pyrimidine synthesis inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pyrimidine synthesis inhibitor	go back to main search page
Accession:	CHEBI:68543	browse the term
Definition:	A pathway inhibitor that inhibits the synthesis of pyrimidine.
Synonyms:	related_synonym:	pyrimidine synthesis inhibitors
	xref:	wikipedia.en:Pyrimidine_metabolism

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Rat (2714 ) Mouse (2721 ) Human (2906 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (2714)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

ISO

brequinar results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily C member 3

affects expression

ISO

brequinar affects the expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases expression

ISO

brequinar results in decreased expression of ABCC4 mRNA

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

acyl-CoA dehydrogenase, long chain

decreases expression

ISO

brequinar results in decreased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

acyl-CoA dehydrogenase medium chain

decreases expression

ISO

brequinar results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA synthetase long-chain family member 1

increases expression

ISO

brequinar results in increased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

adhesion G protein-coupled receptor L4

increases expression

ISO

brequinar results in increased expression of ADGRL4 mRNA

NCBI chr 2:243,014,927...243,117,226
Ensembl chr 2:243,014,796...243,117,222

G

anterior gradient 3, protein disulphide isomerase family member

decreases expression

ISO

brequinar results in decreased expression of AGR3 mRNA

NCBI chr 6:58,370,701...58,393,944
Ensembl chr 6:58,370,701...58,399,859

G

5'-aminolevulinate synthase 1

increases expression

ISO

brequinar results in increased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

anillin, actin binding protein

decreases expression

ISO

brequinar results in decreased expression of ANLN mRNA

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:29,134,222...29,197,513

G

amphiregulin

increases expression

ISO

brequinar results in increased expression of AREG mRNA

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

brequinar results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

activating transcription factor 4

increases expression

ISO

brequinar results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

ATP synthase F1 subunit beta

decreases expression

ISO

brequinar results in decreased expression of ATP5F1B mRNA

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase F1 subunit gamma

decreases expression

ISO

brequinar results in decreased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

brequinar results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

gamma-butyrobetaine hydroxylase 1

decreases expression

ISO

brequinar results in decreased expression of BBOX1 mRNA

NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064

G

branched chain amino acid transaminase 1

increases expression

ISO

brequinar results in increased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

BCL2, apoptosis regulator

decreases expression

ISO

brequinar results in decreased expression of BCL2 mRNA

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

increases expression

ISO

brequinar results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

similar to human chromosome 15 open reading frame 48

affects expression

ISO

brequinar affects the expression of COXFA4L3 mRNA

NCBI chr 3:130,173,535...130,177,088
Ensembl chr 3:130,173,416...130,177,089

G

cysteinyl-tRNA synthetase 1

increases expression

ISO

brequinar results in increased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caveolin 1

decreases expression

ISO

brequinar results in decreased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

C-C motif chemokine ligand 2

decreases expression

ISO

brequinar results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin B1

decreases expression

ISO

brequinar results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

CD44 molecule

increases expression

ISO

brequinar results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

cytidine deaminase

increases expression

ISO

brequinar results in increased expression of CDA mRNA

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541

G

cell division cycle 20

decreases expression

ISO

brequinar results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cadherin 6

decreases expression

ISO

brequinar results in decreased expression of CDH6 mRNA

NCBI chr 2:63,801,630...63,952,309
Ensembl chr 2:63,806,135...63,952,287

G

cyclin-dependent kinase 1

decreases expression

ISO

brequinar results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

brequinar results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 3

decreases expression

ISO

brequinar results in decreased expression of CDKN3 mRNA

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

CCAAT/enhancer binding protein beta

increases expression

ISO

brequinar results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

ceramide transporter 1

decreases expression

ISO

brequinar results in decreased expression of CERT1 mRNA

NCBI chr 2:29,617,202...29,721,734
Ensembl chr 2:29,617,023...29,721,729

G

checkpoint kinase 1

decreases expression

ISO

brequinar results in decreased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

claudin 2

decreases expression

ISO

brequinar results in decreased expression of CLDN2 mRNA

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377

G

calponin 1

decreases expression

ISO

brequinar results in decreased expression of CNN1 mRNA

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482

G

carbamoyl-phosphate synthase 1

decreases expression

ISO

brequinar results in decreased expression of CPS1 mRNA

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

cathepsin B

decreases expression

ISO

brequinar results in decreased expression of CTSB mRNA

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

increases expression

ISO

brequinar results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cytochrome c-1

affects expression

ISO

brequinar affects the expression of CYC1 mRNA

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

cytochrome c, somatic

decreases expression

ISO

brequinar results in decreased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

ISO

brequinar results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

ISO

brequinar results in increased expression of CYP1A2 mRNA

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

ISO

brequinar results in increased expression of CYP2B6 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects expression

ISO

brequinar affects the expression of CYP2C19 mRNA

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases expression

ISO

brequinar results in increased expression of CYP2C8 mRNA

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

ISO

brequinar results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

ISO

brequinar results in increased expression of CYP3A5 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

DNA-damage inducible transcript 3

increases expression

ISO

brequinar results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DEP domain containing 1

decreases expression

ISO

brequinar results in decreased expression of DEPDC1 mRNA

NCBI chr 2:251,343,250...251,376,709
Ensembl chr 2:251,343,281...251,376,709

G

dihydroorotate dehydrogenase

multiple interactions
decreases activity

EXP
ISO

brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of Quinones]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
brequinar results in decreased activity of DHODH protein

PMID:9776318 PMID:9802339 PMID:10658902

NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

ISO

brequinar results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

ETS proto-oncogene 1, transcription factor

increases expression

ISO

brequinar results in increased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

fibroblast growth factor 2

increases expression

ISO

brequinar results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibronectin 1

increases expression

ISO

brequinar results in increased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

brequinar results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

ferritin heavy chain 1

affects expression
increases expression

ISO

brequinar affects the expression of FTH1 mRNA
brequinar results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

increases expression

ISO

brequinar results in increased expression of FTL mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

brequinar results in decreased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

increases expression

ISO

brequinar results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glutamate-cysteine ligase, catalytic subunit

increases expression

ISO

brequinar results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

brequinar results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

ISO

brequinar results in increased expression of GCNT3 mRNA

NCBI chr 8:79,570,081...79,577,389
Ensembl chr 8:79,566,753...79,581,595

G

guanine deaminase

increases expression

ISO

brequinar results in increased expression of GDA mRNA

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

growth differentiation factor 15

increases expression

ISO

brequinar results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gamma-glutamyltransferase 1

decreases expression

ISO

brequinar results in decreased expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

glucosamine-6-phosphate deaminase 1

increases expression

ISO

brequinar results in increased expression of GNPDA1 mRNA

NCBI chr18:30,416,599...30,428,630
Ensembl chr18:30,416,607...30,428,630

G

G protein-coupled receptor 87

increases expression

ISO

brequinar results in increased expression of GPR87 mRNA

NCBI chr 2:145,589,630...145,608,094
Ensembl chr 2:145,589,569...145,604,442

G

glutathione-disulfide reductase

decreases expression

ISO

brequinar results in decreased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 4

decreases expression

ISO

brequinar results in decreased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase mu 2

affects expression

ISO

brequinar affects the expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase, mu 5

increases expression

ISO

brequinar results in increased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase omega 1

increases expression

ISO

brequinar results in increased expression of GSTO1 mRNA

NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167

G

H1.0 linker histone

increases expression

ISO

brequinar results in increased expression of H1-0 mRNA

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:112,473,222...112,475,006

G

H1.4 linker histone, cluster member

decreases expression

ISO

brequinar results in decreased expression of H1-4 mRNA

NCBI chr17:41,914,425...41,915,206
Ensembl chr17:41,914,431...41,916,129

G

H2A.X variant histone

decreases expression

ISO

brequinar results in decreased expression of H2AX mRNA

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H2B clustered histone 14

decreases expression

ISO

brequinar results in decreased expression of H2BC5 mRNA

NCBI chr17:47,488,627...47,489,008

G

hepatitis A virus cellular receptor 1

decreases expression

ISO

brequinar results in decreased expression of HAVCR1 mRNA

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

histone deacetylase 9

increases expression

ISO

brequinar results in increased expression of HDAC9 mRNA

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835

G

histone cluster 1 H2B family member Q

decreases expression

ISO

brequinar results in decreased expression of H2BC7 mRNA

NCBI chr17:41,859,955...41,869,889
Ensembl chr17:41,857,231...41,870,107
Ensembl chr17:41,857,231...41,870,107

G

high mobility group AT-hook 2

increases expression

ISO

brequinar results in increased expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341

G

hyaluronan-mediated motility receptor

decreases expression

ISO

brequinar results in decreased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

heme oxygenase 1

increases expression

ISO

brequinar results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

homeobox A10

decreases expression

ISO

brequinar results in decreased expression of HOXA10 mRNA

NCBI chr 4:82,662,204...82,671,490
Ensembl chr 4:82,662,204...82,665,922

G

homeobox D8

decreases expression

ISO

brequinar results in decreased expression of HOXD8 mRNA

NCBI chr 3:80,015,223...80,017,789
Ensembl chr 3:80,014,735...80,018,765

G

heat shock protein family A (Hsp70) member 13

increases expression

ISO

brequinar results in increased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

brequinar results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

ISO

brequinar results in increased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

brequinar results in decreased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 1

decreases expression

ISO

brequinar results in decreased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

interferon-related developmental regulator 1

increases expression

ISO

brequinar results in increased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

insulin-like growth factor binding protein 1

increases expression

ISO

brequinar results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

interleukin 18 receptor 1

increases expression

ISO

brequinar results in increased expression of IL18R1 mRNA

NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:50,223,200...50,257,367

G

interleukin 1 alpha

increases expression

ISO

brequinar results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 receptor type 1

increases expression

ISO

brequinar results in increased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 23 subunit alpha

increases expression

ISO

brequinar results in increased expression of IL23A mRNA

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 6

increases expression

ISO

brequinar results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinesin family member 20A

decreases expression

ISO

brequinar results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 23

decreases expression

ISO

brequinar results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

keratin 15

increases expression

ISO

brequinar results in increased expression of KRT15 mRNA

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142

G

laminin subunit alpha 3

increases expression

ISO

brequinar results in increased expression of LAMA3 mRNA

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

lipocalin 2

increases expression

ISO

brequinar results in increased expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lymphocyte cytosolic protein 1

increases expression

ISO

brequinar results in increased expression of LCP1 mRNA

NCBI chr15:56,846,375...56,954,090
Ensembl chr15:56,847,433...56,954,092

G

MAF bZIP transcription factor F

increases expression

ISO

brequinar results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor G

increases expression

ISO

brequinar results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

muscleblind-like splicing regulator 1

decreases expression

ISO

brequinar results in decreased expression of MBNL1 mRNA

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

MDM2 proto-oncogene

increases expression

ISO

brequinar results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

mitochondrial pyruvate carrier 2

decreases expression

ISO

brequinar results in decreased expression of MPC2 mRNA

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

decreases expression

ISO

brequinar results in decreased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
Ensembl chr MT:13,531...14,049

G

neutrophil cytosolic factor 2

increases expression

ISO

brequinar results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

nuclear receptor subfamily 2, group F, member 2

decreases expression

ISO

brequinar results in decreased expression of NR2F2 mRNA

NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:133,420,227...133,431,975

G

neuronal cell adhesion molecule

increases expression

ISO

brequinar results in increased expression of NRCAM mRNA

NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:67,129,801...67,430,539

G

nucleolar and spindle associated protein 1

decreases expression

ISO

brequinar results in decreased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

ISO

brequinar results in decreased expression of PDHA1 mRNA

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

pleckstrin homology-like domain, family A, member 1

decreases expression

ISO

brequinar results in decreased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

perilipin 2

increases expression

ISO

brequinar results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

cytochrome p450 oxidoreductase

increases expression

ISO

brequinar results in increased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

PPARG coactivator 1 alpha

decreases expression

ISO

brequinar results in decreased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein phosphatase 1, regulatory subunit 15A

increases expression

ISO

brequinar results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein C, inactivator of coagulation factors Va and VIIIa

decreases expression

ISO

brequinar results in decreased expression of PROC mRNA

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

glutaminyl-tRNA synthetase 1

decreases expression

ISO

brequinar results in decreased expression of QARS1 mRNA

NCBI chr 8:118,086,243...118,094,274
Ensembl chr 8:118,086,228...118,094,274

G

Ras association domain family member 1

decreases expression

ISO

brequinar results in decreased expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RNA binding motif protein 6

increases expression

ISO

brequinar results in increased expression of RBM6 mRNA

NCBI chr 8:117,327,607...117,431,397
Ensembl chr 8:117,331,325...117,431,397

G

regulator of cell cycle

increases expression

ISO

brequinar results in increased expression of RGCC mRNA

NCBI chr15:61,071,574...61,084,408
Ensembl chr15:61,071,574...61,084,408

G

ribosomal protein S20

decreases expression

ISO

brequinar results in decreased expression of RPS20 mRNA

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

sestrin 2

increases expression

ISO

brequinar results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 2 member 2

decreases expression

ISO

brequinar results in decreased expression of SLC2A2 mRNA

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 7 member 11

increases expression

ISO

brequinar results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

snail family transcriptional repressor 2

increases expression

ISO

brequinar results in increased expression of SNAI2 mRNA

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

superoxide dismutase 2

increases expression

ISO

brequinar results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

increases expression

ISO

brequinar results in increased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

sulfiredoxin 1

increases expression

ISO

brequinar results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

sulfotransferase family 2A member 1

increases expression

ISO

brequinar results in increased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

transgelin

decreases expression
increases expression

ISO

brequinar results in decreased expression of TAGLN mRNA
brequinar results in increased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

thrombomodulin

increases expression

ISO

brequinar results in increased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

TP53 induced glycolysis regulatory phosphatase

increases expression

ISO

brequinar results in increased expression of TIGAR mRNA

NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:161,613,306...161,632,229

G

tumor protein p53

increases expression

ISO

brequinar results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tribbles pseudokinase 3

increases expression

ISO

brequinar results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tsukushi, small leucine rich proteoglycan

increases expression

ISO

brequinar results in increased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

tubulin, alpha 1A

decreases expression

ISO

brequinar results in decreased expression of TUBA1A mRNA

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035

G

thioredoxin reductase 1

increases expression

ISO

brequinar results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

UDP glucuronosyltransferase family 1 member A1

increases expression

ISO

brequinar results in increased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

decreases expression

ISO

brequinar results in decreased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

ubiquinol-cytochrome c reductase core protein 1

decreases expression

ISO

brequinar results in decreased expression of UQCRC1 mRNA

NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:118,468,200...118,479,964

G

X-box binding protein 1

increases expression

ISO

brequinar results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AAR2 splicing factor

decreases expression

ISO

leflunomide results in decreased expression of AAR2 mRNA

NCBI chr 3:165,517,467...165,540,260
Ensembl chr 3:165,517,556...165,548,519

G

aminoadipate-semialdehyde synthase

decreases expression

EXP

leflunomide results in decreased expression of AASS mRNA

NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:52,572,147...52,657,600

G

4-aminobutyrate aminotransferase

decreases expression

ISO

leflunomide results in decreased expression of ABAT mRNA

PMID:28988120 PMID:29427785

NCBI chr10:7,503,351...7,599,474
Ensembl chr10:7,492,022...7,599,474

G

ATP binding cassette subfamily A member 8

increases expression

EXP

leflunomide results in increased expression of ABCA8 mRNA

NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452

G

ATP-binding cassette, subfamily A (ABC1), member 8a

decreases expression

EXP

Leflunomide results in decreased expression of ABCA8A mRNA

NCBI chr10:95,501,798...95,571,770
Ensembl chr10:95,501,798...95,571,873

G

ATP binding cassette subfamily B member 4

increases expression
decreases activity

EXP
ISO

leflunomide results in increased expression of ABCB4 mRNA
leflunomide results in decreased activity of ABCB4 protein

PMID:24136188 PMID:28437613

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily B member 6

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of ABCB6 mRNA
leflunomide results in decreased expression of ABCB6 mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

ATP binding cassette subfamily C member 1

increases expression

ISO

leflunomide results in increased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily D member 3

decreases expression

ISO

leflunomide results in decreased expression of ABCD3 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504

G

ATP binding cassette subfamily D member 4

decreases expression

ISO

leflunomide results in decreased expression of ABCD4 mRNA

NCBI chr 6:109,977,541...109,992,050
Ensembl chr 6:109,977,550...109,991,983

G

ATP binding cassette subfamily G member 5

decreases expression

ISO

leflunomide results in decreased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

ATP binding cassette subfamily G member 8

decreases expression

ISO

leflunomide results in decreased expression of ABCG8 mRNA

NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730

G

abhydrolase domain containing 1

increases expression

EXP

leflunomide results in increased expression of ABHD1 mRNA

NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464

G

abhydrolase domain containing 14b

increases expression

EXP

leflunomide results in increased expression of ABHD14B mRNA

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

abhydrolase domain containing 17A, depalmitoylase

increases expression

EXP

leflunomide results in increased expression of ABHD17A mRNA

NCBI chr 7:9,775,016...9,781,447

G

abhydrolase domain containing 2, acylglycerol lipase

decreases expression

EXP

leflunomide results in decreased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

EXP

leflunomide results in increased expression of ABHD4 mRNA

NCBI chr15:31,674,090...31,686,051
Ensembl chr15:31,674,143...31,687,007

G

actin binding LIM protein family, member 3

increases expression

ISO

leflunomide results in increased expression of ABLIM3 mRNA

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:57,527,917...57,646,710

G

ankyrin repeat and BTB domain containing 3

increases expression

ISO
EXP

Leflunomide results in increased expression of ABTB3 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110

G

acetyl-CoA acyltransferase 1A

increases expression

EXP

leflunomide results in increased expression of ACAA1 mRNA

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241

G

acetyl-CoA acyltransferase 2

increases expression

EXP

leflunomide results in increased expression of ACAA2 mRNA

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

acyl-CoA dehydrogenase family, member 9

increases expression

EXP

leflunomide results in increased expression of ACAD9 mRNA

NCBI chr 2:120,871,329...120,894,306
Ensembl chr 2:120,871,227...120,894,709

G

acyl-CoA dehydrogenase, very long chain

increases expression

EXP

leflunomide results in increased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

acetyl-CoA acetyltransferase 1

increases expression

EXP

leflunomide results in increased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acyl-CoA binding domain containing 5

increases expression

ISO

leflunomide results in increased expression of ACBD5 mRNA

NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286

G

acyl-CoA binding domain containing 7

decreases expression

ISO

leflunomide results in decreased expression of ACBD7 mRNA

NCBI chr17:79,813,106...79,821,254
Ensembl chr17:79,813,106...79,818,448

G

aconitase 1

increases expression

EXP

leflunomide results in increased expression of ACO1 mRNA

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

increases expression

EXP

leflunomide results in increased expression of ACO2 mRNA

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 11

increases expression

ISO

leflunomide results in increased expression of ACOT11 mRNA

NCBI chr 5:126,756,255...126,804,526
Ensembl chr 5:126,756,255...126,804,507

G

acyl-CoA thioesterase 2

increases expression

EXP

leflunomide results in increased expression of ACOT2 mRNA

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

acyl-CoA thioesterase 4

increases expression

EXP

leflunomide results in increased expression of ACOT4 mRNA

NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:109,399,578...109,405,138

G

acyl-CoA thioesterase 7

increases expression

EXP

leflunomide results in increased expression of ACOT7 mRNA

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:167,968,895...168,062,033

G

acid phosphatase 2, lysosomal

increases expression

EXP

leflunomide results in increased expression of ACP2 mRNA

NCBI chr 3:97,630,654...97,642,601
Ensembl chr 3:97,631,326...97,642,565

G

acyl-CoA synthetase long-chain family member 3

increases expression

ISO

leflunomide results in increased expression of ACSL3 mRNA

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097

G

acyl-CoA synthetase medium-chain family member 2

increases expression

EXP

leflunomide results in increased expression of ACSM2A mRNA

NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453

G

acyl-CoA synthetase short-chain family member 1

decreases expression

ISO

leflunomide results in decreased expression of ACSS1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748

G

actin, alpha 1, skeletal muscle

increases expression

ISO

leflunomide results in increased expression of ACTA1 mRNA

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actin, beta

increases expression

ISO

leflunomide results in increased expression of ACTB mRNA

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin, gamma 1

increases expression

ISO

leflunomide results in increased expression of ACTG1 mRNA

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

actin gamma 2, smooth muscle

increases expression

ISO

leflunomide results in increased expression of ACTG2 mRNA

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295

G

actinin, alpha 1

increases expression

ISO

leflunomide results in increased expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172

G

actinin alpha 3

decreases expression

ISO

leflunomide results in decreased expression of ACTN3 mRNA

NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:211,588,474...211,604,401

G

actin related protein 5

decreases expression

ISO

leflunomide results in decreased expression of ACTR5 mRNA

NCBI chr 3:167,702,299...167,715,736
Ensembl chr 3:167,702,482...167,715,730

G

activin A receptor type 1

increases expression

ISO

leflunomide results in increased expression of ACVR1 mRNA

NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:63,387,381...63,477,884

G

activin A receptor type 1B

increases expression

ISO

leflunomide results in increased expression of ACVR1B mRNA

NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:134,164,991...134,208,388

G

acylphosphatase 1

decreases expression

ISO

leflunomide results in decreased expression of ACYP1 mRNA

NCBI chr 6:110,650,213...110,663,404
Ensembl chr 6:110,650,213...110,663,612

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

increases expression

EXP

leflunomide results in increased expression of ADAMTS1 mRNA

NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390

G

ADAM metallopeptidase with thrombospondin type 1 motif, 7

decreases expression

EXP

leflunomide results in decreased expression of ADAMTS7 mRNA

NCBI chr 8:99,584,529...99,624,132
Ensembl chr 8:99,584,529...99,624,132

G

ArfGAP with dual PH domains 1

increases expression

ISO

leflunomide results in increased expression of ADAP1 mRNA

NCBI chr12:20,438,091...20,489,961
Ensembl chr12:20,438,063...20,495,020

G

adenylate cyclase 3

decreases expression

ISO

leflunomide results in decreased expression of ADCY3 mRNA

NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:32,843,961...32,923,173

G

adenylate cyclase 6

decreases expression

ISO

leflunomide results in decreased expression of ADCY6 mRNA

NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:131,621,860...131,642,770

G

adenylate cyclase 9

increases expression

ISO

leflunomide results in increased expression of ADCY9 mRNA

NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,645,282...11,765,792

G

adhesion G protein-coupled receptor G1

increases expression

ISO

leflunomide results in increased expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124

G

adhesion G protein-coupled receptor G3

increases expression

ISO

leflunomide results in increased expression of ADGRG3 mRNA

NCBI chr19:9,978,450...10,007,145
Ensembl chr19:9,978,514...10,007,238

G

alcohol dehydrogenase 6 (class V)

decreases expression

ISO

Leflunomide results in decreased expression of ADH6 mRNA

NCBI chr 2:229,576,612...229,608,359
Ensembl chr 2:229,576,636...229,607,914

G

adiponectin receptor 2

decreases expression

ISO

leflunomide results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

adrenomedullin

increases expression

ISO

leflunomide results in increased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

adrenomedullin 2

increases expression

ISO

leflunomide results in increased expression of ADM2 mRNA

NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:122,272,808...122,274,594

G

ADNP homeobox 2

increases expression

ISO

leflunomide results in increased expression of ADNP2 mRNA

NCBI chr18:75,846,860...75,871,638
Ensembl chr18:75,847,165...75,903,317

G

adenosine A2a receptor

affects expression

ISO

leflunomide affects the expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent

increases expression

EXP
ISO

leflunomide results in increased expression of ADPRM mRNA

PMID:24136188 PMID:28988120

NCBI chr10:52,231,085...52,243,637
Ensembl chr10:52,230,233...52,243,569

G

ADP-ribosylserine hydrolase

decreases expression

ISO

Leflunomide results in decreased expression of ADPRS mRNA

PMID:28988120 PMID:29427785

NCBI chr 5:143,898,542...143,903,816
Ensembl chr 5:143,898,542...143,903,816

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

EXP

leflunomide results in increased expression of ADRM1 mRNA

NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:187,642,654...187,648,483

G

AE binding protein 2

increases expression

EXP

leflunomide results in increased expression of AEBP2 mRNA

NCBI chr 4:175,258,286...175,297,149
Ensembl chr 4:175,258,887...175,326,422

G

ALF transcription elongation factor 4

increases expression

ISO

leflunomide results in increased expression of AFF4 mRNA

NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,999,579...38,080,580

G

AFG2 AAA ATPase homolog A

increases expression

ISO

Leflunomide results in increased expression of AFG2A mRNA

NCBI chr 2:122,234,619...122,425,808
Ensembl chr 2:122,234,738...122,425,808

G

AFG2 AAA ATPase homolog B

decreases expression

ISO

Leflunomide results in decreased expression of AFG2B mRNA

NCBI chr 3:130,148,061...130,162,458
Ensembl chr 3:130,148,301...130,162,112

G

arylformamidase

decreases expression

ISO

leflunomide results in decreased expression of AFMID mRNA

NCBI chr10:103,544,822...103,560,408
Ensembl chr10:103,544,841...103,560,408

G

advanced glycosylation end product-specific receptor

decreases expression

ISO

leflunomide results in decreased expression of AGER mRNA

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

1-acylglycerol-3-phosphate O-acyltransferase 3

increases expression

EXP

leflunomide results in increased expression of AGPAT3 mRNA

NCBI chr20:10,330,650...10,415,026
Ensembl chr20:10,394,465...10,410,632

G

1-acylglycerol-3-phosphate O-acyltransferase 5

decreases expression

ISO

leflunomide results in decreased expression of AGPAT5 mRNA

NCBI chr16:77,641,887...77,688,148
Ensembl chr16:77,641,887...77,688,148

G

adenosylhomocysteinase

increases expression

EXP

leflunomide results in increased expression of AHCY mRNA

NCBI chr 3:164,029,338...164,044,562
Ensembl chr 3:164,029,338...164,044,587

G

AHNAK nucleoprotein

decreases expression

ISO

leflunomide results in decreased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

aryl hydrocarbon receptor

affects binding
increases expression

ISO
EXP

leflunomide binds to AHR protein
leflunomide results in increased expression of AHR mRNA

PMID:24136188 PMID:25329374 PMID:28988120

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

activator of HSP90 ATPase homolog 2

decreases expression

ISO

leflunomide results in decreased expression of AHSA2P mRNA

NCBI chr14:101,677,447...101,688,706
Ensembl chr14:101,677,447...101,686,923

G

androgen-induced 1

increases expression

EXP

leflunomide results in increased expression of AIG1 mRNA

NCBI chr 1:9,866,546...10,089,454
Ensembl chr 1:9,866,548...10,089,155

G

adenylate kinase 4

increases expression

EXP

leflunomide results in increased expression of AK4 mRNA

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

A-kinase anchoring protein 10

increases expression

ISO

leflunomide results in increased expression of AKAP10 mRNA

NCBI chr10:47,044,819...47,108,153
Ensembl chr10:47,044,819...47,108,203

G

A-kinase anchoring protein 12

increases expression

ISO

leflunomide results in increased expression of AKAP12 mRNA

NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:43,199,008...43,225,557

G

aldo-keto reductase family 1, member C1

decreases expression

ISO
EXP

Leflunomide results in decreased expression of AKR1C1 mRNA

PMID:24136188 PMID:28988120

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 7, member A2

increases expression

EXP

leflunomide results in increased expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

AKT1 substrate 1

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of AKT1S1 mRNA
leflunomide results in decreased expression of AKT1S1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:104,469,803...104,476,167

G

AKT interacting protein

decreases expression

ISO

leflunomide results in decreased expression of AKTIP mRNA

NCBI chr19:32,039,507...32,059,634
Ensembl chr19:32,039,466...32,067,178

G

5'-aminolevulinate synthase 1

increases expression

EXP

leflunomide results in increased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

aldehyde dehydrogenase family 1, subfamily A7

increases expression

EXP

Leflunomide results in increased expression of ALDH1A7 mRNA

NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523

G

aldehyde dehydrogenase 1 family, member B1

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of ALDH1B1 mRNA
leflunomide results in increased expression of ALDH1B1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365

G

aldehyde dehydrogenase 1 family, member L1

decreases expression

ISO

leflunomide results in decreased expression of ALDH1L1 mRNA

NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:124,617,217...124,664,704

G

aldehyde dehydrogenase 3 family, member A1

increases expression

ISO

leflunomide results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

aldehyde dehydrogenase 5 family, member A1

decreases expression

ISO

leflunomide results in decreased expression of ALDH5A1 mRNA

PMID:28988120 PMID:29427785

NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,558,347...40,586,714

G

ALG2, alpha-1,3/1,6-mannosyltransferase

decreases expression

ISO

leflunomide results in decreased expression of ALG2 mRNA

NCBI chr 5:66,564,328...66,568,887
Ensembl chr 5:66,564,330...66,568,887

G

ALG6, alpha-1,3-glucosyltransferase

decreases expression

ISO

leflunomide results in decreased expression of ALG6 mRNA

NCBI chr 5:119,520,415...119,606,365
Ensembl chr 5:119,520,430...119,606,659

G

ALS2 C-terminal like

increases expression

EXP

leflunomide results in increased expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843

G

adenosylmethionine decarboxylase 1

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of AMD1 mRNA
leflunomide results in decreased expression of AMD1 mRNA

PMID:24136188 PMID:28988120

NCBI chr20:45,250,289...45,324,939
Ensembl chr20:45,250,289...45,265,982

G

APC membrane recruitment protein 1

decreases expression

ISO

leflunomide results in decreased expression of AMER1 mRNA

NCBI chr X:64,310,492...64,326,377
Ensembl chr X:64,300,953...64,326,332

G

antagonist of mitotic exit network 1 homolog

increases expression

ISO

leflunomide results in increased expression of AMN1 mRNA

NCBI chr 4:183,886,469...183,913,411
Ensembl chr 4:183,886,474...183,913,411

G

angiomotin like 2

increases expression

ISO

leflunomide results in increased expression of AMOTL2 mRNA

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030

G

aminomethyltransferase

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of AMT mRNA
leflunomide results in decreased expression of AMT mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:117,859,700...117,866,692
Ensembl chr 8:117,860,345...117,866,803

G

archaelysin family metallopeptidase 2

increases expression

EXP

leflunomide results in increased expression of AMZ2 mRNA

NCBI chr10:94,901,053...94,911,629
Ensembl chr10:94,901,129...94,911,627

G

anaphase promoting complex subunit 10

increases expression

ISO

leflunomide results in increased expression of ANAPC10 mRNA

NCBI chr19:45,057,278...45,109,882
Ensembl chr19:45,029,546...45,109,882

G

anaphase promoting complex subunit 15

decreases expression

ISO

leflunomide results in decreased expression of ANAPC15 mRNA

NCBI chr 1:165,650,478...165,678,004
Ensembl chr 1:165,675,754...165,679,501

G

angiopoietin-like 1

decreases expression

ISO

leflunomide results in decreased expression of ANGPTL1 mRNA

NCBI chr13:71,463,913...71,531,810
Ensembl chr13:71,511,727...71,531,818

G

angiopoietin-like 4

increases expression

ISO

leflunomide results in increased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

angiopoietin-like 6

increases expression

EXP

leflunomide results in increased expression of ANGPTL6 mRNA

NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:27,689,806...27,696,111

G

ANKH inorganic pyrophosphate transport regulator

decreases expression

EXP

leflunomide results in decreased expression of ANKH mRNA

NCBI chr 2:79,883,350...80,011,222
Ensembl chr 2:79,883,544...80,011,699

G

ankyrin repeat and LEM domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of ANKLE1 mRNA

NCBI chr16:18,109,865...18,116,999
Ensembl chr16:18,110,476...18,114,244

G

ankyrin repeat domain 1

increases expression

ISO

leflunomide results in increased expression of ANKRD1 mRNA

NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:243,228,448...243,263,751

G

ankyrin repeat domain 10

decreases expression

ISO

leflunomide results in decreased expression of ANKRD10 mRNA

NCBI chr16:84,566,021...84,591,849
Ensembl chr16:84,568,506...84,591,846

G

ankyrin repeat domain 12

increases expression

ISO

leflunomide results in increased expression of ANKRD12 mRNA

NCBI chr 9:113,030,127...113,134,816
Ensembl chr 9:113,030,919...113,134,762

G

ankyrin repeat domain 13C

increases expression

ISO

leflunomide results in increased expression of ANKRD13C mRNA

NCBI chr 2:249,679,752...249,729,272
Ensembl chr 2:249,681,872...249,729,272

G

ankyrin repeat domain 16

decreases expression

ISO

leflunomide results in decreased expression of ANKRD16 mRNA

NCBI chr17:71,645,171...71,658,377
Ensembl chr17:71,647,107...71,658,377

G

ankyrin repeat domain 33B

increases expression

ISO

leflunomide results in increased expression of ANKRD33B mRNA

NCBI chr 2:83,988,505...84,070,311
Ensembl chr 2:83,993,974...84,070,936

G

ankyrin repeat domain 37

decreases expression

ISO

leflunomide results in decreased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

ankyrin repeat domain containing 50

increases expression

ISO

leflunomide results in increased expression of ANKRD50 mRNA

NCBI chr 2:123,394,311...123,428,788
Ensembl chr 2:123,396,606...123,427,340

G

ankyrin repeat domain 52

decreases expression

ISO

leflunomide results in decreased expression of ANKRD52 mRNA

NCBI chr 7:1,390,730...1,410,139
Ensembl chr 7:1,391,325...1,407,410

G

ankyrin repeat domain 65

decreases expression

ISO

leflunomide results in decreased expression of ANKRD65 mRNA

NCBI chr 5:171,680,597...171,682,854
Ensembl chr 5:171,680,597...171,683,431

G

ankyrin repeat domain 9

increases expression

ISO

leflunomide results in increased expression of ANKRD9 mRNA

NCBI chr 6:135,827,355...135,830,002
Ensembl chr 6:135,775,869...135,837,893

G

ankyrin repeat and sterile alpha motif domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of ANKS3 mRNA

NCBI chr10:11,121,504...11,142,261
Ensembl chr10:11,121,553...11,142,491

G

anoctamin 10

increases expression

EXP

leflunomide results in increased expression of ANO10 mRNA

NCBI chr 8:130,719,177...130,838,243
Ensembl chr 8:130,718,755...130,877,636

G

annexin A2

decreases expression

EXP

leflunomide results in decreased expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

annexin A3

increases expression

ISO

leflunomide results in increased expression of ANXA3 mRNA

NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849

G

annexin A6

increases expression

EXP

leflunomide results in increased expression of ANXA6 mRNA

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359

G

annexin A7

increases expression

EXP

leflunomide results in increased expression of ANXA7 mRNA

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,870,974...3,898,891

G

aldehyde oxidase 1

increases expression

EXP

leflunomide results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

adaptor related protein complex 1 subunit gamma 1

decreases expression

ISO

leflunomide results in decreased expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

adaptor related protein complex 5 subunit sigma 1

decreases expression

ISO

leflunomide results in decreased expression of AP5S1 mRNA

NCBI chr 3:138,882,634...138,885,940
Ensembl chr 3:138,882,634...138,888,899

G

amyloid beta precursor protein binding family B member 1

decreases expression

ISO

leflunomide results in decreased expression of APBB1 mRNA

NCBI chr 1:169,308,719...169,332,372
Ensembl chr 1:169,308,720...169,332,552

G

aph-1 homolog B, gamma secretase subunit

decreases expression

ISO

leflunomide results in decreased expression of APH1B mRNA

NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:76,310,380...76,331,428

G

amyloid beta precursor like protein 2

increases expression

EXP

leflunomide results in increased expression of APLP2 mRNA

NCBI chr 8:37,857,407...37,920,487
Ensembl chr 8:37,857,407...37,920,031

G

apolipoprotein L2

decreases expression

ISO

Leflunomide results in decreased expression of APOL2 mRNA

NCBI chr 7:111,211,944...111,219,209
Ensembl chr 7:111,211,893...111,217,223

G

apolipoprotein L domain containing 1

increases expression

ISO

leflunomide results in increased expression of APOLD1 mRNA

NCBI chr 4:169,499,728...169,557,075
Ensembl chr 4:169,549,679...169,559,176

G

Alu-mediated CDKN1A/p21 transcriptional regulator

decreases expression

ISO

leflunomide results in decreased expression of APTR mRNA

NCBI chr 4:15,030,417...15,031,719

G

aquaporin 3 (Gill blood group)

increases expression

ISO

leflunomide results in increased expression of AQP3 mRNA

NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685

G

aquaporin 8

increases expression

ISO

leflunomide results in increased expression of AQP8 mRNA

NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:187,424,417...187,430,242

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

ISO

leflunomide results in increased expression of ARAP2 mRNA

NCBI chr14:50,921,323...51,120,972
Ensembl chr14:50,921,713...51,120,962

G

ADP-ribosylation factor 2

decreases expression

ISO

Leflunomide results in decreased expression of ARL17B mRNA

NCBI chr10:89,367,843...89,389,644
Ensembl chr10:89,368,044...89,389,651

G

arginase 1

multiple interactions

ISO

leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

arginine and glutamate rich 1

decreases expression

ISO

leflunomide results in decreased expression of ARGLU1 mRNA

NCBI chr16:87,455,097...87,479,148
Ensembl chr16:87,455,113...87,479,148

G

Rho GTPase activating protein 11A

decreases expression

ISO

leflunomide results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:121,045,187...121,071,985
Ensembl chr 3:121,045,187...121,061,468

G

Rho GTPase activating protein 29

increases expression

ISO

leflunomide results in increased expression of ARHGAP29 mRNA

NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729

G

Rho GTPase activating protein 30

increases expression

ISO

leflunomide results in increased expression of ARHGAP30 mRNA

NCBI chr13:86,354,448...86,376,552
Ensembl chr13:86,354,547...86,376,888

G

Rho GTPase activating protein 32

increases expression

ISO

leflunomide results in increased expression of ARHGAP32 mRNA

NCBI chr 8:38,679,368...38,939,960
Ensembl chr 8:38,684,484...38,939,960

G

Rho GTPase activating protein 35

increases expression

EXP

leflunomide results in increased expression of ARHGAP35 mRNA

NCBI chr 1:86,330,566...86,447,414
Ensembl chr 1:86,330,566...86,447,414

G

Rho GTPase activating protein 40

increases expression

ISO

leflunomide results in increased expression of ARHGAP40 mRNA

NCBI chr 3:167,585,665...167,626,433
Ensembl chr 3:167,585,665...167,626,532

G

Rho GTPase activating protein 42

increases expression

ISO

leflunomide results in increased expression of ARHGAP42 mRNA

NCBI chr 8:14,436,478...14,666,588
Ensembl chr 8:14,419,256...14,666,385

G

Rho GDP dissociation inhibitor beta

increases expression

ISO

leflunomide results in increased expression of ARHGDIB mRNA

NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068

G

Rho guanine nucleotide exchange factor 19

decreases expression

EXP

leflunomide results in decreased expression of ARHGEF19 mRNA

NCBI chr 5:158,818,840...158,837,196
Ensembl chr 5:158,818,932...158,837,196

G

Rho guanine nucleotide exchange factor 28

increases expression

ISO

leflunomide results in increased expression of ARHGEF28 mRNA

NCBI chr 2:30,998,292...31,294,757
Ensembl chr 2:30,998,295...31,294,853

G

Rho guanine nucleotide exchange factor 39

decreases expression

ISO

leflunomide results in decreased expression of ARHGEF39 mRNA

NCBI chr 5:62,548,300...62,551,870
Ensembl chr 5:62,548,303...62,551,870

G

AT-rich interaction domain 4B

decreases expression
increases expression

ISO

leflunomide results in decreased expression of ARID4B mRNA
leflunomide results in increased expression of ARID4B mRNA

PMID:19751817 PMID:28988120

NCBI chr17:55,833,908...55,958,382
Ensembl chr17:55,833,908...55,958,382

G

AT-rich interaction domain 5B

increases expression

ISO

leflunomide results in increased expression of ARID5B mRNA

NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686

G

ARF like GTPase 13B

increases expression

ISO

leflunomide results in increased expression of ARL13B mRNA

NCBI chr11:13,597,538...13,663,681
Ensembl chr11:13,597,538...13,663,546

G

ARF like GTPase 4A

affects expression

ISO

leflunomide affects the expression of ARL4A mRNA

NCBI chr 6:62,809,287...62,811,297
Ensembl chr 6:62,804,548...62,820,760

G

ARF like GTPase 5B

increases expression

ISO

leflunomide results in increased expression of ARL5B mRNA

NCBI chr17:82,864,315...82,888,458
Ensembl chr17:82,864,287...82,890,646

G

ARL6 interacting reticulophagy regulator 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of ARL6IP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232

