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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mirtazapine
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Accession:CHEBI:6950 term browser browse the term
Definition:A tetracyclic antidepressant that has formula C17H19N3.
Synonyms:exact_synonym: 2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
 related_synonym: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3;   InChIKey=RONZAEMNMFQXRA-UHFFFAOYSA-N;   SMILES=CN1CCN2C(C1)c1ccccc1Cc1cccnc21;   mirtazapina;   mirtazapinum
 xref: Beilstein:549345;   CAS:61337-67-5;   DrugBank:DB00370;   Drug_Central:1816;   KEGG:C07570;   KEGG:D00563;   LINCS:LSM-1706
 xref_mesh: MESH:C035133
 xref: PMID:10446735;   PMID:10653218;   PMID:16965209;   PMID:18548827;   PMID:33163376;   PMID:33422759;   PMID:33559900;   PMID:33685359;   PMID:33841403;   PMID:33856954;   Patent:DE2614406;   Patent:US4062848;   VSDB:2980;   Wikipedia:Mirtazapine


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mirtazapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of mirtazapine CTD PMID:14550684 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:28623179 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP Mirtazapine results in decreased phosphorylation of AKT1 protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]		 CTD PMID:35066094 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 EXP
ISO		 Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA] CTD PMID:35066094 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of BECN1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]		 CTD PMID:35066094 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Cat catalase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19034656 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]		 CTD PMID:35066094 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP mirtazapine results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein] CTD PMID:12523492 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein] CTD PMID:12523492 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO Ethanol promotes the reaction [Mirtazapine results in increased expression of GPT protein] CTD PMID:35066094 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression		 EXP Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA] CTD PMID:35066094 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO mirtazapine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression		 ISO 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]; mirtazapine binds to and affects the activity of HTR2C protein CTD PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL1B protein] CTD PMID:37403423 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL6 protein] CTD PMID:37403423 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions
decreases expression		 EXP Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein] CTD PMID:35066094 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19034656 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 EXP Mirtazapine results in decreased phosphorylation of MTOR protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]		 CTD PMID:35066094 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Mirtazapine results in increased expression of NFE2L2 protein CTD PMID:37403423 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 ISO
EXP		 Mirtazapine results in increased expression of NPPB mRNA
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of NPPB mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]		 CTD PMID:35066094 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression
multiple interactions		 EXP Mirtazapine results in increased expression of PIK3C3 protein
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]		 CTD PMID:35066094 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Prl prolactin increases expression ISO mirtazapine results in increased expression of PRL protein CTD PMID:15105766 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Mirtazapine results in decreased expression of RELA protein CTD PMID:37403423 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO mirtazapine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO mirtazapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO mirtazapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression ISO mirtazapine results in increased expression of SLC2A5 mRNA CTD PMID:16002093 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 EXP
ISO		 Mirtazapine results in increased expression of SQSTM1 protein
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]		 CTD PMID:35066094 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]
Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]		 CTD PMID:28623179 PMID:35066094 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP Mirtazapine results in decreased expression of TLR4 protein CTD PMID:37403423 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of TNF protein] CTD PMID:37403423 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        pharmacological role 19101
          antagonist 17266
            histamine antagonist 4895
              mirtazapine 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterobicyclic compound 17272
                                      benzazepine 544
                                        mirtazapine 38
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