotane analog results in increased expression of XIAP mRNA CTD PMID:23485034 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      group 19869
        polyatomic entity 19868
          molecule 19737
            cyclic compound 19551
              organic cyclic compound 19533
                organic aromatic compound 19399
                  diarylmethane 9455
                    Mitotane 88
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      p-block molecular entity 19855
                        carbon group molecular entity 19794
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic aromatic compound 19399
                                  diarylmethane 9455
                                    Mitotane 88
paths to the root