G

armadillo repeat containing 5

decreases expression

ISO

leflunomide results in decreased expression of ARMC5 mRNA

NCBI chr 1:192,250,580...192,257,347
Ensembl chr 1:192,249,939...192,257,348

G

armadillo repeat containing 7

decreases expression

ISO

leflunomide results in decreased expression of ARMC7 mRNA

NCBI chr10:101,222,056...101,238,598
Ensembl chr10:101,222,067...101,238,597

G

armadillo repeat containing 9

decreases expression

EXP

leflunomide results in decreased expression of ARMC9 mRNA

NCBI chr 9:94,250,492...94,376,589
Ensembl chr 9:94,250,859...94,376,589

G

actin-related protein 2/3 complex inhibitor

decreases expression

ISO

leflunomide results in decreased expression of ARPIN mRNA

NCBI chr 1:143,273,590...143,282,426
Ensembl chr 1:143,273,590...143,282,532

G

cAMP-regulated phosphoprotein 19

increases expression

EXP

leflunomide results in increased expression of ARPP19 mRNA

NCBI chr 8:84,660,166...84,683,012
Ensembl chr 8:119,691,942...119,692,385
Ensembl chr 8:119,691,942...119,692,385

G

arrestin domain containing 3

increases expression

ISO

leflunomide results in increased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

arrestin domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of ARRDC4 mRNA

NCBI chr 1:131,779,436...131,793,438
Ensembl chr 1:131,779,437...131,793,565

G

arylsulfatase G

increases expression

ISO

leflunomide results in increased expression of ARSG mRNA

NCBI chr10:94,912,094...95,063,021
Ensembl chr10:94,913,152...95,042,447

G

arylsulfatase family, member I

decreases expression

ISO

leflunomide results in decreased expression of ARSI mRNA

NCBI chr18:56,634,556...56,642,168
Ensembl chr18:56,625,487...56,642,168

G

N-acylsphingosine amidohydrolase 2

increases expression

ISO

leflunomide results in increased expression of ASAH2 mRNA

NCBI chr 1:239,278,994...239,386,598
Ensembl chr 1:239,278,994...239,382,024

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

increases expression

ISO

leflunomide results in increased expression of ASAP1 mRNA

NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:97,675,354...97,982,024

G

activating signal cointegrator 1 complex subunit 2

increases expression

ISO

leflunomide results in increased expression of ASCC2 mRNA

NCBI chr14:83,726,975...83,771,312
Ensembl chr14:83,727,049...83,771,316

G

anti-silencing function 1B histone chaperone

decreases expression

ISO

leflunomide results in decreased expression of ASF1B mRNA

NCBI chr19:41,085,786...41,100,352
Ensembl chr19:41,086,114...41,100,352

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

leflunomide results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

asparaginase

decreases expression

EXP

leflunomide results in decreased expression of ASPG mRNA

NCBI chr 6:136,997,832...137,017,417
Ensembl chr 6:136,998,023...137,017,417

G

assembly factor for spindle microtubules

decreases expression

ISO

leflunomide results in decreased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489

G

argininosuccinate synthase 1

increases expression

ISO

leflunomide results in increased expression of ASS1 mRNA

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

ATPase family, AAA domain containing 1

increases expression

ISO

leflunomide results in increased expression of ATAD1 mRNA

NCBI chr 1:239,957,329...240,023,792
Ensembl chr 1:239,957,882...240,009,822

G

ATPase family, AAA domain containing 2B

increases expression

ISO

leflunomide results in increased expression of ATAD2B mRNA

NCBI chr 6:33,646,075...33,789,532
Ensembl chr 6:33,646,075...33,789,532

G

alpha tubulin acetyltransferase 1

decreases expression

ISO

leflunomide results in decreased expression of ATAT1 mRNA

NCBI chr20:2,849,399...2,862,614
Ensembl chr20:2,849,421...2,862,389

G

activating transcription factor 3

increases expression

ISO

leflunomide results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

increases expression
multiple interactions

EXP
ISO

leflunomide results in increased expression of ATF4 mRNA
leflunomide results in increased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]; [Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of ATF4 protein]; Bongkrekic Acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]; MAPK1 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]; MAPK3 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of ATF5 mRNA
leflunomide results in decreased expression of ATF5 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

activating transcription factor 7 interacting protein

increases expression

ISO

leflunomide results in increased expression of ATF7IP mRNA

NCBI chr 4:171,117,122...171,202,871
Ensembl chr 4:171,117,122...171,202,867

G

activating transcription factor 7 interacting protein 2

increases expression

ISO

leflunomide results in increased expression of ATF7IP2 mRNA

NCBI chr10:5,909,898...5,952,844
Ensembl chr10:5,909,658...5,952,995

G

autophagy related 16-like 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of ATG16L2 mRNA
leflunomide results in decreased expression of ATG16L2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:165,100,946...165,123,307
Ensembl chr 1:165,102,936...165,115,473

G

autophagy related 9A

increases expression

EXP

leflunomide results in increased expression of ATG9A mRNA

NCBI chr 9:84,126,071...84,136,723
Ensembl chr 9:84,126,071...84,136,666

G

ATM interactor

decreases expression

ISO

leflunomide results in decreased expression of ATMIN mRNA

NCBI chr19:61,905,343...61,922,443
Ensembl chr19:61,905,144...61,922,443

G

atonal bHLH transcription factor 8

increases expression

EXP
ISO

leflunomide results in increased expression of ATOH8 mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:105,818,203...105,850,379

G

atos homolog A

decreases expression

EXP

Leflunomide results in decreased expression of ATOSA mRNA

NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:84,575,370...84,653,091

G

ATPase phospholipid transporting 11C

decreases expression

ISO

leflunomide results in decreased expression of ATP11C mRNA

NCBI chr X:143,600,763...143,788,407
Ensembl chr X:143,600,767...143,788,432

G

ATPase 13A5

increases expression

ISO

leflunomide results in increased expression of ATP13A5 mRNA

NCBI chr11:84,881,196...85,020,597
Ensembl chr11:84,881,230...85,020,593

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

ISO

leflunomide results in increased expression of ATP2A2 mRNA

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATPase plasma membrane Ca2+ transporting 2

increases expression

ISO

leflunomide results in increased expression of ATP2B2 mRNA

NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:148,450,207...148,696,239

G

ATP synthase membrane subunit c locus 1

decreases expression

ISO

Leflunomide results in decreased expression of ATP5MC1 mRNA

PMID:28988120 PMID:29427785

NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,520,765...81,523,363

G

ATPase H+ transporting accessory protein 2

increases expression

EXP

leflunomide results in increased expression of ATP6AP2 mRNA

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:12,855,859...12,905,875

G

ATPase H+ transporting V0 subunit a1

decreases expression

ISO

leflunomide results in decreased expression of ATP6V0A1 mRNA

NCBI chr10:86,436,089...86,490,185
Ensembl chr10:86,436,141...86,490,181

G

ATPase H+ transporting V1 subunit A

increases expression

ISO

leflunomide results in increased expression of ATP6V1A mRNA

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

leflunomide results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ATPase H+ transporting V1 subunit F

increases expression

EXP

leflunomide results in increased expression of ATP6V1F mRNA

NCBI chr 4:59,033,020...59,035,980

G

ATPase H+ transporting V1 subunit G1

increases expression

EXP

leflunomide results in increased expression of ATP6V1G1 mRNA

NCBI chr 5:81,976,959...81,983,139
Ensembl chr 5:81,977,015...81,985,930

G

ATPase H+ transporting V1 subunit H

increases expression

EXP
ISO

leflunomide results in increased expression of ATP6V1H mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:19,176,849...19,282,516
Ensembl chr 5:19,176,849...19,282,516

G

ATP synthase c subunit lysine N-methyltransferase

decreases expression

ISO

Leflunomide results in decreased expression of ATPSCKMT mRNA

NCBI chr 2:84,313,991...84,329,195
Ensembl chr 2:84,313,921...84,329,194

G

ataxin 7

increases expression

ISO

leflunomide results in increased expression of ATXN7 mRNA

NCBI chr15:13,547,859...13,693,311
Ensembl chr15:13,547,862...13,693,526

G

ataxin 7-like 3

decreases expression

ISO

leflunomide results in decreased expression of ATXN7L3 mRNA

NCBI chr10:87,742,993...87,750,247
Ensembl chr10:87,744,369...87,750,245

G

AUP1, lipid droplet regulating VLDL assembly factor

increases expression

EXP

leflunomide results in increased expression of AUP1 mRNA

NCBI chr 4:117,118,035...117,121,063
Ensembl chr 4:117,117,999...117,121,061

G

aurora kinase A

decreases expression

ISO

leflunomide results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

aurora kinase B

decreases expression

ISO

leflunomide results in decreased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

arginine vasopressin receptor 1A

increases expression

EXP

leflunomide results in increased expression of AVPR1A mRNA

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837

G

Axl receptor tyrosine kinase

increases expression

ISO

leflunomide results in increased expression of AXL mRNA

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

increases expression

ISO

leflunomide results in increased expression of B3GNT3 mRNA

NCBI chr16:18,434,114...18,444,851
Ensembl chr16:18,435,378...18,444,738

G

B9 domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of B9D1 mRNA

NCBI chr10:46,685,410...46,698,580
Ensembl chr10:46,686,133...46,695,428

G

BRISC and BRCA1 A complex member 2

increases expression

EXP

leflunomide results in increased expression of BABAM2 mRNA

NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:30,071,611...30,467,341

G

BTB domain and CNC homolog 1

increases expression

ISO

leflunomide results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BAG cochaperone 2

decreases expression

ISO

leflunomide results in decreased expression of BAG2 mRNA

NCBI chr 9:43,465,993...43,476,637
Ensembl chr 9:43,465,995...43,476,752

G

BAG cochaperone 3

decreases expression

ISO

leflunomide results in decreased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BMP and activin membrane-bound inhibitor

increases expression

ISO

leflunomide results in increased expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

Bardet-Biedl syndrome 2

increases expression

EXP

leflunomide results in increased expression of BBS2 mRNA

NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921

G

Bardet-Biedl syndrome 4

decreases expression

ISO

leflunomide results in decreased expression of BBS4 mRNA

NCBI chr 8:68,627,739...68,661,232
Ensembl chr 8:68,627,656...68,661,358

G

BCL3, transcription coactivator

increases expression

ISO

leflunomide results in increased expression of BCL3 mRNA

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368

G

BCL6, transcription repressor

increases expression

ISO

leflunomide results in increased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BCL6B, transcription repressor

decreases expression

EXP

leflunomide results in decreased expression of BCL6B mRNA

NCBI chr10:55,439,566...55,444,631
Ensembl chr10:55,432,382...55,444,631

G

BAF chromatin remodeling complex subunit BCL7C

increases expression

EXP

leflunomide results in increased expression of BCL7C mRNA

NCBI chr 1:191,703,432...191,754,751
Ensembl chr 1:191,691,089...191,754,641

G

BCL6 co-repressor

increases expression

ISO

leflunomide results in increased expression of BCOR mRNA

NCBI chr X:13,282,431...13,402,254
Ensembl chr X:13,360,376...13,402,254

G

BCL6 co-repressor-like 1

decreases expression

ISO

leflunomide results in decreased expression of BCORL1 mRNA

NCBI chr X:132,394,703...132,462,414
Ensembl chr X:132,397,069...132,461,976

G

BEN domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of BEND3 mRNA

NCBI chr20:48,562,383...48,599,194
Ensembl chr20:48,576,311...48,596,808

G

BEN domain containing 7

increases expression

ISO

leflunomide results in increased expression of BEND7 mRNA

NCBI chr17:78,392,489...78,475,459
Ensembl chr17:78,393,601...78,475,223

G

basic helix-loop-helix family, member e40

increases expression

ISO

leflunomide results in increased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

BicC family RNA binding protein 1

increases expression

ISO

leflunomide results in increased expression of BICC1 mRNA

NCBI chr20:17,448,745...17,685,887
Ensembl chr20:17,448,765...17,685,885

G

BICD cargo adaptor 2

decreases expression

ISO

leflunomide results in decreased expression of BICD2 mRNA

NCBI chr17:15,449,011...15,511,423
Ensembl chr17:15,435,894...15,511,305

G

BICD family like cargo adaptor 1

increases expression

ISO

leflunomide results in increased expression of BICDL1 mRNA

NCBI chr12:46,537,525...46,626,876
Ensembl chr12:46,538,396...46,628,866

G

BICRA like chromatin remodeling complex associated protein

increases expression

ISO

leflunomide results in increased expression of BICRAL mRNA

NCBI chr 9:21,597,886...21,682,985
Ensembl chr 9:21,597,855...21,682,983

G

BH3 interacting domain death agonist

increases expression

EXP

leflunomide results in increased expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

increases expression

ISO

leflunomide results in increased expression of BIK mRNA

PMID:28988120 PMID:29427785

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 3

increases expression

ISO

leflunomide results in increased expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

leflunomide results in decreased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BLCAP, apoptosis inducing factor

decreases expression

ISO

leflunomide results in decreased expression of BLCAP mRNA

NCBI chr 3:166,642,676...166,656,924
Ensembl chr 3:166,642,677...166,652,829

G

biogenesis of lysosomal organelles complex-1, subunit 3

decreases expression

ISO

leflunomide results in decreased expression of BLOC1S3 mRNA

NCBI chr 1:88,283,864...88,286,244
Ensembl chr 1:88,280,115...88,294,060

G

bridge-like lipid transfer protein family member 3B

increases expression

EXP

Leflunomide results in increased expression of BLTP3B mRNA

NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:26,068,955...26,149,083

G

biliverdin reductase B

increases expression

EXP

leflunomide results in increased expression of BLVRB mRNA

NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:91,866,258...91,884,225

G

Bcl2 modifying factor

increases expression

ISO

leflunomide results in increased expression of BMF mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BCL2 interacting protein 1

increases expression

ISO

leflunomide results in increased expression of BNIP1 mRNA

NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,891,317...16,903,561

G

BCL2 interacting protein 2

increases expression

ISO

leflunomide results in increased expression of BNIP2 mRNA

NCBI chr 8:79,521,375...79,539,148
Ensembl chr 8:79,521,363...79,547,368

G

BCL2 interacting protein 3

increases expression

EXP

leflunomide results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

increases expression

EXP

leflunomide results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

bolA family member 1

increases expression

EXP

leflunomide results in increased expression of BOLA1 mRNA

NCBI chr 2:186,447,386...186,448,402
Ensembl chr 2:186,443,583...186,501,358

G

bolA family member 3

increases expression

EXP

leflunomide results in increased expression of BOLA3 mRNA

NCBI chr 4:117,411,044...117,420,491
Ensembl chr 4:117,410,680...117,420,491

G

BLOC-1 related complex subunit 6

decreases expression

ISO

leflunomide results in decreased expression of BORCS6 mRNA

NCBI chr10:54,259,349...54,261,203
Ensembl chr10:54,256,949...54,261,387

G

bisphosphoglycerate mutase

decreases expression

ISO

leflunomide results in decreased expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627

G

3'(2'), 5'-bisphosphate nucleotidase 1

increases expression

EXP

leflunomide results in increased expression of BPNT1 mRNA

NCBI chr13:99,397,127...99,425,056
Ensembl chr13:99,400,115...99,425,053

G

B-Raf proto-oncogene, serine/threonine kinase

increases expression

ISO

leflunomide results in increased expression of BRAF mRNA

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931

G

bromodomain containing 2

decreases expression

ISO

leflunomide results in decreased expression of BRD2 mRNA

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290

G

bromodomain containing 4

increases expression

ISO

leflunomide results in increased expression of BRD4 mRNA

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923

G

bromodomain containing 8

decreases expression

ISO

leflunomide results in decreased expression of BRD8 mRNA

NCBI chr18:26,455,824...26,504,106
Ensembl chr18:26,455,512...26,504,006

G

brain protein I3

decreases expression

ISO

leflunomide results in decreased expression of BRI3 mRNA

NCBI chr12:15,454,673...15,478,319
Ensembl chr12:15,454,673...15,478,319

G

BRMS1 like transcriptional repressor

decreases expression

ISO

leflunomide results in decreased expression of BRMS1L mRNA

NCBI chr 6:79,001,803...79,035,735
Ensembl chr 6:79,000,615...79,035,734

G

BTB domain containing 8

increases expression

ISO

leflunomide results in increased expression of BTBD8 mRNA

NCBI chr14:2,410,093...2,483,114
Ensembl chr14:2,410,093...2,479,202

G

Bruton tyrosine kinase

decreases expression

ISO

leflunomide results in decreased expression of BTK mRNA

NCBI chr X:102,016,070...102,055,448
Ensembl chr X:102,016,074...102,055,143

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

ISO

leflunomide results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

ISO

leflunomide results in decreased expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:126,017,045...126,069,796

G

similar to human chromosome 17 open reading frame 58

increases expression

EXP

Leflunomide results in increased expression of C10H17ORF58 mRNA

NCBI chr10:92,472,779...92,477,330
Ensembl chr10:92,471,934...92,477,330

G

similar to human chromosome 5 open reading frame 15

increases expression

EXP

Leflunomide results in increased expression of C10H5ORF15 mRNA

NCBI chr10:37,064,889...37,077,493
Ensembl chr10:37,064,728...37,077,493

G

similar to human chromosome 3 open reading frame 70

decreases expression

ISO

leflunomide results in decreased expression of C3ORF70 mRNA

NCBI chr11:92,850,327...92,900,608
Ensembl chr11:92,850,327...92,900,608

G

similar to human chromosome 12 open reading frame 43

decreases expression

ISO

leflunomide results in decreased expression of C12ORF43 mRNA

NCBI chr12:47,332,740...47,338,461
Ensembl chr12:47,332,027...47,338,359

G

similar to human chromosome 14 open reading frame 119

increases expression
decreases expression

EXP
ISO

Leflunomide results in increased expression of C15H14ORF119 mRNA
leflunomide results in decreased expression of C14ORF119 mRNA

PMID:24136188 PMID:28988120

NCBI chr15:32,116,220...32,121,425
Ensembl chr15:32,116,021...32,122,416

G

similar to human chromosome 6 open reading frame 62

decreases expression

ISO

leflunomide results in decreased expression of C6ORF62 mRNA

NCBI chr17:40,684,236...40,695,874
Ensembl chr17:40,684,236...40,704,043

G

similar to human chromosome 7 open reading frame 25

increases expression

EXP

Leflunomide results in increased expression of C17H7ORF25 mRNA

NCBI chr17:55,238,751...55,245,399
Ensembl chr17:55,236,313...55,246,284

G

similar to human chromosome 18 open reading frame 54

decreases expression

ISO

leflunomide results in decreased expression of C18ORF54 mRNA

NCBI chr18:66,340,567...66,364,831
Ensembl chr18:66,340,567...66,362,348

G

similar to human chromosome 16 open reading frame 87

increases expression

ISO

leflunomide results in increased expression of C16ORF87 mRNA

NCBI chr19:37,800,187...37,827,091
Ensembl chr19:37,799,799...37,827,452

G

similar to human chromosome 9 open reading frame 40

decreases expression

ISO

leflunomide results in decreased expression of C9ORF40 mRNA

NCBI chr 1:225,555,300...225,559,509
Ensembl chr 1:225,555,280...225,559,693

G

similar to human chromosome 21 open reading frame 58

decreases expression

ISO

leflunomide results in decreased expression of C21ORF58 mRNA

NCBI chr20:12,165,853...12,187,271
Ensembl chr20:12,174,928...12,186,503

G

C2 calcium-dependent domain containing 5

decreases expression

ISO

leflunomide results in decreased expression of C2CD5 mRNA

NCBI chr 4:177,700,515...177,790,576
Ensembl chr 4:177,700,516...177,786,717

G

similar to human chromosome 5 open reading frame 22

increases expression

ISO

leflunomide results in increased expression of C5ORF22 mRNA

NCBI chr 2:63,576,348...63,591,764
Ensembl chr 2:63,576,348...63,591,585

G

similar to human chromosome 5 open reading frame 34

increases expression

ISO

leflunomide results in increased expression of C5ORF34 mRNA

NCBI chr 2:53,287,353...53,309,804
Ensembl chr 2:53,287,957...53,309,806

G

complement C3a receptor 1

increases expression

ISO

leflunomide results in increased expression of C3AR1 mRNA

NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323

G

similar to human chromosome 2 open reading frame 68

decreases expression

ISO

leflunomide results in decreased expression of C2ORF68 mRNA

NCBI chr 4:105,960,543...105,966,509
Ensembl chr 4:105,960,751...105,966,508

G

complement C5

increases expression

EXP

leflunomide results in increased expression of C5 mRNA

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

complement C5a receptor 1

increases expression

ISO

leflunomide results in increased expression of C5AR1 mRNA

NCBI chr 1:86,077,309...86,088,001

G

similar to human chromosome 1 open reading frame 174

decreases expression

ISO

leflunomide results in decreased expression of C1ORF174 mRNA

NCBI chr 5:169,798,004...169,802,449
Ensembl chr 5:169,797,951...169,802,448

G

similar to human chromosome 1 open reading frame 50

increases expression

EXP

Leflunomide results in increased expression of C5H1ORF50 mRNA

NCBI chr 5:138,122,595...138,126,973
Ensembl chr 5:138,122,236...138,127,240

G

complement C5 like 1

increases expression

EXP

Leflunomide results in increased expression of C5L1 mRNA

NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:38,799,731...38,817,527

G

complement C6

decreases expression

EXP

leflunomide results in decreased expression of C6 mRNA

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

similar to human chromosome 11 open reading frame 54

decreases expression

EXP

Leflunomide results in decreased expression of C8H11ORF54 mRNA

NCBI chr 8:20,405,240...20,427,811
Ensembl chr 8:20,405,241...20,427,811

G

similar to human chromosome 11 open reading frame 65

increases expression
decreases expression

EXP
ISO

Leflunomide results in increased expression of C8H11ORF65 mRNA
leflunomide results in decreased expression of C11ORF65 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:62,692,568...62,720,946

G

carbonic anhydrase 3

decreases expression

EXP

leflunomide results in decreased expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

Cdk5 and Abl enzyme substrate 1

increases expression

ISO

leflunomide results in increased expression of CABLES1 mRNA

NCBI chr18:3,349,681...3,455,956
Ensembl chr18:3,351,652...3,455,956

G

calcium voltage-gated channel subunit alpha1 H

increases expression

ISO

leflunomide results in increased expression of CACNA1H mRNA

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

decreases expression

ISO

leflunomide results in decreased expression of CACNA2D1 mRNA

NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147

G

calcium voltage-gated channel auxiliary subunit beta 4

increases expression

ISO

leflunomide results in increased expression of CACNB4 mRNA

NCBI chr 3:57,315,900...57,578,271
Ensembl chr 3:57,315,900...57,578,220

G

calcyclin binding protein

increases expression

EXP

leflunomide results in increased expression of CACYBP mRNA

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

decreases expression

ISO

leflunomide results in decreased expression of CAD mRNA

NCBI chr 6:31,012,091...31,035,098
Ensembl chr 6:31,012,091...31,035,297

G

cell adhesion molecule 1

increases expression

EXP

leflunomide results in increased expression of CADM1 mRNA

NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:56,744,372...57,080,192

G

calcium binding and coiled coil domain 1

decreases expression

ISO

leflunomide results in decreased expression of CALCOCO1 mRNA

NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928

G

calcitonin receptor like receptor

decreases expression

ISO

leflunomide results in decreased expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350

G

calmodulin 1

decreases expression

ISO

leflunomide results in decreased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calmodulin 3

decreases expression

ISO

leflunomide results in decreased expression of CALM3 mRNA

NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960

G

calcium activated nucleotidase 1

decreases expression

ISO

leflunomide results in decreased expression of CANT1 mRNA

NCBI chr10:104,135,676...104,148,854
Ensembl chr10:104,135,682...104,148,698

G

calpain 3

increases expression

ISO

leflunomide results in increased expression of CAPN3 mRNA

NCBI chr 3:127,860,002...127,913,677
Ensembl chr 3:127,861,589...127,911,638

G

calpain 5

increases expression

ISO

leflunomide results in increased expression of CAPN5 mRNA

NCBI chr 1:161,827,474...161,884,142
Ensembl chr 1:161,827,474...161,884,142

G

carbonic anhydrase 2

decreases expression

EXP

leflunomide results in decreased expression of CAR2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

calcium responsive transcription factor

increases expression

ISO

leflunomide results in increased expression of CARF mRNA

NCBI chr 9:68,996,419...69,046,480
Ensembl chr 9:68,996,250...69,046,479

G

calcium regulated heat stable protein 1

decreases expression

ISO

leflunomide results in decreased expression of CARHSP1 mRNA

NCBI chr10:7,453,602...7,467,218
Ensembl chr10:7,452,978...7,467,770

G

caspase 1

multiple interactions

ISO

leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 2

decreases expression

ISO

leflunomide results in decreased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 9

decreases expression

ISO

leflunomide results in decreased expression of CASP9 mRNA

Ensembl chr 5:159,391,188...159,409,648

G

Cas scaffold protein family member 4

decreases expression

ISO

leflunomide results in decreased expression of CASS4 mRNA

NCBI chr 3:181,580,954...181,620,945
Ensembl chr 3:181,581,902...181,620,945

G

catalase

decreases expression

ISO

leflunomide results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolae associated protein 1

decreases expression

ISO

leflunomide results in decreased expression of CAVIN1 mRNA

NCBI chr10:86,384,401...86,398,240
Ensembl chr10:86,384,401...86,396,383

G

caveolae associated protein 2

increases expression

ISO

leflunomide results in increased expression of CAVIN2 mRNA

NCBI chr 9:57,794,007...57,806,024
Ensembl chr 9:57,794,019...57,806,024

G

caveolae associated protein 3

increases expression

EXP

leflunomide results in increased expression of CAVIN3 mRNA

NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:169,238,384...169,239,981

G

Cbl proto-oncogene like 1

increases expression

ISO

leflunomide results in increased expression of CBLL1 mRNA

NCBI chr 6:53,798,712...53,812,890
Ensembl chr 6:53,798,712...53,813,880

G

cerebellin 1 precursor

decreases expression

ISO

leflunomide results in decreased expression of CBLN1 mRNA

NCBI chr19:35,782,151...35,785,960
Ensembl chr19:35,781,952...35,785,960

G

carbonyl reductase 1

increases expression

EXP

Leflunomide results in increased expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

chromobox 2

decreases expression

ISO

leflunomide results in decreased expression of CBX2 mRNA

NCBI chr10:104,777,054...104,785,922
Ensembl chr10:104,777,056...104,785,926

G

chromobox 4

increases expression

ISO

leflunomide results in increased expression of CBX4 mRNA

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,835,685...104,841,727

G

chromobox 5

increases expression

ISO

leflunomide results in increased expression of CBX5 mRNA

NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118

G

coiled-coil domain containing 115

decreases expression

ISO

Leflunomide results in decreased expression of VMA22 mRNA

NCBI chr 9:44,146,287...44,150,250
Ensembl chr 9:44,145,161...44,149,899

G

coiled-coil domain containing 117

increases expression

EXP

leflunomide results in increased expression of CCDC117 mRNA

NCBI chr14:84,614,282...84,623,648
Ensembl chr14:84,614,283...84,624,087

G

coiled-coil domain containing 120

decreases expression

ISO

leflunomide results in decreased expression of CCDC120 mRNA

NCBI chr X:17,437,219...17,443,716
Ensembl chr X:17,425,624...17,444,717

G

coiled-coil domain containing 137

decreases expression

ISO

leflunomide results in decreased expression of CCDC137 mRNA

NCBI chr10:106,229,099...106,235,502
Ensembl chr10:106,229,099...106,235,502

G

coiled-coil domain containing 142

decreases expression

ISO

leflunomide results in decreased expression of CCDC142 mRNA

NCBI chr 4:117,164,055...117,172,286
Ensembl chr 4:117,166,135...117,173,935

G

coiled-coil domain containing 15

decreases expression

ISO

leflunomide results in decreased expression of CCDC15 mRNA

NCBI chr 8:45,165,297...45,257,641
Ensembl chr 8:45,134,596...45,277,989

G

coiled-coil domain containing 157

decreases expression

ISO

leflunomide results in decreased expression of CCDC157 mRNA

NCBI chr14:83,236,010...83,255,012
Ensembl chr14:83,237,956...83,267,666

G

coiled-coil domain containing 174

increases expression

ISO

leflunomide results in increased expression of CCDC174 mRNA

NCBI chr 4:125,949,203...125,976,179
Ensembl chr 4:125,949,420...125,976,178

G

coiled-coil domain containing 180

decreases expression

ISO

leflunomide results in decreased expression of CCDC180 mRNA

NCBI chr 5:64,950,522...65,019,127
Ensembl chr 5:64,950,515...65,019,127

G

coiled-coil domain containing 186

increases expression

ISO

leflunomide results in increased expression of CCDC186 mRNA

NCBI chr 1:265,840,429...265,878,082
Ensembl chr 1:265,843,039...265,877,131

G

coiled-coil domain containing 50

increases expression

ISO

leflunomide results in increased expression of CCDC50 mRNA

NCBI chr11:86,837,624...86,900,164
Ensembl chr11:86,837,624...86,899,980

G

coiled-coil domain containing 59

increases expression

ISO

leflunomide results in increased expression of CCDC59 mRNA

NCBI chr 7:43,029,272...43,035,655
Ensembl chr 7:43,029,272...43,035,655

G

coiled-coil domain containing 6

increases expression

EXP

leflunomide results in increased expression of CCDC6 mRNA

NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,431,243...18,527,227

G

coiled-coil domain containing 68

increases expression

ISO

leflunomide results in increased expression of CCDC68 mRNA

NCBI chr18:65,817,232...65,859,529
Ensembl chr18:65,786,926...65,859,526

G

coiled-coil domain containing 69

increases expression

ISO

leflunomide results in increased expression of CCDC69 mRNA

NCBI chr10:39,673,984...39,701,080
Ensembl chr10:39,673,985...39,700,579

G

coiled-coil domain containing 77

decreases expression

ISO

leflunomide results in decreased expression of CCDC77 mRNA

NCBI chr 4:155,206,402...155,238,235
Ensembl chr 4:155,193,275...155,239,207

G

coiled-coil domain containing 86

increases expression

ISO

leflunomide results in increased expression of CCDC86 mRNA

NCBI chr 1:217,015,059...217,021,439
Ensembl chr 1:217,014,848...217,021,468

G

coiled coil domain containing 88A

decreases expression

ISO

leflunomide results in decreased expression of CCDC88A mRNA

NCBI chr14:107,304,654...107,456,104
Ensembl chr14:107,305,199...107,453,285

G

C-C motif chemokine ligand 20

increases expression

ISO

leflunomide results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 26

multiple interactions

ISO

leflunomide inhibits the reaction [IL4 protein results in increased expression of CCL26 protein]

NCBI chr12:26,745,972...26,750,924

G

cellular communication network factor 1

increases expression

ISO

Leflunomide results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

increases expression

ISO

Leflunomide results in increased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A2

decreases expression

ISO

leflunomide results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

EXP
ISO

leflunomide results in decreased expression of CCNB1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B1 interacting protein 1

increases expression

ISO

leflunomide results in increased expression of CCNB1IP1 mRNA

NCBI chr15:26,488,462...26,504,167
Ensembl chr15:26,488,465...26,502,028

G

cyclin B2

decreases expression

EXP
ISO

leflunomide results in decreased expression of CCNB2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

increases expression

ISO

leflunomide results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E2

decreases expression

ISO

leflunomide results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin F

decreases expression

EXP
ISO

leflunomide results in decreased expression of CCNF mRNA

PMID:24136188 PMID:28988120

NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,758,421...13,783,837

G

cyclin H

increases expression

ISO

leflunomide results in increased expression of CCNH mRNA

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860

G

cyclin J

increases expression

ISO

leflunomide results in increased expression of CCNJ mRNA

NCBI chr 1:249,608,991...249,626,798
Ensembl chr 1:249,608,969...249,626,794

G

cyclin J-like

increases expression

ISO

leflunomide results in increased expression of CCNJL mRNA

NCBI chr10:28,497,144...28,554,877
Ensembl chr10:28,496,990...28,554,877

G

cyclin L1

increases expression

ISO

leflunomide results in increased expression of CCNL1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

cyclin L2

increases expression

EXP

leflunomide results in increased expression of CCNL2 mRNA

NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:171,699,689...171,711,231

G

cell cycle progression 1

increases expression

ISO

leflunomide results in increased expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246

G

C-C motif chemokine receptor 6

increases expression

ISO

leflunomide results in increased expression of CCR6 mRNA

NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059

G

C-C motif chemokine receptor 7

increases expression

ISO

leflunomide results in increased expression of CCR7 mRNA

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501

G

coiled-coil serine-rich protein 2

increases expression

ISO

leflunomide results in increased expression of CCSER2 mRNA

NCBI chr16:12,633,374...12,746,045
Ensembl chr16:12,637,083...12,746,003

G

CD109 molecule

increases expression

ISO

leflunomide results in increased expression of CD109 mRNA

NCBI chr 8:88,334,736...88,449,463
Ensembl chr 8:88,334,736...88,449,462

G

CD22 molecule

increases expression

ISO

leflunomide results in increased expression of CD22 mRNA

NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:95,244,868...95,259,730

G

CD274 molecule

decreases expression

ISO

leflunomide results in decreased expression of CD274 mRNA

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

Cd2 (cytoplasmic tail) binding protein 2

decreases expression

ISO

leflunomide results in decreased expression of CD2BP2 mRNA

NCBI chr 1:191,239,899...191,244,395
Ensembl chr 1:191,239,901...191,243,398

G

CD55 molecule (Cromer blood group)

increases expression

ISO

leflunomide results in increased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

CD83 molecule

decreases expression

ISO

leflunomide results in decreased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

CD9 molecule

increases expression

ISO

leflunomide results in increased expression of CD9 mRNA

NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444

G

CD93 molecule

increases expression

ISO

leflunomide results in increased expression of CD93 mRNA

NCBI chr 3:156,345,019...156,351,537
Ensembl chr 3:156,345,019...156,351,537

G

cytidine and dCMP deaminase domain containing 1

increases expression

EXP

leflunomide results in increased expression of CDADC1 mRNA

NCBI chr15:37,902,789...37,934,853
Ensembl chr15:37,886,258...37,931,920

G

codanin 1

decreases expression

ISO

leflunomide results in decreased expression of CDAN1 mRNA

NCBI chr 3:128,129,664...128,143,520
Ensembl chr 3:128,129,301...128,143,549

G

cell division cycle 14A

increases expression

ISO

leflunomide results in increased expression of CDC14A mRNA

NCBI chr 2:206,910,475...207,070,537
Ensembl chr 2:206,910,475...207,091,722

G

cell division cycle 14B

increases expression

ISO

leflunomide results in increased expression of CDC14B mRNA

NCBI chr17:850,272...938,972
Ensembl chr17:850,390...971,164

G

cell division cycle 20

decreases expression

EXP

leflunomide results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 23

decreases expression

ISO

leflunomide results in decreased expression of CDC23 mRNA

NCBI chr18:26,511,019...26,534,872
Ensembl chr18:26,510,355...26,532,646

G

cell division cycle 25C

decreases expression

ISO

leflunomide results in decreased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cell division cycle 26

decreases expression

ISO

leflunomide results in decreased expression of CDC26 mRNA

NCBI chr 5:80,861,658...80,875,326
Ensembl chr 5:80,861,659...80,875,326

G

cell division cycle 37-like 1

increases expression

EXP

leflunomide results in increased expression of CDC37L1 mRNA

NCBI chr 1:236,118,630...236,147,527
Ensembl chr 1:236,118,555...236,207,079

G

CDC42 effector protein 4

decreases expression

ISO

leflunomide results in decreased expression of CDC42EP4 mRNA

NCBI chr10:99,271,750...99,298,551
Ensembl chr10:99,267,540...99,300,168

G

cell division cycle associated 2

decreases expression

ISO

leflunomide results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:46,071,360...46,116,639

G

cell division cycle associated 3

decreases expression

EXP
ISO

leflunomide results in decreased expression of CDCA3 mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cell division cycle associated 4

decreases expression

ISO

leflunomide results in decreased expression of CDCA4 mRNA

NCBI chr 6:137,713,390...137,722,652
Ensembl chr 6:137,713,051...137,722,580

G

cell division cycle associated 5

decreases expression

ISO

leflunomide results in decreased expression of CDCA5 mRNA

NCBI chr 1:212,807,863...212,821,313
Ensembl chr 1:212,804,014...212,821,309

G

cell division cycle associated 8

decreases expression

ISO

leflunomide results in decreased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:142,461,084...142,483,283

G

cyclin-dependent kinase 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of CDK1 mRNA

PMID:24136188 PMID:28988120

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 13

decreases expression

ISO

leflunomide results in decreased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257

G

cyclin-dependent kinase 17

increases expression

ISO

leflunomide results in increased expression of CDK17 mRNA

NCBI chr 7:29,570,982...29,677,613
Ensembl chr 7:29,570,816...29,652,008

G

cyclin-dependent kinase 20

increases expression

EXP

leflunomide results in increased expression of CDK20 mRNA

NCBI chr17:706,863...717,828
Ensembl chr17:706,865...713,567

G

CDK5 regulatory subunit associated protein 1-like 1

increases expression

ISO

leflunomide results in increased expression of CDKAL1 mRNA

NCBI chr17:34,927,221...35,479,827
Ensembl chr17:34,950,157...35,479,905

G

cyclin-dependent kinase-like 5

increases expression

ISO

leflunomide results in increased expression of CDKL5 mRNA

NCBI chr X:37,566,320...37,796,766
Ensembl chr X:37,566,378...37,796,760

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

leflunomide results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CDKN2A interacting protein

increases expression

ISO

leflunomide results in increased expression of CDKN2AIP mRNA

NCBI chr16:51,266,613...51,274,051
Ensembl chr16:51,268,896...51,274,049

G

cyclin-dependent kinase inhibitor 2C

decreases expression

EXP
ISO

leflunomide results in decreased expression of CDKN2C mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

cell adhesion associated, oncogene regulated

increases expression

ISO

leflunomide results in increased expression of CDON mRNA

NCBI chr 8:42,032,921...42,119,451
Ensembl chr 8:42,033,042...42,119,345

G

cerebellar degeneration-related protein 2

increases expression

ISO

leflunomide results in increased expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:184,934,129...184,968,863

G

cerebellar degeneration-related protein 2-like

decreases expression

ISO

leflunomide results in decreased expression of CDR2L mRNA

NCBI chr10:101,123,777...101,137,634
Ensembl chr10:101,123,777...101,137,634

G

CEA cell adhesion molecule 1

increases expression

EXP
ISO

leflunomide results in increased expression of CEACAM1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

CEA cell adhesion molecule 4

increases expression

EXP

leflunomide results in increased expression of CEACAM10 mRNA

NCBI chr 1:89,504,555...89,510,831
Ensembl chr 1:89,504,555...89,510,831

G

CCAAT/enhancer binding protein beta

increases expression

EXP
ISO

leflunomide results in increased expression of CEBPB mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein epsilon

decreases expression

ISO

leflunomide results in decreased expression of CEBPE mRNA

NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476

G

CCAAT/enhancer binding protein gamma

increases expression

ISO

leflunomide results in increased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

CUGBP, Elav-like family member 6

decreases expression

ISO

leflunomide results in decreased expression of CELF6 mRNA

NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:68,871,093...68,901,863

G

cell migration inducing hyaluronidase 1

increases expression

ISO

leflunomide results in increased expression of CEMIP mRNA

NCBI chr 1:147,316,052...147,471,552
Ensembl chr 1:147,316,052...147,471,768

G

centromere protein A

decreases expression

ISO

leflunomide results in decreased expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703

G

centromere protein C

decreases expression

ISO

leflunomide results in decreased expression of CENPC mRNA

NCBI chr14:22,342,910...22,401,522
Ensembl chr14:22,342,927...22,438,590

G

centromere protein F

decreases expression

ISO

leflunomide results in decreased expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:103,715,344...103,760,886

