CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: zingerone
Accession: CHEBI:68657
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Definition: A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.
Synonyms: exact_synonym: 4-(4-hydroxy-3-methoxyphenyl)butan-2-one
related_synonym: (0)-Paradol; (4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone; 2-(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone; 3-Methoxy-4-hydroxybenzylacetone; 4-(3-Methoxy-4-hydroxyphenyl)-2-butanone; 4-(3-methoxy-4-hydroxyphenyl)butan-2-one; 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone; 4-Hydroxy-3-methoxybenzylacetone; Formula=C11H14O3; Gingerone; InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3; InChIKey=OJYLAHXKWMRDGS-UHFFFAOYSA-N; SMILES=COc1cc(CCC(C)=O)ccc1O; Vanillylacetone; Zingherone; Zingiberone
xref: CAS:122-48-5; HMDB:HMDB0032590; KEGG:C17497
xref_mesh: MESH:C013738
xref: PMID:18472135; PMID:18670185; PMID:19367122; PMID:19459736; PMID:19463966; PMID:20211236; PMID:20606379; PMID:20713432; PMID:20799069; PMID:21335001; PMID:21551955; PMID:21769642; PMID:21802408; PMID:21929329; PMID:22173270; PMID:22329630; PMID:22596078; Patent:DE102009055915; Patent:EP1336602; Patent:EP2327393; Patent:US2002051800; Patent:US2003068276; Patent:US5035882; Patent:US5908770; Patent:US6306429; Patent:US6432441; Patent:US6500797; Patent:WO2011063863; Patent:WO2011063864; Patent:WO2011063865; Reaxys:2051099; Wikipedia:Zingerone
G
Acaca
acetyl-CoA carboxylase alpha
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ACACA mRNA]
CTD
PMID:33845646
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Ache
acetylcholinesterase
multiple interactions affects activity
EXP
zingerone affects the reaction [Vancomycin affects the activity of ACHE protein] zingerone affects the activity of ACHE protein
CTD
PMID:31454121
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acox1
acyl-CoA oxidase 1
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of ACOX1 mRNA]
CTD
PMID:33845646
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acsl1
acyl-CoA synthetase long-chain family member 1
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ACSL1 mRNA]
CTD
PMID:33845646
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
zingerone results in decreased expression of and results in decreased phosphorylation of AKT1 protein
CTD
PMID:32905641
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AKT2 mRNA] zingerone results in increased expression of AKT2 mRNA
CTD
PMID:36822304
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Ar
androgen receptor
multiple interactions
ISO
zingerone binds to and results in decreased activity of AR protein
CTD
PMID:20226658
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
EXP ISO
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein]; zingerone inhibits the reaction [Ethanol results in increased expression of BAX protein] zingerone results in increased expression of BAX protein
CTD
PMID:28442378 PMID:31476248 PMID:36822304
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
affects activity multiple interactions
EXP
zingerone affects the activity of BCHE protein zingerone affects the reaction [Vancomycin affects the activity of BCHE protein]
CTD
PMID:31454121
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression increases expression
EXP ISO
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]; zingerone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein] zingerone results in decreased expression of BCL2 protein zingerone results in increased expression of BCL2 mRNA
CTD
PMID:28442378 PMID:31476248 PMID:36822304
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Becn1
beclin 1
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 mRNA]
CTD
PMID:36822304
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bid
BH3 interacting domain death agonist
increases expression
ISO
zingerone results in increased expression of BID protein
CTD
PMID:31476248
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Casp3
caspase 3
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA]; zingerone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD
PMID:28442378 PMID:36822304
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
CTD
PMID:28442378
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased activity of CAT protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]
CTD
PMID:31476248 PMID:33845646 PMID:36822304
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnd1
cyclin D1
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1]
CTD
PMID:30720227
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of CPT1A mRNA]
CTD
PMID:33845646
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cyb5a
cytochrome b5 type A
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of CYB5A protein]
CTD
PMID:28442378
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyb5r3
cytochrome b5 reductase 3
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein]
CTD
PMID:28442378
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein]; zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]
CTD
PMID:28442378 PMID:30720227
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Fasn
fatty acid synthase
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of FASN mRNA]
CTD
PMID:33845646
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Foxo1
forkhead box O1
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FOXO1 mRNA] zingerone results in increased expression of FOXO1 mRNA
CTD
PMID:36822304
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Gsr
glutathione-disulfide reductase
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
CTD
PMID:31476248
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein]
