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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deferiprone
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Accession:CHEBI:68554 term browser browse the term
Definition:A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Synonyms:related_synonym: 1,2-Dimethyl-3-hydroxypyrid-4-one;   3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;   3-hydroxy-1,2-dimethylpyridin-4(1H)-one;   Ferriprox
 xref: CAS:30652-11-0
 xref_mesh: MESH:C044919
 xref: Reaxys:1447108;   drugcentral:4188;   kegg.drug:D07416;   lincs.smallmolecule:LSM-36972;   pubmed:21853518;   pubmed:22025507;   pubmed:22034002;   pubmed:22130677;   pubmed:22171759;   pubmed:22180427;   pubmed:22277065;   pubmed:22354281;   pubmed:22406440;   pubmed:22454828;   pubmed:22457166;   pubmed:22459459;   pubmed:22468647;   pubmed:22565013;   pubmed:22572843;   pubmed:22579919;   pubmed:22621771;   pubmed:22622672;   pubmed:22664119;   pubmed:22759897;   pubmed:22850524;   pubmed:22943064;   pubmed:22978744;   wikipedia.en:Deferiprone
 chemrof_formula: C7H9NO2
 chemrof_smiles: Cc1c(O)c(=O)ccn1C
 chemrof_inchi: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
 chemrof_inchikey: TZXKOCQBRNJULO-UHFFFAOYSA-N


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deferiprone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:33285147 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:33285147 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP 		deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein] 		CTD PMID:14576080 PMID:25813056 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO 		deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] 		CTD PMID:17172471 PMID:33285147 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP
ISO 		Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] 		CTD PMID:32937103 PMID:33285147 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Fxn frataxin increases expression ISO deferiprone results in increased expression of FXN mRNA; deferiprone results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:231,300,150...231,323,989 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO 		Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] 		CTD PMID:17172471 PMID:33285147 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO 		deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] 		CTD PMID:17172471 PMID:33285147 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33285147 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP deferiprone inhibits the reaction [Doxorubicin results in decreased activity of SOD1 protein] CTD PMID:17007740 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Tf transferrin increases expression
decreases uptake 		ISO deferiprone results in increased expression of TF mRNA; deferiprone results in increased expression of TF protein
deferiprone results in decreased uptake of TF protein 		CTD PMID:9763218 PMID:10865941 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        ligand 5973
          chelator 5960
            iron chelator 1331
              deferiprone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteromonocyclic compound 18004
                                    pyridines 12197
                                      pyridone 166
                                        4-pyridones 35
                                          deferiprone 19
paths to the root