G

centromere protein I

decreases expression

ISO

leflunomide results in decreased expression of CENPI mRNA

NCBI chr X:101,809,192...101,860,935
Ensembl chr X:101,809,659...101,860,934

G

centrosomal protein 19

increases expression

EXP

leflunomide results in increased expression of CEP19 mRNA

NCBI chr11:82,182,868...82,192,134
Ensembl chr11:82,182,868...82,192,032

G

centrosomal protein 57-like 1

decreases expression

ISO

leflunomide results in decreased expression of CEP57L1 mRNA

NCBI chr20:46,820,350...46,876,911
Ensembl chr20:46,820,353...46,876,926

G

centrosomal protein 68

decreases expression

ISO

leflunomide results in decreased expression of CEP68 mRNA

NCBI chr14:98,649,993...98,671,892
Ensembl chr14:98,649,993...98,671,868

G

centrosomal protein 76

decreases expression

ISO

leflunomide results in decreased expression of CEP76 mRNA

NCBI chr18:63,444,389...63,478,358
Ensembl chr18:63,443,746...63,478,358

G

centrosomal protein 85

decreases expression

ISO

leflunomide results in decreased expression of CEP85 mRNA

NCBI chr 5:151,640,316...151,687,891
Ensembl chr 5:151,639,282...151,687,860

G

ceramide synthase 6

increases expression

ISO

leflunomide results in increased expression of CERS6 mRNA

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

cilia and flagella associated protein 119

decreases expression

ISO

Leflunomide results in decreased expression of CFAP119 mRNA

NCBI chr 1:191,627,662...191,647,429
Ensembl chr 1:191,623,673...191,632,829

G

cilia and flagella associated protein 298

increases expression

EXP

leflunomide results in increased expression of CFAP298 mRNA

NCBI chr11:43,667,996...43,678,049
Ensembl chr11:43,668,014...43,677,382

G

cilia and flagella associated protein 97

increases expression

ISO

leflunomide results in increased expression of CFAP97 mRNA

NCBI chr16:52,818,693...52,867,775
Ensembl chr16:52,818,697...52,868,061

G

coiled-coil-helix-coiled-coil-helix domain containing 3

increases expression

EXP

leflunomide results in increased expression of CHCHD3 mRNA

NCBI chr 4:62,327,574...62,584,085
Ensembl chr 4:62,327,576...62,584,035

G

coiled-coil-helix-coiled-coil-helix domain containing 5

increases expression

EXP

leflunomide results in increased expression of CHCHD5 mRNA

NCBI chr 3:136,815,034...136,819,230
Ensembl chr 3:136,815,048...136,821,914

G

chromodomain helicase DNA binding protein 1-like

increases expression

EXP

leflunomide results in increased expression of CHD1L mRNA

NCBI chr 2:187,819,869...187,906,359
Ensembl chr 2:187,811,954...187,890,477

G

chromodomain helicase DNA binding protein 2

increases expression

ISO

leflunomide results in increased expression of CHD2 mRNA

NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:136,599,900...136,710,335

G

chromodomain helicase DNA binding protein 6

increases expression

ISO

leflunomide results in increased expression of CHD6 mRNA

NCBI chr 3:170,016,204...170,177,480
Ensembl chr 3:170,016,204...170,177,558

G

chromodomain helicase DNA binding protein 7

increases expression

ISO

leflunomide results in increased expression of CHD7 mRNA

NCBI chr 5:26,609,245...26,792,736
Ensembl chr 5:26,609,407...26,792,734

G

chromodomain helicase DNA binding protein 9

increases expression

ISO

leflunomide results in increased expression of CHD9 mRNA

PMID:19751817 PMID:28988120

NCBI chr19:32,114,379...32,337,488
Ensembl chr19:32,115,920...32,319,042

G

choline dehydrogenase

decreases expression

ISO

leflunomide results in decreased expression of CHDH mRNA

PMID:28988120 PMID:29427785

NCBI chr16:5,199,738...5,232,067
Ensembl chr16:5,200,763...5,232,997

G

checkpoint kinase 1

decreases expression

EXP

leflunomide results in decreased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

choline kinase alpha

increases expression

EXP
ISO

leflunomide results in increased expression of CHKA mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752

G

chimerin 2

increases expression

EXP
ISO

Leflunomide results in increased expression of CHN2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:84,478,989...84,738,068
Ensembl chr 4:84,704,862...84,738,068

G

cysteine and histidine rich domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of CHORDC1 mRNA

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

choline phosphotransferase 1

increases expression

EXP

leflunomide results in increased expression of CHPT1 mRNA

NCBI chr 7:24,753,880...24,802,529
Ensembl chr 7:24,750,343...24,802,521

G

chromatin accessibility complex subunit 1

increases expression

EXP

leflunomide results in increased expression of CHRAC1 mRNA

NCBI chr 7:106,901,841...106,905,441

G

carbohydrate sulfotransferase 10

decreases expression

ISO

leflunomide results in decreased expression of CHST10 mRNA

NCBI chr 9:48,588,575...48,618,487
Ensembl chr 9:48,588,575...48,618,442

G

carbohydrate sulfotransferase 15

increases expression

ISO

leflunomide results in increased expression of CHST15 mRNA

NCBI chr 1:196,458,978...196,540,088
Ensembl chr 1:196,460,425...196,491,444

G

carbohydrate sulfotransferase 3

increases expression

ISO

leflunomide results in increased expression of CHST3 mRNA

NCBI chr20:28,657,308...28,694,976
Ensembl chr20:28,657,308...28,694,526

G

chromosome transmission fidelity factor 8

decreases expression

ISO

leflunomide results in decreased expression of CHTF8 mRNA

NCBI chr19:51,691,776...51,702,076
Ensembl chr19:51,678,543...51,707,144

G

churchill domain containing 1

increases expression

EXP

leflunomide results in increased expression of CHURC1 mRNA

NCBI chr 6:101,203,778...101,218,364
Ensembl chr 6:101,203,841...101,237,748

G

ciliary microtubule inner protein 2A

decreases expression

ISO

Leflunomide results in decreased expression of CIMIP2A mRNA

NCBI chr 3:28,429,413...28,437,210
Ensembl chr 3:28,431,410...28,436,125

G

cold inducible RNA binding protein

decreases expression

ISO

leflunomide results in decreased expression of CIRBP mRNA

NCBI chr 7:10,184,515...10,189,623

G

CDGSH iron sulfur domain 2

increases expression

EXP

leflunomide results in increased expression of CISD2 mRNA

NCBI chr 2:226,502,517...226,527,325
Ensembl chr 2:226,502,517...226,540,080

G

cytokine inducible SH2-containing protein

increases expression

ISO

leflunomide results in increased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

citron rho-interacting serine/threonine kinase

decreases expression

ISO

leflunomide results in decreased expression of CIT mRNA

NCBI chr12:46,263,881...46,425,642
Ensembl chr12:46,266,369...46,424,656

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of CITED2 mRNA
leflunomide results in increased expression of CITED2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

cytoskeleton associated protein 2

decreases expression

ISO

leflunomide results in decreased expression of CKAP2 mRNA

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:76,542,104...76,567,352

G

cytoskeleton associated protein 2-like

decreases expression

ISO

leflunomide results in decreased expression of CKAP2L mRNA

NCBI chr 3:136,950,390...136,977,503
Ensembl chr 3:136,950,381...136,977,565

G

CDC28 protein kinase regulatory subunit 2

decreases expression

EXP
ISO

leflunomide results in decreased expression of CKS2 mRNA

PMID:24136188 PMID:28988120

NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519

G

CLK4-associating serine/arginine rich protein

increases expression

ISO

leflunomide results in increased expression of CLASRP mRNA

NCBI chr 1:88,360,235...88,384,343
Ensembl chr 1:88,360,235...88,384,343

G

cardiotrophin-like cytokine factor 1

increases expression

ISO

leflunomide results in increased expression of CLCF1 mRNA

NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:210,937,255...210,947,064

G

chloride voltage-gated channel 3

increases expression

ISO

leflunomide results in increased expression of CLCN3 mRNA

NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984

G

chloride voltage-gated channel 4

increases expression

EXP

leflunomide results in increased expression of CLCN4 mRNA

NCBI chr X:27,290,769...27,356,967
Ensembl chr X:27,290,868...27,356,939

G

claudin 1

increases expression

ISO

leflunomide results in increased expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 7

decreases expression

ISO

leflunomide results in decreased expression of CLDN7 mRNA

NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905

G

calmegin

increases expression

ISO

leflunomide results in increased expression of CLGN mRNA

NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325

G

chloride intracellular channel 1

increases expression

ISO

leflunomide results in increased expression of CLIC1 mRNA

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367

G

CDC-like kinase 1

increases expression

ISO

leflunomide results in increased expression of CLK1 mRNA

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

CDC-like kinase 3

increases expression

EXP
ISO

leflunomide results in increased expression of CLK3 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:67,048,121...67,063,192
Ensembl chr 8:67,048,123...67,062,881

G

CDC-like kinase 4

increases expression

ISO

leflunomide results in increased expression of CLK4 mRNA

NCBI chr10:36,024,364...36,042,366
Ensembl chr10:36,024,427...36,042,372

G

CLN5, intracellular trafficking protein

increases expression

ISO

leflunomide results in increased expression of CLN5 mRNA

NCBI chr15:86,308,286...86,321,679
Ensembl chr 2:67,620,667...67,622,952
Ensembl chr15:67,620,667...67,622,952

G

cleavage factor polyribonucleotide kinase subunit 1

decreases expression

ISO

leflunomide results in decreased expression of CLP1 mRNA

NCBI chr 3:90,213,461...90,217,165
Ensembl chr 3:90,213,465...90,217,538

G

CLPTM1 regulator of GABA type A receptor forward trafficking

decreases expression

ISO

leflunomide results in decreased expression of CLPTM1 mRNA

NCBI chr 1:88,417,447...88,449,047
Ensembl chr 1:88,417,447...88,449,446

G

clathrin, light chain B

increases expression

EXP

leflunomide results in increased expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

C-x(9)-C motif containing 1

increases expression

EXP

leflunomide results in increased expression of CMC1 mRNA

NCBI chr 8:126,677,560...126,778,403
Ensembl chr 8:126,677,560...126,778,499

G

c-Maf-inducing protein

increases expression

ISO

leflunomide results in increased expression of CMIP mRNA

NCBI chr19:62,213,402...62,419,443
Ensembl chr19:62,213,365...62,417,500

G

CKLF-like MARVEL transmembrane domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of CMTM4 mRNA

NCBI chr19:582,642...622,546
Ensembl chr19:582,621...677,816

G

CKLF-like MARVEL transmembrane domain containing 8

increases expression

EXP

leflunomide results in increased expression of CMTM8 mRNA

NCBI chr 8:123,360,168...123,425,291
Ensembl chr 8:123,360,170...123,425,276

G

cardiomyopathy associated 5

decreases expression

EXP

leflunomide results in decreased expression of CMYA5 mRNA

NCBI chr 2:26,014,545...26,113,273
Ensembl chr 2:26,014,177...26,113,376

G

CTD nuclear envelope phosphatase 1 regulatory subunit 1

decreases expression

ISO

leflunomide results in decreased expression of CNEP1R1 mRNA

NCBI chr19:35,106,802...35,121,101
Ensembl chr19:35,106,802...35,121,101

G

Cnksr family member 3

increases expression

ISO

leflunomide results in increased expression of CNKSR3 mRNA

NCBI chr 1:45,904,581...45,996,921
Ensembl chr 1:45,904,581...45,996,921

G

calponin 1

increases expression

ISO

leflunomide results in increased expression of CNN1 mRNA

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482

G

calponin 2

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of CNN2 mRNA
leflunomide results in increased expression of CNN2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:10,363,102...10,370,312

G

calponin 3

increases expression

EXP

leflunomide results in increased expression of CNN3 mRNA

NCBI chr 2:212,203,661...212,234,772
Ensembl chr 2:212,226,640...212,234,815

G

cyclin and CBS domain divalent metal cation transport mediator 1

increases expression

ISO

leflunomide results in increased expression of CNNM1 mRNA

NCBI chr 1:252,245,377...252,304,205
Ensembl chr 1:252,245,623...252,304,205

G

CCR4-NOT transcription complex subunit 9

increases expression

EXP

leflunomide results in increased expression of CNOT9 mRNA

NCBI chr 9:83,533,369...83,558,207
Ensembl chr 9:83,533,369...83,558,197

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression

ISO

leflunomide results in decreased expression of CNP mRNA

PMID:28988120 PMID:29427785

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

canopy FGF signaling regulator 2

decreases expression

ISO

leflunomide results in decreased expression of CNPY2 mRNA

NCBI chr 7:1,332,293...1,338,081
Ensembl chr 7:1,334,335...1,340,333

G

centlein

increases expression

ISO

leflunomide results in increased expression of CNTLN mRNA

NCBI chr 5:104,340,801...104,622,491
Ensembl chr 5:104,342,173...104,630,976

G

centrobin, centriole duplication and spindle assembly protein

decreases expression

ISO

leflunomide results in decreased expression of CNTROB mRNA

NCBI chr10:54,521,338...54,546,569
Ensembl chr10:54,521,663...54,543,657

G

cytochrome C oxidase assembly factor 5

decreases expression

ISO

leflunomide results in decreased expression of COA5 mRNA

NCBI chr 9:47,147,267...47,160,724
Ensembl chr 9:47,147,267...47,160,672

G

Coenzyme A synthase

increases expression

EXP

leflunomide results in increased expression of COASY mRNA

NCBI chr10:86,514,850...86,519,130
Ensembl chr10:86,514,874...86,519,130

G

collagen type XXVII alpha 1 chain

increases expression

EXP

leflunomide results in increased expression of COL27A1 mRNA

NCBI chr 5:81,662,822...81,781,502
Ensembl chr 5:81,661,685...81,781,502

G

collagen type II alpha 1 chain

multiple interactions

ISO

[leflunomide co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; [leflunomide co-treated with COL2A1 protein] results in increased expression of IL10 protein; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]; leflunomide inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

COP9 signalosome subunit 4

increases expression

EXP

leflunomide results in increased expression of COPS4 mRNA

NCBI chr14:9,382,897...9,413,216
Ensembl chr14:9,382,900...9,413,107

G

coenzyme Q10A

decreases expression

EXP

leflunomide results in decreased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:1,376,591...1,382,722

G

coenzyme Q10B

increases expression

ISO

leflunomide results in increased expression of COQ10B mRNA

PMID:28988120 PMID:29427785

NCBI chr 9:64,048,168...64,068,082
Ensembl chr 9:64,048,103...64,068,322

G

coenzyme Q4

decreases expression

ISO

leflunomide results in decreased expression of COQ4 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:33,457,834...33,468,387
Ensembl chr 3:33,457,596...33,468,379

G

coenzyme Q6 monooxygenase

increases expression

EXP

leflunomide results in increased expression of COQ6 mRNA

NCBI chr 6:109,738,934...109,750,315
Ensembl chr 6:109,738,951...109,750,310

G

coenzyme Q9

decreases expression

ISO

leflunomide results in decreased expression of COQ9 mRNA

NCBI chr19:10,172,943...10,185,960
Ensembl chr19:10,172,949...10,185,937

G

coronin 1C

decreases expression

EXP

leflunomide results in decreased expression of CORO1C mRNA

NCBI chr12:48,373,573...48,445,718
Ensembl chr12:48,373,597...48,445,716

G

cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

increases expression

ISO

leflunomide results in increased expression of COX10 mRNA

NCBI chr10:49,130,209...49,242,009
Ensembl chr10:49,130,209...49,242,009

G

cytochrome c oxidase copper chaperone COX17

increases expression

EXP

leflunomide results in increased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

cytochrome c oxidase subunit 5A

increases expression

EXP

leflunomide results in increased expression of COX5A mRNA

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

ceruloplasmin

increases expression

EXP

leflunomide results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

cytoplasmic polyadenylation element binding protein 4

increases expression

ISO

leflunomide results in increased expression of CPEB4 mRNA

NCBI chr10:16,222,271...16,284,248
Ensembl chr10:16,225,672...16,283,787

G

copine 1

decreases expression

ISO

leflunomide results in decreased expression of CPNE1 mRNA

NCBI chr 3:165,047,615...165,089,994

G

cleavage and polyadenylation specific factor 6

decreases expression

ISO

leflunomide results in decreased expression of CPSF6 mRNA

NCBI chr 7:54,798,452...54,887,711
Ensembl chr 7:54,842,490...54,873,998

G

carnitine palmitoyltransferase 1A

increases expression

ISO
EXP

leflunomide results in increased expression of CPT1A mRNA

PMID:19751817 PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of CPT2 mRNA
leflunomide results in decreased expression of CPT2 mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

carnitine O-acetyltransferase

increases expression

EXP

leflunomide results in increased expression of CRAT mRNA

NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099

G

cAMP responsive element binding protein 3-like 3

decreases expression

ISO

leflunomide results in decreased expression of CREB3L3 mRNA

NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:9,273,338...9,281,778

G

CREB binding protein

increases expression

EXP

leflunomide results in increased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

CREB3 regulatory factor

increases expression

ISO

leflunomide results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,903,547...16,966,430

G

cysteine-rich with EGF-like domains 2

decreases expression

EXP

leflunomide results in decreased expression of CRELD2 mRNA

NCBI chr 7:121,788,754...121,796,230
Ensembl chr 7:121,788,745...121,796,228

G

cAMP responsive element modulator

decreases expression

EXP

leflunomide results in decreased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

cysteine rich protein 1

decreases expression

EXP

leflunomide results in decreased expression of CRIP mRNA

NCBI chr 6:138,047,801...138,055,672
Ensembl chr 6:138,047,801...138,055,672

G

cysteine-rich protein 3

decreases expression

ISO

leflunomide results in decreased expression of CRIP3 mRNA

NCBI chr 9:22,052,039...22,054,933
Ensembl chr 9:22,052,039...22,054,891

G

CXXC repeat containing interactor of PDZ3 domain

decreases expression

ISO

leflunomide results in decreased expression of CRIPT mRNA

NCBI chr 6:13,334,978...13,342,934
Ensembl chr 6:13,334,954...13,345,044

G

cripto, EGF-CFC family member

increases expression

ISO

Leflunomide results in increased expression of CRIPTO mRNA

NCBI chr 8:119,803,182...119,808,714
Ensembl chr 8:119,803,220...119,808,948

G

CREB regulated transcription coactivator 3

increases expression

ISO

leflunomide results in increased expression of CRTC3 mRNA

NCBI chr 1:143,962,038...144,064,324
Ensembl chr 1:143,962,038...144,064,288

G

crystallin, mu

decreases expression

EXP

leflunomide results in decreased expression of CRYM mRNA

NCBI chr 1:183,991,752...184,006,923
Ensembl chr 1:183,991,745...184,006,962

G

colony stimulating factor 1

increases expression

ISO

leflunomide results in increased expression of CSF1 mRNA

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

chondroitin sulfate N-acetylgalactosaminyltransferase 2

increases expression

ISO

leflunomide results in increased expression of CSGALNACT2 mRNA

NCBI chr 4:152,944,154...152,981,237
Ensembl chr 4:152,950,028...152,981,220

G

C-terminal Src kinase

increases expression

EXP

leflunomide results in increased expression of CSK mRNA

NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274

G

casein kinase 1, alpha 1

increases expression

ISO

leflunomide results in increased expression of CSNK1A1 mRNA

NCBI chr18:57,285,156...57,320,540
Ensembl chr18:57,287,412...57,320,538

G

casein kinase 1, gamma 1

increases expression

ISO

leflunomide results in increased expression of CSNK1G1 mRNA

NCBI chr 8:75,334,751...75,472,339
Ensembl chr 8:75,334,895...75,467,515

G

casein kinase 1, gamma 3

increases expression

ISO

leflunomide results in increased expression of CSNK1G3 mRNA

NCBI chr18:49,497,839...49,584,828
Ensembl chr18:49,497,839...49,584,828

G

cysteine and serine rich nuclear protein 1

increases expression

EXP
ISO

leflunomide results in increased expression of CSRNP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:128,582,365...128,588,469

G

cysteine and glycine-rich protein 1

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of CSRP1 mRNA
leflunomide results in increased expression of CSRP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr13:49,709,928...49,731,141
Ensembl chr13:49,709,914...49,731,139

G

cysteine and glycine-rich protein 2

decreases expression

ISO

leflunomide results in decreased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cardiotrophin 1

increases expression

EXP

leflunomide results in increased expression of CTF1 mRNA

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

cystathionine gamma-lyase

increases expression

ISO

leflunomide results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cathepsin D

increases expression

EXP

leflunomide results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin L

increases expression

EXP

leflunomide results in increased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cullin 3

decreases expression

ISO

leflunomide results in decreased expression of CUL3 mRNA

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

cutC copper transporter

decreases expression

ISO

leflunomide results in decreased expression of CUTC mRNA

NCBI chr 1:252,571,489...252,586,269
Ensembl chr 1:252,571,521...252,597,272

G

C-X-C motif chemokine ligand 12

decreases expression

EXP

leflunomide results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

CXXC finger protein 5

increases expression

ISO

leflunomide results in increased expression of CXXC5 mRNA

NCBI chr18:27,701,650...27,732,633
Ensembl chr18:27,701,188...27,732,635

G

cytochrome b561 family, member A3

decreases expression

ISO

leflunomide results in decreased expression of CYB561A3 mRNA

NCBI chr 1:216,641,108...216,662,495
Ensembl chr 1:216,651,128...216,662,492

G

cytochrome b561 family, member D1

decreases expression

ISO

leflunomide results in decreased expression of CYB561D1 mRNA

NCBI chr 2:198,523,031...198,525,671
Ensembl chr 2:198,523,031...198,525,676

G

cytochrome b5 domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of CYB5D2 mRNA

NCBI chr10:57,892,799...57,911,831
Ensembl chr10:57,895,296...57,912,030

G

cytoplasmic FMR1 interacting protein 2

increases expression

EXP

leflunomide results in increased expression of CYFIP2 mRNA

NCBI chr10:31,122,653...31,242,440
Ensembl chr10:31,122,653...31,242,440

G

CYLD lysine 63 deubiquitinase

decreases expression

ISO

leflunomide results in decreased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

EXP

leflunomide results in decreased expression of CYP17A1 mRNA

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

ISO

leflunomide results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

EXP
ISO

leflunomide results in increased expression of CYP1A1 mRNA
Leflunomide results in decreased activity of CYP1A1 protein

PMID:24136188 PMID:26221077 PMID:28988120 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

EXP
ISO

leflunomide results in increased expression of CYP1A2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
decreases activity

EXP
ISO

leflunomide results in increased expression of CYP1B1 mRNA
Leflunomide results in decreased activity of CYP1B1 protein

PMID:24136188 PMID:28988120 PMID:33814510

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

ISO

leflunomide results in increased expression of CYP24A1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

ISO

leflunomide results in decreased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

EXP

leflunomide results in increased expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

ISO

Leflunomide results in increased expression of CYP2B6 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily j, polypeptide 3

increases expression

EXP

leflunomide results in increased expression of CYP2J3 mRNA

NCBI chr 5:116,335,755...116,360,677
Ensembl chr 5:116,335,755...116,360,499

G

cytochrome P450, family 2, subfamily u, polypeptide 1

decreases expression

EXP

leflunomide results in decreased expression of CYP2U1 mRNA

NCBI chr 2:222,523,516...222,541,055
Ensembl chr 2:222,523,518...222,541,124

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance
multiple interactions

ISO

CYP3A4 protein results in increased susceptibility to Leflunomide
[Leflunomide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in decreased susceptibility to Leflunomide

PMID:21540358 PMID:25455453 PMID:25860621

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

EXP

Leflunomide results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

EXP

leflunomide results in increased expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily a, polypeptide 2

increases expression

EXP

leflunomide results in increased expression of CYP4A2 mRNA

NCBI chr 5:134,160,356...134,170,908
Ensembl chr 5:134,160,358...134,176,156

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

EXP

leflunomide results in increased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytochrome P450, family 51

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of CYP51 mRNA
leflunomide results in decreased expression of CYP51A1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cytohesin 1

increases expression

ISO

leflunomide results in increased expression of CYTH1 mRNA

NCBI chr10:103,901,376...103,984,496
Ensembl chr10:103,864,804...103,984,383

G

DALR anticodon binding domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of DALRD3 mRNA

NCBI chr 8:118,142,009...118,147,082
Ensembl chr 8:118,144,197...118,147,822

G

death-associated protein kinase 3

increases expression

ISO

leflunomide results in increased expression of DAPK3 mRNA

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

death-domain associated protein

decreases expression

ISO

leflunomide results in decreased expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

debranching RNA lariats 1

decreases expression

ISO

leflunomide results in decreased expression of DBR1 mRNA

NCBI chr 8:109,018,364...109,030,092
Ensembl chr 8:109,018,325...109,031,406

G

DDB1 and CUL4 associated factor 10

increases expression

ISO

leflunomide results in increased expression of DCAF10 mRNA

NCBI chr 5:64,402,307...64,442,839
Ensembl chr 5:64,403,451...64,440,614

G

DDB1 and CUL4 associated factor 6

decreases expression

ISO

leflunomide results in decreased expression of DCAF6 mRNA

NCBI chr13:80,159,282...80,260,510
Ensembl chr13:80,159,321...80,260,510

G

doublecortin domain containing 2

affects expression

ISO

leflunomide affects the expression of DCDC2 mRNA

NCBI chr17:40,274,009...40,459,757
Ensembl chr17:40,274,009...40,458,790

G

DNA cross-link repair 1B

decreases expression

ISO

leflunomide results in decreased expression of DCLRE1B mRNA

NCBI chr 2:193,998,350...194,006,873
Ensembl chr 2:193,998,354...194,006,864

G

dCTP pyrophosphatase 1

decreases expression

EXP

leflunomide results in decreased expression of DCTPP1 mRNA

NCBI chr 1:191,307,933...191,311,326
Ensembl chr 1:191,307,935...191,313,405

G

damage specific DNA binding protein 2

decreases expression

ISO

leflunomide results in decreased expression of DDB2 mRNA

NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066

G

dopa decarboxylase

decreases expression

EXP

leflunomide results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DNA damage inducible 1 homolog 2

decreases expression

ISO

leflunomide results in decreased expression of DDI2 mRNA

NCBI chr 5:159,272,625...159,318,365
Ensembl chr 5:159,272,625...159,318,310

G

DNA damage-induced apoptosis suppressor

decreases expression

ISO

leflunomide results in decreased expression of DDIAS mRNA

NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:156,318,563...156,342,869

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

ISO

leflunomide results in increased expression of DDIT3 mRNA; leflunomide results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]; [Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of DDIT3 protein]; Bongkrekic Acid inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]; MAPK1 protein affects the reaction [leflunomide results in increased expression of DDIT3 protein]; MAPK3 protein affects the reaction [leflunomide results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

ISO

leflunomide results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DNA-damage-inducible transcript 4-like

increases expression

ISO

leflunomide results in increased expression of DDIT4L mRNA

NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:228,801,705...228,806,225

G

DDRGK domain containing 1

increases expression

EXP

leflunomide results in increased expression of DDRGK1 mRNA

NCBI chr 3:138,315,006...138,336,691
Ensembl chr 3:138,315,282...138,335,766

G

DEAD/H-box helicase 11

decreases expression

ISO

leflunomide results in decreased expression of DDX11 mRNA

NCBI chr 9:113,204,886...113,309,692
Ensembl chr 9:113,276,985...113,316,152

G

DExD-box helicase 21

increases expression

ISO

leflunomide results in increased expression of DDX21 mRNA

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

DEAD-box helicase 23

decreases expression

ISO

leflunomide results in decreased expression of DDX23 mRNA

NCBI chr 7:131,676,636...131,693,917
Ensembl chr 7:131,676,636...131,689,074

G

DEAD-box helicase 3, X-linked

decreases expression

ISO

leflunomide results in decreased expression of DDX3X mRNA

NCBI chr X:12,152,346...12,165,983
Ensembl chr X:12,152,346...12,165,983

G

DEAD-box helicase 6

decreases expression

ISO

leflunomide results in decreased expression of DDX6 mRNA

NCBI chr 8:53,827,661...53,864,538
Ensembl chr 8:53,827,835...53,860,977

G

2,4-dienoyl-CoA reductase 1

increases expression

EXP

leflunomide results in increased expression of DECR1 mRNA

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

2,4-dienoyl-CoA reductase 2

increases expression

EXP

leflunomide results in increased expression of DECR2 mRNA

NCBI chr10:15,609,389...15,617,779
Ensembl chr10:15,611,092...15,617,397

G

death effector domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of DEDD2 mRNA

NCBI chr 1:89,916,906...89,934,663
Ensembl chr 1:89,919,524...89,936,804

G

DENN domain containing 1A

increases expression

ISO

leflunomide results in increased expression of DENND1A mRNA

NCBI chr 3:41,974,502...42,461,816
Ensembl chr 3:41,974,502...42,461,886

G

DENN domain containing 4A

increases expression

ISO

leflunomide results in increased expression of DENND4A mRNA

NCBI chr 8:74,218,131...74,331,543
Ensembl chr 8:74,218,191...74,331,542

G

DENN domain containing 5A

increases expression

ISO

leflunomide results in increased expression of DENND5A mRNA

NCBI chr 1:173,362,959...173,428,973
Ensembl chr 1:173,362,959...173,428,926

G

DEP domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of DEPDC1 mRNA

NCBI chr 2:251,343,250...251,376,709
Ensembl chr 2:251,343,281...251,376,709

G

DEP domain containing 7

decreases expression

ISO

leflunomide results in decreased expression of DEPDC7 mRNA

NCBI chr 3:111,554,701...111,575,979
Ensembl chr 3:111,554,706...111,575,979

G

deoxyribose-phosphate aldolase

decreases expression

ISO

leflunomide results in decreased expression of DERA mRNA

NCBI chr 4:172,394,971...172,473,746
Ensembl chr 4:172,394,962...172,490,142

G

desumoylating isopeptidase 2

increases expression

EXP

leflunomide results in increased expression of DESI2 mRNA

NCBI chr13:92,493,765...92,543,307
Ensembl chr13:92,493,989...92,564,981

G

Dexi homolog

decreases expression

ISO

leflunomide results in decreased expression of DEXI mRNA

NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,632,961...5,645,648

G

DNA fragmentation factor subunit beta

decreases expression

ISO

leflunomide results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

DGCR8 microprocessor complex subunit

decreases expression

ISO

leflunomide results in decreased expression of DGCR8 mRNA

NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551

G

diacylglycerol kinase, delta

increases expression

EXP

leflunomide results in increased expression of DGKD mRNA

NCBI chr 9:95,964,507...96,055,160
Ensembl chr 9:95,964,148...96,055,160

G

24-dehydrocholesterol reductase

increases expression

EXP

leflunomide results in increased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

7-dehydrocholesterol reductase

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of DHCR7 mRNA
leflunomide results in decreased expression of DHCR7 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

dihydrofolate reductase

increases expression

EXP

leflunomide results in increased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004

G

dihydroorotate dehydrogenase

decreases activity

EXP
ISO

leflunomide results in decreased activity of DHODH protein

NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496

G

dehydrogenase/reductase 1

decreases expression

ISO

leflunomide results in decreased expression of DHRS1 mRNA

PMID:28988120 PMID:29427785

NCBI chr15:33,206,449...33,213,776
Ensembl chr15:33,206,451...33,213,734

G

DEAH-box helicase 16

increases expression

EXP

leflunomide results in increased expression of DHX16 mRNA

NCBI chr20:2,866,804...2,879,790
Ensembl chr20:2,866,804...2,879,751

G

DExH-box helicase 9

increases expression

EXP

leflunomide results in increased expression of DHX9 mRNA

NCBI chr13:68,152,813...68,189,580
Ensembl chr13:68,152,813...68,189,546

G

diaphanous-related formin 2

increases expression

ISO

leflunomide results in increased expression of DIAPH2 mRNA

NCBI chr X:96,700,535...97,528,080
Ensembl chr X:96,700,726...97,528,080

G

diaphanous-related formin 3

increases expression

ISO

leflunomide results in increased expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:68,951,989...69,421,552

G

death inducer-obliterator 1

decreases expression

ISO

leflunomide results in decreased expression of DIDO1 mRNA

NCBI chr 3:188,150,100...188,203,445
Ensembl chr 3:188,150,100...188,194,823

G

DISC1 scaffold protein

increases expression

ISO

leflunomide results in increased expression of DISC1 mRNA

NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970

G

DIX domain containing 1

increases expression

ISO

leflunomide results in increased expression of DIXDC1 mRNA

NCBI chr 8:59,904,218...59,977,595
Ensembl chr 8:59,904,218...59,978,447

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

ISO

leflunomide results in decreased expression of DKK1 mRNA

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

DLC1 Rho GTPase activating protein

increases expression

ISO

leflunomide results in increased expression of DLC1 mRNA

NCBI chr16:61,954,177...62,374,819
Ensembl chr16:61,995,001...62,374,819

G

DLG associated protein 5

decreases expression

EXP
ISO

leflunomide results in decreased expression of DLGAP5 mRNA

PMID:24136188 PMID:28988120

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

delta like canonical Notch ligand 4

increases expression

ISO

leflunomide results in increased expression of DLL4 mRNA

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

distal-less homeobox 6

decreases expression

ISO

leflunomide results in decreased expression of DLX6 mRNA

NCBI chr 4:35,951,005...35,956,354
Ensembl chr 4:35,951,005...35,956,354

G

dimethylglycine dehydrogenase

increases expression

EXP

leflunomide results in increased expression of DMGDH mRNA

NCBI chr 2:26,647,540...26,722,496
Ensembl chr 2:26,647,565...26,723,071

G

dematin actin binding protein

decreases expression

EXP

leflunomide results in decreased expression of DMTN mRNA

NCBI chr15:52,087,667...52,111,956
Ensembl chr15:52,087,667...52,112,128

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

ISO

leflunomide results in decreased expression of DNAJA1 mRNA

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression
affects expression

EXP
ISO

leflunomide results in increased expression of DNAJB1 mRNA
leflunomide affects the expression of DNAJB1 mRNA

PMID:24136188 PMID:28988120

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B12

increases expression

EXP

leflunomide results in increased expression of DNAJB12 mRNA

NCBI chr20:28,371,180...28,389,390
Ensembl chr20:28,371,199...28,389,389

G

DnaJ heat shock protein family (Hsp40) member C12

increases expression

ISO

leflunomide results in increased expression of DNAJC12 mRNA

NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251

G

DnaJ heat shock protein family (Hsp40) member C15

increases expression

EXP

leflunomide results in increased expression of DNAJC15 mRNA

NCBI chr15:59,594,314...59,658,862
Ensembl chr15:59,594,314...59,658,987

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

ISO

leflunomide results in decreased expression of DNAJC19 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:118,851,497...118,875,813
Ensembl chr 2:118,869,413...118,873,781

G

DnaJ heat shock protein family (Hsp40) member C22

increases expression

EXP

leflunomide results in increased expression of DNAJC22 mRNA

NCBI chr 7:132,136,516...132,141,802
Ensembl chr 7:132,136,545...132,142,758

G

DnaJ heat shock protein family (Hsp40) member C6

increases expression

ISO

leflunomide results in increased expression of DNAJC6 mRNA

NCBI chr 5:121,232,532...121,398,775
Ensembl chr 5:121,235,425...121,398,775

G

DnaJ heat shock protein family (Hsp40) member C9

decreases expression

EXP

leflunomide results in decreased expression of DNAJC9 mRNA

NCBI chr15:3,970,843...4,003,009
Ensembl chr15:3,970,114...3,977,304

G

DNA methyltransferase 3 beta

decreases expression

ISO

leflunomide results in decreased expression of DNMT3B mRNA

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

EXP

leflunomide results in decreased expression of DNPH1 mRNA

NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:21,978,894...21,981,631

G

double C2 domain beta

decreases expression

ISO

leflunomide results in decreased expression of DOC2B mRNA

NCBI chr10:61,126,295...61,151,533
Ensembl chr10:61,126,295...61,151,533

G

docking protein 6

increases expression

ISO

leflunomide results in increased expression of DOK6 mRNA

NCBI chr18:84,847,491...85,290,647
Ensembl chr18:84,847,491...85,290,647

G

diphthamide biosynthesis 3

increases expression

EXP

leflunomide results in increased expression of DPH3 mRNA

NCBI chr16:7,294,580...7,299,996
Ensembl chr16:7,294,580...7,299,996

G

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

increases expression

EXP

leflunomide results in increased expression of DPM1 mRNA

NCBI chr 3:177,338,855...177,358,398
Ensembl chr 3:177,338,855...177,358,412

G

dihydropyrimidinase-like 2

decreases expression

ISO

leflunomide results in decreased expression of DPYSL2 mRNA

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

down-regulator of transcription 1

increases expression

ISO

leflunomide results in increased expression of DR1 mRNA

NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,603,204...1,614,556

G

dynein regulatory complex subunit 3

decreases expression

ISO

leflunomide results in decreased expression of DRC3 mRNA

NCBI chr10:45,620,045...45,698,902
Ensembl chr10:45,648,410...45,698,900

G

dopamine receptor D5

increases expression

ISO

leflunomide results in increased expression of DRD5 mRNA

NCBI chr14:76,700,244...76,703,344
Ensembl chr14:76,700,241...76,703,466

G

DSN1 component of MIS12 kinetochore complex

decreases expression

ISO

leflunomide results in decreased expression of DSN1 mRNA

NCBI chr 3:166,072,775...166,089,029
Ensembl chr 3:166,074,033...166,085,890

G

desmoplakin

increases expression

ISO

leflunomide results in increased expression of DSP mRNA

NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121

G

dystonin

increases expression

EXP

leflunomide results in increased expression of DST mRNA

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:43,631,517...44,025,533

G

destrin, actin depolymerizing factor

increases expression

EXP

leflunomide results in increased expression of DSTN mRNA

NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769

G

dual serine/threonine and tyrosine protein kinase

decreases expression

ISO

leflunomide results in decreased expression of DSTYK mRNA

NCBI chr13:46,409,412...46,457,426
Ensembl chr13:46,409,412...46,457,424

G

deltex E3 ubiquitin ligase 4

decreases expression

ISO

leflunomide results in decreased expression of DTX4 mRNA

NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:218,832,284...218,917,130

G

deoxythymidylate kinase

decreases expression

ISO

leflunomide results in decreased expression of DTYMK mRNA

NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504

G

dual specificity phosphatase 1

increases expression

ISO

leflunomide results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 10

increases expression

ISO

leflunomide results in increased expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

dual specificity phosphatase 14

decreases expression

ISO

leflunomide results in decreased expression of DUSP14 mRNA

NCBI chr10:69,433,949...69,463,863
Ensembl chr10:69,426,730...69,462,837

G

dual specificity phosphatase 15

increases expression

ISO

leflunomide results in increased expression of DUSP15 mRNA

NCBI chr 3:161,868,746...161,880,432
Ensembl chr 3:161,868,749...161,879,250

G

dual specificity phosphatase 16

increases expression

ISO

leflunomide results in increased expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508

G

dual specificity phosphatase 5

increases expression

ISO

leflunomide results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 6

increases expression

ISO

leflunomide results in increased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

dual specificity phosphatase 8

increases expression

ISO

leflunomide results in increased expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441

G

dynein light chain LC8-type 1

decreases expression

ISO

leflunomide results in decreased expression of DYNLL1 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dynein light chain LC8-type 2

decreases expression

ISO

leflunomide results in decreased expression of DYNLL2 mRNA

PMID:28988120 PMID:29427785

NCBI chr10:73,264,260...73,283,042
Ensembl chr10:73,264,261...73,272,285

G

dual specificity tyrosine phosphorylation regulated kinase 1A

increases expression

ISO

leflunomide results in increased expression of DYRK1A mRNA

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:47,360,850...47,479,033

G

dual specificity tyrosine phosphorylation regulated kinase 3

decreases expression

ISO

leflunomide results in decreased expression of DYRK3 mRNA

NCBI chr13:45,146,383...45,157,082
Ensembl chr13:45,146,384...45,157,249

G

E2F transcription factor 2

decreases expression

ISO

leflunomide results in decreased expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

E2F transcription factor 8

decreases expression

ISO

leflunomide results in decreased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

ELL associated factor 1

increases expression

ISO

leflunomide results in increased expression of EAF1 mRNA

NCBI chr16:6,704,727...6,719,476
Ensembl chr16:6,704,727...6,719,476

G

glutamyl-tRNA synthetase 2, mitochondrial

increases expression

EXP

leflunomide results in increased expression of EARS2 mRNA

NCBI chr 1:186,025,740...186,057,165

G

enoyl-CoA hydratase 1

increases expression

EXP

leflunomide results in increased expression of ECH1 mRNA

NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440

G

enoyl-CoA delta isomerase 1

increases expression

EXP

leflunomide results in increased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

enoyl-CoA delta isomerase 2

increases expression

EXP

leflunomide results in increased expression of ECI2 mRNA

NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161

G

extracellular matrix protein 1

increases expression

EXP

leflunomide results in increased expression of ECM1 mRNA

NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606

G

Ecm29 proteasome adaptor and scaffold

increases expression

EXP

leflunomide results in increased expression of ECPAS mRNA

NCBI chr 5:78,398,449...78,509,077
Ensembl chr 5:78,398,718...78,512,908

G

ectodysplasin-A

increases expression

ISO

leflunomide results in increased expression of EDA mRNA

NCBI chr X:69,118,577...69,520,274
Ensembl chr X:69,118,796...69,520,274

G

ectodysplasin A2 receptor

decreases expression

ISO

leflunomide results in decreased expression of EDA2R mRNA

NCBI chr X:66,225,557...66,280,674
Ensembl chr X:66,236,111...66,280,663

G

enhancer of mRNA decapping 4

decreases expression

ISO

leflunomide results in decreased expression of EDC4 mRNA

NCBI chr19:50,683,924...50,695,916
Ensembl chr19:50,683,897...50,697,620

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

EXP

leflunomide results in increased expression of EDEM1 mRNA

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

endothelin 1

increases expression

ISO

leflunomide results in increased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

embryonic ectoderm development

decreases expression

ISO

leflunomide results in decreased expression of EED mRNA

NCBI chr 1:153,280,419...153,307,537
Ensembl chr 1:153,280,422...153,307,500

G

EEF1A lysine methyltransferase 3

decreases expression

ISO

leflunomide results in decreased expression of EEF1AKMT3 mRNA

NCBI chr 7:64,738,726...64,749,904
Ensembl chr 7:64,740,232...64,750,055

G

eukaryotic elongation factor-2 kinase

decreases expression

ISO

leflunomide results in decreased expression of EEF2K mRNA

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048

G

endonuclease/exonuclease/phosphatase family domain containing 1

increases expression

ISO

leflunomide results in increased expression of EEPD1 mRNA

NCBI chr 8:32,233,834...32,340,148
Ensembl chr 8:32,233,070...32,340,147

G

ephrin A1

increases expression

ISO

leflunomide results in increased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

ephrin A3

decreases expression

ISO

leflunomide results in decreased expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:177,026,933...177,044,843

