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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indacaterol
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Accession:CHEBI:68575 term browser browse the term
Definition:A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease.
Synonyms:exact_synonym: 5-{(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one
 related_synonym: 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one;   Formula=C24H28N2O3;   InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1;   InChIKey=QZZUEBNBZAPZLX-QFIPXVFZSA-N;   QAB-149;   QAB149;   SMILES=CCc1cc2CC(Cc2cc1CC)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
 xref: CAS:312753-06-3;   DrugBank:DB05039;   Drug_Central:4183;   HMDB:HMDB0015608;   KEGG:D09318
 xref_mesh: MESH:C510790
 xref: PMID:21740451;   PMID:21883146;   PMID:22035851;   PMID:22079756;   PMID:22119310;   PMID:22122202;   PMID:22356291;   PMID:22383666;   PMID:22419862;   PMID:22452977;   PMID:22471750;   PMID:22483398;   PMID:22499359;   PMID:22544891;   PMID:22573707;   PMID:22578206;   PMID:22583463;   PMID:22611179;   PMID:22648561;   PMID:22682643;   PMID:22726538;   PMID:22732017;   PMID:22735463;   PMID:22848154;   PMID:22932315;   Patent:WO2005123684;   Patent:WO2006128675;   Patent:WO2010114472;   Reaxys:10392427;   Wikipedia:Indacaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:68574


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indacaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 increases activity ISO indacaterol results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            bronchodilator agent 3813
              indacaterol 1
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Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organonitrogen heterocyclic compound 18153
                                    quinolines 2658
                                      hydroxyquinoline 331
                                        monohydroxyquinoline 328
                                          indacaterol 1
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