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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:inuviscolide
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Accession:CHEBI:69345 term browser browse the term
Definition:A sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group at position 5, a methyl group at position 5 and methylidene groups at positions 3 and 8 (the 3aR,4aR,5R,7aS,9aS stereoisomer). Isolated from the aerial parts of Inula hupehensis, it exhibits anti-inflammatory activity.
Synonyms:exact_synonym: (3aR,4aR,5R,7aS,9aS)-5-hydroxy-5-methyl-3,8-dimethylidenedecahydroazuleno[6,5-b]furan-2(3H)-one
 related_synonym: Formula=C15H20O3;   InChI=1S/C15H20O3/c1-8-6-13-11(9(2)14(16)18-13)7-12-10(8)4-5-15(12,3)17/h10-13,17H,1-2,4-7H2,3H3/t10-,11-,12-,13+,15-/m1/s1;   InChIKey=GTYUWNQOOLJZBM-XLFUENPSSA-N;   SMILES=C[C@@]1(O)CC[C@H]2[C@H]1C[C@H]1[C@H](CC2=C)OC(=O)C1=C
 xref_mesh: MESH:C458886
 xref: PMID:11731914;   PMID:17490829;   PMID:21894898;   Reaxys:4234313


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inuviscolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO inuviscolide results in decreased expression of BIRC5 protein CTD PMID:17919456 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity ISO inuviscolide results in increased activity of CASP3 protein CTD PMID:17919456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO inuviscolide affects the expression of CCNB1 protein CTD PMID:17919456 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO inuviscolide results in decreased expression of and affects the phosphorylation of CDK1 protein CTD PMID:17919456 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO inuviscolide results in increased expression of CDKN1A protein CTD PMID:17919456 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO inuviscolide results in decreased expression of RELA protein CTD PMID:17919456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; inuviscolide results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:17919456 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          inuviscolide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  ester 17458
                                    carboxylic ester 16743
                                      lactone 13299
                                        terpene lactone 2188
                                          sesquiterpene lactone 2048
                                            inuviscolide 7
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