G

ephrin A4

decreases expression

ISO

leflunomide results in decreased expression of EFNA4 mRNA

NCBI chr 2:177,046,463...177,050,713
Ensembl chr 2:177,046,463...177,050,713

G

ephrin B1

decreases expression

ISO

leflunomide results in decreased expression of EFNB1 mRNA

NCBI chr X:68,297,529...68,310,335
Ensembl chr X:68,297,492...68,349,546

G

epidermal growth factor

multiple interactions

ISO

Leflunomide inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Leflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

increases expression
multiple interactions

ISO

leflunomide results in increased expression of EGFR mRNA
Leflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

PMID:28988120 PMID:30364229

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

increases expression

ISO

leflunomide results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 3

increases expression

ISO

leflunomide results in increased expression of EGR3 mRNA

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

early growth response 4

increases expression

ISO

leflunomide results in increased expression of EGR4 mRNA

NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368

G

EH domain binding protein 1

increases expression

ISO

leflunomide results in increased expression of EHBP1 mRNA

NCBI chr14:100,294,585...100,581,764
Ensembl chr14:100,294,585...100,546,579

G

EH-domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of EHD1 mRNA

NCBI chr 1:213,009,113...213,031,488
Ensembl chr 1:213,008,049...213,031,485

G

EH-domain containing 2

decreases expression

EXP

leflunomide results in decreased expression of EHD2 mRNA

NCBI chr 1:85,767,757...85,786,974
Ensembl chr 1:85,768,667...85,786,943

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

EXP

leflunomide results in increased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 1A domain containing

decreases expression

ISO

leflunomide results in decreased expression of EIF1AD mRNA

NCBI chr 1:212,103,715...212,109,015
Ensembl chr 1:212,103,892...212,109,017

G

eukaryotic translation initiation factor 2D

increases expression

EXP

leflunomide results in increased expression of EIF2D mRNA

NCBI chr13:45,168,161...45,189,362
Ensembl chr13:45,139,967...45,191,974

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

ISO

leflunomide results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 4E family member 2

decreases expression

ISO

leflunomide results in decreased expression of EIF4E2 mRNA

NCBI chr 9:95,333,439...95,362,366
Ensembl chr 9:95,333,989...95,362,362

G

eukaryotic translation initiation factor 4 gamma, 3

decreases expression

ISO

leflunomide results in decreased expression of EIF4G3 mRNA

NCBI chr 5:155,481,378...155,702,194
Ensembl chr 5:155,481,378...155,702,194

G

eukaryotic translation initiation factor 5

decreases expression

ISO

leflunomide results in decreased expression of EIF5 mRNA

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 6

increases expression

ISO

leflunomide results in increased expression of EIF6 mRNA

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

E74 like ETS transcription factor 3

increases expression

ISO

leflunomide results in increased expression of ELF3 mRNA

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380

G

E74 like ETS transcription factor 4

increases expression

ISO

leflunomide results in increased expression of ELF4 mRNA

NCBI chr X:132,465,290...132,508,175
Ensembl chr X:132,468,539...132,478,689

G

ETS transcription factor ELK1

multiple interactions

ISO

Leflunomide inhibits the reaction [EGF protein results in increased activity of ELK1 protein]

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

elongation factor for RNA polymerase II 2

increases expression

EXP
ISO

leflunomide results in increased expression of ELL2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:6,910,446...6,990,654
Ensembl chr 2:6,921,771...7,016,199

G

ELMO domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of ELMOD3 mRNA

NCBI chr 4:106,172,819...106,211,286
Ensembl chr 4:106,172,828...106,211,229

G

elongator acetyltransferase complex subunit 5

decreases expression

ISO

leflunomide results in decreased expression of ELP5 mRNA

NCBI chr10:55,191,223...55,202,949
Ensembl chr10:55,191,227...55,203,617

G

elongator acetyltransferase complex subunit 6

decreases expression

ISO

leflunomide results in decreased expression of ELP6 mRNA

NCBI chr 8:119,158,380...119,173,483
Ensembl chr 8:119,158,396...119,174,244

G

embigin

increases expression

ISO

leflunomide results in increased expression of EMB mRNA

NCBI chr 2:50,803,468...50,858,001
Ensembl chr 2:50,801,973...50,862,920

G

ER membrane protein complex subunit 8

increases expression

EXP

leflunomide results in increased expression of EMC8 mRNA

NCBI chr19:65,620,365...65,630,328
Ensembl chr19:65,620,375...65,630,235

G

elastin microfibril interfacer 3

decreases expression

ISO

leflunomide results in decreased expression of EMILIN3 mRNA

NCBI chr 3:169,978,488...169,984,718
Ensembl chr 3:169,978,672...169,984,488

G

EMAP like 4

increases expression

EXP

leflunomide results in increased expression of EML4 mRNA

NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439

G

ENAH, actin regulator

increases expression

ISO

leflunomide results in increased expression of ENAH mRNA

NCBI chr13:96,149,437...96,269,841
Ensembl chr13:96,149,437...96,269,796

G

ectodermal-neural cortex 1

increases expression

EXP
ISO

leflunomide results in increased expression of ENC1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

enolase 2

increases expression

ISO

leflunomide results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

ISO

leflunomide results in increased expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

EXP

leflunomide results in increased expression of ENPP2 mRNA

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

EXP

leflunomide results in increased expression of ENTPD5 mRNA

NCBI chr 6:109,750,210...109,786,376
Ensembl chr 6:109,753,204...109,786,495

G

ectonucleoside triphosphate diphosphohydrolase 7

decreases expression

ISO

leflunomide results in decreased expression of ENTPD7 mRNA

NCBI chr 1:252,508,594...252,550,269
Ensembl chr 1:252,508,594...252,550,269

G

endosome associated trafficking regulator 1

increases expression

EXP

Leflunomide results in increased expression of ENTR1 mRNA

NCBI chr 3:29,599,059...29,605,780
Ensembl chr 3:29,599,059...29,605,898

G

endothelial PAS domain protein 1

increases expression

ISO

leflunomide results in increased expression of EPAS1 mRNA

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

erythrocyte membrane protein band 4.1 like 4B

increases expression

ISO

leflunomide results in increased expression of EPB41L4B mRNA

NCBI chr 5:76,486,886...76,647,752
Ensembl chr 5:76,486,902...76,647,752

G

erythrocyte membrane protein band 4.1 like 5

increases expression

EXP

leflunomide results in increased expression of EPB41L5 mRNA

NCBI chr13:33,221,705...33,321,400
Ensembl chr13:33,223,589...33,321,133

G

enhancer of polycomb homolog 1

increases expression

ISO

leflunomide results in increased expression of EPC1 mRNA

NCBI chr17:59,198,513...59,289,535
Ensembl chr17:59,197,677...59,289,519

G

enhancer of polycomb homolog 2

increases expression

ISO

leflunomide results in increased expression of EPC2 mRNA

NCBI chr 3:54,276,187...54,376,373
Ensembl chr 3:54,276,239...54,376,916

G

Eph receptor A2

increases expression

ISO

leflunomide results in increased expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234

G

epoxide hydrolase 2

decreases expression

ISO

leflunomide results in decreased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

EPM2A interacting protein 1

decreases expression

ISO

leflunomide results in decreased expression of EPM2AIP1 mRNA

NCBI chr 8:120,112,265...120,119,613
Ensembl chr 8:120,112,084...120,121,458

G

elongin BC and polycomb repressive complex 2 associated protein

decreases expression

ISO

leflunomide results in decreased expression of EPOP mRNA

NCBI chr10:83,120,767...83,122,287
Ensembl chr10:83,119,970...83,122,423

G

EGFR pathway substrate 8, signaling adaptor

increases expression

ISO

leflunomide results in increased expression of EPS8 mRNA

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160

G

erbb2 interacting protein

increases expression

ISO

leflunomide results in increased expression of ERBIN mRNA

NCBI chr 2:36,660,399...36,762,584
Ensembl chr 2:36,660,399...36,762,153

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

ISO

leflunomide results in decreased expression of ERCC6L mRNA

NCBI chr X:71,285,380...71,301,186
Ensembl chr X:71,285,380...71,301,186

G

ergosterol biosynthesis 28 homolog

increases expression

EXP

leflunomide results in increased expression of ERG28 mRNA

NCBI chr 6:111,205,102...111,214,068
Ensembl chr 6:111,205,103...111,214,068

G

endoplasmic reticulum to nucleus signaling 1

increases expression

ISO

leflunomide results in increased expression of ERN1 mRNA

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

ERBB receptor feedback inhibitor 1

increases expression

ISO

leflunomide results in increased expression of ERRFI1 mRNA

NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

ISO

leflunomide results in increased expression of ESCO1 mRNA

NCBI chr18:1,904,748...1,959,609
Ensembl chr18:1,904,762...1,959,805

G

ESF1 nucleolar pre-rRNA processing protein homolog

increases expression

ISO

leflunomide results in increased expression of ESF1 mRNA

NCBI chr 3:147,908,405...147,961,567
Ensembl chr 3:147,908,405...147,961,485

G

extra spindle pole bodies like 1, separase

decreases expression

ISO

leflunomide results in decreased expression of ESPL1 mRNA

NCBI chr 7:135,302,460...135,329,570
Ensembl chr 7:135,302,716...135,329,570

G

ETHE1, persulfide dioxygenase

decreases expression

EXP

leflunomide results in decreased expression of ETHE1 mRNA

NCBI chr 1:89,311,948...89,327,000
Ensembl chr 1:89,311,934...89,326,998

G

ETS proto-oncogene 1, transcription factor

increases expression

ISO

leflunomide results in increased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

ETS proto-oncogene 2, transcription factor

increases expression

EXP
ISO

leflunomide results in increased expression of ETS2 mRNA

PMID:24136188 PMID:28988120

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842

G

ETS variant transcription factor 4

increases expression

ISO

leflunomide results in increased expression of ETV4 mRNA

NCBI chr10:87,206,977...87,222,202
Ensembl chr10:87,206,977...87,222,318

G

eva-1 homolog A, regulator of programmed cell death

increases expression

ISO

leflunomide results in increased expression of EVA1A mRNA

NCBI chr 4:116,151,595...116,200,827
Ensembl chr 4:116,151,173...116,200,827

G

EvC ciliary complex subunit 1

decreases expression

ISO

leflunomide results in decreased expression of EVC mRNA

NCBI chr14:77,680,901...77,722,608
Ensembl chr14:77,680,943...77,723,100

G

exonuclease 5

decreases expression

ISO

leflunomide results in decreased expression of EXO5 mRNA

NCBI chr 5:139,779,646...139,782,963
Ensembl chr 5:139,777,987...139,783,034

G

exocyst complex component 3

increases expression

EXP

leflunomide results in increased expression of EXOC3 mRNA

NCBI chr 1:30,919,871...30,950,624

G

exocyst complex component 3-like 2

increases expression

EXP

leflunomide results in increased expression of EXOC3L2 mRNA

NCBI chr 1:88,241,784...88,273,352
Ensembl chr 1:88,240,477...88,276,847

G

exocyst complex component 7

increases expression

EXP

leflunomide results in increased expression of EXOC7 mRNA

NCBI chr10:102,019,805...102,039,333
Ensembl chr10:102,019,806...102,039,447

G

exosome component 4

increases expression

EXP

leflunomide results in increased expression of EXOSC4 mRNA

NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820

G

exostosin glycosyltransferase 1

increases expression

ISO

leflunomide results in increased expression of EXT1 mRNA

NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567

G

exostosin-like glycosyltransferase 1

decreases expression

EXP

leflunomide results in decreased expression of EXTL1 mRNA

NCBI chr 5:151,857,629...151,872,830
Ensembl chr 5:151,857,629...151,872,830

G

exostosin-like glycosyltransferase 2

decreases expression

ISO

leflunomide results in decreased expression of EXTL2 mRNA

NCBI chr 2:206,607,106...206,631,861
Ensembl chr 2:206,607,151...206,631,861

G

exostosin-like glycosyltransferase 3

decreases expression

ISO

leflunomide results in decreased expression of EXTL3 mRNA

NCBI chr15:43,469,293...43,559,760
Ensembl chr15:43,471,366...43,495,356

G

EYA transcriptional coactivator and phosphatase 4

increases expression

ISO

leflunomide results in increased expression of EYA4 mRNA

NCBI chr 1:23,991,431...24,235,132
Ensembl chr 1:23,991,431...24,235,131

G

ezrin

decreases expression

ISO

leflunomide results in decreased expression of EZR mRNA

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

F2R like trypsin receptor 1

increases expression

ISO

leflunomide results in increased expression of F2RL1 mRNA

NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954

G

coagulation factor V

increases expression

EXP

leflunomide results in increased expression of F5 mRNA

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247

G

fatty acid amide hydrolase

decreases expression

EXP

leflunomide results in decreased expression of FAAH mRNA

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396

G

FA core complex associated protein 24

decreases expression

ISO

leflunomide results in decreased expression of FAAP24 mRNA

NCBI chr 1:97,188,678...97,194,899
Ensembl chr 1:97,188,678...97,194,882

G

Fas associated via death domain

decreases expression

ISO

leflunomide results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fumarylacetoacetate hydrolase domain containing 2A

decreases expression

ISO

Leflunomide results in decreased expression of FAHD2A mRNA

NCBI chr 3:135,110,480...135,118,653
Ensembl chr 3:135,109,482...135,118,853

G

Fas apoptotic inhibitory molecule

decreases expression

ISO

leflunomide results in decreased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

family with sequence similarity 107, member B

increases expression

ISO

leflunomide results in increased expression of FAM107B mRNA

NCBI chr17:79,387,795...79,594,165
Ensembl chr17:79,387,795...79,594,288

G

family with sequence similarity 110, member A

decreases expression

ISO

leflunomide results in decreased expression of FAM110A mRNA

NCBI chr 3:160,934,815...160,945,405
Ensembl chr 3:160,931,777...160,949,897

G

family with sequence similarity 110, member B

increases expression

ISO

leflunomide results in increased expression of FAM110B mRNA

NCBI chr 5:23,587,093...23,727,188
Ensembl chr 5:23,586,867...23,799,583

G

family with sequence similarity 110, member C

increases expression

ISO

leflunomide results in increased expression of FAM110C mRNA

NCBI chr 6:53,366,013...53,372,270
Ensembl chr 6:53,352,870...53,401,117

G

FAM111 trypsin like peptidase A

decreases expression

ISO

leflunomide results in decreased expression of FAM111A mRNA

NCBI chr 1:219,065,542...219,081,213
Ensembl chr 1:219,065,601...219,081,211

G

family with sequence similarity 117, member A

decreases expression

ISO

leflunomide results in decreased expression of FAM117A mRNA

NCBI chr10:80,778,229...80,822,119
Ensembl chr10:80,755,883...80,822,119

G

family with sequence similarity 120 member C

decreases expression

ISO

leflunomide results in decreased expression of FAM120C mRNA

NCBI chr X:23,765,089...23,922,059
Ensembl chr X:23,766,976...23,920,840

G

family with sequence similarity 167, member B

increases expression

EXP

leflunomide results in increased expression of FAM167B mRNA

NCBI chr 5:147,205,018...147,206,660
Ensembl chr 5:147,204,653...147,206,652

G

family with sequence similarity 169, member A

increases expression

ISO

leflunomide results in increased expression of FAM169A mRNA

NCBI chr 2:30,115,307...30,175,972
Ensembl chr 2:30,119,381...30,175,962

G

family with sequence similarity 171, member A1

increases expression

ISO

leflunomide results in increased expression of FAM171A1 mRNA

NCBI chr17:79,933,742...80,057,495
Ensembl chr17:79,934,050...80,057,495

G

family with sequence similarity 174, member A

increases expression

ISO

leflunomide results in increased expression of FAM174A mRNA

NCBI chr 9:103,190,144...103,208,419
Ensembl chr 9:103,190,127...103,209,228

G

family with sequence similarity 184, member B

decreases expression

ISO

leflunomide results in decreased expression of FAM184B mRNA

NCBI chr14:69,688,031...69,803,922
Ensembl chr14:69,688,031...69,803,922

G

family with sequence similarity 193, member A

increases expression

ISO

leflunomide results in increased expression of FAM193A mRNA

NCBI chr14:80,480,742...80,607,086
Ensembl chr14:80,480,742...80,607,024

G

FAM20A, golgi associated secretory pathway pseudokinase

increases expression

ISO

leflunomide results in increased expression of FAM20A mRNA

NCBI chr10:95,136,799...95,197,176
Ensembl chr10:95,142,458...95,197,053

G

family with sequence similarity 217, member B

decreases expression

ISO

leflunomide results in decreased expression of FAM217B mRNA

NCBI chr 3:185,883,277...185,892,976
Ensembl chr 3:185,883,367...185,892,974

G

family with sequence similarity 222, member B

increases expression

ISO

leflunomide results in increased expression of FAM222B mRNA

NCBI chr10:63,484,651...63,550,422
Ensembl chr10:63,484,652...63,550,288

G

family with sequence similarity 229, member A

decreases expression

ISO

leflunomide results in decreased expression of FAM229A mRNA

NCBI chr 5:147,114,054...147,115,043
Ensembl chr 5:147,113,997...147,114,785

G

family with sequence similarity 241 member A

increases expression

ISO

leflunomide results in increased expression of FAM241A mRNA

NCBI chr 2:219,019,025...219,049,648
Ensembl chr 2:219,018,241...219,049,770

G

family with sequence similarity 32, member A

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of FAM32A mRNA
leflunomide results in decreased expression of FAM32A mRNA

PMID:24136188 PMID:28988120

NCBI chr16:17,637,078...17,641,448
Ensembl chr16:17,637,087...17,641,399

G

FAM3 metabolism regulating signaling molecule A

increases expression

EXP

leflunomide results in increased expression of FAM3A mRNA

NCBI chr X:157,317,993...157,326,640
Ensembl chr X:157,317,990...157,326,612

G

family with sequence similarity 43, member A

increases expression

ISO

leflunomide results in increased expression of FAM43A mRNA

NCBI chr11:83,633,165...83,636,313
Ensembl chr11:83,633,154...83,695,297

G

family with sequence similarity 43, member B

decreases expression

ISO

leflunomide results in decreased expression of FAM43B mRNA

NCBI chr 5:155,893,961...155,896,359
Ensembl chr 5:155,893,968...155,898,755

G

family with sequence similarity 47, member E

increases expression

ISO

leflunomide results in increased expression of FAM47E mRNA

NCBI chr14:15,769,441...15,805,911
Ensembl chr14:15,769,050...15,806,061

G

family with sequence similarity 76, member B

decreases expression

ISO

leflunomide results in decreased expression of FAM76B mRNA

NCBI chr 8:18,971,357...18,993,442
Ensembl chr 8:18,971,100...18,995,039

G

family with sequence similarity 83, member D

decreases expression

ISO

leflunomide results in decreased expression of FAM83D mRNA

NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061

G

family with sequence similarity 89, member A

increases expression

ISO

leflunomide results in increased expression of FAM89A mRNA

NCBI chr19:69,607,391...69,620,019
Ensembl chr19:69,607,391...69,620,019

G

FA complementation group D2

decreases expression

ISO

leflunomide results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group L

decreases expression

ISO

leflunomide results in decreased expression of FANCL mRNA

NCBI chr14:104,449,403...104,515,297
Ensembl chr14:104,394,590...104,515,297

G

FA complementation group M

decreases expression

ISO

leflunomide results in decreased expression of FANCM mRNA

NCBI chr 6:88,862,898...88,916,701
Ensembl chr 6:88,863,306...88,921,652

G

fatty acyl CoA reductase 1

decreases expression

ISO

leflunomide results in decreased expression of FAR1 mRNA

NCBI chr 1:177,078,973...177,140,363
Ensembl chr 1:177,079,150...177,161,696

G

fatty acid synthase

multiple interactions

ISO

[Colforsin co-treated with Leflunomide] results in increased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

FAST kinase domains 5

decreases expression

ISO

leflunomide results in decreased expression of FASTKD5 mRNA

NCBI chr 3:138,283,315...138,300,803
Ensembl chr 3:138,272,928...138,301,291

G

fatty acid hydroxylase domain containing 2

increases expression

ISO

leflunomide results in increased expression of FAXDC2 mRNA

NCBI chr10:42,747,323...42,772,156
Ensembl chr10:42,747,524...42,781,458

G

fibrillin 1

decreases expression

ISO

leflunomide results in decreased expression of FBN1 mRNA

NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283

G

F-box and leucine-rich repeat protein 20

increases expression

ISO

leflunomide results in increased expression of FBXL20 mRNA

NCBI chr10:83,577,038...83,640,022
Ensembl chr10:83,577,038...83,639,977

G

F-box protein 21

increases expression

EXP

leflunomide results in increased expression of FBXO21 mRNA

NCBI chr12:44,231,918...44,266,035
Ensembl chr12:44,231,923...44,266,035

G

F-box protein 25

increases expression

ISO

leflunomide results in increased expression of FBXO25 mRNA

NCBI chr16:82,370,123...82,404,002
Ensembl chr16:82,370,059...82,403,919

G

F-box protein 27

increases expression

ISO

leflunomide results in increased expression of FBXO27 mRNA

NCBI chr 1:93,092,900...93,115,312
Ensembl chr 1:93,093,024...93,122,181

G

F-box protein 3

decreases expression

ISO

leflunomide results in decreased expression of FBXO3 mRNA

NCBI chr 3:110,872,185...110,904,479
Ensembl chr 3:110,872,220...110,904,479

G

F-box protein 30

increases expression

ISO

leflunomide results in increased expression of FBXO30 mRNA

NCBI chr 1:7,475,636...7,491,719
Ensembl chr 1:7,475,575...7,493,199

G

F-box protein 31

increases expression

EXP

leflunomide results in increased expression of FBXO31 mRNA

NCBI chr19:66,533,437...66,564,674
Ensembl chr19:66,533,437...66,564,674

G

F-box protein 43

decreases expression

ISO

leflunomide results in decreased expression of FBXO43 mRNA

NCBI chr 7:69,218,298...69,231,873
Ensembl chr 7:69,218,299...69,230,310

G

F-box protein 46

increases expression

ISO

leflunomide results in increased expression of FBXO46 mRNA

NCBI chr 1:87,898,029...87,914,615
Ensembl chr 1:87,897,888...87,926,021

G

F-box protein 5

decreases expression

ISO

leflunomide results in decreased expression of FBXO5 mRNA

NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:44,601,412...44,607,781

G

F-box protein 8

increases expression

ISO

leflunomide results in increased expression of FBXO8 mRNA

NCBI chr16:38,676,011...38,721,849
Ensembl chr16:38,676,014...38,721,906

G

f-box protein 9

decreases expression

ISO

leflunomide results in decreased expression of FBXO9 mRNA

NCBI chr 8:87,838,787...87,864,362
Ensembl chr 8:87,838,789...87,864,504

G

Fc gamma binding protein

decreases expression

ISO

leflunomide results in decreased expression of FCGBP mRNA

NCBI chr 1:92,502,461...92,540,658
Ensembl chr 1:92,499,498...92,540,658

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

ISO

leflunomide results in decreased expression of FDFT1 mRNA

PMID:19751817 PMID:28988120

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

fem-1 homolog C

increases expression

ISO

leflunomide results in increased expression of FEM1C mRNA

NCBI chr18:41,419,511...41,445,300
Ensembl chr18:41,419,511...41,445,300

G

flap structure-specific endonuclease 1

decreases expression

ISO

leflunomide results in decreased expression of FEN1 mRNA

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

FERM domain containing kindlin 2

increases expression

ISO

leflunomide results in increased expression of FERMT2 mRNA

NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115

G

FYVE, RhoGEF and PH domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of FGD1 mRNA

NCBI chr X:23,466,791...23,509,773
Ensembl chr X:23,467,530...23,509,979

G

FYVE, RhoGEF and PH domain containing 4

increases expression

ISO

leflunomide results in increased expression of FGD4 mRNA

NCBI chr11:97,904,182...98,055,190
Ensembl chr11:97,904,182...98,055,190

G

fibroblast growth factor 2

increases expression

ISO

leflunomide results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

EXP

leflunomide results in decreased expression of FGR mRNA

NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169

G

four and a half LIM domains 2

increases expression

ISO

leflunomide results in increased expression of FHL2 mRNA

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

formin homology 2 domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of FHOD3 mRNA

NCBI chr18:16,267,830...16,700,508
Ensembl chr18:16,267,977...16,700,508

G

filamin A interacting protein 1-like

increases expression

ISO

leflunomide results in increased expression of FILIP1L mRNA

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:56,410,582...56,646,402

G

four-jointed box kinase 1

decreases expression

ISO

leflunomide results in decreased expression of FJX1 mRNA

NCBI chr 3:109,229,223...109,231,324
Ensembl chr 3:109,227,170...109,232,479

G

FKBP prolyl isomerase 7

decreases expression

ISO

leflunomide results in decreased expression of FKBP7 mRNA

NCBI chr 3:82,016,647...82,030,913
Ensembl chr 3:82,016,513...82,028,573

G

FKBP prolyl isomerase like

decreases expression

ISO

leflunomide results in decreased expression of FKBPL mRNA

NCBI chr20:4,104,457...4,105,927
Ensembl chr20:4,104,019...4,105,615

G

flavin adenine dinucleotide synthetase 1

increases expression

EXP

leflunomide results in increased expression of FLAD1 mRNA

NCBI chr 2:177,117,183...177,126,650
Ensembl chr 2:177,117,655...177,126,650

G

folliculin

increases expression

EXP

leflunomide results in increased expression of FLCN mRNA

NCBI chr10:45,088,164...45,107,581
Ensembl chr10:45,088,167...45,107,309

G

formin-like 2

increases expression

ISO

leflunomide results in increased expression of FMNL2 mRNA

NCBI chr 3:57,758,236...58,033,832
Ensembl chr 3:57,758,191...58,033,831

G

flavin containing dimethylaniline monoxygenase 5

increases expression

EXP

leflunomide results in increased expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

fructosamine 3 kinase

decreases expression

EXP

leflunomide results in decreased expression of FN3K mRNA

NCBI chr10:107,198,566...107,214,176
Ensembl chr10:107,198,892...107,214,175

G

formin binding protein 1-like

increases expression

ISO

leflunomide results in increased expression of FNBP1L mRNA

NCBI chr 2:213,331,871...213,432,821
Ensembl chr 2:213,318,662...213,423,051

G

formin binding protein 4

increases expression

ISO

leflunomide results in increased expression of FNBP4 mRNA

NCBI chr 3:97,188,852...97,218,916
Ensembl chr 3:97,188,884...97,219,435

G

fibronectin type III domain containing 3B

increases expression

ISO

leflunomide results in increased expression of FNDC3B mRNA

NCBI chr 2:112,240,108...112,546,113
Ensembl chr 2:112,243,202...112,546,306

G

folliculin interacting protein 1

increases expression

ISO

leflunomide results in increased expression of FNIP1 mRNA

NCBI chr10:39,068,432...39,151,552
Ensembl chr10:39,068,445...39,151,552

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

leflunomide results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

leflunomide results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

increases expression

ISO

leflunomide results in increased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box A1

decreases expression

ISO

leflunomide results in decreased expression of FOXA1 mRNA

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box D2

decreases expression

ISO

leflunomide results in decreased expression of FOXD2 mRNA

NCBI chr 5:133,664,760...133,667,483
Ensembl chr 5:133,664,760...133,667,483

G

forkhead box J3

increases expression

ISO

leflunomide results in increased expression of FOXJ3 mRNA

NCBI chr 5:138,425,623...138,513,760
Ensembl chr 5:138,424,923...138,513,760

G

forkhead box L1

decreases expression

ISO

leflunomide results in decreased expression of FOXL1 mRNA

NCBI chr19:66,105,953...66,109,366

G

forkhead box N3

increases expression

ISO

leflunomide results in increased expression of FOXN3 mRNA

NCBI chr 6:124,191,695...124,572,070
Ensembl chr 6:124,195,701...124,572,040

G

forkhead box O1

increases expression

ISO

leflunomide results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O3

increases expression

ISO

leflunomide results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

forkhead box P1

increases expression

ISO

leflunomide results in increased expression of FOXP1 mRNA

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272

G

forkhead box P3

multiple interactions

ISO

[leflunomide co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA

NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894

G

forkhead box Q1

increases expression

ISO

leflunomide results in increased expression of FOXQ1 mRNA

NCBI chr17:33,121,454...33,124,087
Ensembl chr17:33,121,545...33,123,720

G

folylpolyglutamate synthase

increases expression

EXP

leflunomide results in increased expression of FPGS mRNA

NCBI chr 3:36,370,505...36,391,314
Ensembl chr 3:36,370,300...36,391,068

G

fyn-related Src family tyrosine kinase

increases expression

ISO

leflunomide results in increased expression of FRK mRNA

NCBI chr20:39,820,441...39,926,065
Ensembl chr20:39,820,295...39,926,362

G

FERM domain containing 3

increases expression

ISO

leflunomide results in increased expression of FRMD3 mRNA

NCBI chr 5:92,810,989...93,077,326
Ensembl chr 5:92,810,736...93,077,325

G

FERM domain containing 8

decreases expression

ISO

leflunomide results in decreased expression of FRMD8 mRNA

NCBI chr 1:212,572,534...212,593,181
Ensembl chr 1:212,572,537...212,592,695

G

fibronectin type III and SPRY domain containing 1-like

increases expression

ISO

leflunomide results in increased expression of FSD1L mRNA

NCBI chr 5:73,052,565...73,130,292
Ensembl chr 5:73,054,274...73,130,292

G

follistatin

increases expression

ISO

leflunomide results in increased expression of FST mRNA

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

far upstream element binding protein 1

decreases expression

ISO

leflunomide results in decreased expression of FUBP1 mRNA

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428

G

Fus RNA binding protein

decreases expression

ISO

leflunomide results in decreased expression of FUS mRNA

NCBI chr 1:192,007,011...192,020,887
Ensembl chr 1:192,007,006...192,020,884

G

fucosyltransferase 1

increases expression

ISO

leflunomide results in increased expression of FUT1 mRNA

NCBI chr 1:105,223,399...105,226,817
Ensembl chr 1:105,223,390...105,227,513

G

fucosyltransferase 11

decreases expression

ISO

Leflunomide results in decreased expression of POFUT4 mRNA

NCBI chr15:3,648,022...3,651,582
Ensembl chr15:3,643,009...3,651,610

G

FXYD domain-containing ion transport regulator 2

decreases expression

ISO

leflunomide results in decreased expression of FXYD2 mRNA

NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:54,609,658...54,616,957

G

frizzled class receptor 4

decreases expression

ISO

leflunomide results in decreased expression of FZD4 mRNA

NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372

G

frizzled class receptor 5

increases expression

ISO

leflunomide results in increased expression of FZD5 mRNA

NCBI chr 9:73,606,860...73,614,039
Ensembl chr 9:73,606,860...73,618,612

G

frizzled class receptor 7

increases expression

ISO

leflunomide results in increased expression of FZD7 mRNA

NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:68,411,259...68,432,585

G

frizzled class receptor 8

increases expression

EXP

leflunomide results in increased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961

G

G0/G1switch 2

increases expression

ISO

leflunomide results in increased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

ISO

Leflunomide results in increased expression of G6PC1 mRNA
Colforsin inhibits the reaction [Leflunomide results in increased expression of G6PC1 mRNA]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

alpha glucosidase

increases expression

EXP

leflunomide results in increased expression of GAA mRNA

NCBI chr10:105,028,106...105,045,365
Ensembl chr10:105,028,307...105,045,366

G

GRB2-associated binding protein 2

increases expression

ISO

leflunomide results in increased expression of GAB2 mRNA

NCBI chr 1:160,841,066...161,036,940
Ensembl chr 1:160,841,066...161,036,940

G

GABA type A receptor associated protein like 1

increases expression

EXP

leflunomide results in increased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578

G

GABA type A receptor associated protein like 2

increases expression

EXP

leflunomide results in increased expression of GABARAPL2 mRNA

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

ISO

leflunomide results in increased expression of GABBR1 mRNA

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607

G

glutamate decarboxylase 1

increases expression

ISO

leflunomide results in increased expression of GAD1 mRNA

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

growth arrest and DNA-damage-inducible, alpha

increases expression

EXP
ISO

leflunomide results in increased expression of GADD45A mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

increases expression

ISO

leflunomide results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

galactokinase 1

increases expression

EXP

leflunomide results in increased expression of GALK1 mRNA

NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258

G

polypeptide N-acetylgalactosaminyltransferase 2

increases expression

EXP

leflunomide results in increased expression of GALNT2 mRNA

NCBI chr19:69,110,657...69,222,237
Ensembl chr19:69,110,657...69,222,237

G

polypeptide N-acetylgalactosaminyltransferase 6

increases expression

ISO

leflunomide results in increased expression of GALNT6 mRNA

NCBI chr 7:133,668,612...133,715,909
Ensembl chr 7:133,668,615...133,698,439

G

GRB2 associated regulator of MAPK1 subtype 1

increases expression

ISO

leflunomide results in increased expression of GAREM1 mRNA

NCBI chr18:12,695,082...12,860,219
Ensembl chr18:12,695,082...12,860,219

G

granule associated Rac and RHOG effector 1

increases expression

ISO

Leflunomide results in increased expression of GARRE1 mRNA

NCBI chr 1:95,999,305...96,077,641
Ensembl chr 1:95,996,429...96,051,620

G

glycyl-tRNA synthetase 1

increases expression

ISO

Leflunomide results in increased expression of GARS1 mRNA

NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876

G

growth arrest specific 5

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of GAS5 mRNA
leflunomide results in decreased expression of GAS5 mRNA

PMID:19751817 PMID:24136188

NCBI chr13:75,836,963...75,840,284

G

growth arrest specific 6

decreases expression

EXP

leflunomide results in decreased expression of GAS6 mRNA

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

golgi associated kinase 1B

increases expression

ISO

Leflunomide results in increased expression of GASK1B mRNA

NCBI chr 2:167,345,738...167,410,606
Ensembl chr 2:167,345,809...167,410,603

G

GATA binding protein 6

decreases expression

EXP

leflunomide results in decreased expression of GATA6 mRNA

NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322

G

glycine amidinotransferase

decreases expression

ISO

leflunomide results in decreased expression of GATM mRNA

NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355

G

glucosylceramidase beta 1

increases expression

EXP

Leflunomide results in increased expression of GBA1 mRNA

NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:176,907,154...176,916,985

G

guanylate binding protein 2

increases expression

ISO

leflunomide results in increased expression of GBP2 mRNA

NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:234,008,590...234,021,810

G

gastrulation brain homeobox 2

increases expression

ISO

leflunomide results in increased expression of GBX2 mRNA

NCBI chr 9:97,957,304...97,959,883
Ensembl chr 9:97,957,304...97,959,883

G

glutaryl-CoA dehydrogenase

increases expression

EXP

leflunomide results in increased expression of GCDH mRNA

NCBI chr19:40,168,038...40,174,536
Ensembl chr19:40,168,141...40,175,686

G

glutamate-cysteine ligase, catalytic subunit

increases expression

EXP

leflunomide results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glial cells missing transcription factor 1

increases expression

ISO

leflunomide results in increased expression of GCM1 mRNA

NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:87,805,993...87,819,229

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

ISO

leflunomide results in increased expression of GCNT3 mRNA

NCBI chr 8:79,570,081...79,577,389
Ensembl chr 8:79,566,753...79,581,595

G

glycine cleavage system protein H

decreases expression

ISO

leflunomide results in decreased expression of GCSH mRNA

NCBI chr19:61,944,850...61,955,607
Ensembl chr19:61,944,850...61,955,607

G

ganglioside-induced differentiation-associated protein 1-like 1

decreases expression

ISO

leflunomide results in decreased expression of GDAP1L1 mRNA

NCBI chr 3:172,529,523...172,549,128
Ensembl chr 3:172,509,564...172,549,125

G

glycerophosphodiester phosphodiesterase 1

increases expression

EXP

leflunomide results in increased expression of GDE1 mRNA

NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772

G

growth differentiation factor 15

increases expression

ISO

leflunomide results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

GDP-D-glucose phosphorylase 1

decreases expression

ISO

leflunomide results in decreased expression of GDPGP1 mRNA

NCBI chr 1:143,593,379...143,602,542
Ensembl chr 1:143,592,802...143,611,480

G

gem (nuclear organelle) associated protein 4

decreases expression

ISO

Leflunomide results in decreased expression of GEMIN4 mRNA

NCBI chr10:61,560,172...61,571,765
Ensembl chr10:61,564,657...61,596,532

G

gem (nuclear organelle) associated protein 6

increases expression

EXP

leflunomide results in increased expression of GEMIN6 mRNA

NCBI chr 6:20,538,325...20,542,867
Ensembl chr 6:20,538,325...20,542,852

G

gem (nuclear organelle) associated protein 7

decreases expression

ISO

leflunomide results in decreased expression of GEMIN7 mRNA

NCBI chr 1:88,343,032...88,352,473
Ensembl chr 1:88,342,361...88,354,571

G

GEN1 Holliday junction 5' flap endonuclease

decreases expression

ISO

leflunomide results in decreased expression of GEN1 mRNA

NCBI chr 6:39,666,675...39,697,480
Ensembl chr 6:39,667,286...39,697,480

G

guided entry of tail-anchored proteins factor 1

decreases expression

ISO

Leflunomide results in decreased expression of GET1 mRNA

NCBI chr11:48,915,298...48,929,235
Ensembl chr11:48,915,289...48,929,416

G

Gfo/Idh/MocA-like oxidoreductase domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of GFOD2 mRNA

