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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-methyl-L-tyrosine
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Accession:CHEBI:6912 term browser browse the term
Definition:An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.
Synonyms:related_synonym: (S)-alpha-Methyltyrosine;   Formula=C10H13NO3;   InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1;   InChIKey=NHTGHBARYWONDQ-JTQLQIEISA-N;   L-alpha-Methyltyrosine;   Methyltyrosine;   Metyrosine;   SMILES=C[C@](N)(Cc1ccc(O)cc1)C(O)=O;   alpha-Methyltyrosine;   alpha-methyl-L-p-tyrosine;   alpha-methyl-p-tyrosine;   alpha-methyl-para-tyrosine;   metirosina;   metirosine;   metirosinum
 xref: CAS:672-87-7;   DrugBank:DB00765;   Drug_Central:1792;   KEGG:C07921;   KEGG:D00762;   PMID:28716505;   PMID:29353821;   PMID:29438107;   PMID:29668781;   Patent:US2011104765;   Reaxys:2368400;   Wikipedia:Metirosine


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Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        pharmaceutical 19558
          drug 19558
            cardiovascular drug 8742
              antihypertensive agent 1949
                alpha-methyl-L-tyrosine 0
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  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            organic hydride 18713
                              organic fundamental parent 18713
                                hydrocarbon 18460
                                  cyclic hydrocarbon 17249
                                    monocyclic hydrocarbon 6206
                                      annulene 5859
                                        aromatic annulene 5859
                                          benzene 5859
                                            alkylbenzene 3544
                                              methylbenzene 3398
                                                toluene 3270
                                                  benzyl group 2680
                                                    phenylalanine 2680
                                                      phenylalanine derivative 2642
                                                        tyrosine derivative 466
                                                          L-tyrosine derivative 6
                                                            alpha-methyl-L-tyrosine 0
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