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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chaetoglobosin A
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Accession:CHEBI:68798 term browser browse the term
Definition:A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
Synonyms:exact_synonym: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16bR)-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trione
 related_synonym: Formula=C32H36N2O5;   InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7+,13-12+,18-14+/t17-,19-,22-,24-,27-,28+,29?,31+,32+/m0/s1;   InChIKey=OUMWCYMRLMEZJH-VOXRAUTJSA-N;   SMILES=[H][C@@]12O[C@]1(C)[C@@H](C)[C@@]1([H])[C@H](CC3=CNC4=CC=CC=C34)NC(=O)[C@@]11[C@H]2\\C=C\\C[C@H](C)\\C=C(C)\\[C@@H](O)C(=O)\\C=C\\C1=O
 xref: CAS:50335-03-0;   KNApSAcK:C00011307;   LIPID_MAPS_instance:LMPK11000003
 xref_mesh: MESH:C019290
 xref: PMID:12483566;   PMID:19246197;   PMID:23214998;   PMID:23611317;   PMID:436014;   Reaxys:5787518;   Wikipedia:Chaetoglobosin_A


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chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]		 CTD PMID:18040759 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 EXP chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]		 CTD PMID:18040759 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:33285210 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33285210 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33285210 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA] CTD PMID:33285210 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18040759 PMID:33285210 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18040759 PMID:33285210 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA] CTD PMID:33285210 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33285210 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33285210 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation EXP chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33285210 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:33285210 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 PMID:33285210 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      molecular entity 19878
        main group molecular entity 19817
          gas molecular entity 18472
            oxirane 11285
              epoxide 11284
                chaetoglobosin A 16
                  chaetoglobosin P 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      benzopyrrole 9742
                                        isoindoles 1150
                                          cytochalasin 82
                                            cytochalasan alkaloid 18
                                              chaetoglobosin A 16
                                                chaetoglobosin P 0
paths to the root