NCBI chr19:50,508,626...50,556,945
Ensembl chr19:50,513,709...50,557,132

G

growth hormone inducible transmembrane protein

increases expression

EXP

leflunomide results in increased expression of GHITM mRNA

NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123

G

GINS complex subunit 1

decreases expression

ISO

leflunomide results in decreased expression of GINS1 mRNA

NCBI chr 3:160,184,920...160,206,334
Ensembl chr 3:160,180,151...160,206,332

G

GINS complex subunit 3

decreases expression

ISO

leflunomide results in decreased expression of GINS3 mRNA

NCBI chr19:9,426,140...9,435,192
Ensembl chr19:9,399,759...9,434,679

G

gap junction protein, alpha 1

increases expression

ISO
EXP

leflunomide results in increased expression of GJA1 mRNA

PMID:19751817 PMID:24136188

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, gamma 1

decreases expression

ISO

leflunomide results in decreased expression of GJC1 mRNA

NCBI chr10:88,262,840...88,285,646
Ensembl chr10:88,249,489...88,285,853

G

glucocorticoid induced 1

decreases expression

ISO

leflunomide results in decreased expression of GLCCI1 mRNA

NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802

G

glucuronic acid epimerase

decreases expression

ISO

leflunomide results in decreased expression of GLCE mRNA

NCBI chr 8:71,441,607...71,507,639
Ensembl chr 8:71,441,616...71,507,587

G

GLI pathogenesis-related 1

increases expression

ISO

leflunomide results in increased expression of GLIPR1 mRNA

NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:49,373,581...49,384,640

G

glomulin, FKBP associated protein

decreases expression

ISO

leflunomide results in decreased expression of GLMN mRNA

NCBI chr14:2,332,052...2,375,366
Ensembl chr14:2,332,497...2,375,695

G

glycine receptor, alpha 1

increases expression

ISO

leflunomide results in increased expression of GLRA1 mRNA

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:40,130,121...40,227,815

G

glutaredoxin

increases expression

EXP

leflunomide results in increased expression of GLRX mRNA

NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543

G

glutaminase 2

decreases expression

EXP

leflunomide results in decreased expression of GLS2 mRNA

NCBI chr 7:1,201,757...1,218,014
Ensembl chr 7:1,201,838...1,218,013

G

glutamate-ammonia ligase

increases expression

ISO

leflunomide results in increased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glycine-N-acyltransferase-like 2

increases expression

EXP

Leflunomide results in increased expression of GLYATL2 mRNA

NCBI chr 1:219,232,154...219,265,142
Ensembl chr 1:219,232,103...219,266,322

G

glucocorticoid modulatory element binding protein 1

increases expression

ISO

leflunomide results in increased expression of GMEB1 mRNA

NCBI chr 5:149,703,035...149,746,474
Ensembl chr 5:149,705,825...149,737,259

G

guanosine monophosphate reductase 2

increases expression

EXP

leflunomide results in increased expression of GMPR2 mRNA

NCBI chr15:33,135,455...33,144,923
Ensembl chr15:33,135,682...33,144,899

G

G protein subunit alpha 13

increases expression

ISO

leflunomide results in increased expression of GNA13 mRNA

NCBI chr10:94,837,271...94,870,290
Ensembl chr10:94,836,444...94,874,968

G

G protein subunit alpha i1

increases expression

ISO

leflunomide results in increased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha q

increases expression

ISO

leflunomide results in increased expression of GNAQ mRNA

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742

G

G protein subunit alpha z

increases expression

ISO

leflunomide results in increased expression of GNAZ mRNA

NCBI chr20:13,642,853...13,693,616
Ensembl chr20:13,644,020...13,669,287

G

G protein subunit beta 3

decreases expression

ISO

leflunomide results in decreased expression of GNB3 mRNA

NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:159,325,742...159,331,445

G

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

decreases expression

EXP

leflunomide results in decreased expression of GNE mRNA

NCBI chr 5:63,062,953...63,103,320
Ensembl chr 5:63,062,850...63,103,251

G

G protein subunit gamma 12

increases expression

EXP

leflunomide results in increased expression of GNG12 mRNA

NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476

G

glycine N-methyltransferase

decreases expression

ISO

leflunomide results in decreased expression of GNMT mRNA

NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692

G

glucosamine-6-phosphate deaminase 2

increases expression

ISO

leflunomide results in increased expression of GNPDA2 mRNA

NCBI chr14:38,874,611...38,892,688
Ensembl chr14:38,874,647...38,892,683

G

glucosamine-phosphate N-acetyltransferase 1

decreases expression

ISO

leflunomide results in decreased expression of GNPNAT1 mRNA

NCBI chr15:21,076,129...21,088,526
Ensembl chr15:21,076,130...21,088,423

G

N-acetylglucosamine-1-phosphate transferase subunit gamma

increases expression

EXP

leflunomide results in increased expression of GNPTG mRNA

NCBI chr10:14,756,685...14,761,636

G

G patch domain containing 2

increases expression

ISO

leflunomide results in increased expression of GPATCH2 mRNA

NCBI chr13:101,316,413...101,457,109
Ensembl chr13:101,316,413...101,457,109

G

G patch domain containing 2-like

increases expression

ISO

leflunomide results in increased expression of GPATCH2L mRNA

NCBI chr 6:111,614,344...111,666,603
Ensembl chr 6:111,614,416...111,666,602

G

glypican 6

increases expression

ISO

leflunomide results in increased expression of GPC6 mRNA

NCBI chr15:100,437,415...101,435,038
Ensembl chr15:100,437,943...101,435,027

G

glycerophosphocholine phosphodiesterase 1

increases expression

ISO

leflunomide results in increased expression of GPCPD1 mRNA

NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372

G

glycerol-3-phosphate dehydrogenase 1

decreases expression

ISO

leflunomide results in decreased expression of GPD1 mRNA

NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368

G

glycosylphosphatidylinositol specific phospholipase D1

decreases expression

ISO

leflunomide results in decreased expression of GPLD1 mRNA

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

G protein-coupled receptor 137C

increases expression

ISO

leflunomide results in increased expression of GPR137C mRNA

NCBI chr15:20,905,923...20,972,318
Ensembl chr15:20,905,958...20,970,541

G

G protein-coupled receptor 146

increases expression

EXP

leflunomide results in increased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

G protein-coupled receptor 3

increases expression

ISO

leflunomide results in increased expression of GPR3 mRNA

NCBI chr 5:150,695,406...150,698,526
Ensembl chr 5:150,695,251...150,706,529

G

G protein-coupled receptor, class C, group 5, member C

increases expression

ISO

leflunomide results in increased expression of GPRC5C mRNA

NCBI chr10:100,385,682...100,407,953
Ensembl chr10:100,383,631...100,426,962

G

GRAM domain containing 1A

increases expression

ISO

leflunomide results in increased expression of GRAMD1A mRNA

NCBI chr 1:95,494,378...95,520,730
Ensembl chr 1:95,494,378...95,520,716

G

growth factor receptor bound protein 10

increases expression

ISO

leflunomide results in increased expression of GRB10 mRNA

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

growth factor receptor bound protein 7

decreases expression

ISO

leflunomide results in decreased expression of GRB7 mRNA

NCBI chr10:83,936,538...83,949,344
Ensembl chr10:83,939,299...83,949,382

G

grainyhead-like transcription factor 3

increases expression

ISO

leflunomide results in increased expression of GRHL3 mRNA

NCBI chr 5:153,057,760...153,089,890
Ensembl chr 5:153,057,760...153,089,890

G

glutamate ionotropic receptor NMDA type subunit 2A

increases expression

ISO

leflunomide results in increased expression of GRIN2A mRNA

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

ISO

leflunomide results in decreased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression

ISO

leflunomide results in increased expression of GRIN2D mRNA

NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236

G

G protein-coupled receptor kinase 5

increases expression

ISO

leflunomide results in increased expression of GRK5 mRNA

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

GrpE-like 2, mitochondrial

increases expression

ISO

leflunomide results in increased expression of GRPEL2 mRNA

PMID:28988120 PMID:29427785

NCBI chr18:57,438,168...57,450,408
Ensembl chr18:57,438,168...57,450,717

G

gamma-secretase activating protein

decreases expression

ISO

leflunomide results in decreased expression of GSAP mRNA

NCBI chr 4:14,705,237...14,800,057
Ensembl chr 4:14,705,237...14,800,005

G

Gse1 coiled-coil protein

increases expression

ISO

leflunomide results in increased expression of GSE1 mRNA

NCBI chr19:65,182,678...65,538,183
Ensembl chr19:65,446,263...65,538,176

G

glutathione-disulfide reductase

increases expression

EXP

leflunomide results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione synthetase

increases expression

EXP

leflunomide results in increased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306

G

glutathione S-transferase alpha 2

increases expression
decreases expression

EXP
ISO

Leflunomide results in increased expression of GSTA2 mRNA
leflunomide results in decreased expression of GSTA2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

increases expression

EXP

Leflunomide results in increased expression of GSTA3 mRNA

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase alpha 4

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of GSTA4 mRNA
leflunomide results in decreased expression of GSTA4 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase pi 1

increases expression

EXP
ISO

leflunomide results in increased expression of GSTP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase pi 3

decreases expression

EXP

Leflunomide results in decreased expression of GSTP3 mRNA

NCBI chr 1:210,785,151...210,787,705
Ensembl chr 1:210,785,151...210,787,684

G

general transcription factor III A

increases expression

EXP

leflunomide results in increased expression of GTF3A mRNA

NCBI chr12:13,250,643...13,258,587
Ensembl chr12:13,250,644...13,258,587

G

GTP binding protein 1

increases expression

ISO

leflunomide results in increased expression of GTPBP1 mRNA

NCBI chr 7:113,128,645...113,153,094
Ensembl chr 7:113,128,670...113,154,621

G

G-2 and S-phase expressed 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of GTSE1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:118,829,793...118,846,662
Ensembl chr 7:118,829,903...118,846,661

G

GTP binding elongation factor GUF1

decreases expression

ISO

leflunomide results in decreased expression of GUF1 mRNA

NCBI chr14:38,891,905...38,911,283
Ensembl chr14:38,891,905...38,911,283

G

glucoside xylosyltransferase 1

decreases expression

ISO

leflunomide results in decreased expression of GXYLT1 mRNA

NCBI chr 7:126,280,349...126,320,803
Ensembl chr 7:126,280,349...126,314,237

G

GDNF-inducible zinc finger protein 1

increases expression

ISO

leflunomide results in increased expression of GZF1 mRNA

NCBI chr 3:156,572,152...156,584,369
Ensembl chr 3:156,572,250...156,584,363

G

H2A clustered histone 6

increases expression

ISO

Leflunomide results in increased expression of H2AC6 mRNA

NCBI chr17:47,403,701...47,404,167

G

H2A.J histone

increases expression

EXP

Leflunomide results in increased expression of H2AJ mRNA

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

H2A.P histone

decreases expression

ISO

Leflunomide results in decreased expression of H2AP mRNA

NCBI chr X:15,580,476...15,581,030
Ensembl chr X:15,580,359...15,581,315

G

H2A.X variant histone

decreases expression

ISO

Leflunomide results in decreased expression of H2AX mRNA

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H2A.Z variant histone 1

decreases expression

ISO

Leflunomide results in decreased expression of H2AZ1 mRNA

NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:229,028,843...229,031,411

G

H2B clustered histone 18

increases expression

ISO

Leflunomide results in increased expression of H2BC18 mRNA

NCBI chr 2:186,527,197...186,531,634

G

H2B clustered histone 21

increases expression

ISO

Leflunomide results in increased expression of H2BC11 mRNA

NCBI chr 2:186,469,452...186,471,899

G

H3 clustered histone 1

decreases expression

ISO

Leflunomide results in decreased expression of H3C1 mRNA

NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,795,396...41,797,281
Ensembl chr17:41,795,396...41,797,281

G

H3.3 histone A

decreases expression

ISO

Leflunomide results in decreased expression of H3-3A mRNA

NCBI chr13:95,065,085...95,076,695
Ensembl chr13:95,065,085...95,076,695

G

H1.3 linker histone, cluster member

increases expression

ISO

Leflunomide results in increased expression of H1-3 mRNA

NCBI chr17:41,979,562...41,980,341
Ensembl chr17:41,796,116...41,980,485

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

increases expression

EXP

leflunomide results in increased expression of H6PD mRNA

NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

EXP

leflunomide results in increased expression of HACD3 mRNA

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression

EXP

leflunomide results in increased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

EXP

leflunomide results in increased expression of HADHB mRNA

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

histidine ammonia lyase

decreases expression

EXP

leflunomide results in decreased expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hepcidin antimicrobial peptide

increases expression

ISO

leflunomide results in increased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heart and neural crest derivatives expressed 1

increases expression

ISO

leflunomide results in increased expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

hydroxyacid oxidase 1

decreases expression

EXP

leflunomide results in decreased expression of HAO1 mRNA

NCBI chr 3:142,102,873...142,281,527
Ensembl chr 3:142,224,612...142,281,494

G

hydroxyacid oxidase 2

decreases expression

EXP

leflunomide results in decreased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

histone H3 associated protein kinase

increases expression

ISO

leflunomide results in increased expression of HASPIN mRNA

NCBI chr10:58,246,244...58,249,031
Ensembl chr10:58,240,447...58,249,249

G

HAUS augmin-like complex, subunit 4

decreases expression

EXP

leflunomide results in decreased expression of HAUS4 mRNA

NCBI chr15:31,964,555...31,976,853
Ensembl chr15:31,964,556...31,975,941

G

HAUS augmin like complex subunit 6

increases expression

ISO

Leflunomide results in increased expression of HAUS6 mRNA

NCBI chr 5:106,162,526...106,201,503
Ensembl chr 5:106,162,526...106,199,072

G

HAUS augmin-like complex, subunit 8

decreases expression

ISO

leflunomide results in decreased expression of HAUS8 mRNA

NCBI chr16:17,964,813...17,979,313
Ensembl chr16:17,964,814...17,979,192

G

heparin-binding EGF-like growth factor

increases expression

ISO

leflunomide results in increased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

HMG-box transcription factor 1

increases expression

ISO

leflunomide results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

HBS1-like translational GTPase

decreases expression

ISO

leflunomide results in decreased expression of HBS1L mRNA

NCBI chr 1:17,912,139...17,989,651
Ensembl chr 1:17,912,070...17,989,646

G

hydroxycarboxylic acid receptor 2

increases expression

ISO

leflunomide results in increased expression of HCAR2 mRNA

NCBI chr12:38,387,163...38,389,149
Ensembl chr12:38,387,230...38,389,391

G

HDGF like 1

decreases expression

ISO

leflunomide results in decreased expression of HDGFL1 mRNA

NCBI chr17:38,636,053...38,638,049
Ensembl chr17:38,636,072...38,637,957

G

haloacid dehalogenase-like hydrolase domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of HDHD3 mRNA

NCBI chr 5:80,966,878...80,970,345
Ensembl chr 5:80,954,610...80,970,854

G

HEAT repeat containing 5A

decreases expression

ISO

leflunomide results in decreased expression of HEATR5A mRNA

NCBI chr 6:75,057,226...75,155,207
Ensembl chr 6:75,057,226...75,155,120

G

heart development protein with EGF-like domains 1

increases expression

ISO

leflunomide results in increased expression of HEG1 mRNA

NCBI chr11:80,512,096...80,600,150
Ensembl chr11:80,512,096...80,600,092

G

helicase, POLQ-like

increases expression

ISO

leflunomide results in increased expression of HELQ mRNA

NCBI chr14:9,122,978...9,167,310
Ensembl chr14:9,122,978...9,167,310

G

HECT and RLD domain containing E3 ubiquitin protein ligase 2

decreases expression

ISO

leflunomide results in decreased expression of HERC2 mRNA

NCBI chr 1:116,009,681...116,243,888
Ensembl chr 1:116,040,736...116,243,884

G

hes family bHLH transcription factor 1

increases expression

ISO

leflunomide results in increased expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

HEXIM P-TEFb complex subunit 1

decreases expression

ISO

leflunomide results in decreased expression of HEXIM1 mRNA

NCBI chr10:88,562,889...88,565,001
Ensembl chr10:88,560,519...88,580,000

G

HEXIM P-TEFb complex subunit 2

decreases expression

ISO

leflunomide results in decreased expression of HEXIM2 mRNA

NCBI chr10:88,572,102...88,584,856
Ensembl chr10:88,578,996...88,584,855

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

ISO

leflunomide results in increased expression of HEY1 mRNA

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624

G

HGF activator

increases expression

EXP

leflunomide results in increased expression of HGFAC mRNA

NCBI chr14:79,932,219...79,938,773
Ensembl chr14:79,932,222...79,939,029

G

hematopoietically expressed homeobox

decreases expression

ISO

leflunomide results in decreased expression of HHEX mRNA

NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604

G

3-hydroxyisobutyryl-CoA hydrolase

increases expression

EXP

leflunomide results in increased expression of HIBCH mRNA

NCBI chr 9:56,082,082...56,161,796
Ensembl chr 9:56,082,091...56,161,886

G

hypoxia inducible factor 1 subunit alpha

increases expression

ISO

leflunomide results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hypoxia inducible factor 1 subunit alpha inhibitor

decreases expression

ISO

leflunomide results in decreased expression of HIF1AN mRNA

NCBI chr 1:253,368,400...253,385,495
Ensembl chr 1:253,367,683...253,385,491

G

HIG1 hypoxia inducible domain family, member 2A

increases expression

EXP

leflunomide results in increased expression of HIGD2A mRNA

NCBI chr17:10,026,961...10,027,885
Ensembl chr17:10,026,961...10,027,874

G

hypoxia inducible lipid droplet-associated

decreases expression

ISO

leflunomide results in decreased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

HIVEP zinc finger 1

increases expression

ISO

leflunomide results in increased expression of HIVEP1 mRNA

NCBI chr17:22,790,855...22,920,359
Ensembl chr17:22,790,855...22,917,196

G

hexokinase 2

increases expression

ISO

leflunomide results in increased expression of HK2 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

hexokinase domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of HKDC1 mRNA

NCBI chr20:30,878,037...30,917,044
Ensembl chr20:30,878,319...30,916,704

G

histocompatibility minor 13

increases expression

EXP

leflunomide results in increased expression of HM13 mRNA

NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:161,606,052...161,644,805

G

high mobility group box 2

decreases expression

EXP

leflunomide results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

high mobility group box 3

decreases expression

ISO

leflunomide results in decreased expression of HMGB3 mRNA

NCBI chr X:154,341,106...154,346,087
Ensembl chr X:154,340,935...154,346,097

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

EXP

leflunomide results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

ISO

leflunomide results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

high mobility group nucleosome binding domain 1

increases expression

EXP

leflunomide results in increased expression of HMGN1 mRNA

NCBI chr11:48,891,813...48,897,732
Ensembl chr11:48,891,814...48,897,771

G

high mobility group nucleosomal binding domain 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of HMGN2 mRNA
leflunomide results in decreased expression of HMGN2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:151,475,907...151,479,361
Ensembl chr 5:151,475,909...151,479,397

G

high mobility group nucleosomal binding domain 3

decreases expression

ISO

leflunomide results in decreased expression of HMGN3 mRNA

NCBI chr 8:92,902,555...92,939,980

G

HMG-box containing 4

increases expression

ISO

leflunomide results in increased expression of HMGXB4 mRNA

NCBI chr19:13,370,559...13,409,306
Ensembl chr19:13,370,376...13,409,306

G

hyaluronan-mediated motility receptor

decreases expression

ISO

leflunomide results in decreased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

HNF1 homeobox B

increases expression

ISO

leflunomide results in increased expression of HNF1B mRNA

NCBI chr10:69,233,377...69,287,360
Ensembl chr10:69,233,131...69,287,361

G

heterogeneous nuclear ribonucleoprotein A0

decreases expression

ISO

leflunomide results in decreased expression of HNRNPA0 mRNA

NCBI chr17:6,513,129...6,515,786
Ensembl chr17:6,512,629...6,516,127

G

heterogeneous nuclear ribonucleoprotein H3

decreases expression

ISO

leflunomide results in decreased expression of HNRNPH3 mRNA

NCBI chr20:25,619,540...25,624,397
Ensembl chr20:25,615,577...25,625,162

G

4-hydroxy-2-oxoglutarate aldolase 1

decreases expression

ISO

leflunomide results in decreased expression of HOGA1 mRNA

NCBI chr 1:250,806,430...250,833,544
Ensembl chr 1:250,806,255...250,833,869

G

homeobox and leucine zipper encoding

decreases expression

ISO

leflunomide results in decreased expression of HOMEZ mRNA

NCBI chr15:32,292,897...32,309,564
Ensembl chr15:32,291,048...32,321,319

G

homeobox A3

decreases expression

ISO

leflunomide results in decreased expression of HOXA3 mRNA

NCBI chr 4:82,599,860...82,643,831
Ensembl chr 4:82,599,860...82,643,831

G

homeo box D1

decreases expression

ISO

leflunomide results in decreased expression of HOXD1 mRNA

NCBI chr 3:80,073,041...80,075,180
Ensembl chr 3:80,073,041...80,075,180

G

HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

decreases expression

ISO

leflunomide results in decreased expression of HPS6 mRNA

NCBI chr 1:254,802,250...254,804,859
Ensembl chr 1:254,802,119...254,804,937

G

HR, lysine demethylase and nuclear receptor corepressor

increases expression

ISO

leflunomide results in increased expression of HR mRNA

NCBI chr15:52,036,540...52,056,019
Ensembl chr15:52,036,540...52,056,015

G

histidine rich calcium binding protein

increases expression

ISO

leflunomide results in increased expression of HRC mRNA

NCBI chr 1:104,949,750...104,953,475
Ensembl chr 1:104,949,741...104,954,193

G

harakiri, BCL2 interacting protein

increases expression

ISO

leflunomide results in increased expression of HRK mRNA

PMID:28988120 PMID:29427785

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

heparan sulfate-glucosamine 3-sulfotransferase 3B1

increases expression

ISO

leflunomide results in increased expression of HS3ST3B1 mRNA

NCBI chr10:49,060,693...49,093,185
Ensembl chr10:49,060,693...49,093,185

G

heparan sulfate-glucosamine 3-sulfotransferase 5

increases expression

ISO

leflunomide results in increased expression of HS3ST5 mRNA

NCBI chr20:41,661,785...41,972,550
Ensembl chr20:41,773,601...41,972,542

G

heparan sulfate 6-O-sulfotransferase 2

decreases expression

ISO

leflunomide results in decreased expression of HS6ST2 mRNA

NCBI chr X:135,887,224...136,182,388
Ensembl chr X:135,888,472...136,182,353

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

EXP

leflunomide results in decreased expression of HSD11B2 mRNA

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

EXP

leflunomide results in increased expression of HSD17B12 mRNA

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

hydroxysteroid (17-beta) dehydrogenase 13

increases expression

EXP

leflunomide results in increased expression of HSD17B13 mRNA

NCBI chr14:6,056,708...6,071,463
Ensembl chr14:6,056,774...6,072,823

G

hydroxysteroid (17-beta) dehydrogenase 2

increases expression

ISO

leflunomide results in increased expression of HSD17B2 mRNA

NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943

G

hydroxysteroid (17-beta) dehydrogenase 6

decreases expression

EXP

leflunomide results in decreased expression of HSD17B6 mRNA

NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

increases expression

EXP

leflunomide results in increased expression of HSD3B7 mRNA

NCBI chr 1:191,842,688...191,845,919
Ensembl chr 1:191,842,636...191,845,921

G

hydroxysteroid dehydrogenase like 2

increases expression

EXP

leflunomide results in increased expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

heat shock transcription factor 5

decreases expression

ISO

leflunomide results in decreased expression of HSF5 mRNA

NCBI chr10:72,913,730...72,957,649
Ensembl chr10:72,914,382...72,957,648

G

heat shock protein 90 alpha family class A member 1

increases expression

EXP

leflunomide results in increased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

increases expression

EXP

leflunomide results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 12A

increases expression

ISO

leflunomide results in increased expression of HSPA12A mRNA

NCBI chr 1:267,921,780...268,083,171
Ensembl chr 1:267,921,782...268,082,794

G

heat shock protein family A (Hsp70) member 1A

decreases expression

ISO

leflunomide results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

affects expression

ISO

leflunomide affects the expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 4 like

increases expression

ISO

leflunomide results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

ISO

Leflunomide results in increased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

leflunomide results in decreased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 1

increases expression

EXP

leflunomide results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family B (small) member 6

decreases expression

ISO

leflunomide results in decreased expression of HSPB6 mRNA

NCBI chr 1:94,934,372...94,936,516
Ensembl chr 1:94,933,543...94,936,512

G

HSPB1 associated protein 1

increases expression

ISO

leflunomide results in increased expression of HSPBAP1 mRNA

NCBI chr11:78,445,376...78,500,034
Ensembl chr11:78,445,376...78,500,034

G

heat shock protein family E (Hsp10) member 1

decreases expression

ISO

leflunomide results in decreased expression of HSPE1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

heat shock protein family H (Hsp110) member 1

increases expression

EXP

leflunomide results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

HIV-1 Tat specific factor 1

decreases expression

EXP

leflunomide results in decreased expression of HTATSF1 mRNA

NCBI chr X:139,972,742...139,986,923
Ensembl chr X:139,972,742...139,986,923

G

hyccin PI4KA lipid kinase complex subunit 2

increases expression

ISO

Leflunomide results in increased expression of HYCC2 mRNA

NCBI chr 9:67,551,064...67,623,353
Ensembl chr 9:67,551,064...67,587,186

G

HYLS1, centriolar and ciliogenesis associated

decreases expression

EXP

leflunomide results in decreased expression of HYLS1 mRNA

NCBI chr 8:42,170,505...42,179,573
Ensembl chr 8:42,168,546...42,179,725

G

isoleucyl-tRNA synthetase 2, mitochondrial

increases expression

EXP

leflunomide results in increased expression of IARS2 mRNA

NCBI chr13:99,363,035...99,397,068
Ensembl chr13:99,362,696...99,397,068

G

intercellular adhesion molecule 1

decreases expression

EXP

leflunomide results in decreased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

isoprenylcysteine carboxyl methyltransferase

increases expression

EXP

leflunomide results in increased expression of ICMT mRNA

NCBI chr 5:168,084,487...168,097,519
Ensembl chr 5:168,086,057...168,093,094

G

inducible T-cell co-stimulator ligand

increases expression

ISO

leflunomide results in increased expression of ICOSLG mRNA

NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,078...10,610,365

G

inhibitor of DNA binding 1

increases expression

EXP
ISO

leflunomide results in increased expression of ID1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 2

increases expression

ISO

leflunomide results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of DNA binding 3

increases expression

ISO

leflunomide results in increased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

inhibitor of DNA binding 4

decreases expression

ISO

leflunomide results in decreased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

insulin degrading enzyme

increases expression

EXP

leflunomide results in increased expression of IDE mRNA

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526

G

isocitrate dehydrogenase (NADP(+)) 1

decreases expression

ISO

leflunomide results in decreased expression of IDH1 mRNA

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

leflunomide results in decreased expression of IDI1 mRNA

PMID:19751817 PMID:28988120

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

immediate early response 2

increases expression

ISO

leflunomide results in increased expression of IER2 mRNA

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:40,398,160...40,402,708

G

immediate early response 3

increases expression

ISO

leflunomide results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

immediate early response 5

affects expression

ISO

leflunomide affects the expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

interferon gamma

multiple interactions

ISO

leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 1

increases expression

ISO

leflunomide results in increased expression of IFNGR1 mRNA

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

interferon, lambda receptor 1

increases expression

ISO

leflunomide results in increased expression of IFNLR1 mRNA

NCBI chr 5:153,203,597...153,225,911
Ensembl chr 5:153,203,597...153,225,911

G

intraflagellar transport 20

decreases expression

ISO

leflunomide results in decreased expression of IFT20 mRNA

NCBI chr10:63,930,629...63,936,174
Ensembl chr10:63,930,681...63,936,172

G

intraflagellar transport 25

decreases expression

ISO

Leflunomide results in decreased expression of IFT25 mRNA

NCBI chr 5:127,264,450...127,291,225
Ensembl chr 5:127,264,498...127,291,225

G

intraflagellar transport 46

decreases expression

ISO

leflunomide results in decreased expression of IFT46 mRNA

NCBI chr 8:53,975,085...54,000,837
Ensembl chr 8:53,984,242...54,000,836

G

insulin-like growth factor 1

increases expression

ISO

leflunomide results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

EXP

leflunomide results in decreased expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 1

increases expression

EXP
ISO

leflunomide results in increased expression of IGFBP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

increases expression

EXP

leflunomide results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 3

increases expression

ISO

leflunomide results in increased expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

insulin-like growth factor binding protein 4

increases expression

ISO

leflunomide results in increased expression of IGFBP4 mRNA

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

IgA-inducing protein

decreases expression

ISO

leflunomide results in decreased expression of IGIP mRNA

NCBI chr18:28,178,048...28,179,539

G

immunoglobulin superfamily, member 11

increases expression

EXP

leflunomide results in increased expression of IGSF11 mRNA

NCBI chr11:75,238,706...75,389,748
Ensembl chr11:75,236,545...75,390,425

G

immunoglobulin superfamily, member 3

decreases expression

ISO

leflunomide results in decreased expression of IGSF3 mRNA

NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:191,500,045...191,588,249

G

interleukin 10

multiple interactions

ISO

[leflunomide co-treated with COL2A1 protein] results in increased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 11

increases expression

ISO

leflunomide results in increased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 13

multiple interactions

ISO

leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 17A

multiple interactions

ISO

leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17D

decreases expression

ISO

leflunomide results in decreased expression of IL17D mRNA

NCBI chr15:35,786,898...35,804,391
Ensembl chr15:35,786,898...35,804,391

G

interleukin 18 binding protein

decreases expression

ISO

leflunomide results in decreased expression of IL18BP mRNA

NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:165,784,069...165,786,955

G

interleukin 1 beta

multiple interactions

ISO

leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]

PMID:16393772 PMID:26640276

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

increases expression

EXP

leflunomide results in increased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 1 receptor accessory protein

increases expression

EXP

leflunomide results in increased expression of IL1RAP mRNA

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342

G

interleukin 1 receptor antagonist

increases expression

ISO

leflunomide results in increased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 33

decreases expression

EXP

leflunomide results in decreased expression of IL33 mRNA

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901

G

interleukin 4

multiple interactions

ISO

leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]; leflunomide inhibits the reaction [IL4 protein results in increased expression of CCL26 protein]
leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein]; leflunomide inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]; leflunomide promotes the reaction [IL4 protein results in increased expression of TNF mRNA]

PMID:16045735 PMID:21775527 PMID:26091108 PMID:26699812

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 receptor

increases expression

EXP

leflunomide results in increased expression of IL4RA mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 6

multiple interactions

ISO

leflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases expression

EXP

leflunomide results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

increases expression

ISO

leflunomide results in increased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

immunoglobulin-like domain containing receptor 2

decreases expression

ISO

leflunomide results in decreased expression of ILDR2 mRNA

NCBI chr13:81,051,723...81,113,590
Ensembl chr13:81,051,647...81,109,861

G

ilvB acetolactate synthase like

increases expression

EXP

Leflunomide results in increased expression of ILVBL mRNA

NCBI chr 7:11,690,445...11,700,498
Ensembl chr 7:11,690,445...11,700,498

G

IMP U3 small nucleolar ribonucleoprotein 3

decreases expression

ISO

leflunomide results in decreased expression of IMP3 mRNA

NCBI chr 8:66,235,498...66,236,386

G

inositol monophosphatase 2

increases expression

EXP

leflunomide results in increased expression of IMPA2 mRNA

NCBI chr18:63,104,113...63,135,232
Ensembl chr18:63,104,083...63,137,543

G

impact RWD domain protein

increases expression

EXP

leflunomide results in increased expression of IMPACT mRNA

NCBI chr18:4,383,546...4,422,280
Ensembl chr18:4,383,575...4,422,278

G

innate immunity activator

increases expression

ISO

leflunomide results in increased expression of INAVA mRNA

NCBI chr13:50,218,149...50,238,430
Ensembl chr13:50,218,150...50,238,454

G

inner centromere protein

decreases expression

ISO

leflunomide results in decreased expression of INCENP mRNA

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:215,948,283...215,977,084

G

inhibitor of growth family, member 4

decreases expression

ISO

leflunomide results in decreased expression of ING4 mRNA

NCBI chr 4:159,528,183...159,536,762
Ensembl chr 4:159,528,189...159,536,761

G

inhibin subunit beta B

increases expression

ISO

leflunomide results in increased expression of INHBB mRNA

NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609

G

inhibin subunit beta E

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of INHBE mRNA
leflunomide results in increased expression of INHBE mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

INO80 complex subunit C

increases expression

EXP

leflunomide results in increased expression of INO80C mRNA

NCBI chr18:15,653,508...15,752,455
Ensembl chr18:15,653,511...15,668,144

G

inositol polyphosphate-1-phosphatase

increases expression

ISO

leflunomide results in increased expression of INPP1 mRNA

NCBI chr 9:56,161,816...56,209,774
Ensembl chr 9:56,161,852...56,234,569

G

insulin induced gene 1

increases expression

EXP

leflunomide results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

insulin receptor

increases expression

EXP

leflunomide results in increased expression of INSR mRNA

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

integrator complex subunit 12

decreases expression

ISO

leflunomide results in decreased expression of INTS12 mRNA

NCBI chr 2:224,265,787...224,283,523
Ensembl chr 2:224,265,736...224,283,516

G

integrator complex subunit 3

decreases expression

ISO

leflunomide results in decreased expression of INTS3 mRNA

NCBI chr 2:178,157,015...178,209,263
Ensembl chr 2:178,157,015...178,209,137

G

integrator complex subunit 5

decreases expression

ISO

leflunomide results in decreased expression of INTS5 mRNA

NCBI chr 1:215,218,012...215,222,790
Ensembl chr 1:215,218,017...215,223,240

G

integrator complex subunit 6

decreases expression

ISO

leflunomide results in decreased expression of INTS6 mRNA

NCBI chr15:41,080,584...41,224,350
Ensembl chr15:41,109,125...41,197,519

G

inositol hexakisphosphate kinase 2

increases expression

EXP

leflunomide results in increased expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667

G

inositol polyphosphate multikinase

increases expression

ISO

leflunomide results in increased expression of IPMK mRNA

NCBI chr20:17,216,151...17,250,826
Ensembl chr20:17,216,151...17,250,757

G

intracisternal A particle-promoted polypeptide

decreases expression

ISO

leflunomide results in decreased expression of IPP mRNA

NCBI chr 5:135,199,198...135,237,912
Ensembl chr 5:135,180,109...135,238,000

G

IQ motif containing C

decreases expression

ISO

leflunomide results in decreased expression of IQCC mRNA

NCBI chr 5:147,242,221...147,246,453
Ensembl chr 5:147,242,221...147,246,453

G

IQ motif containing D

increases expression

ISO

Leflunomide results in increased expression of DRC10 mRNA

NCBI chr12:41,616,107...41,633,244
Ensembl chr12:41,616,107...41,623,352

G

IQ motif containing H

increases expression

ISO

leflunomide results in increased expression of IQCH mRNA

NCBI chr 8:72,784,932...72,978,632
Ensembl chr 8:72,787,756...72,978,598

G

IQ motif containing GTPase activating protein 3

decreases expression

ISO

leflunomide results in decreased expression of IQGAP3 mRNA

NCBI chr 2:175,840,001...175,881,799
Ensembl chr 2:175,839,949...175,881,797

G

interleukin-1 receptor-associated kinase 1

increases expression

EXP

leflunomide results in increased expression of IRAK1 mRNA

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 2

increases expression

ISO

leflunomide results in increased expression of IRAK2 mRNA

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

interferon regulatory factor 1

increases expression

ISO

leflunomide results in increased expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

interferon regulatory factor 2 binding protein 2

increases expression

ISO

leflunomide results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

interferon regulatory factor 2 binding protein-like

increases expression

ISO

leflunomide results in increased expression of IRF2BPL mRNA

NCBI chr 6:112,258,149...112,262,264
Ensembl chr 6:112,258,188...112,263,280

G

immunity-related GTPase Q

decreases expression

ISO

leflunomide results in decreased expression of IRGQ mRNA

NCBI chr 1:89,251,846...89,259,799
Ensembl chr 1:89,239,205...89,259,799

G

insulin receptor substrate 1

decreases expression
increases expression

ISO

leflunomide results in decreased expression of IRS1 mRNA
leflunomide results in increased expression of IRS1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

insulin receptor substrate 2

increases expression

EXP

leflunomide results in increased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

isthmin 1

increases expression

ISO

leflunomide results in increased expression of ISM1 mRNA

NCBI chr 3:147,476,983...147,555,900
Ensembl chr 3:147,475,533...147,555,908

G

integrin subunit alpha 1

increases expression

ISO

leflunomide results in increased expression of ITGA1 mRNA

NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:48,386,249...48,545,284

G

integrin subunit alpha 2

increases expression

ISO

leflunomide results in increased expression of ITGA2 mRNA

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

integrin subunit alpha 4

decreases expression

ISO

leflunomide results in decreased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

ISO

leflunomide results in increased expression of ITPR3 mRNA

NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184

G

ITPR interacting domain containing 2

increases expression

ISO

leflunomide results in increased expression of ITPRID2 mRNA

NCBI chr 3:84,943,572...84,980,993
Ensembl chr 3:84,939,808...84,980,899

G

inositol 1,4,5-trisphosphate receptor interacting protein

increases expression

ISO

leflunomide results in increased expression of ITPRIP mRNA

NCBI chr 1:256,704,087...256,727,661
Ensembl chr 1:256,699,832...256,727,644

G

ITPRIP like 1

decreases expression

ISO

leflunomide results in decreased expression of ITPRIPL1 mRNA

NCBI chr 3:134,858,316...134,861,241
Ensembl chr 3:134,854,417...134,868,960

G

ITPRIP like 2

increases expression

ISO

leflunomide results in increased expression of ITPRIPL2 mRNA

NCBI chr 1:182,235,361...182,237,256
Ensembl chr 1:182,231,093...182,245,858

G

jagged canonical Notch ligand 1

increases expression

ISO

leflunomide results in increased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

jagunal homolog 1

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of JAGN1 mRNA
leflunomide results in decreased expression of JAGN1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:148,147,229...148,151,915

G

junction adhesion molecule like

increases expression

ISO

leflunomide results in increased expression of JAML mRNA

NCBI chr 8:54,281,596...54,313,655
Ensembl chr 8:54,281,644...54,313,500

G

joining chain of multimeric IgA and IgM

decreases expression

ISO

leflunomide results in decreased expression of JCHAIN mRNA

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

ISO

leflunomide results in increased expression of JMJD6 mRNA

NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986

G

Josephin domain containing 1

increases expression

EXP

leflunomide results in increased expression of JOSD1 mRNA

NCBI chr 7:113,110,709...113,124,632
Ensembl chr 7:113,110,717...113,124,632

G

Jrk helix-turn-helix protein

decreases expression

ISO

leflunomide results in decreased expression of JRK mRNA

NCBI chr 7:108,479,646...108,484,329
Ensembl chr 7:108,453,398...108,495,813

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
increases phosphorylation

ISO

leflunomide results in increased expression of JUN mRNA
pyrazolanthrone inhibits the reaction [leflunomide results in increased phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

leflunomide results in increased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

leflunomide results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

kalirin, RhoGEF kinase

increases expression

ISO

leflunomide results in increased expression of KALRN mRNA

NCBI chr11:79,703,345...80,309,210
Ensembl chr11:79,703,366...80,133,329

G

kelch repeat and BTB domain containing 2

increases expression

ISO

leflunomide results in increased expression of KBTBD2 mRNA

NCBI chr 4:87,358,133...87,380,399
Ensembl chr 4:87,358,133...87,380,399

G

kelch repeat and BTB domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of KBTBD4 mRNA

NCBI chr 3:97,339,500...97,345,599
Ensembl chr 3:97,339,084...97,345,598

G

kelch repeat and BTB domain containing 6

decreases expression

ISO

leflunomide results in decreased expression of KBTBD6 mRNA

NCBI chr15:61,257,360...61,259,117

G

potassium channel modulatory factor 1

increases expression

ISO

leflunomide results in increased expression of KCMF1 mRNA

NCBI chr 4:106,447,974...106,508,359
Ensembl chr 4:106,447,981...106,508,359

G

potassium voltage-gated channel subfamily E regulatory subunit 3

decreases expression
increases expression

ISO

leflunomide results in decreased expression of KCNE3 mRNA
leflunomide results in increased expression of KCNE3 mRNA

PMID:19751817 PMID:28988120

NCBI chr 1:163,936,035...163,942,998
Ensembl chr 1:163,935,991...163,950,162

G

potassium voltage-gated channel modifier subfamily G member 3

increases expression

ISO

leflunomide results in increased expression of KCNG3 mRNA

NCBI chr 6:16,803,842...16,851,791
Ensembl chr 6:16,803,665...16,851,791

G

potassium inwardly-rectifying channel, subfamily J, member 15

increases expression

ISO

leflunomide results in increased expression of KCNJ15 mRNA

NCBI chr11:48,046,953...48,091,285
Ensembl chr11:48,035,655...48,092,457

G

potassium channel tetramerization domain containing 13

increases expression

ISO

leflunomide results in increased expression of KCTD13 mRNA

NCBI chr 1:190,965,073...190,983,381
Ensembl chr 1:190,965,075...190,985,419

G

potassium channel tetramerization domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of KCTD2 mRNA

NCBI chr10:101,162,091...101,173,721
Ensembl chr10:101,162,091...101,173,721

G

potassium channel tetramerization domain containing 7

decreases expression

ISO

leflunomide results in decreased expression of KCTD7 mRNA

NCBI chr12:32,157,141...32,168,463
Ensembl chr12:32,159,297...32,168,292

G

lysine demethylase 3A

increases expression

ISO

leflunomide results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

lysine demethylase 4A

decreases expression

ISO

leflunomide results in decreased expression of KDM4A mRNA

NCBI chr 5:136,958,178...137,004,942
Ensembl chr 5:136,958,178...137,004,951

G

lysine demethylase 5A

increases expression

ISO

leflunomide results in increased expression of KDM5A mRNA

NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121

G

lysine demethylase 6A

increases expression

ISO

leflunomide results in increased expression of KDM6A mRNA

NCBI chr X:6,920,374...7,060,027
Ensembl chr X:6,920,343...7,059,960

G

lysine demethylase 6B

multiple interactions
increases expression

ISO

leflunomide inhibits the reaction [Asbestos, Serpentine results in increased expression of KDM6B mRNA]
leflunomide results in increased expression of KDM6B mRNA

PMID:26699812 PMID:28988120

NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,619,544...54,629,610

G

lysine demethylase 7A

increases expression

ISO

leflunomide results in increased expression of KDM7A mRNA

NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:68,871,677...68,931,506

G

lysine demethylase 8

decreases expression

ISO

leflunomide results in decreased expression of KDM8 mRNA

NCBI chr 1:189,444,527...189,459,507
Ensembl chr 1:189,444,555...189,459,491

G

Kelch-like ECH-associated protein 1

increases expression

EXP

leflunomide results in increased expression of KEAP1 mRNA

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

KH domain containing 4, pre-mRNA splicing factor

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of KHDC4 mRNA
leflunomide results in decreased expression of KHDC4 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:176,446,895...176,475,405
Ensembl chr 2:176,446,910...176,475,392