CTD
PMID:28442378
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Ifng
interferon gamma
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG protein]
CTD
PMID:29289488
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
multiple interactions decreases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL1B mRNA] zingerone results in decreased expression of IL1B mRNA; zingerone results in decreased expression of IL1B protein
CTD
PMID:36822304
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO EXP
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL6 mRNA]
CTD
PMID:29289488 PMID:30720227 PMID:36822304
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf3
interferon regulatory factor 3
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]
CTD
PMID:29289488
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of LCAT protein]
CTD
PMID:28442378
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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Lpl
lipoprotein lipase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of LPL protein]
CTD
PMID:28442378
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
EXP
zingerone results in decreased phosphorylation of MAPK1 protein
CTD
PMID:20211236
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK14 mRNA]
CTD
PMID:36822304
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk15
mitogen-activated protein kinase 15
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK15 mRNA]
CTD
PMID:36822304
NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
EXP
zingerone results in decreased phosphorylation of MAPK3 protein
CTD
PMID:20211236
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA] zingerone results in increased expression of MAPK8 mRNA
CTD
PMID:36822304
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mki67
marker of proliferation Ki-67
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]
CTD
PMID:30720227
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
zingerone results in decreased expression of and results in decreased phosphorylation of MTOR protein
CTD
PMID:32905641
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NFE2L2 protein]
CTD
PMID:30720227
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
affects localization decreases expression multiple interactions
EXP
zingerone affects the localization of NFKB1 protein zingerone results in decreased expression of NFKB1 mRNA zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFKB1 mRNA]
CTD
PMID:20211236 PMID:36822304
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]
CTD
PMID:29289488
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
decreases expression multiple interactions
EXP
zingerone results in decreased expression of NOS2 protein zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOS2 mRNA]
CTD
PMID:20211236 PMID:30720227 PMID:36822304
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NPHS1 protein]
CTD
PMID:36822304
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of NQO1 protein]
CTD
PMID:28442378
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of NR1H3 mRNA]
CTD
PMID:33845646
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Or5d18
olfactory receptor family 5 subfamily D member 18
multiple interactions
ISO
zingerone binds to and results in increased activity of OR5D18 protein
CTD
PMID:21142015
NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858 Ensembl chr 3:73,516,364...73,519,858
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
CTD
PMID:30720227
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pon1
paraoxonase 1
multiple interactions affects activity
EXP
zingerone affects the reaction [Vancomycin results in decreased activity of PON1 protein] zingerone affects the activity of PON1 protein
CTD
PMID:31454121
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Por
cytochrome p450 oxidoreductase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of POR protein]
CTD
PMID:28442378
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of PPARA mRNA]
CTD
PMID:33845646
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Psgb1
pregnancy-specific beta 1-glycoprotein
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CEACAM5 protein]
CTD
PMID:31476248
NCBI chr 1:77,923,170...77,932,605
Ensembl chr 1:77,923,170...77,932,053
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression multiple interactions
EXP
zingerone results in decreased expression of PTGS2 protein zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA]
CTD
PMID:20211236 PMID:30720227 PMID:36822304
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
zingerone affects the localization of and results in increased phosphorylation of RELA protein; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]
CTD
PMID:20211236 PMID:30720227
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of SREBF1 mRNA]
CTD
PMID:33845646
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
zingerone inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
CTD
PMID:28904557
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tlr4
toll-like receptor 4
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein]
CTD
PMID:29289488
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO EXP
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA] zingerone results in decreased expression of TNF mRNA
CTD
PMID:29289488 PMID:30720227 PMID:36822304
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnni3
troponin I3, cardiac type
multiple interactions
EXP
zingerone inhibits the reaction [[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of TNNI3 protein]
CTD
PMID:33845646
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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