G

KH RNA binding domain containing, signal transduction associated 3

increases expression

ISO

leflunomide results in increased expression of KHDRBS3 mRNA

NCBI chr 7:102,726,628...102,884,545
Ensembl chr 7:102,726,843...102,884,541

G

ketohexokinase

decreases expression

EXP

leflunomide results in decreased expression of KHK mRNA

NCBI chr 6:31,165,246...31,175,779
Ensembl chr 6:31,165,248...31,175,481

G

KIAA0232 homolog

decreases expression

ISO

leflunomide results in decreased expression of KIAA0232 mRNA

NCBI chr14:78,318,660...78,384,012
Ensembl chr14:78,319,105...78,384,014

G

KICSTOR subunit 2

increases expression

ISO

Leflunomide results in increased expression of KICS2 mRNA

NCBI chr 7:59,169,703...59,182,974
Ensembl chr 7:59,169,543...59,184,551

G

kinesin family member 11

decreases expression

ISO

leflunomide results in decreased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 14

decreases expression

ISO

leflunomide results in decreased expression of KIF14 mRNA

NCBI chr13:50,478,646...50,542,256
Ensembl chr13:50,478,721...50,542,248

G

kinesin family member 18A

decreases expression

ISO

leflunomide results in decreased expression of KIF18A mRNA

NCBI chr 3:116,219,007...116,279,378
Ensembl chr 3:116,219,007...116,279,227

G

kinesin family member 18B

decreases expression

ISO

leflunomide results in decreased expression of KIF18B mRNA

NCBI chr10:88,370,520...88,392,388
Ensembl chr10:88,370,524...88,389,691

G

kinesin family member 20A

decreases expression

EXP
ISO

leflunomide results in decreased expression of KIF20A mRNA

PMID:24136188 PMID:28988120

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 20B

decreases expression

ISO

leflunomide results in decreased expression of KIF20B mRNA

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:241,840,987...241,896,451

G

kinesin family member 23

decreases expression

ISO

leflunomide results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kinesin family member 2C

decreases expression

ISO

leflunomide results in decreased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

kinesin family member 9

decreases expression

ISO

leflunomide results in decreased expression of KIF9 mRNA

NCBI chr 8:119,338,014...119,406,632
Ensembl chr 8:119,338,088...119,383,137

G

kinesin family member C1

decreases expression

ISO

leflunomide results in decreased expression of KIFC1 mRNA

NCBI chr20:5,000,929...5,018,967
Ensembl chr20:5,000,648...5,018,988

G

klotho beta

decreases expression

ISO

leflunomide results in decreased expression of KLB mRNA

NCBI chr14:43,253,963...43,304,532
Ensembl chr14:43,253,255...43,304,515

G

kinesin light chain 4

decreases expression

ISO

leflunomide results in decreased expression of KLC4 mRNA

NCBI chr 9:21,834,765...21,848,676
Ensembl chr 9:21,835,092...21,848,675

G

KLF transcription factor 10

increases expression

ISO

leflunomide results in increased expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 11

increases expression

ISO

leflunomide results in increased expression of KLF11 mRNA

NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:47,014,326...47,037,044

G

KLF transcription factor 12

decreases expression

ISO

leflunomide results in decreased expression of KLF12 mRNA

NCBI chr15:83,037,548...83,469,998
Ensembl chr15:83,045,463...83,670,640

G

KLF transcription factor 15

increases expression

EXP

leflunomide results in increased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

KLF transcription factor 3

increases expression

ISO

leflunomide results in increased expression of KLF3 mRNA

NCBI chr14:43,828,387...43,859,418
Ensembl chr14:43,828,387...43,850,826

G

KLF transcription factor 5

increases expression

ISO

leflunomide results in increased expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

KLF transcription factor 6

increases expression

ISO

leflunomide results in increased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

KLF transcription factor 7

increases expression

ISO

Leflunomide results in increased expression of KLF7 mRNA

NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056

G

KLF transcription factor 9

increases expression

ISO

leflunomide results in increased expression of KLF9 mRNA

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641

G

kelch domain containing 1

increases expression

ISO

leflunomide results in increased expression of KLHDC1 mRNA

NCBI chr 6:93,406,226...93,501,475
Ensembl chr 6:93,448,758...93,501,702

G

kelch domain containing 7A

decreases expression

ISO

leflunomide results in decreased expression of KLHDC7A mRNA

NCBI chr 5:157,501,740...157,507,843
Ensembl chr 5:157,485,191...157,507,954

G

kelch-like family member 14

decreases expression

ISO

leflunomide results in decreased expression of KLHL14 mRNA

NCBI chr18:13,079,159...13,192,728
Ensembl chr18:13,079,159...13,193,557

G

kelch-like family member 21

increases expression

ISO

leflunomide results in increased expression of KLHL21 mRNA

NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:167,797,591...167,806,276

G

kelch-like family member 40

decreases expression

ISO

leflunomide results in decreased expression of KLHL40 mRNA

NCBI chr 8:130,318,793...130,324,309
Ensembl chr 8:130,318,794...130,326,299

G

kelch-like family member 41

decreases expression

ISO

leflunomide results in decreased expression of KLHL41 mRNA

NCBI chr 3:74,842,118...74,855,244

G

kelch-like family member 5

increases expression

ISO

leflunomide results in increased expression of KLHL5 mRNA

NCBI chr14:43,497,915...43,565,833
Ensembl chr14:43,497,918...43,537,894

G

killer cell lectin like receptor G1

decreases expression

EXP

leflunomide results in decreased expression of KLRG1 mRNA

NCBI chr 4:157,127,571...157,139,372
Ensembl chr 4:157,127,571...157,139,372

G

lysine methyltransferase 2E

increases expression

ISO

leflunomide results in increased expression of KMT2E mRNA

NCBI chr 4:12,550,570...12,655,329
Ensembl chr 4:12,550,570...12,619,721

G

kinetochore scaffold 1

decreases expression

ISO

Leflunomide results in decreased expression of KNL1 mRNA

NCBI chr 3:126,483,498...126,545,774
Ensembl chr 3:126,483,544...126,545,774

G

lysine-rich nucleolar protein 1

decreases expression

ISO

leflunomide results in decreased expression of KNOP1 mRNA

NCBI chr 1:182,611,758...182,630,610
Ensembl chr 1:182,611,758...182,630,901

G

kinetochore-localized astrin/SPAG5 binding protein

decreases expression

ISO

leflunomide results in decreased expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418

G

karyopherin subunit alpha 2

decreases expression

EXP
ISO

leflunomide results in decreased expression of KPNA2 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:92,433,679...92,445,937

G

karyopherin subunit alpha 5

increases expression

ISO

leflunomide results in increased expression of KPNA5 mRNA

NCBI chr20:31,365,647...31,430,793
Ensembl chr20:31,365,656...31,430,792

G

lysine-rich coiled-coil 1

increases expression

ISO

leflunomide results in increased expression of KRCC1 mRNA

NCBI chr 4:104,819,958...104,832,987
Ensembl chr 4:104,819,190...104,855,484

G

keratin 17

increases expression

ISO

leflunomide results in increased expression of KRT17 mRNA

NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787

G

keratin 31

increases expression

ISO

leflunomide results in increased expression of KRT31 mRNA

NCBI chr10:85,479,533...85,483,300
Ensembl chr10:85,479,796...85,483,300

G

kinase suppressor of ras 1

increases expression

ISO

leflunomide results in increased expression of KSR1 mRNA

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082

G

kynurenine aminotransferase 1

increases expression

EXP

leflunomide results in increased expression of KYAT1 mRNA

NCBI chr 3:33,857,407...33,891,153
Ensembl chr 3:33,857,743...33,890,642

G

trans-L-3-hydroxyproline dehydratase

decreases expression

EXP

leflunomide results in decreased expression of L3HYPDH mRNA

NCBI chr 6:96,372,243...96,383,039

G

L3MBTL histone methyl-lysine binding protein 4

increases expression

ISO

leflunomide results in increased expression of L3MBTL4 mRNA

NCBI chr 9:115,741,720...116,194,592
Ensembl chr 9:115,776,638...116,194,591

G

laminin subunit alpha 3

increases expression

EXP

leflunomide results in increased expression of LAMA3 mRNA

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

LanC like glutathione S-transferase 1

increases expression

EXP

leflunomide results in increased expression of LANCL1 mRNA

NCBI chr 9:75,968,284...75,998,397
Ensembl chr 9:75,968,286...76,003,475

G

linker for activation of T cells

decreases expression

ISO

leflunomide results in decreased expression of LAT mRNA

NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:190,367,109...190,372,153

G

large tumor suppressor kinase 1

increases expression

ISO

leflunomide results in increased expression of LATS1 mRNA

NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029

G

lipopolysaccharide binding protein

increases expression

EXP

leflunomide results in increased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

lamin B receptor

decreases expression

ISO

leflunomide results in decreased expression of LBR mRNA

NCBI chr13:96,071,058...96,095,709
Ensembl chr13:96,071,081...96,095,709

G

ladybird homeobox 2

decreases expression

ISO

leflunomide results in decreased expression of LBX2 mRNA

NCBI chr 4:117,149,690...117,151,575
Ensembl chr 4:117,149,690...117,151,575

G

lebercilin LCA5

increases expression

ISO

leflunomide results in increased expression of LCA5 mRNA

NCBI chr 8:93,187,735...93,255,060
Ensembl chr 8:93,197,702...93,254,991

G

lipocalin 10

increases expression

ISO

leflunomide results in increased expression of LCN10 mRNA

NCBI chr 3:28,888,901...28,892,454
Ensembl chr 3:28,888,860...28,892,453

G

ligand dependent nuclear receptor corepressor

increases expression

ISO

leflunomide results in increased expression of LCOR mRNA

NCBI chr 1:250,247,965...250,354,985
Ensembl chr 1:250,247,934...250,354,985

G

lipid droplet assembly factor 1

decreases expression

ISO

Leflunomide results in decreased expression of LDAF1 mRNA

NCBI chr 1:183,915,919...183,934,374
Ensembl chr 1:183,849,812...183,934,666

G

lactate dehydrogenase D

decreases expression

EXP
ISO

leflunomide results in decreased expression of LDHD mRNA

PMID:24136188 PMID:28988120

NCBI chr19:56,492,827...56,497,695
Ensembl chr19:56,482,924...56,509,197

G

low density lipoprotein receptor

decreases expression
increases expression

ISO

leflunomide results in decreased expression of LDLR mRNA
leflunomide results in increased expression of LDLR mRNA

PMID:19751817 PMID:28988120

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

low density lipoprotein receptor class A domain containing 4

increases expression

ISO

leflunomide results in increased expression of LDLRAD4 mRNA

NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064

G

liver enriched antimicrobial peptide 2

increases expression

ISO

Leflunomide results in increased expression of LEAP2 mRNA

NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073

G

leukocyte cell-derived chemotaxin 2

increases expression

EXP

leflunomide results in increased expression of LECT2 mRNA

NCBI chr17:8,050,034...8,056,256
Ensembl chr17:8,050,034...8,056,256

G

lens epithelial protein

decreases expression

ISO

leflunomide results in decreased expression of LENEP mRNA

NCBI chr 2:177,117,171...177,117,859
Ensembl chr 2:177,117,171...177,117,859

G

leukocyte receptor cluster member 8

decreases expression

EXP

leflunomide results in decreased expression of LENG8 mRNA

NCBI chr 1:79,113,038...79,124,868
Ensembl chr 1:79,113,038...79,124,738

G

leptin receptor overlapping transcript-like 1

increases expression

EXP
ISO

leflunomide results in increased expression of LEPROTL1 mRNA

PMID:24136188 PMID:28988120

NCBI chr16:64,744,148...64,756,776
Ensembl chr16:64,743,717...64,756,776

G

leucine zipper and EF-hand containing transmembrane protein 2

increases expression

ISO

leflunomide results in increased expression of LETM2 mRNA

NCBI chr16:73,171,768...73,192,336
Ensembl chr16:73,167,727...73,192,373

G

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

decreases expression

ISO

leflunomide results in decreased expression of LFNG mRNA

NCBI chr12:19,144,474...19,152,951
Ensembl chr12:19,124,662...19,152,918

G

galectin 3

increases expression

ISO

leflunomide results in increased expression of LGALS3 mRNA

PMID:28988120 PMID:29427785

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737

G

galectin 8

increases expression

EXP

leflunomide results in increased expression of LGALS8 mRNA

NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482

G

leucine-rich repeat-containing G protein-coupled receptor 4

decreases expression

ISO

leflunomide results in decreased expression of LGR4 mRNA

NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:116,901,968...117,004,153

G

leucine rich repeat containing G protein coupled receptor 5

increases expression

ISO

leflunomide results in increased expression of LGR5 mRNA

NCBI chr 7:52,973,151...53,107,964
Ensembl chr 7:52,974,332...53,108,163

G

LHFPL tetraspan subfamily member 3

increases expression

ISO

leflunomide results in increased expression of LHFPL3 mRNA

G

LIM homeobox 8

increases expression

ISO

leflunomide results in increased expression of LHX8 mRNA

NCBI chr 2:245,904,712...245,929,376
Ensembl chr 2:245,904,712...245,929,376

G

LIF, interleukin 6 family cytokine

increases expression

ISO

leflunomide results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

LIM domain kinase 2

increases expression

EXP
ISO

leflunomide results in increased expression of LIMK2 mRNA

PMID:24136188 PMID:28988120

NCBI chr14:82,384,256...82,509,755
Ensembl chr14:82,435,480...82,509,644

G

lin-37 DREAM MuvB core complex component

increases expression

EXP

leflunomide results in increased expression of LIN37 mRNA

NCBI chr 1:94,936,512...94,940,444
Ensembl chr 1:94,936,512...94,940,444

G

lin-54 DREAM MuvB core complex component

increases expression

ISO

leflunomide results in increased expression of LIN54 mRNA

NCBI chr14:9,434,093...9,514,091
Ensembl chr14:9,434,112...9,492,106

G

lin-7 homolog A, crumbs cell polarity complex component

increases expression

ISO

leflunomide results in increased expression of LIN7A mRNA

NCBI chr 7:44,473,568...44,629,074
Ensembl chr 7:44,473,347...44,625,208

G

leucine rich repeat and Ig domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of LINGO2 mRNA

NCBI chr 5:55,166,250...56,488,672
Ensembl chr 5:55,156,997...56,489,155

G

leucine rich repeat and Ig domain containing 4

increases expression

ISO

leflunomide results in increased expression of LINGO4 mRNA

NCBI chr 2:184,724,554...184,729,819
Ensembl chr 2:184,724,554...184,729,819

G

lines homolog 1

increases expression

ISO

leflunomide results in increased expression of LINS1 mRNA

NCBI chr 1:129,677,815...129,705,399
Ensembl chr 1:129,692,225...129,703,826

G

lipase G, endothelial type

increases expression

ISO

leflunomide results in increased expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

limb and CNS expressed 1 like

decreases expression

ISO

leflunomide results in decreased expression of LIX1L mRNA

NCBI chr 2:186,824,864...186,850,761
Ensembl chr 2:186,824,884...186,850,759

G

LLP homolog, long-term synaptic facilitation factor

decreases expression

ISO

leflunomide results in decreased expression of LLPH mRNA

NCBI chr 7:57,620,925...57,625,924
Ensembl chr 7:57,620,993...57,625,925

G

lectin, mannose-binding 2-like

increases expression

EXP

Leflunomide results in increased expression of LMAN2L mRNA

NCBI chr 9:46,157,596...46,181,151
Ensembl chr 9:46,157,596...46,181,207

G

lamin A/C

increases expression

EXP

leflunomide results in increased expression of LMNA mRNA

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

lamin B1

decreases expression

ISO

leflunomide results in decreased expression of LMNB1 mRNA

NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283

G

LIM domain only 4

increases expression

ISO

leflunomide results in increased expression of LMO4 mRNA

NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:235,924,403...235,941,275

G

lemur tyrosine kinase 2

increases expression

ISO

leflunomide results in increased expression of LMTK2 mRNA

NCBI chr12:15,540,428...15,622,392
Ensembl chr12:15,540,428...15,622,392

G

ligand of numb-protein X 2

increases expression

ISO

leflunomide results in increased expression of LNX2 mRNA

NCBI chr12:13,119,139...13,184,401
Ensembl chr12:13,119,139...13,184,401

G

zinc finger protein 709-like

increases expression

ISO

Leflunomide results in increased expression of ZNF136 mRNA

NCBI chr 7:12,496,595...12,519,259
Ensembl chr 7:12,504,501...12,519,295

G

small nucleolar RNA SNORA13

decreases expression

ISO

Leflunomide results in decreased expression of SNORA13 mRNA

NCBI chr18:25,678,566...25,678,699
Ensembl chr18:25,678,566...25,678,699

G

uncharacterized LOC130046242

increases expression

ISO

Leflunomide results in increased expression of ZNF57 mRNA

NCBI chr 7:8,663,437...8,669,068
Ensembl chr 7:8,663,217...8,667,271

G

LON peptidase N-terminal domain and ring finger 1

decreases expression

ISO

leflunomide results in decreased expression of LONRF1 mRNA

NCBI chr16:62,687,931...62,718,525
Ensembl chr16:62,687,746...62,718,520

G

LON peptidase N-terminal domain and ring finger 3

increases expression

ISO

leflunomide results in increased expression of LONRF3 mRNA

NCBI chr X:120,430,975...120,469,648
Ensembl chr X:120,430,996...120,464,572

G

lysyl oxidase-like 1

decreases expression

ISO

leflunomide results in decreased expression of LOXL1 mRNA

NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224

G

lysophosphatidic acid receptor 5

increases expression

ISO

leflunomide results in increased expression of LPAR5 mRNA

NCBI chr 4:159,556,735...159,570,216
Ensembl chr 4:159,554,805...159,571,894

G

lysophosphatidylcholine acyltransferase 3

increases expression

EXP

leflunomide results in increased expression of LPCAT3 mRNA

NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:159,154,158...159,196,358

G

lipin 1

increases expression

EXP

leflunomide results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lipin 3

decreases expression

ISO

leflunomide results in decreased expression of LPIN3 mRNA

NCBI chr 3:169,953,479...169,978,034
Ensembl chr 3:169,960,522...169,978,031

G

lipoprotein lipase

increases expression

EXP

leflunomide results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LIM domain containing preferred translocation partner in lipoma

increases expression

ISO

leflunomide results in increased expression of LPP mRNA

NCBI chr11:89,292,060...89,933,973
Ensembl chr11:89,305,187...89,805,264

G

leupaxin

increases expression

ISO

leflunomide results in increased expression of LPXN mRNA

NCBI chr 1:219,353,319...219,387,743
Ensembl chr 1:219,353,708...219,387,742

G

leucine rich repeats and calponin homology domain containing 1

increases expression

ISO

leflunomide results in increased expression of LRCH1 mRNA

NCBI chr15:56,469,403...56,659,201
Ensembl chr15:56,481,395...56,659,100

G

leucine rich repeat and fibronectin type III domain containing 5

increases expression

ISO

leflunomide results in increased expression of LRFN5 mRNA

NCBI chr 6:85,201,465...85,557,872
Ensembl chr 6:85,201,364...85,558,539

G

leucine-rich repeats and immunoglobulin-like domains 2

increases expression

ISO

leflunomide results in increased expression of LRIG2 mRNA

NCBI chr 2:194,635,686...194,705,014
Ensembl chr 2:194,638,182...194,700,940

G

leucine-rich repeats and immunoglobulin-like domains 3

increases expression

ISO

leflunomide results in increased expression of LRIG3 mRNA

NCBI chr 7:63,701,724...63,751,898
Ensembl chr 7:63,701,778...63,752,261

G

LDL receptor related protein 11

increases expression

ISO

leflunomide results in increased expression of LRP11 mRNA

NCBI chr 1:3,868,665...3,928,513
Ensembl chr 1:3,899,985...3,928,507

G

LDL receptor related protein 4

increases expression

ISO

leflunomide results in increased expression of LRP4 mRNA

NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370

G

LDL receptor related protein 8

increases expression

ISO

leflunomide results in increased expression of LRP8 mRNA

NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:127,792,299...127,864,207

G

LDL receptor related protein associated protein 1

increases expression

EXP

leflunomide results in increased expression of LRPAP1 mRNA

NCBI chr14:79,876,002...79,888,011
Ensembl chr14:79,875,708...79,890,034

G

leucine rich repeat protein 1

decreases expression

ISO

leflunomide results in decreased expression of LRR1 mRNA

NCBI chr 6:93,379,159...93,387,950
Ensembl chr 6:93,379,169...93,387,950

G

leucine rich repeat containing 14

decreases expression

ISO

leflunomide results in decreased expression of LRRC14 mRNA

PMID:19751817 PMID:28988120

NCBI chr 7:110,311,384...110,317,757
Ensembl chr 7:110,311,369...110,317,760

G

leucine rich repeat containing 20

decreases expression

ISO

leflunomide results in decreased expression of LRRC20 mRNA

NCBI chr20:29,965,673...30,071,185
Ensembl chr20:29,972,001...30,071,184

G

leucine rich repeat containing 25

increases expression

ISO

leflunomide results in increased expression of LRRC25 mRNA

NCBI chr16:18,840,867...18,847,722
Ensembl chr16:18,840,867...18,846,464

G

leucine rich repeat containing 28

increases expression

EXP

leflunomide results in increased expression of LRRC28 mRNA

NCBI chr 1:130,526,757...130,655,991
Ensembl chr 1:130,537,930...130,655,949

G

leucine rich repeat containing 8 VRAC subunit A

increases expression

ISO

leflunomide results in increased expression of LRRC8A mRNA

NCBI chr 3:33,902,299...33,934,989
Ensembl chr 3:33,908,268...33,933,625

G

leucine rich repeat containing 8 VRAC subunit D

increases expression

ISO

leflunomide results in increased expression of LRRC8D mRNA

NCBI chr14:4,335,114...4,411,549
Ensembl chr14:4,332,130...4,445,639

G

LSM10, U7 small nuclear RNA associated

increases expression

EXP

leflunomide results in increased expression of LSM10 mRNA

NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:143,615,360...143,663,986

G

lymphotoxin beta

decreases expression

ISO

leflunomide results in decreased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054

G

lymphotoxin beta receptor

increases expression

EXP

leflunomide results in increased expression of LTBR mRNA

NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:159,795,115...159,807,296

G

LUC7 pre-mRNA splicing factor like 3

decreases expression

ISO

leflunomide results in decreased expression of LUC7L3 mRNA

NCBI chr10:79,737,457...79,773,478
Ensembl chr10:79,736,853...79,773,429

G

leucine rich adaptor protein 1-like

increases expression

ISO

leflunomide results in increased expression of LURAP1L mRNA

NCBI chr 5:100,402,921...100,455,479
Ensembl chr 5:100,407,483...100,455,478

G

lymphocyte antigen 6 family member G5B

decreases expression

ISO

leflunomide results in decreased expression of LY6G5B mRNA

NCBI chr20:3,710,132...3,712,193
Ensembl chr20:3,710,710...3,712,192

G

lymphocyte antigen 86

decreases expression

EXP

leflunomide results in decreased expression of LY86 mRNA

NCBI chr17:27,621,313...27,705,336
Ensembl chr17:27,621,313...27,692,743

G

LYN proto-oncogene, Src family tyrosine kinase

increases expression

EXP

leflunomide results in increased expression of LYN mRNA

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461

G

Ly6/Plaur domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of LYPD3 mRNA

NCBI chr 1:89,354,354...89,358,806
Ensembl chr 1:89,354,335...89,358,810

G

LysM domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of LYSMD4 mRNA

NCBI chr 1:130,249,340...130,255,357
Ensembl chr 1:130,249,479...130,255,357

G

mab-21 like 1

decreases expression

ISO

leflunomide results in decreased expression of MAB21L1 mRNA

NCBI chr 2:142,093,618...142,096,007
Ensembl chr 2:142,093,618...142,096,007

G

mab-21 like 3

increases expression

ISO

leflunomide results in increased expression of MAB21L3 mRNA

NCBI chr 2:191,937,451...191,960,204
Ensembl chr 2:191,937,451...191,960,204

G

macrophage immunometabolism regulator

increases expression

EXP

Leflunomide results in increased expression of MACIR mRNA

NCBI chr 9:105,868,072...105,888,128
Ensembl chr 9:105,866,641...105,889,758

G

MAF bZIP transcription factor F

increases expression

ISO

leflunomide results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor G

increases expression

ISO

leflunomide results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

MAF bZIP transcription factor K

increases expression

EXP

leflunomide results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

myelin-associated glycoprotein

increases expression

ISO

leflunomide results in increased expression of MAG mRNA

NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:95,275,635...95,291,060

G

MAGE family member E1

decreases expression

ISO

leflunomide results in decreased expression of MAGEE1 mRNA

NCBI chr X:74,254,848...74,258,395
Ensembl chr X:74,254,958...74,258,371

G

MAGE family member H1

decreases expression

ISO

leflunomide results in decreased expression of MAGEH1 mRNA

NCBI chr X:21,725,709...21,726,965
Ensembl chr X:21,718,669...21,727,219

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

decreases expression
increases expression

ISO

leflunomide results in decreased expression of MAGI1 mRNA
leflunomide results in increased expression of MAGI1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833

G

membrane associated guanylate kinase, WW and PDZ domain containing 3

increases expression

ISO

leflunomide results in increased expression of MAGI3 mRNA

NCBI chr 2:194,206,587...194,405,468
Ensembl chr 2:194,206,934...194,405,157

G

mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1

increases expression

EXP

leflunomide results in increased expression of MAGMAS-PS1 mRNA

NCBI chr10:89,102,411...89,102,931

G

MAK16 homolog

increases expression

ISO

leflunomide results in increased expression of MAK16 mRNA

NCBI chr16:67,675,757...67,684,188
Ensembl chr16:67,675,735...67,684,836

G

mal, T-cell differentiation protein 2

increases expression

EXP

leflunomide results in increased expression of MAL2 mRNA

NCBI chr 7:87,790,239...87,823,219
Ensembl chr 7:87,790,239...87,850,403

G

MAM and LDL receptor class A domain containing 1

increases expression

ISO

leflunomide results in increased expression of MALRD1 mRNA

NCBI chr17:83,327,372...84,039,558
Ensembl chr17:83,327,372...84,039,559

G

mitochondrial assembly of ribosomal large subunit 1

decreases expression

ISO

leflunomide results in decreased expression of MALSU1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:79,381,963...79,390,786
Ensembl chr 4:79,374,393...79,411,608

G

mastermind-like transcriptional coactivator 2

increases expression

ISO

leflunomide results in increased expression of MAML2 mRNA

NCBI chr 8:18,552,480...18,869,923
Ensembl chr 8:18,552,281...18,869,900

G

mannosidase, alpha, class 2A, member 1

increases expression

EXP

leflunomide results in increased expression of MAN2A1 mRNA

NCBI chr 9:111,698,913...111,855,257
Ensembl chr 9:111,698,913...111,867,850

G

mannosidase beta like

decreases expression

ISO

leflunomide results in decreased expression of MANBAL mRNA

NCBI chr 3:166,455,067...166,484,652
Ensembl chr 3:166,455,066...166,487,431

G

microtubule-associated protein 1B

increases expression

ISO

leflunomide results in increased expression of MAP1B mRNA

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

microtubule-associated protein 1 light chain 3 beta

increases expression

EXP
ISO

leflunomide results in increased expression of MAP1LC3B mRNA

PMID:24136188 PMID:28988120

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 2

decreases expression

ISO

leflunomide results in decreased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen-activated protein kinase kinase kinase 14

increases expression

ISO

leflunomide results in increased expression of MAP3K14 mRNA

NCBI chr10:88,665,417...88,715,669
Ensembl chr10:88,665,417...88,715,592

G

mitogen-activated protein kinase kinase kinase 8

increases expression

ISO

leflunomide results in increased expression of MAP3K8 mRNA

NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452

G

MAP7 domain containing 1

increases expression

EXP

leflunomide results in increased expression of MAP7D1 mRNA

NCBI chr 5:143,812,467...143,837,597
Ensembl chr 5:143,811,924...143,837,021

G

mitogen activated protein kinase 1

increases expression
multiple interactions
increases phosphorylation

EXP
ISO

leflunomide results in increased expression of MAPK1 mRNA
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Leflunomide results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [Leflunomide results in increased expression of ATF4 protein]; MAPK1 protein affects the reaction [Leflunomide results in increased expression of DDIT3 protein]
leflunomide results in increased phosphorylation of MAPK1 protein

PMID:24136188 PMID:28988120

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [leflunomide results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]; MAPK3 protein affects the reaction [leflunomide results in increased expression of DDIT3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 6

increases expression

ISO

leflunomide results in increased expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

MAPK associated protein 1

decreases expression

ISO

leflunomide results in decreased expression of MAPKAP1 mRNA

NCBI chr 3:38,113,268...38,315,913
Ensembl chr 3:38,113,323...38,315,913

G

microtubule-associated protein, RP/EB family, member 2

decreases expression

EXP

leflunomide results in decreased expression of MAPRE2 mRNA

NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796

G

microtubule-associated protein tau

increases expression

ISO

leflunomide results in increased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

membrane associated ring-CH-type finger 5

increases expression

EXP

Leflunomide results in increased expression of MARCHF5 mRNA

NCBI chr 1:244,343,674...244,365,160
Ensembl chr 1:244,343,630...244,366,462

G

membrane associated ring-CH-type finger 9

decreases expression

ISO

Leflunomide results in decreased expression of MARCHF9 mRNA

NCBI chr 7:64,764,346...64,767,824
Ensembl chr 7:64,764,347...64,767,824

G

meiosis regulator and mRNA stability factor 1

decreases expression

ISO

leflunomide results in decreased expression of MARF1 mRNA

NCBI chr10:1,395,271...1,439,974
Ensembl chr10:1,395,282...1,439,974

G

microtubule affinity regulating kinase 4

increases expression

ISO

leflunomide results in increased expression of MARK4 mRNA

NCBI chr 1:88,203,352...88,239,858
Ensembl chr 1:88,203,393...88,236,553

G

MARVEL domain containing 2

increases expression

ISO

leflunomide results in increased expression of MARVELD2 mRNA

NCBI chr 2:33,474,750...33,498,225
Ensembl chr 2:33,462,950...33,498,077

G

MARVEL domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of MARVELD3 mRNA

NCBI chr19:54,818,180...54,832,871
Ensembl chr19:54,818,180...54,832,871

G

methionine adenosyltransferase 2A

decreases expression

ISO

leflunomide results in decreased expression of MAT2A mRNA

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

methyl-CpG binding domain protein 3

increases expression

EXP

leflunomide results in increased expression of MBD3 mRNA

NCBI chr 7:9,961,053...9,970,845
Ensembl chr 7:9,963,797...9,970,265

G

methyl-CpG binding domain 4 DNA glycosylase

decreases expression

ISO

leflunomide results in decreased expression of MBD4 mRNA

NCBI chr 4:150,565,646...150,577,433
Ensembl chr 4:150,565,655...150,577,578

G

mannose binding lectin 2

increases expression

ISO

leflunomide results in increased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546

G

muscleblind-like splicing regulator 1

increases expression

ISO

leflunomide results in increased expression of MBNL1 mRNA

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

muscleblind-like splicing regulator 2

increases expression

ISO

leflunomide results in increased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

myelin basic protein

increases expression

ISO

leflunomide results in increased expression of MBP mRNA

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

MCC regulator of WNT signaling pathway

increases expression

ISO

leflunomide results in increased expression of MCC mRNA

NCBI chr18:37,042,350...37,517,114
Ensembl chr18:37,049,253...37,517,076

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

ISO

leflunomide results in increased expression of MCL1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

mucolipin TRP cation channel 1

increases expression

EXP

leflunomide results in increased expression of MCOLN1 mRNA

NCBI chr12:6,357,851...6,372,151
Ensembl chr12:6,357,807...6,372,151

G

microcephalin 1

increases expression

ISO

leflunomide results in increased expression of MCPH1 mRNA

NCBI chr16:77,724,251...77,926,773
Ensembl chr16:77,724,251...77,926,462

G

malate dehydrogenase 1

decreases expression

EXP

leflunomide results in decreased expression of MDH1 mRNA

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

MDM2 proto-oncogene

increases expression

ISO

leflunomide results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

increases expression

ISO

leflunomide results in increased expression of MDM4 mRNA

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

malic enzyme 1

increases expression

EXP

leflunomide results in increased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

MTOR associated protein, eak-7 homolog

decreases expression

ISO

leflunomide results in decreased expression of MEAK7 mRNA

NCBI chr19:64,722,528...64,745,443
Ensembl chr19:64,722,528...64,751,330

G

mitochondrial trans-2-enoyl-CoA reductase

increases expression

EXP

leflunomide results in increased expression of MECR mRNA

NCBI chr 5:149,313,765...149,339,964
Ensembl chr 5:149,313,774...149,342,825

G

mediator complex subunit 1

increases expression

ISO

leflunomide results in increased expression of MED1 mRNA

NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545

G

mediator complex subunit 13L

increases expression

ISO

leflunomide results in increased expression of MED13L mRNA

NCBI chr12:43,468,556...43,665,819
Ensembl chr12:43,468,556...43,665,819

G

mediator complex subunit 20

decreases expression

ISO

leflunomide results in decreased expression of MED20 mRNA

NCBI chr 9:20,867,681...20,880,288
Ensembl chr 9:20,867,681...20,880,011

G

mediator complex subunit 22

decreases expression

ISO

leflunomide results in decreased expression of MED22 mRNA

NCBI chr 3:30,631,829...30,636,911
Ensembl chr 3:30,631,829...30,636,911

G

mediator complex subunit 25

decreases expression

ISO

leflunomide results in decreased expression of MED25 mRNA

NCBI chr 1:104,496,447...104,513,061
Ensembl chr 1:104,496,447...104,512,391

G

mediator complex subunit 29

increases expression

EXP

leflunomide results in increased expression of MED29 mRNA

NCBI chr 1:92,805,505...92,810,908

G

mediator complex subunit 30

increases expression

ISO

leflunomide results in increased expression of MED30 mRNA

NCBI chr 7:85,894,638...85,916,373
Ensembl chr 7:85,894,605...85,917,973

G

mediator complex subunit 31

decreases expression

ISO

leflunomide results in decreased expression of MED31 mRNA

NCBI chr10:57,335,507...57,338,889
Ensembl chr10:57,335,507...57,338,889

G

mediator complex subunit 6

decreases expression

ISO

leflunomide results in decreased expression of MED6 mRNA

NCBI chr 6:107,001,664...107,015,130
Ensembl chr 6:106,990,116...107,015,130

G

myocyte enhancer factor 2a

increases expression

ISO

leflunomide results in increased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

myocyte enhancer factor 2D

increases expression

ISO

leflunomide results in increased expression of MEF2D mRNA

NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760

G

multiple EGF-like-domains 8

decreases expression

ISO

leflunomide results in decreased expression of MEGF8 mRNA

NCBI chr 1:90,030,057...90,079,423
Ensembl chr 1:90,030,388...90,079,422

G

Meis homeobox 2

increases expression

ISO

leflunomide results in increased expression of MEIS2 mRNA

NCBI chr 3:123,197,066...123,399,002
Ensembl chr 3:123,197,066...123,397,751

G

menin 1

decreases expression

ISO

leflunomide results in decreased expression of MEN1 mRNA

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:213,068,166...213,074,120

G

methylphosphate capping enzyme

decreases expression

ISO

leflunomide results in decreased expression of MEPCE mRNA

NCBI chr12:24,548,596...24,553,315
Ensembl chr12:24,548,596...24,553,877

G

mesoderm posterior bHLH transcription factor 1

decreases expression

ISO

leflunomide results in decreased expression of MESP1 mRNA

NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:143,147,671...143,149,189

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

EXP

leflunomide results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methyltransferase 22, Kin17 lysine

increases expression

EXP

leflunomide results in increased expression of METTL22 mRNA

NCBI chr10:7,620,279...7,637,334
Ensembl chr10:7,620,279...7,638,222

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

ISO

leflunomide results in decreased expression of METTL3 mRNA

NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487

G

methyltransferase 4, N6-adenosine

decreases expression

ISO

leflunomide results in decreased expression of METTL4 mRNA

NCBI chr 9:118,887,740...118,967,433
Ensembl chr 9:118,887,528...118,911,364

G

mex-3 RNA binding family member B

decreases expression

ISO

leflunomide results in decreased expression of MEX3B mRNA

NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:146,264,318...146,268,543

G

mex-3 RNA binding family member C

increases expression

ISO

leflunomide results in increased expression of MEX3C mRNA

NCBI chr18:69,442,850...69,463,843
Ensembl chr18:69,442,152...69,463,846

G

microfibrillar-associated protein 1A

decreases expression

ISO

leflunomide results in decreased expression of MFAP1 mRNA

NCBI chr 3:128,893,880...128,910,460
Ensembl chr 3:128,893,880...128,911,481

G

mitofusin 1

decreases expression

ISO

leflunomide results in decreased expression of MFN1 mRNA

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

major facilitator superfamily domain containing 1

increases expression

EXP

leflunomide results in increased expression of MFSD1 mRNA

NCBI chr 2:154,156,167...154,176,209
Ensembl chr 2:154,156,166...154,177,086

G

major facilitator superfamily domain containing 4B1

increases expression

EXP

Leflunomide results in increased expression of MFSD4B1 mRNA

NCBI chr20:44,991,384...45,004,590
Ensembl chr20:44,991,384...45,006,161

G

major facilitator superfamily domain containing 5

decreases expression

ISO

Leflunomide results in decreased expression of SLC61A1 mRNA

NCBI chr 7:135,287,683...135,289,964
Ensembl chr 7:135,269,076...135,290,342

G

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

decreases expression

ISO

leflunomide results in decreased expression of MGAT1 mRNA

NCBI chr10:34,064,548...34,083,833
Ensembl chr10:34,062,837...34,095,975

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

decreases expression

EXP

leflunomide results in decreased expression of MGAT4B mRNA

NCBI chr10:35,049,421...35,060,307
Ensembl chr10:35,050,512...35,060,309

G

monoglyceride lipase

decreases expression

EXP

leflunomide results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

microsomal glutathione S-transferase 2

increases expression

EXP

leflunomide results in increased expression of MGST2 mRNA

NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661

G

microsomal glutathione S-transferase 3

decreases expression

EXP
ISO

leflunomide results in decreased expression of MGST3 mRNA

PMID:24136188 PMID:28988120

NCBI chr13:82,059,480...82,080,418
Ensembl chr13:82,059,480...82,080,575

G

MIA SH3 domain ER export factor 2

increases expression

ISO

leflunomide results in increased expression of MIA2 mRNA

NCBI chr 6:82,522,398...82,620,136
Ensembl chr 6:82,522,422...82,620,178

G

mitochondrial calcium uptake family, member 3

increases expression

ISO

leflunomide results in increased expression of MICU3 mRNA

NCBI chr16:58,624,702...58,714,302
Ensembl chr16:58,629,208...58,714,045

G

MID1 interacting protein 1

decreases expression

EXP

leflunomide results in decreased expression of MID1IP1 mRNA

NCBI chr X:14,733,539...14,735,859
Ensembl chr X:14,732,830...14,739,079

G

mitotic deacetylase associated SANT domain protein

increases expression

ISO

Leflunomide results in increased expression of MIDEAS mRNA

NCBI chr 6:109,519,011...109,585,631
Ensembl chr 6:109,519,011...109,560,312

G

mitochondrial elongation factor 2

decreases expression

ISO

leflunomide results in decreased expression of MIEF2 mRNA

PMID:28988120 PMID:29427785

NCBI chr10:45,907,576...45,913,658
Ensembl chr10:45,908,706...45,913,658

G

MINDY lysine 48 deubiquitinase 1

decreases expression

ISO

leflunomide results in decreased expression of MINDY1 mRNA

NCBI chr 2:185,550,026...185,561,987
Ensembl chr 2:185,548,993...185,561,986

G

mirror-image polydactyly 1

increases expression

ISO

leflunomide results in increased expression of MIPOL1 mRNA

NCBI chr 6:80,490,330...80,825,413
Ensembl chr 6:80,490,312...80,825,413

G

microRNA let-7d

decreases expression

ISO

leflunomide results in decreased expression of MIRLET7D mRNA

NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,322,260...16,322,357

G

MIS18 kinetochore protein A

decreases expression

ISO

leflunomide results in decreased expression of MIS18A mRNA

NCBI chr11:43,454,129...43,467,157
Ensembl chr11:43,454,161...43,476,264

G

MISP family member 3

decreases expression

ISO

leflunomide results in decreased expression of MISP3 mRNA

NCBI chr19:41,043,408...41,046,761
Ensembl chr19:41,044,765...41,052,107

G

Mix paired-like homeobox 1

increases expression

ISO

leflunomide results in increased expression of MIXL1 mRNA

NCBI chr13:94,953,907...94,957,938
Ensembl chr13:94,953,907...94,957,938

G

marker of proliferation Ki-67

decreases expression

ISO

leflunomide results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

MKKS centrosomal shuttling protein

decreases expression

ISO

leflunomide results in decreased expression of MKKS mRNA

NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:144,654,566...144,672,831

G

MKS transition zone complex subunit 1

decreases expression

ISO

leflunomide results in decreased expression of MKS1 mRNA

NCBI chr10:73,152,599...73,167,451
Ensembl chr10:73,153,186...73,163,886

G

malectin

decreases expression

ISO

leflunomide results in decreased expression of MLEC mRNA

NCBI chr12:47,118,918...47,133,598
Ensembl chr12:47,118,855...47,130,064

G

myeloid leukemia factor 1

increases expression

ISO

leflunomide results in increased expression of MLF1 mRNA

NCBI chr 2:153,958,060...153,991,705
Ensembl chr 2:153,958,546...153,994,220

G

mutL homolog 3

decreases expression

ISO

leflunomide results in decreased expression of MLH3 mRNA

NCBI chr 6:110,612,535...110,649,408
Ensembl chr 6:110,612,535...110,648,999

G

MLLT10, histone lysine methyltransferase DOT1L cofactor

increases expression

ISO

leflunomide results in increased expression of MLLT10 mRNA

PMID:19751817 PMID:28988120

NCBI chr17:85,729,964...85,857,791
Ensembl chr17:85,730,751...85,857,789

G

MLLT3, super elongation complex subunit

decreases expression

ISO

leflunomide results in decreased expression of MLLT3 mRNA

NCBI chr 5:107,305,008...107,561,352
Ensembl chr 5:107,284,766...107,561,352

G

MAX dimerization protein MLX

increases expression

EXP

leflunomide results in increased expression of MLX mRNA

NCBI chr10:86,519,517...86,524,607
Ensembl chr10:86,519,864...86,524,772

G

malonyl-CoA decarboxylase

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of MLYCD mRNA
leflunomide results in decreased expression of MLYCD mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr19:64,356,582...64,372,447
Ensembl chr19:64,356,223...64,372,446

G

metabolism of cobalamin associated B

decreases expression

ISO

leflunomide results in decreased expression of MMAB mRNA

PMID:28988120 PMID:29427785

NCBI chr12:47,819,757...47,833,127
Ensembl chr12:47,819,724...47,833,118

G

monocyte to macrophage differentiation-associated

increases expression

ISO

leflunomide results in increased expression of MMD mRNA

NCBI chr10:75,570,366...75,598,610
Ensembl chr10:75,570,397...75,598,609

G

matrix metallopeptidase 19

decreases expression

ISO

leflunomide results in decreased expression of MMP19 mRNA

NCBI chr 7:1,805,732...1,814,054
Ensembl chr 7:1,805,860...1,814,863

G

matrix metallopeptidase 2

increases expression

EXP

leflunomide results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

MOB kinase activator 1A

decreases expression

ISO

leflunomide results in decreased expression of MOB1A mRNA

NCBI chr 4:117,389,278...117,406,255
Ensembl chr 4:117,389,186...117,406,250

G

MOB kinase activator 2

decreases expression

ISO

leflunomide results in decreased expression of MOB2 mRNA

NCBI chr 1:206,522,523...206,579,502
Ensembl chr 1:206,522,523...206,579,449

G

MOB kinase activator 3C

decreases expression

ISO

leflunomide results in decreased expression of MOB3C mRNA

NCBI chr 5:134,542,929...134,552,017
Ensembl chr 5:134,543,243...134,551,991

G

motile sperm domain containing 2

increases expression

EXP

leflunomide results in increased expression of MOSPD2 mRNA

NCBI chr X:33,052,063...33,105,550
Ensembl chr X:33,052,004...33,107,635

G

motile sperm domain containing 3

increases expression

EXP

leflunomide results in increased expression of MOSPD3 mRNA

NCBI chr12:24,728,012...24,737,078
Ensembl chr12:24,732,008...24,736,244

G

mitochondrial pyruvate carrier 2

increases expression

EXP

leflunomide results in increased expression of MPC2 mRNA

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668

G

MAGUK p55 scaffold protein 7

increases expression

ISO

leflunomide results in increased expression of MPP7 mRNA

NCBI chr17:60,135,096...60,401,814
Ensembl chr17:60,137,701...60,401,739

G

myelin protein zero-like 2

increases expression

ISO

leflunomide results in increased expression of MPZL2 mRNA

NCBI chr 8:54,244,920...54,256,064
Ensembl chr 8:54,243,556...54,256,074

G

myelin protein zero-like 3

increases expression

ISO

leflunomide results in increased expression of MPZL3 mRNA

NCBI chr 8:54,257,235...54,277,422
Ensembl chr 8:54,257,226...54,279,665

G

muscle RAS oncogene homolog

increases expression

ISO

leflunomide results in increased expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

mannose receptor, C type 2

increases expression

ISO

leflunomide results in increased expression of MRC2 mRNA

NCBI chr10:90,761,751...90,823,055
Ensembl chr10:90,761,878...90,823,055

G

melanoregulin

decreases expression

ISO

leflunomide results in decreased expression of MREG mRNA

NCBI chr 9:81,236,019...81,291,601
Ensembl chr 9:81,236,019...81,291,310

G

MAS related GPR family member X1

increases expression

ISO

leflunomide results in increased expression of MRGPRX4 mRNA

NCBI chr 1:106,942,343...106,943,314
Ensembl chr 1:106,942,343...106,943,314

G

mitochondrial rRNA methyltransferase 2

decreases expression

ISO

leflunomide results in decreased expression of MRM2 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:19,423,448...19,428,662
Ensembl chr12:19,423,452...19,428,621

G

MRN complex interacting protein

increases expression

ISO

leflunomide results in increased expression of MRNIP mRNA

NCBI chr10:35,002,440...35,026,555

G

mitochondrial ribosomal protein L11

increases expression

EXP

leflunomide results in increased expression of MRPL11 mRNA

NCBI chr 1:211,693,807...211,696,667
Ensembl chr 1:211,693,804...211,697,177

G

mitochondrial ribosomal protein L14

increases expression

EXP

leflunomide results in increased expression of MRPL14 mRNA

NCBI chr 9:22,800,286...22,812,711
Ensembl chr 9:22,795,744...22,812,855

G

mitochondrial ribosomal protein L19

increases expression

EXP

leflunomide results in increased expression of MRPL19 mRNA

NCBI chr 4:116,079,654...116,083,883
Ensembl chr 4:116,079,654...116,083,883

G

mitochondrial ribosomal protein L20

increases expression

EXP

leflunomide results in increased expression of MRPL20 mRNA

NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728

G

mitochondrial ribosomal protein L34

increases expression

EXP

leflunomide results in increased expression of MRPL34 mRNA

NCBI chr16:18,186,447...18,187,182
Ensembl chr16:18,185,306...18,187,181

G

mitochondrial ribosomal protein L49

decreases expression

ISO

leflunomide results in decreased expression of MRPL49 mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:212,775,357...212,779,364
Ensembl chr 1:212,775,357...212,779,888

G

mitochondrial ribosomal protein L50

increases expression

EXP

leflunomide results in increased expression of MRPL50 mRNA

NCBI chr 5:68,662,933...68,668,087
Ensembl chr 5:68,662,939...68,669,748

G

mitochondrial ribosomal protein L51

decreases expression

ISO

leflunomide results in decreased expression of MRPL51 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:159,677,988...159,681,650
Ensembl chr 4:159,677,827...159,681,641

G

mitochondrial ribosomal protein L58

increases expression

EXP

leflunomide results in increased expression of MRPL58 mRNA

NCBI chr10:101,145,342...101,151,838
Ensembl chr10:101,145,162...101,151,838

G

mitochondrial ribosomal protein S17

decreases expression

ISO

leflunomide results in decreased expression of MRPS17 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:32,584,635...32,587,934
Ensembl chr12:32,584,635...32,587,812

G

mitochondrial ribosomal protein S18C

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of MRPS18C mRNA
leflunomide results in decreased expression of MRPS18C mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr14:9,116,688...9,122,943

G

mitochondrial ribosomal protein S21

decreases expression

ISO

leflunomide results in decreased expression of MRPS21 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:186,095,729...186,103,351
Ensembl chr 2:186,095,732...186,103,351

G

mitochondrial ribosomal protein S26

decreases expression

ISO

leflunomide results in decreased expression of MRPS26 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:138,222,324...138,223,987
Ensembl chr 3:138,222,165...138,223,987

G

mitochondrial ribosomal protein S30

increases expression

ISO

leflunomide results in increased expression of MRPS30 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:52,189,049...52,196,136
Ensembl chr 2:52,189,058...52,195,904

G

mitochondrial ribosomal protein S31

decreases expression

ISO

leflunomide results in decreased expression of MRPS31 mRNA

PMID:28988120 PMID:29427785

NCBI chr16:76,303,807...76,332,970
Ensembl chr16:76,301,645...76,333,065

G

mitochondrial ribosomal protein S33

increases expression

EXP

leflunomide results in increased expression of MRPS33 mRNA

NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:69,563,503...69,572,177

G

mitochondrial ribosomal protein S34

increases expression

EXP

leflunomide results in increased expression of MRPS34 mRNA

NCBI chr10:14,420,543...14,421,674
Ensembl chr10:14,408,136...14,421,771

G

mutS homolog 6

decreases expression

ISO

leflunomide results in decreased expression of MSH6 mRNA

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844

G

musashi RNA-binding protein 2

increases expression

ISO

leflunomide results in increased expression of MSI2 mRNA

NCBI chr10:73,640,960...74,007,497
Ensembl chr10:73,646,139...74,007,552

G

methylsterol monooxygenase 1

decreases expression

ISO

leflunomide results in decreased expression of MSMO1 mRNA

PMID:19751817 PMID:28988120

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

methionine sulfoxide reductase B1

decreases expression

ISO

leflunomide results in decreased expression of MSRB1 mRNA

NCBI chr10:14,269,414...14,275,140
Ensembl chr10:14,269,414...14,274,184

G

metallothionein 1, pseudogene 3

increases expression

ISO

Leflunomide results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

increases expression

EXP

leflunomide results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metastasis associated 1 family, member 2

decreases expression

ISO

leflunomide results in decreased expression of MTA2 mRNA

NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062

G

MDM2 binding protein

increases expression

ISO

leflunomide results in increased expression of MTBP mRNA

NCBI chr 7:88,862,939...88,945,491
Ensembl chr 7:88,862,927...88,945,493

G

mitochondrial transcription termination factor 1

decreases expression

ISO

leflunomide results in decreased expression of MTERF1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:31,181,048...31,188,130
Ensembl chr 4:31,180,832...31,189,651

G

mitochondrial transcription termination factor 2

decreases expression

ISO

leflunomide results in decreased expression of MTERF2 mRNA

PMID:28988120 PMID:29427785

NCBI chr 7:20,485,901...20,495,979
Ensembl chr 7:20,485,461...20,548,043

G

mitochondrial transcription termination factor 4

increases expression

ISO

leflunomide results in increased expression of MTERF4 mRNA

NCBI chr 9:101,281,560...101,286,236
Ensembl chr 9:101,281,543...101,286,259

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

ISO

leflunomide results in increased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

methenyltetrahydrofolate synthetase

increases expression

EXP

leflunomide results in increased expression of MTHFS mRNA

NCBI chr 8:98,609,410...98,681,901
Ensembl chr 8:98,609,399...98,752,036

G

myotubularin related protein 4

decreases expression

ISO

leflunomide results in decreased expression of MTMR4 mRNA

NCBI chr10:72,890,665...72,913,598
Ensembl chr10:72,889,827...72,913,598

G

myotubularin related protein 6

increases expression

ISO

leflunomide results in increased expression of MTMR6 mRNA

NCBI chr15:38,596,091...38,634,023
Ensembl chr15:38,596,032...38,636,672

G

mitochondrial translation release factor in rescue

decreases expression

ISO

Leflunomide results in decreased expression of MTRFR mRNA

NCBI chr12:37,922,532...37,936,219
Ensembl chr12:37,919,398...37,936,219

G

microtubule associated scaffold protein 1

increases expression

ISO

leflunomide results in increased expression of MTUS1 mRNA

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474

G

metaxin 3

increases expression

ISO

leflunomide results in increased expression of MTX3 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:25,800,530...25,814,755
Ensembl chr 2:25,801,411...25,814,754

G

mucin 5B, oligomeric mucus/gel-forming

increases expression

ISO

leflunomide results in increased expression of MUC5B mRNA

NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:206,346,400...206,378,367

G

mucin 6, oligomeric mucus/gel-forming

decreases expression

ISO

leflunomide results in decreased expression of MUC6 mRNA

NCBI chr 1:206,155,826...206,194,384
Ensembl chr 1:206,155,593...206,191,864

G

mevalonate diphosphate decarboxylase

decreases expression

ISO

leflunomide results in decreased expression of MVD mRNA

NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366

G

max dimerization protein 1

increases expression

ISO

leflunomide results in increased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

myeloid-associated differentiation marker-like 2

increases expression

ISO

leflunomide results in increased expression of MYADML2 mRNA

NCBI chr10:106,420,856...106,425,899
Ensembl chr10:106,421,419...106,426,224

G

MYB proto-oncogene, transcription factor

decreases expression

ISO

leflunomide results in decreased expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYC proto-oncogene, bHLH transcription factor

increases expression

ISO

leflunomide results in increased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

MYCL proto-oncogene, bHLH transcription factor

increases expression

ISO

leflunomide results in increased expression of MYCL mRNA

NCBI chr 5:140,559,843...140,566,704
Ensembl chr 5:140,560,152...140,566,699

G

MYCN proto-oncogene, bHLH transcription factor

increases expression

ISO

leflunomide results in increased expression of MYCN mRNA

NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:41,446,684...41,452,508

G

myosin heavy chain 10

decreases expression

EXP

leflunomide results in decreased expression of MYH10 mRNA

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036

G

myosin heavy chain 3

decreases expression

ISO

leflunomide results in decreased expression of MYH3 mRNA

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

myosin light chain 12A

increases expression

ISO

leflunomide results in increased expression of MYL12A mRNA

NCBI chr 9:118,338,592...118,346,277
Ensembl chr 9:118,338,604...118,342,634

G

myosin light chain 9

increases expression

ISO

leflunomide results in increased expression of MYL9 mRNA

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin X

increases expression

ISO

leflunomide results in increased expression of MYO10 mRNA

NCBI chr 2:77,831,532...78,036,137
Ensembl chr 2:77,831,532...78,036,137

G

myosin IE

increases expression

ISO

leflunomide results in increased expression of MYO1E mRNA

NCBI chr 8:79,768,828...79,961,048
Ensembl chr 8:79,753,596...79,961,045

G

myogenic differentiation 1

decreases expression

ISO

leflunomide results in decreased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

myomesin 3

decreases expression

ISO

leflunomide results in decreased expression of MYOM3 mRNA

NCBI chr 5:153,276,306...153,326,847
Ensembl chr 5:153,276,261...153,326,839

G

NEDD4 binding protein 2-like 2

decreases expression

ISO

leflunomide results in decreased expression of N4BP2L2 mRNA

NCBI chr12:4,972,967...5,038,027
Ensembl chr12:4,972,990...5,033,405

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

increases expression

EXP

leflunomide results in increased expression of NAA38 mRNA

NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,592,990...54,617,715

G

Ngfi-A binding protein 2

increases expression

ISO

leflunomide results in increased expression of NAB2 mRNA

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:65,382,863...65,389,255

G

nucleic acid binding protein 1

increases expression

ISO

leflunomide results in increased expression of NABP1 mRNA

NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:57,618,505...57,626,052

G

NACC family member 2

decreases expression

ISO

leflunomide results in decreased expression of NACC2 mRNA

NCBI chr 3:29,278,077...29,345,098
Ensembl chr 3:29,281,190...29,344,840

G

N-acetylglucosamine kinase

decreases expression

ISO

leflunomide results in decreased expression of NAGK mRNA

NCBI chr 4:117,838,761...117,846,304
Ensembl chr 4:117,838,826...117,847,836

G

nicotinamide phosphoribosyltransferase

increases expression

ISO

leflunomide results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

nuclear prelamin A recognition factor

decreases expression

ISO

leflunomide results in decreased expression of NARF mRNA

NCBI chr10:107,017,344...107,035,777
Ensembl chr10:107,016,510...107,037,283

G

neuron navigator 2

increases expression

ISO

leflunomide results in increased expression of NAV2 mRNA

NCBI chr 1:107,799,968...108,458,546
Ensembl chr 1:107,805,096...108,458,546

G

non-SMC condensin I complex, subunit D2

decreases expression

ISO

leflunomide results in decreased expression of NCAPD2 mRNA

NCBI chr 4:159,655,051...159,677,938
Ensembl chr 4:159,655,051...159,677,938

G

non-SMC condensin I complex, subunit G

decreases expression

ISO

leflunomide results in decreased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

non-SMC condensin I complex, subunit H

decreases expression

EXP

leflunomide results in decreased expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

neurochondrin

decreases expression

ISO

leflunomide results in decreased expression of NCDN mRNA

NCBI chr 5:144,322,287...144,332,117
Ensembl chr 5:144,322,287...144,332,047

G

nuclear receptor coactivator 3

increases expression

ISO

leflunomide results in increased expression of NCOA3 mRNA

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

nuclear receptor coactivator 4

increases expression

ISO

leflunomide results in increased expression of NCOA4 mRNA

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

nuclear receptor coactivator 5

decreases expression

ISO

leflunomide results in decreased expression of NCOA5 mRNA

NCBI chr 3:174,155,731...174,188,862
Ensembl chr 3:174,155,741...174,188,862

G

nuclear receptor coactivator 7

increases expression

EXP
ISO

leflunomide results in increased expression of NCOA7 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:28,674,614...28,835,891
Ensembl chr 1:28,675,426...28,835,886

G

nuclear receptor co-repressor 2

increases expression

ISO

leflunomide results in increased expression of NCOR2 mRNA

NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612

G

NDC80 kinetochore complex component

decreases expression

ISO

leflunomide results in decreased expression of NDC80 mRNA

NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:118,853,806...118,887,568

G

NDRG family member 4

decreases expression

ISO

leflunomide results in decreased expression of NDRG4 mRNA

NCBI chr19:9,357,470...9,393,465
Ensembl chr19:9,357,470...9,392,972

G

NADH:ubiquinone oxidoreductase complex assembly factor 5

increases expression

ISO

leflunomide results in increased expression of NDUFAF5 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:147,961,612...147,991,128
Ensembl chr 3:147,961,599...147,991,126

G

NADH:ubiquinone oxidoreductase subunit B8

increases expression

EXP

leflunomide results in increased expression of NDUFB8 mRNA

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936

G

NECAP endocytosis associated 2

decreases expression

ISO

leflunomide results in decreased expression of NECAP2 mRNA

NCBI chr 5:158,653,347...158,665,761
Ensembl chr 5:158,653,347...158,666,901

G

nectin cell adhesion molecule 1

decreases expression

ISO

leflunomide results in decreased expression of NECTIN1 mRNA

NCBI chr 8:52,998,662...53,061,745
Ensembl chr 8:52,998,662...53,086,664

G

nectin cell adhesion molecule 3

increases expression

ISO

leflunomide results in increased expression of NECTIN3 mRNA

NCBI chr11:67,825,296...67,931,999
Ensembl chr11:67,827,137...67,871,383

G

NEDD4 like E3 ubiquitin protein ligase

increases expression

ISO

leflunomide results in increased expression of NEDD4L mRNA

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

ISO

leflunomide results in increased expression of NEDD9 mRNA

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

neuronal growth regulator 1

decreases expression

EXP

leflunomide results in decreased expression of NEGR1 mRNA

NCBI chr 2:248,283,164...249,015,538
Ensembl chr 2:248,283,353...249,018,410

G

NIMA-related kinase 2

decreases expression

ISO

leflunomide results in decreased expression of NEK2 mRNA

PMID:19751817 PMID:28988120

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:105,936,788...105,950,056

G

NIMA-related kinase 6

increases expression

EXP

leflunomide results in increased expression of NEK6 mRNA

NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773

G

nuclear envelope integral membrane protein 1

decreases expression

ISO

leflunomide results in decreased expression of NEMP1 mRNA

NCBI chr 7:65,399,297...65,424,054
Ensembl chr 7:65,399,381...65,424,055

G

nuclear envelope integral membrane protein 2

decreases expression

ISO

leflunomide results in decreased expression of NEMP2 mRNA

NCBI chr 9:56,353,233...56,372,586
Ensembl chr 9:56,353,233...56,372,493

G

neuroepithelial cell transforming 1

increases expression

ISO

leflunomide results in increased expression of NET1 mRNA

NCBI chr17:71,251,145...71,280,345
Ensembl chr17:71,251,149...71,289,270

G

neuraminidase 1

increases expression

EXP

leflunomide results in increased expression of NEU1 mRNA

NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,902,120...3,906,383

G

neuraminidase 3

decreases expression

ISO

leflunomide results in decreased expression of NEU3 mRNA

NCBI chr 1:163,549,834...163,560,997
Ensembl chr 1:163,549,738...163,561,049

G

neurogenin 2

increases expression

ISO

leflunomide results in increased expression of NEUROG2 mRNA

NCBI chr 2:218,767,205...218,769,772
Ensembl chr 2:218,765,949...218,769,784

G

nexilin (F actin binding protein)

increases expression

ISO

leflunomide results in increased expression of NEXN mRNA

NCBI chr 2:243,846,736...243,878,268
Ensembl chr 2:243,846,433...243,887,114

G

nuclear factor of activated T-cells 2 interacting protein

decreases expression

ISO

leflunomide results in decreased expression of NFATC2IP mRNA

NCBI chr 1:190,385,416...190,403,309
Ensembl chr 1:190,387,437...190,402,413

G

nuclear factor, erythroid 2

decreases expression

ISO

leflunomide results in decreased expression of NFE2 mRNA

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:136,261,236...136,268,585

G

NFE2 like bZIP transcription factor 2

increases expression

EXP
ISO

leflunomide results in increased expression of NFE2L2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor I/A

decreases expression

ISO

leflunomide results in decreased expression of NFIA mRNA

NCBI chr 5:117,359,006...117,897,391
Ensembl chr 5:117,359,077...117,891,395

G

nuclear factor I/B

increases expression

ISO

leflunomide results in increased expression of NFIB mRNA

NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:101,805,168...102,019,945

G

nuclear factor, interleukin 3 regulated

increases expression

ISO

leflunomide results in increased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

NFKB inhibitor alpha

increases expression

ISO

leflunomide results in increased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor epsilon

decreases expression

ISO

leflunomide results in decreased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NFKB inhibitor zeta

increases expression

EXP

leflunomide results in increased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

nuclear transcription factor Y subunit alpha

decreases expression

ISO

leflunomide results in decreased expression of NFYA mRNA

NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:20,085,073...20,111,504

G

NHERF family PDZ scaffold protein 1

decreases expression

EXP

Leflunomide results in decreased expression of NHERF1 mRNA

NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579

G

NHL repeat containing 2

increases expression

ISO

leflunomide results in increased expression of NHLRC2 mRNA

NCBI chr 1:265,594,915...265,655,647
Ensembl chr 1:265,594,915...265,676,143

G

NHL repeat containing 3

decreases expression

ISO

leflunomide results in decreased expression of NHLRC3 mRNA

NCBI chr 2:139,678,127...139,692,423
Ensembl chr 2:139,679,866...139,692,691

G

ninein-like

decreases expression

ISO

leflunomide results in decreased expression of NINL mRNA

NCBI chr 3:160,208,757...160,275,077
Ensembl chr 3:160,196,883...160,275,108

G

NIPA magnesium transporter 1

increases expression

ISO

leflunomide results in increased expression of NIPA1 mRNA

NCBI chr 1:115,608,221...116,010,503
Ensembl chr 1:115,974,481...116,010,812

G

NIPBL, cohesin loading factor

decreases expression

ISO

leflunomide results in decreased expression of NIPBL mRNA

NCBI chr 2:59,126,676...59,314,841
Ensembl chr 2:59,126,676...59,293,277

G

Sodium/potassium transporting ATPase interacting 1

increases expression

ISO

leflunomide results in increased expression of NKAIN1 mRNA

NCBI chr 5:148,031,685...148,076,834
Ensembl chr 5:148,031,338...148,076,834

G

NKD inhibitor of WNT signaling pathway 1

increases expression

ISO

leflunomide results in increased expression of NKD1 mRNA

NCBI chr19:34,649,803...34,722,846

G

NKD inhibitor of WNT signaling pathway 2

increases expression

ISO

leflunomide results in increased expression of NKD2 mRNA

NCBI chr 1:31,268,856...31,299,390
Ensembl chr 1:31,272,519...31,299,387

G

NFKB repressing factor

decreases expression

ISO

leflunomide results in decreased expression of NKRF mRNA

NCBI chr X:120,992,038...121,010,251
Ensembl chr X:120,992,038...121,010,251

G

NK2 homeobox 5

increases expression

ISO

leflunomide results in increased expression of NKX2-5 mRNA

NCBI chr10:16,844,888...16,851,458
Ensembl chr10:16,848,582...16,851,452

G

NMD3 ribosome export adaptor

increases expression

ISO

leflunomide results in increased expression of NMD3 mRNA

NCBI chr 2:156,285,773...156,348,394
Ensembl chr 2:156,322,963...156,350,903

G

NME/NM23 family member 7

increases expression

EXP

leflunomide results in increased expression of NME7 mRNA

NCBI chr13:79,190,462...79,319,890
Ensembl chr13:79,190,334...79,319,890

G

N-myristoyltransferase 2

decreases expression

ISO

leflunomide results in decreased expression of NMT2 mRNA

NCBI chr17:79,826,999...79,874,088
Ensembl chr17:79,826,999...79,870,259

G

NOC3-like DNA replication regulator

decreases expression

ISO

leflunomide results in decreased expression of NOC3L mRNA

NCBI chr 1:245,969,179...245,997,761
Ensembl chr 1:245,969,179...245,997,708

G

nucleolar protein with MIF4G domain 1

increases expression

ISO

leflunomide results in increased expression of NOM1 mRNA

NCBI chr 4:6,562,931...6,586,093
Ensembl chr 4:6,567,836...6,585,036

G

NOP56 ribonucleoprotein

decreases expression

ISO

leflunomide results in decreased expression of NOP56 mRNA

NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:137,929,646...137,934,959

G

nitric oxide synthase 1

increases activity

EXP

leflunomide results in increased activity of NOS1 protein

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 1 adaptor protein

increases expression

EXP

leflunomide results in increased expression of NOS1AP mRNA

NCBI chr13:85,080,558...85,353,741
Ensembl chr13:85,063,350...85,353,741

G

nitric oxide synthase 2

multiple interactions

ISO

leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase trafficking

decreases expression

ISO

leflunomide results in decreased expression of NOSTRIN mRNA

NCBI chr 3:74,312,594...74,378,852
Ensembl chr 3:74,312,647...74,396,455

G

notch receptor 2

increases expression

EXP

leflunomide results in increased expression of NOTCH2 mRNA

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823

G

NPL4 homolog, ubiquitin recognition factor

increases expression

EXP

leflunomide results in increased expression of NPLOC4 mRNA

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

natriuretic peptide receptor 2

decreases expression

ISO

leflunomide results in decreased expression of NPR2 mRNA

NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:62,678,367...62,697,343

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

leflunomide results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group D, member 1

increases expression

ISO

leflunomide results in increased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group D, member 2

increases expression

ISO

leflunomide results in increased expression of NR1D2 mRNA

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 3

increases expression

EXP

leflunomide results in increased expression of NR1H3 mRNA

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

ISO

leflunomide results in increased activity of NR1I2 protein
[leflunomide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

increases expression

EXP
ISO

leflunomide results in increased expression of NR1I3 mRNA
Leflunomide results in increased expression of NR1I3 mRNA

PMID:24136188 PMID:30364229

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of NR3C1 mRNA
leflunomide results in increased expression of NR3C1 mRNA

PMID:24136188 PMID:28988120

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

increases expression

ISO

leflunomide results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 3

increases expression

ISO

leflunomide results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

neurotrophin receptor associated death domain

decreases expression

EXP

leflunomide results in decreased expression of NRADD mRNA

NCBI chr 8:119,478,055...119,481,336
Ensembl chr 8:119,477,240...119,481,214

G

Notch-regulated ankyrin repeat protein

decreases expression

ISO

leflunomide results in decreased expression of NRARP mRNA

NCBI chr 3:28,390,745...28,393,299
Ensembl chr 3:28,390,733...28,393,453

G

nuclear receptor binding protein 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of NRBP2 mRNA
leflunomide results in decreased expression of NRBP2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:109,679,330...109,685,656
Ensembl chr 7:109,679,330...109,685,588

G

neuronal regeneration related protein

decreases expression

EXP

leflunomide results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

nuclear receptor interacting protein 1

increases expression

ISO

leflunomide results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

nurim

decreases expression

ISO

leflunomide results in decreased expression of NRM mRNA

NCBI chr20:2,893,126...2,897,725
Ensembl chr20:2,882,369...2,896,605

G

neuropilin 1

increases expression

EXP
ISO

leflunomide results in increased expression of NRP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL

decreases expression

ISO

leflunomide results in decreased expression of NSDHL mRNA

NCBI chr X:155,817,301...155,848,224
Ensembl chr X:155,817,340...155,848,220

G

NOP2/Sun RNA methyltransferase 3

increases expression

ISO

leflunomide results in increased expression of NSUN3 mRNA

NCBI chr11:50,960,187...51,062,366
Ensembl chr11:50,960,192...51,045,220

G

NOP2/Sun RNA methyltransferase 6

increases expression

ISO

leflunomide results in increased expression of NSUN6 mRNA

NCBI chr17:82,820,938...82,864,140
Ensembl chr17:82,820,941...82,858,539

G

5'-nucleotidase domain containing 1

increases expression

EXP

leflunomide results in increased expression of NT5DC1 mRNA

NCBI chr20:39,660,707...39,763,647
Ensembl chr20:39,660,707...39,786,449

G

5'-nucleotidase domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of NT5DC2 mRNA

NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,328,523...6,336,980

G

netrin 4

decreases expression

ISO

leflunomide results in decreased expression of NTN4 mRNA

NCBI chr 7:30,073,637...30,187,407
Ensembl chr 7:30,073,333...30,188,309

G

NUAK family kinase 2

increases expression

ISO

leflunomide results in increased expression of NUAK2 mRNA

NCBI chr13:46,305,744...46,322,755
Ensembl chr13:46,305,975...46,322,748

G

NUBP iron-sulfur cluster assembly factor 2

increases expression

EXP

leflunomide results in increased expression of NUBP2 mRNA

NCBI chr10:14,407,743...14,411,428
Ensembl chr10:14,407,745...14,411,600

G

nudix hydrolase 19

increases expression

EXP

leflunomide results in increased expression of NUDT19 mRNA

NCBI chr 1:97,351,373...97,362,969
Ensembl chr 1:97,351,378...97,362,969

G

nudix hydrolase 4

increases expression

ISO

leflunomide results in increased expression of NUDT4 mRNA

NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:32,075,002...32,091,491

G

nudix hydrolase 7

increases expression

EXP

leflunomide results in increased expression of NUDT7 mRNA

NCBI chr19:59,034,808...59,049,148
Ensembl chr19:59,034,839...59,063,994

G

NUF2 component of NDC80 kinetochore complex

decreases expression

EXP
ISO

leflunomide results in decreased expression of NUF2 mRNA

PMID:24136188 PMID:28988120

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:84,226,509...84,255,598

G

nucleoporin 42

decreases expression

ISO

Leflunomide results in decreased expression of NUP42 mRNA

NCBI chr 4:11,877,957...11,894,991
Ensembl chr 4:11,877,957...11,894,991

G

nucleoporin 43

decreases expression

ISO

leflunomide results in decreased expression of NUP43 mRNA

NCBI chr 1:3,964,814...3,978,277
Ensembl chr 1:3,938,825...3,978,277

G

nucleoporin 62

decreases expression

ISO

leflunomide results in decreased expression of NUP62 mRNA

NCBI chr 1:104,435,532...104,451,392
Ensembl chr 1:104,432,093...104,452,710

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

leflunomide results in increased expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

nucleolar and spindle associated protein 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of NUSAP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

nuclear VCP-like

increases expression

ISO

leflunomide results in increased expression of NVL mRNA

NCBI chr13:95,385,389...95,438,490
Ensembl chr13:95,372,641...95,442,291

G

nuclear RNA export factor 1

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of NXF1 mRNA
leflunomide results in decreased expression of NXF1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:215,084,563...215,097,756
Ensembl chr 1:215,084,099...215,097,756

G

out at first homolog

decreases expression

EXP

leflunomide results in decreased expression of OAF mRNA

NCBI chr 8:52,491,314...52,509,285
Ensembl chr 8:52,491,315...52,509,285

G

2'-5' oligoadenylate synthetase 1A

increases expression

ISO

leflunomide results in increased expression of OAS1 mRNA

NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128

G

ornithine aminotransferase

decreases expression

EXP

leflunomide results in decreased expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

ornithine decarboxylase antizyme 2

decreases expression

ISO

leflunomide results in decreased expression of OAZ2 mRNA

NCBI chr 8:75,094,817...75,108,634
Ensembl chr 8:75,094,798...75,108,630

G

occludin/ELL domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of OCEL1 mRNA

NCBI chr16:18,076,428...18,079,068
Ensembl chr16:18,077,266...18,079,374

G

osteoclast stimulatory transmembrane protein

increases expression

ISO

leflunomide results in increased expression of OCSTAMP mRNA

NCBI chr 3:174,550,420...174,560,907
Ensembl chr 3:174,550,935...174,556,289

G

ornithine decarboxylase 1

increases expression

EXP

leflunomide results in increased expression of ODC1 mRNA

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

outer dense fiber of sperm tails 2-like

decreases expression

ISO

leflunomide results in decreased expression of ODF2L mRNA

NCBI chr 2:236,696,158...236,733,090
Ensembl chr 2:236,696,389...236,733,086

G

odr-4 GPCR localization factor homolog

increases expression

ISO

leflunomide results in increased expression of ODR4 mRNA

NCBI chr13:64,925,573...64,974,395
Ensembl chr13:64,944,713...64,974,316

G

O-GlcNAcase

increases expression

ISO

Leflunomide results in increased expression of OGA mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

opioid growth factor receptor

decreases expression

ISO

leflunomide results in decreased expression of OGFR mRNA

NCBI chr 3:188,080,743...188,087,028
Ensembl chr 3:188,080,042...188,087,471

G

Opa interacting protein 5

decreases expression

ISO

leflunomide results in decreased expression of OIP5 mRNA

NCBI chr 3:127,047,559...127,057,043
Ensembl chr 3:127,047,559...127,057,043

G

one cut homeobox 2

increases expression

ISO

leflunomide results in increased expression of ONECUT2 mRNA

NCBI chr18:60,101,967...60,161,095
Ensembl chr18:60,102,126...60,107,668

G

optineurin

increases expression

EXP
ISO

leflunomide results in increased expression of OPTN mRNA

PMID:24136188 PMID:28988120

NCBI chr17:78,118,847...78,169,543
Ensembl chr17:78,118,866...78,169,543

G

origin recognition complex, subunit 6

decreases expression

ISO

leflunomide results in decreased expression of ORC6 mRNA

NCBI chr19:37,931,085...37,938,856
Ensembl chr19:37,931,090...37,938,856

G

orosomucoid 1

increases expression

ISO

leflunomide results in increased expression of ORM1 mRNA

NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667

G

ORMDL sphingolipid biosynthesis regulator 1

decreases expression

ISO

leflunomide results in decreased expression of ORMDL1 mRNA

NCBI chr 9:55,735,081...55,745,287
Ensembl chr 9:55,735,097...55,745,340

G

oxysterol binding protein-like 11

decreases expression

ISO

leflunomide results in decreased expression of OSBPL11 mRNA

NCBI chr11:81,038,759...81,121,887
Ensembl chr11:81,038,985...81,101,299

G

oxysterol binding protein-like 7

decreases expression

ISO

leflunomide results in decreased expression of OSBPL7 mRNA

NCBI chr10:82,532,335...82,549,999
Ensembl chr10:82,532,411...82,549,999

G

oxidative stress responsive serine-rich 1

increases expression

ISO

leflunomide results in increased expression of OSER1 mRNA

NCBI chr 3:172,486,417...172,504,607
Ensembl chr 3:172,486,440...172,504,597

G

O-sialoglycoprotein endopeptidase-like 1

decreases expression

ISO

leflunomide results in decreased expression of OSGEPL1 mRNA

NCBI chr 9:55,707,389...55,725,325
Ensembl chr 9:55,707,392...55,721,346

G

oxidative stress induced growth inhibitor 1

increases expression

EXP

leflunomide results in increased expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

oxidative stress induced growth inhibitor family member 2

increases expression

ISO

leflunomide results in increased expression of OSGIN2 mRNA

NCBI chr 5:34,297,417...34,316,353
Ensembl chr 5:34,297,417...34,316,931

G

oncostatin M receptor

increases expression

ISO

leflunomide results in increased expression of OSMR mRNA

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

otogelin

increases expression

ISO

leflunomide results in increased expression of OTOG mRNA

NCBI chr 1:105,882,747...105,951,825
Ensembl chr 1:105,882,747...105,951,824

G

OTU deubiquitinase 4

increases expression

ISO

leflunomide results in increased expression of OTUD4 mRNA

NCBI chr19:45,141,043...45,184,136
Ensembl chr19:45,141,043...45,184,136

G

orthodenticle homeobox 1

decreases expression

ISO

leflunomide results in decreased expression of OTX1 mRNA

NCBI chr14:100,283,406...100,290,421
Ensembl chr14:100,283,406...100,290,421

G

ovo like transcriptional repressor 1

increases expression

ISO

leflunomide results in increased expression of OVOL1 mRNA

NCBI chr 1:212,284,601...212,296,106
Ensembl chr 1:212,284,605...212,296,106

G

prolyl 4-hydroxylase subunit alpha 1

increases expression

EXP

leflunomide results in increased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

increases expression

ISO

Leflunomide results in increased expression of PABIR1 mRNA

NCBI chr 1:231,541,411...231,542,717
Ensembl chr 1:231,537,357...231,612,411

G

poly(A) binding protein interacting protein 2B

decreases expression

ISO

leflunomide results in decreased expression of PAIP2B mRNA

NCBI chr 4:117,849,625...117,881,021
Ensembl chr 4:117,839,367...117,881,006

G

paralemmin A kinase anchor protein

increases expression

ISO

Leflunomide results in increased expression of PALM2AKAP2 mRNA

NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656

G

phosphatase domain containing, paladin 1

increases expression

EXP

leflunomide results in increased expression of PALD1 mRNA

NCBI chr20:29,812,650...29,877,733
Ensembl chr20:29,812,650...29,850,063

G

palladin, cytoskeletal associated protein

increases expression

ISO

leflunomide results in increased expression of PALLD mRNA

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:33,238,956...33,632,232

G

pantothenate kinase 3

increases expression

ISO

leflunomide results in increased expression of PANK3 mRNA

NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015

G

Pannexin 1

decreases expression

ISO

leflunomide results in decreased expression of PANX1 mRNA

NCBI chr 8:20,128,783...20,171,200
Ensembl chr 8:20,132,165...20,171,200

G

poly(A) polymerase gamma

increases expression

ISO

leflunomide results in increased expression of PAPOLG mRNA

NCBI chr14:102,028,842...102,062,155
Ensembl chr14:102,028,842...102,062,155

G

progestin and adipoQ receptor family member 4

decreases expression

ISO

leflunomide results in decreased expression of PAQR4 mRNA

NCBI chr10:13,263,559...13,267,237
Ensembl chr10:13,263,559...13,267,173

G

progestin and adipoQ receptor family member 6

decreases expression

ISO

leflunomide results in decreased expression of PAQR6 mRNA

NCBI chr 2:176,131,345...176,136,266
Ensembl chr 2:176,131,859...176,136,265

G

progestin and adipoQ receptor family member 9

decreases expression

ISO

leflunomide results in decreased expression of PAQR9 mRNA

NCBI chr 8:104,993,884...104,996,180
Ensembl chr 8:104,993,827...104,998,285

G

par-3 family cell polarity regulator

increases expression

ISO

leflunomide results in increased expression of PARD3 mRNA

NCBI chr19:71,977,420...72,527,273
Ensembl chr19:71,977,470...72,526,941

G

par-6 family cell polarity regulator beta

increases expression

ISO

leflunomide results in increased expression of PARD6B mRNA

NCBI chr 3:177,209,429...177,230,509
Ensembl chr 3:177,209,258...177,230,510

G

poly (ADP-ribose) polymerase 2

decreases expression

ISO

leflunomide results in decreased expression of PARP2 mRNA

NCBI chr15:26,494,722...26,517,893
Ensembl chr15:26,494,731...26,517,891

G

poly (ADP-ribose) polymerase family, member 4

decreases expression

ISO

leflunomide results in decreased expression of PARP4 mRNA

NCBI chr15:34,806,203...34,908,492
Ensembl chr15:34,816,701...34,944,433

G

pro-apoptotic WT1 regulator

increases expression

ISO

leflunomide results in increased expression of PAWR mRNA

NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492

G

PDZ binding kinase

decreases expression

ISO

leflunomide results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

phenazine biosynthesis-like protein domain containing 1

increases expression

EXP

leflunomide results in increased expression of PBLD1 mRNA

NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,549,974...25,565,226

G

PBX homeobox interacting protein 1

decreases expression

ISO

leflunomide results in decreased expression of PBXIP1 mRNA

NCBI chr 2:177,154,056...177,167,810
Ensembl chr 2:177,154,101...177,167,328

G

protocadherin 1

increases expression

ISO

leflunomide results in increased expression of PCDH1 mRNA

NCBI chr18:30,258,154...30,290,828
Ensembl chr18:30,258,154...30,290,436

G

protocadherin 7

decreases expression

ISO

leflunomide results in decreased expression of PCDH7 mRNA

NCBI chr14:56,684,817...57,114,976
Ensembl chr14:56,687,725...57,112,665

G

PC-esterase domain containing 1A

decreases expression

ISO

leflunomide results in decreased expression of PCED1A mRNA

NCBI chr 3:138,049,747...138,076,107
Ensembl chr 3:138,067,891...138,075,146

G

PCF11 cleavage and polyadenylation factor subunit

increases expression
decreases expression

ISO

leflunomide results in increased expression of PCF11 mRNA
leflunomide results in decreased expression of PCF11 mRNA

PMID:19751817 PMID:28988120

NCBI chr 1:156,109,724...156,136,950
Ensembl chr 1:156,109,724...156,136,435

G

phosphoenolpyruvate carboxykinase 1

increases expression
multiple interactions

ISO

Leflunomide results in increased expression of PCK1 mRNA
Colforsin inhibits the reaction [Leflunomide results in increased expression of PCK1 mRNA]

PMID:28988120 PMID:30364229

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

PCNA clamp associated factor

decreases expression

EXP

leflunomide results in decreased expression of PCLAF mRNA

NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:75,315,707...75,328,106

G

proliferating cell nuclear antigen

decreases expression

ISO

leflunomide results in decreased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

Purkinje cell protein 2

increases expression

ISO

leflunomide results in increased expression of PCP2 mRNA

NCBI chr12:6,479,554...6,481,550
Ensembl chr12:6,479,554...6,485,159

G

proprotein convertase subtilisin/kexin type 6

increases expression

EXP

leflunomide results in increased expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:128,839,232...129,052,128

G

phosphatidylcholine transfer protein

increases expression

EXP

leflunomide results in increased expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

programmed cell death 4

decreases expression

ISO

leflunomide results in decreased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

programmed cell death 6

increases expression

EXP

leflunomide results in increased expression of PDCD6 mRNA

NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773

G

programmed cell death 7

decreases expression

ISO

leflunomide results in decreased expression of PDCD7 mRNA

NCBI chr 8:74,757,768...74,772,495
Ensembl chr 8:74,757,768...74,781,634

G

phosducin like

decreases expression

ISO

leflunomide results in decreased expression of PDCL mRNA

NCBI chr 3:41,519,953...41,529,545
Ensembl chr 3:41,519,954...41,527,794
Ensembl chr 3:41,519,954...41,527,794

G

phosphodiesterase 2A

increases expression

EXP

leflunomide results in increased expression of PDE2A mRNA

NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466

G

phosphodiesterase 3A

increases expression

ISO

leflunomide results in increased expression of PDE3A mRNA

NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270

G

phosphodiesterase 4D

increases expression

ISO

leflunomide results in increased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569

G

phosphodiesterase 9A

increases expression

ISO

leflunomide results in increased expression of PDE9A mRNA

NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286

G

platelet derived growth factor subunit A

increases expression

ISO

leflunomide results in increased expression of PDGFA mRNA

NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322

G

platelet derived growth factor receptor alpha

increases expression

EXP

leflunomide results in increased expression of PDGFRA mRNA

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516

G

pyruvate dehydrogenase complex, component X

increases expression

EXP

leflunomide results in increased expression of PDHX mRNA

NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:109,827,209...109,886,905

G

PDZ and LIM domain 5

increases expression

ISO

leflunomide results in increased expression of PDLIM5 mRNA

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

PDZ and LIM domain 7

increases expression

ISO

leflunomide results in increased expression of PDLIM7 mRNA

NCBI chr17:9,129,603...9,144,956
Ensembl chr17:9,129,525...9,144,956

G

pyruvate dehydrogenase phosphatase catalytic subunit 2

decreases expression

EXP
ISO

leflunomide results in decreased expression of PDP2 mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr19:392,858...400,529
Ensembl chr19:392,183...400,902

G

penta-EF hand domain containing 1

increases expression

EXP

leflunomide results in increased expression of PEF1 mRNA

NCBI chr 5:147,735,973...147,759,239
Ensembl chr 5:147,735,976...147,761,092

G

paternally expressed 10

decreases expression

ISO

leflunomide results in decreased expression of PEG10 mRNA

NCBI chr 4:33,809,026...33,822,224
Ensembl chr 4:33,817,190...33,819,166
Ensembl chr 4:33,817,190...33,819,166

G

paternally expressed 3

increases expression

ISO

leflunomide results in increased expression of PEG3 mRNA

NCBI chr 1:76,130,965...76,157,774
Ensembl chr 1:76,130,948...76,157,743

G

pellino E3 ubiquitin protein ligase 1

increases expression

ISO

leflunomide results in increased expression of PELI1 mRNA

NCBI chr14:99,455,970...99,510,474
Ensembl chr14:99,455,811...99,510,466

G

period circadian regulator 2

increases expression

EXP

leflunomide results in increased expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

p53 apoptosis effector related to PMP22

increases expression

EXP

leflunomide results in increased expression of PERP mRNA

NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:15,361,778...15,374,687

G

peroxisomal biogenesis factor 11 alpha

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of PEX11A mRNA
leflunomide results in decreased expression of PEX11A mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645

G

peroxisomal biogenesis factor 12

decreases expression

ISO

leflunomide results in decreased expression of PEX12 mRNA

NCBI chr10:68,593,307...68,596,938
Ensembl chr10:68,593,308...68,596,938

G

peroxisomal biogenesis factor 13

increases expression

ISO

leflunomide results in increased expression of PEX13 mRNA

NCBI chr14:101,804,673...101,822,367
Ensembl chr14:101,804,673...101,822,367

G

peroxisomal biogenesis factor 7

increases expression

EXP

leflunomide results in increased expression of PEX7 mRNA

NCBI chr 1:16,402,319...16,466,304
Ensembl chr 1:16,402,320...16,466,366

G

prefoldin subunit 2

increases expression

ISO

leflunomide results in increased expression of PFDN2 mRNA

NCBI chr13:86,305,037...86,323,008

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression

ISO

leflunomide results in increased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

piggyBac transposable element derived 1

decreases expression

ISO

leflunomide results in decreased expression of PGBD1 mRNA

NCBI chr17:47,863,948...47,898,044

G

piggyBac transposable element derived 5

decreases expression

ISO

leflunomide results in decreased expression of PGBD5 mRNA

NCBI chr19:69,234,171...69,299,315
Ensembl chr19:69,234,171...69,299,560

G

phosphogluconate dehydrogenase

increases expression

EXP

leflunomide results in increased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphatase and actin regulator 2

increases expression

ISO

leflunomide results in increased expression of PHACTR2 mRNA

NCBI chr 1:9,411,412...9,680,648
Ensembl chr 1:9,418,085...9,680,583

G

phosphatase and actin regulator 3

increases expression

ISO

leflunomide results in increased expression of PHACTR3 mRNA

NCBI chr 3:185,582,134...185,801,404
Ensembl chr 3:185,582,796...185,801,822

G

phagophore assembly factor 1

decreases expression

ISO

Leflunomide results in decreased expression of PHAF1 mRNA

NCBI chr19:50,011,350...50,050,880
Ensembl chr19:50,011,369...50,053,987

G

prohibitin 1

increases expression

EXP

Leflunomide results in increased expression of PHB1 mRNA

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

polyhomeotic homolog 3

increases expression

ISO

leflunomide results in increased expression of PHC3 mRNA

NCBI chr 2:114,337,180...114,412,132
Ensembl chr 2:114,337,227...114,405,816

G

PHD finger protein 23

decreases expression

ISO

leflunomide results in decreased expression of PHF23 mRNA

NCBI chr10:55,217,351...55,221,471
Ensembl chr10:55,217,351...55,221,471

G

PHD finger protein 3

increases expression

ISO

leflunomide results in increased expression of PHF3 mRNA

NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:40,559,929...40,632,056

G

PHD finger protein 8

decreases expression

ISO

leflunomide results in decreased expression of PHF8 mRNA

NCBI chr X:23,967,126...24,066,473
Ensembl chr X:23,967,556...24,066,471

G

pleckstrin homology-like domain, family A, member 1

increases expression

ISO

leflunomide results in increased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

pleckstrin homology-like domain, family A, member 3

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of PHLDA3 mRNA
leflunomide results in increased expression of PHLDA3 mRNA

PMID:19751817 PMID:24136188 PMID:28988120

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

putative homeodomain transcription factor 1

decreases expression

EXP

leflunomide results in decreased expression of PHTF1 mRNA

NCBI chr 2:194,161,343...194,249,925
Ensembl chr 2:194,161,000...194,219,530

G

putative homeodomain transcription factor 2

increases expression

ISO

leflunomide results in increased expression of PHTF2 mRNA

NCBI chr 4:15,107,341...15,222,683
Ensembl chr 4:15,107,373...15,222,692

G

phosphatidylinositol 4-kinase alpha

increases expression

EXP

leflunomide results in increased expression of PI4KA mRNA

NCBI chr11:97,113,390...97,234,374
Ensembl chr11:97,113,245...97,228,315

G

phosphatidylinositol 4-kinase beta

decreases expression

ISO

leflunomide results in decreased expression of PI4KB mRNA

NCBI chr 2:185,229,392...185,261,697
Ensembl chr 2:185,228,799...185,261,693

G

phosphatidylinositol binding clathrin assembly protein

decreases expression

ISO

leflunomide results in decreased expression of PICALM mRNA

NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:153,469,202...153,550,237

G

piercer of microtubule wall 1

decreases expression

ISO

Leflunomide results in decreased expression of PIERCE1 mRNA

NCBI chr 3:32,195,024...32,201,111
Ensembl chr 3:32,195,024...32,199,561

G

PIF1 5'-to-3' DNA helicase

decreases expression

ISO

leflunomide results in decreased expression of PIF1 mRNA

NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:75,006,815...75,015,331

G

phosphatidylinositol glycan anchor biosynthesis, class P

decreases expression

ISO

leflunomide results in decreased expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:47,148,465...47,160,082

G

phosphatidylinositol glycan anchor biosynthesis, class W

decreases expression

ISO

leflunomide results in decreased expression of PIGW mRNA

NCBI chr10:70,246,904...70,248,412
Ensembl chr10:70,243,810...70,250,329

G

phosphatidylinositol glycan anchor biosynthesis, class X

increases expression

EXP

leflunomide results in increased expression of PIGX mRNA

NCBI chr11:82,192,125...82,208,062
Ensembl chr11:82,192,092...82,208,061

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

ISO

leflunomide results in decreased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

ISO

leflunomide results in increased expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

Pim-2 proto-oncogene, serine/threonine kinase

decreases expression

ISO

leflunomide results in decreased expression of PIM2 mRNA

PMID:28988120 PMID:29427785

NCBI chr X:17,289,509...17,294,778
Ensembl chr X:17,289,509...17,294,778

G

Pim-3 proto-oncogene, serine/threonine kinase

increases expression

ISO

leflunomide results in increased expression of PIM3 mRNA

NCBI chr 7:121,822,076...121,836,257
Ensembl chr 7:121,832,742...121,836,259

G

PICALM interacting mitotic regulator

decreases expression

ISO

leflunomide results in decreased expression of PIMREG mRNA

NCBI chr10:57,168,136...57,173,713
Ensembl chr10:57,167,797...57,173,063

G

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

decreases expression

ISO

leflunomide results in decreased expression of PIP4P1 mRNA

NCBI chr15:26,620,399...26,624,369
Ensembl chr15:26,620,401...26,624,246

G

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2

increases expression

ISO

leflunomide results in increased expression of PIP4P2 mRNA

NCBI chr 5:33,057,046...33,104,448
Ensembl chr 5:33,056,684...33,104,451

G

phosphatidylinositol-4-phosphate 5-kinase type 1 beta

increases expression

ISO

leflunomide results in increased expression of PIP5K1B mRNA

NCBI chr 1:231,331,836...231,610,092
Ensembl chr 1:231,340,606...231,496,812

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

decreases expression

ISO

leflunomide results in decreased expression of PIP5K1C mRNA

NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716

G

pirin

increases expression

EXP

leflunomide results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

praja ring finger ubiquitin ligase 2

increases expression

ISO

leflunomide results in increased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703

G

polycystin 2, transient receptor potential cation channel

decreases expression

ISO

leflunomide results in decreased expression of PKD2 mRNA

NCBI chr14:5,541,821...5,585,140
Ensembl chr14:5,495,401...5,587,594

G

protein kinase domain containing, cytoplasmic

increases expression

EXP

leflunomide results in increased expression of PKDCC mRNA

NCBI chr 6:17,208,171...17,217,488
Ensembl chr 6:17,208,171...17,218,042

G

pyruvate kinase L/R

decreases expression

EXP

leflunomide results in decreased expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

protein kinase N3

decreases expression

ISO

leflunomide results in decreased expression of PKN3 mRNA

NCBI chr 3:33,747,610...33,761,405
Ensembl chr 3:33,747,867...33,761,405

G

plakophilin 2

increases expression

ISO

leflunomide results in increased expression of PKP2 mRNA

NCBI chr11:98,165,974...98,231,916
Ensembl chr11:98,165,974...98,231,916

G

phospholipase A1 member A

increases expression

EXP

leflunomide results in increased expression of PLA1A mRNA

NCBI chr11:75,825,626...75,863,296
Ensembl chr11:75,825,585...75,878,165

G

phospholipase A2, group XIIA

increases expression

EXP

leflunomide results in increased expression of PLA2G12A mRNA

NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964

G

phospholipase A2, group IVF

increases expression

ISO

leflunomide results in increased expression of PLA2G4F mRNA

NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:127,703,841...127,718,348

G

phospholipase A2, activating protein

increases expression

ISO

leflunomide results in increased expression of PLAA mRNA

NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:114,544,325...114,576,109

G

placenta associated 8

increases expression

ISO

leflunomide results in increased expression of PLAC8 mRNA

NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572

G

PLAG1 zinc finger

increases expression

ISO

leflunomide results in increased expression of PLAG1 mRNA

NCBI chr 5:21,699,650...21,754,325
Ensembl chr 5:21,702,987...21,711,240

G

PLAG1 like zinc finger 2

decreases expression

ISO

leflunomide results in decreased expression of PLAGL2 mRNA

NCBI chr 3:162,155,554...162,168,748
Ensembl chr 3:162,155,554...162,168,748

G

plasminogen activator, urokinase

increases expression

ISO

leflunomide results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

phospholipase D2

decreases expression

ISO

leflunomide results in decreased expression of PLD2 mRNA

NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435

G

phospholipase D family, member 6

increases expression

ISO

leflunomide results in increased expression of PLD6 mRNA

PMID:28988120 PMID:29427785

NCBI chr10:45,078,081...45,080,732
Ensembl chr10:45,077,080...45,087,160

G

pleckstrin homology and FYVE domain containing 2

increases expression

ISO

leflunomide results in increased expression of PLEKHF2 mRNA

NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:28,868,469...28,923,514

G

pleckstrin homology domain containing O2

decreases expression

ISO

leflunomide results in decreased expression of PLEKHO2 mRNA

NCBI chr 8:74,973,578...75,000,532
Ensembl chr 8:74,974,740...75,000,430

G

perilipin 2

increases expression

ISO

leflunomide results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

polo-like kinase 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of PLK1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 2

increases expression

ISO

leflunomide results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

polo-like kinase 3

increases expression

ISO

leflunomide results in increased expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

phospholipid phosphatase 1

decreases expression

ISO

leflunomide results in decreased expression of PLPP1 mRNA

NCBI chr 2:46,172,202...46,233,632
Ensembl chr 2:46,172,197...46,234,676

G

phospholipid scramblase 4

increases expression

ISO

leflunomide results in increased expression of PLSCR4 mRNA

NCBI chr 8:101,867,057...101,905,827
Ensembl chr 8:101,866,888...101,905,831

G

plexin C1

decreases expression

ISO

leflunomide results in decreased expression of PLXNC1 mRNA

NCBI chr 7:31,276,978...31,430,823
Ensembl chr 7:31,276,978...31,431,092

G

peptidase M20 domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of PM20D2 mRNA

NCBI chr 5:52,362,384...52,382,647
Ensembl chr 5:52,362,392...52,382,532

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

leflunomide results in increased expression of PMAIP1 mRNA

PMID:28988120 PMID:29427785

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

phosphomannomutase 1

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of PMM1 mRNA
leflunomide results in decreased expression of PMM1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:115,346,767...115,357,137
Ensembl chr 7:115,346,771...115,357,024

G

PNN interacting serine and arginine rich protein

decreases expression

ISO

leflunomide results in decreased expression of PNISR mRNA

NCBI chr 5:40,190,214...40,219,619
Ensembl chr 5:40,192,735...40,219,611

G

pinin, desmosome associated protein

decreases expression

ISO

leflunomide results in decreased expression of PNN mRNA

NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933

G

patatin-like phospholipase domain containing 2

increases expression

EXP

leflunomide results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

patatin-like phospholipase domain containing 7

increases expression

EXP

leflunomide results in increased expression of PNPLA7 mRNA

NCBI chr 3:28,180,670...28,259,673
Ensembl chr 3:28,180,751...28,259,672

G

patatin-like phospholipase domain containing 8

increases expression

EXP

leflunomide results in increased expression of PNPLA8 mRNA

NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512

G

proline-rich nuclear receptor coactivator 2

decreases expression

ISO

leflunomide results in decreased expression of PNRC2 mRNA

NCBI chr 5:153,387,522...153,390,506
Ensembl chr 5:153,378,863...153,390,748

G

POC1 centriolar protein A

decreases expression

ISO

leflunomide results in decreased expression of POC1A mRNA

NCBI chr 8:115,801,335...115,869,812
Ensembl chr 8:115,801,396...115,870,392

G

DNA polymerase alpha 2, accessory subunit

decreases expression

ISO

leflunomide results in decreased expression of POLA2 mRNA

NCBI chr 1:212,656,500...212,680,667
Ensembl chr 1:212,656,501...212,680,542

G

DNA polymerase delta 4, accessory subunit

increases expression

EXP

leflunomide results in increased expression of POLD4 mRNA

NCBI chr 1:210,956,110...210,957,863
Ensembl chr 1:210,956,099...210,957,860

G

DNA polymerase epsilon 2, accessory subunit

decreases expression

ISO

leflunomide results in decreased expression of POLE2 mRNA

NCBI chr 6:93,410,713...93,448,782
Ensembl chr 6:93,410,758...93,435,361

G

DNA polymerase epsilon 3, accessory subunit

decreases expression

ISO

leflunomide results in decreased expression of POLE3 mRNA

NCBI chr 5:80,989,508...80,992,742
Ensembl chr 5:80,989,511...80,992,742
Ensembl chr 7:80,989,511...80,992,742

G

DNA polymerase gamma, catalytic subunit

decreases expression

ISO

leflunomide results in decreased expression of POLG mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:142,792,119...142,808,838

G

DNA polymerase eta

decreases expression

ISO

leflunomide results in decreased expression of POLH mRNA

NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:22,275,946...22,310,577

G

RNA polymerase I and III subunit C

decreases expression

ISO

leflunomide results in decreased expression of POLR1C mRNA

NCBI chr 9:22,233,318...22,237,430
Ensembl chr 9:22,233,305...22,237,428

G

RNA polymerase I subunit G

decreases expression

ISO

Leflunomide results in decreased expression of POLR1G mRNA

NCBI chr 1:88,135,493...88,138,769
Ensembl chr 1:88,135,493...88,138,769

G

RNA polymerase II subunit A

decreases expression

ISO

leflunomide results in decreased expression of POLR2A mRNA

NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179

G

RNA polymerase II subunit B

decreases expression

ISO

leflunomide results in decreased expression of POLR2B mRNA

NCBI chr14:31,151,534...31,189,222
Ensembl chr14:31,151,390...31,189,222

G

RNA polymerase II subunit I

increases expression

EXP

leflunomide results in increased expression of POLR2I mRNA

NCBI chr 1:94,610,976...94,612,413
Ensembl chr 1:94,610,942...94,613,000

G

RNA polymerase II subunit M

increases expression

EXP

leflunomide results in increased expression of POLR2M mRNA

NCBI chr 8:81,012,770...81,020,201
Ensembl chr 8:81,012,771...81,020,302

G

protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)

decreases expression

ISO

leflunomide results in decreased expression of POMGNT2 mRNA

NCBI chr 8:130,522,607...130,538,273
Ensembl chr 8:130,521,459...130,571,943

G

POP5 homolog, ribonuclease P/MRP subunit

decreases expression

ISO

leflunomide results in decreased expression of POP5 mRNA

NCBI chr12:47,037,451...47,045,778
Ensembl chr12:47,029,403...47,042,032

G

POP7 homolog, ribonuclease P/MRP subunit

decreases expression

ISO

leflunomide results in decreased expression of POP7 mRNA

NCBI chr12:24,826,161...24,827,202
Ensembl chr12:24,809,994...24,827,522

G

cytochrome p450 oxidoreductase

increases expression

EXP
ISO

leflunomide results in increased expression of POR mRNA

PMID:24136188 PMID:28988120

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POU class 2 homeobox associating factor 1

increases expression

ISO

leflunomide results in increased expression of POU2AF1 mRNA

NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176

G

POU class 4 homeobox 1

decreases expression

ISO

leflunomide results in decreased expression of POU4F1 mRNA

NCBI chr15:87,668,328...87,674,643
Ensembl chr15:87,668,328...87,674,643

G

POU class 5 homeobox 1

decreases expression

ISO

leflunomide results in decreased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

leflunomide results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

increases expression

ISO

leflunomide results in increased expression of PPARGC1A mRNA

PMID:28988120 PMID:29427785

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

phosphopantothenoylcysteine synthetase

increases expression

EXP

leflunomide results in increased expression of PPCS mRNA

NCBI chr 5:138,308,394...138,312,047
Ensembl chr 5:138,308,397...138,312,012

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

increases expression

ISO

leflunomide results in increased expression of PPM1A mRNA

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase 1, regulatory subunit 10

decreases expression

ISO

leflunomide results in decreased expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418

G

protein phosphatase 1, regulatory subunit 13 like

decreases expression

ISO

leflunomide results in decreased expression of PPP1R13L mRNA

NCBI chr 1:88,139,000...88,158,714
Ensembl chr 1:88,140,532...88,158,714

G

protein phosphatase 1, regulatory subunit 15A

increases expression

ISO

leflunomide results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 1, regulatory subunit 15B

increases expression

ISO

leflunomide results in increased expression of PPP1R15B mRNA

NCBI chr13:47,130,000...47,137,805
Ensembl chr13:47,129,967...47,137,798

G

protein phosphatase 1, regulatory subunit 3E

decreases expression

ISO

leflunomide results in decreased expression of PPP1R3E mRNA

NCBI chr15:32,318,435...32,319,595

G

protein phosphatase 3 catalytic subunit gamma

increases expression

ISO

leflunomide results in increased expression of PPP3CC mRNA

PMID:28988120 PMID:29427785

NCBI chr15:51,699,586...51,771,763
Ensembl chr15:51,700,255...51,771,538

G

protein phosphatase 4, regulatory subunit 2

decreases expression
increases expression

ISO

leflunomide results in decreased expression of PPP4R2 mRNA
leflunomide results in increased expression of PPP4R2 mRNA

PMID:19751817 PMID:28988120

NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844

G

peptidylprolyl isomerase domain and WD repeat containing 1

decreases expression

ISO

leflunomide results in decreased expression of PPWD1 mRNA

NCBI chr 2:37,069,744...37,094,252
Ensembl chr 2:37,071,083...37,094,242

G

protease-associated domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of PRADC1 mRNA

NCBI chr 4:119,542,239...119,546,536
Ensembl chr 4:119,541,605...119,547,331

G

PEAK1 related kinase activating pseudokinase 1

increases expression

ISO

leflunomide results in increased expression of PRAG1 mRNA

NCBI chr16:62,791,249...62,844,532
Ensembl chr16:62,786,329...62,844,532

G

protein regulator of cytokinesis 1

decreases expression

EXP

leflunomide results in decreased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

proline rich mitotic checkpoint control factor

decreases expression

ISO

leflunomide results in decreased expression of PRCC mRNA

NCBI chr 2:175,624,134...175,649,664
Ensembl chr 2:175,624,134...175,649,664

G

PRELI domain containing 3A

decreases expression

ISO

leflunomide results in decreased expression of PRELID3A mRNA

NCBI chr18:63,268,824...63,301,772
Ensembl chr18:63,268,766...63,301,770

G

DNA primase subunit 1

decreases expression

EXP

leflunomide results in decreased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134

G

protein kinase AMP-activated non-catalytic subunit beta 1

decreases expression

EXP

leflunomide results in decreased expression of PRKAB1 mRNA

NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482

G

protein kinase AMP-activated non-catalytic subunit beta 2

decreases expression

ISO

leflunomide results in decreased expression of PRKAB2 mRNA

NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608

G

protein kinase C, alpha

increases expression

ISO

leflunomide results in increased expression of PRKCA mRNA

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

increases expression

ISO

leflunomide results in increased expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

prolactin receptor

decreases expression

EXP

leflunomide results in decreased expression of PRLR mRNA

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

protein arginine methyltransferase 5

decreases expression

ISO

leflunomide results in decreased expression of PRMT5 mRNA

NCBI chr15:31,938,927...31,948,318
Ensembl chr15:31,938,719...31,948,426

G

protein arginine methyltransferase 7

decreases expression

ISO

leflunomide results in decreased expression of PRMT7 mRNA

NCBI chr19:51,020,596...51,071,401
Ensembl chr19:51,020,512...51,072,424

G

prokineticin receptor 2

decreases expression

ISO

leflunomide results in decreased expression of PROKR2 mRNA

NCBI chr 3:140,077,629...140,092,327
Ensembl chr 3:140,077,630...140,092,093

G

proline and serine rich 2

increases expression

EXP
ISO

leflunomide results in increased expression of PROSER2 mRNA

PMID:24136188 PMID:28988120

NCBI chr17:77,061,371...77,096,788
Ensembl chr17:77,077,727...77,095,194

G

prospero homeobox 1

increases expression

ISO

leflunomide results in increased expression of PROX1 mRNA

NCBI chr13:104,196,615...104,251,007
Ensembl chr13:104,200,378...104,250,975

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

decreases expression

ISO

leflunomide results in decreased expression of PRPSAP1 mRNA

NCBI chr10:102,199,949...102,221,642
Ensembl chr10:102,199,950...102,221,642

G

proline rich 11

decreases expression

ISO

leflunomide results in decreased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:72,398,667...72,418,275

G

proline rich 15-like

decreases expression

ISO

leflunomide results in decreased expression of PRR15L mRNA

NCBI chr10:82,412,934...82,418,897
Ensembl chr10:82,402,733...82,419,558

G

proline rich and Gla domain 1

increases expression

ISO

leflunomide results in increased expression of PRRG1 mRNA

NCBI chr X:46,381,329...46,493,677
Ensembl chr X:46,383,967...46,493,700

G

serine protease 23

increases expression

ISO

leflunomide results in increased expression of PRSS23 mRNA

NCBI chr 1:152,815,301...152,835,005
Ensembl chr 1:152,813,670...152,947,871

G

protogenin

increases expression

ISO

leflunomide results in increased expression of PRTG mRNA

NCBI chr 8:82,429,106...82,538,612
Ensembl chr 8:82,429,132...82,538,602

G

prune exopolyphosphatase 1

decreases expression

ISO

leflunomide results in decreased expression of PRUNE1 mRNA

NCBI chr 2:185,519,569...185,548,402
Ensembl chr 2:185,520,781...185,548,402

G

peroxiredoxin like 2C

increases expression

EXP

leflunomide results in increased expression of PRXL2C mRNA

NCBI chr17:817,932...849,965
Ensembl chr17:817,949...840,940

G

protein serine kinase H1

decreases expression

ISO

leflunomide results in decreased expression of PSKH1 mRNA

NCBI chr19:50,704,780...50,736,890
Ensembl chr19:50,704,781...50,736,892

G

proteasome 20S subunit alpha 1

increases expression

EXP

leflunomide results in increased expression of PSMA1 mRNA

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:177,875,353...177,887,949

G

proteasome 20S subunit alpha 5

increases expression

EXP

leflunomide results in increased expression of PSMA5 mRNA

NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:198,584,505...198,607,867

G

proteasome 20S subunit beta 1

increases expression

EXP

leflunomide results in increased expression of PSMB1 mRNA

NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:65,114,724...65,136,640

G

proteasome 20S subunit beta 3

increases expression

EXP

leflunomide results in increased expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 20S subunit beta 4

increases expression

EXP

leflunomide results in increased expression of PSMB4 mRNA

NCBI chr 2:185,131,787...185,134,561
Ensembl chr 2:185,131,786...185,135,287

G

proteasome 20S subunit beta 6

increases expression

EXP

leflunomide results in increased expression of PSMB6 mRNA

NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218

G

proteasome 20S subunit beta 8

decreases expression

EXP

leflunomide results in decreased expression of PSMB8 mRNA

NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031

G

proteasome 20S subunit beta 9

decreases expression

EXP

leflunomide results in decreased expression of PSMB9 mRNA

NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421

G

proteasome 26S subunit, ATPase 1

increases expression

EXP

leflunomide results in increased expression of PSMC1 mRNA

NCBI chr 6:125,122,497...125,134,859
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

increases expression

EXP

leflunomide results in increased expression of PSMC3 mRNA

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 4

increases expression

EXP

leflunomide results in increased expression of PSMC4 mRNA

NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:92,476,690...92,485,060

G

proteasome 26S subunit, ATPase 5

increases expression

EXP

leflunomide results in increased expression of PSMC5 mRNA

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 1

increases expression

EXP

leflunomide results in increased expression of PSMD1 mRNA

NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:94,157,971...94,233,218

G

proteasome 26S subunit, non-ATPase 12

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of PSMD12 mRNA
leflunomide results in decreased expression of PSMD12 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:92,937,957...92,956,601
Ensembl chr10:92,901,133...92,988,964

G

proteasome 26S subunit, non-ATPase 13

increases expression

EXP

leflunomide results in increased expression of PSMD13 mRNA

NCBI chr 1:205,394,248...205,406,525
Ensembl chr 1:205,393,746...205,411,651

G

proteasome 26S subunit, non-ATPase 14

increases expression

EXP

leflunomide results in increased expression of PSMD14 mRNA

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

increases expression

EXP

leflunomide results in increased expression of PSMD2 mRNA

NCBI chr11:93,752,761...93,763,388
Ensembl chr11:93,752,763...93,763,388

G

proteasome 26S subunit, non-ATPase 3

increases expression

EXP

leflunomide results in increased expression of PSMD3 mRNA

NCBI chr10:84,139,249...84,151,879
Ensembl chr10:84,139,677...84,151,878

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

increases expression

EXP

leflunomide results in increased expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

proteasome 26S subunit, non-ATPase 5

increases expression

EXP

leflunomide results in increased expression of PSMD5 mRNA

NCBI chr 3:38,531,206...38,552,085
Ensembl chr 3:38,530,951...38,548,490

G

proteasome 26S subunit, non-ATPase 7

increases expression

EXP

leflunomide results in increased expression of PSMD7 mRNA

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

proteasome 26S subunit, non-ATPase 8

increases expression

EXP

leflunomide results in increased expression of PSMD8 mRNA

NCBI chr 1:93,601,857...93,608,689
Ensembl chr 1:93,601,853...93,608,689

G

phosphoserine phosphatase

increases expression

EXP

leflunomide results in increased expression of PSPH mRNA

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:32,519,269...32,541,180

G

proline and serine rich coiled-coil 1

increases expression
decreases expression

ISO

leflunomide results in increased expression of PSRC1 mRNA
leflunomide results in decreased expression of PSRC1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 2:198,710,427...198,715,001
Ensembl chr 2:198,705,839...198,714,997

G

phosphatase and tensin homolog

increases expression

ISO

leflunomide results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin D2 receptor 2

increases expression

ISO

leflunomide results in increased expression of PTGDR2 mRNA

NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:216,995,629...217,022,393

G

prostaglandin reductase 1

decreases expression

EXP

leflunomide results in decreased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin reductase 3

increases expression

EXP

Leflunomide results in increased expression of PTGR3 mRNA

NCBI chr18:79,729,282...79,738,632
Ensembl chr18:79,729,282...79,738,632

G

parathyroid hormone-like hormone

increases expression

ISO

leflunomide results in increased expression of PTHLH mRNA

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

prothymosin alpha

decreases expression

EXP

leflunomide results in decreased expression of PTMA mRNA

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

protein tyrosine phosphatase 4A1

increases expression

ISO

leflunomide results in increased expression of PTP4A1 mRNA

NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176

G

protein tyrosine phosphatase domain containing 1

increases expression

ISO

leflunomide results in increased expression of PTPDC1 mRNA

NCBI chr17:16,235,311...16,284,160
Ensembl chr17:16,235,263...16,284,158

G

protein tyrosine phosphatase, non-receptor type 12

increases expression

ISO

leflunomide results in increased expression of PTPN12 mRNA

NCBI chr 4:14,913,071...14,985,084
Ensembl chr 4:14,913,218...14,985,284

G

protein tyrosine phosphatase, non-receptor type 18

decreases expression

ISO

leflunomide results in decreased expression of PTPN18 mRNA

NCBI chr 9:44,166,571...44,185,885
Ensembl chr 9:44,168,269...44,186,917

G

protein tyrosine phosphatase, receptor type, B

increases expression

ISO

leflunomide results in increased expression of PTPRB mRNA

NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:53,816,097...53,920,760

G

protein tyrosine phosphatase, receptor type, G

increases expression

EXP
ISO

leflunomide results in increased expression of PTPRG mRNA

PMID:24136188 PMID:28988120

NCBI chr15:15,298,669...15,982,581
Ensembl chr15:15,302,133...15,982,668

G

protein tyrosine phosphatase, receptor type, H

increases expression

ISO

leflunomide results in increased expression of PTPRH mRNA

NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:78,271,276...78,318,977

G

protein tyrosine phosphatase, receptor type, J

increases expression

ISO

leflunomide results in increased expression of PTPRJ mRNA

NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:96,861,785...97,017,656

G

protein tyrosine phosphatase, receptor type, N

decreases expression

EXP

leflunomide results in decreased expression of PTPRN mRNA

NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:84,189,676...84,204,850

G

PTTG1 regulator of sister chromatid separation, securin

decreases expression

EXP
ISO

leflunomide results in decreased expression of PTTG1 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

purine rich element binding protein B

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of PURB mRNA
leflunomide results in decreased expression of PURB mRNA

PMID:24136188 PMID:28988120

NCBI chr14:85,556,296...85,558,779
Ensembl chr14:85,550,417...85,572,205

G

PVR cell adhesion molecule

increases expression

ISO

leflunomide results in increased expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630

G

Pvt1 oncogene

increases expression

ISO

leflunomide results in increased expression of PVT1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 7:95,545,916...95,769,306

G

PWWP domain containing 3A, DNA repair factor

decreases expression

ISO

Leflunomide results in decreased expression of PWWP3A mRNA

NCBI chr 7:10,115,865...10,132,696
Ensembl chr 7:10,115,866...10,130,925

G

PX domain containing 1

increases expression

ISO

leflunomide results in increased expression of PXDC1 mRNA

NCBI chr17:30,481,336...30,510,330
Ensembl chr17:30,481,373...30,510,331

G

pyridine nucleotide-disulphide oxidoreductase domain 1

increases expression

ISO

leflunomide results in increased expression of PYROXD1 mRNA

NCBI chr 4:177,023,137...177,042,152
Ensembl chr 4:177,023,138...177,055,586

G

Q-nucleotide N-glycosylase 1

decreases expression

ISO

Leflunomide results in decreased expression of QNG1 mRNA

NCBI chr17:6,286,801...6,294,400
Ensembl chr17:6,286,827...6,294,399

G

R3H domain containing 2

decreases expression

EXP

leflunomide results in decreased expression of R3HDM2 mRNA

NCBI chr 7:65,097,685...65,225,863
Ensembl chr 7:65,097,923...65,225,862

G

RAB11 family interacting protein 3

increases expression

EXP

leflunomide results in increased expression of RAB11FIP3 mRNA

NCBI chr10:15,507,151...15,591,173
Ensembl chr10:15,507,151...15,591,173

G

RAB11 family interacting protein 5

decreases expression

ISO

leflunomide results in decreased expression of RAB11FIP5 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:119,428,766...119,466,277
Ensembl chr 4:119,428,766...119,466,213

G

RAB27A, member RAS oncogene family

decreases expression

ISO

leflunomide results in decreased expression of RAB27A mRNA

NCBI chr 8:82,663,373...82,717,267
Ensembl chr 8:82,663,276...82,717,262

G

RAB30, member RAS oncogene family

increases expression

EXP
ISO

leflunomide results in increased expression of RAB30 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:156,216,137...156,310,778
Ensembl chr 1:156,216,137...156,310,778

G

RAB32, member RAS oncogene family

decreases expression

EXP

leflunomide results in decreased expression of RAB32 mRNA

NCBI chr 1:6,766,448...6,781,258
Ensembl chr 1:6,766,455...6,781,258

G

RAB33B, member RAS oncogene family

increases expression

EXP

leflunomide results in increased expression of RAB33B mRNA

NCBI chr 2:137,678,953...137,689,581
Ensembl chr 2:137,678,978...137,689,581

G

RAB34, member RAS oncogene family

increases expression

EXP

leflunomide results in increased expression of RAB34 mRNA

NCBI chr10:63,581,542...63,585,608
Ensembl chr10:63,580,997...63,586,083

G

RAB38, member RAS oncogene family

decreases expression

EXP

leflunomide results in decreased expression of RAB38 mRNA

NCBI chr 1:151,595,153...151,675,492
Ensembl chr 1:151,595,078...151,675,493

G

RAB3 GTPase activating non-catalytic protein subunit 2

increases expression

ISO

leflunomide results in increased expression of RAB3GAP2 mRNA

NCBI chr13:99,288,984...99,362,817
Ensembl chr13:99,288,647...99,361,053

G

Rab40b, member RAS oncogene family

decreases expression

ISO

leflunomide results in decreased expression of RAB40B mRNA

NCBI chr10:107,129,801...107,157,375
Ensembl chr10:107,129,801...107,157,457

G

RAB5B, member RAS oncogene family

decreases expression

ISO

leflunomide results in decreased expression of RAB5B mRNA

NCBI chr 7:1,693,971...1,712,936
Ensembl chr 7:1,693,989...1,712,780

G

RAB9A, member RAS oncogene family

increases expression

ISO

leflunomide results in increased expression of RAB9A mRNA

NCBI chr X:31,610,089...31,632,128
Ensembl chr X:31,583,944...31,645,743

G

Rab geranylgeranyltransferase subunit alpha

increases expression

EXP

leflunomide results in increased expression of RABGGTA mRNA

NCBI chr15:33,176,268...33,183,320
Ensembl chr15:33,176,099...33,183,271

G

Rab geranylgeranyltransferase subunit beta

increases expression

ISO

leflunomide results in increased expression of RABGGTB mRNA

NCBI chr 2:245,504,586...245,510,878
Ensembl chr 2:245,504,586...245,510,774

G

RAB interacting factor

decreases expression

ISO

leflunomide results in decreased expression of RABIF mRNA

NCBI chr13:48,488,370...48,500,853
Ensembl chr13:48,488,348...48,502,013

G

Rac GTPase-activating protein 1

decreases expression

ISO

leflunomide results in decreased expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:132,620,595...132,659,738

G

RAD23 homolog B, nucleotide excision repair protein

increases expression

EXP

leflunomide results in increased expression of RAD23B mRNA

NCBI chr 5:74,885,518...74,923,621
Ensembl chr 5:74,885,516...74,962,426

G

RAD51 recombinase

decreases expression

ISO

leflunomide results in decreased expression of RAD51 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

RAD51 paralog C

decreases expression

ISO

leflunomide results in decreased expression of RAD51C mRNA

NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,702,299...72,729,143

G

RAD54 homolog B

decreases expression

ISO

leflunomide results in decreased expression of RAD54B mRNA

NCBI chr 5:29,829,465...29,901,967
Ensembl chr 5:29,855,304...29,901,964

G

RAD54 like 2

increases expression

ISO

leflunomide results in increased expression of RAD54L2 mRNA

NCBI chr 8:116,203,655...116,305,723
Ensembl chr 8:116,203,655...116,305,849

G

Ral GTPase activating protein catalytic subunit alpha 2

increases expression

ISO

leflunomide results in increased expression of RALGAPA2 mRNA

NCBI chr 3:154,112,005...154,392,070
Ensembl chr 3:154,112,014...154,392,138

G

ral guanine nucleotide dissociation stimulator like 1

increases expression

ISO

leflunomide results in increased expression of RGL1 mRNA

NCBI chr13:67,184,402...67,454,019
Ensembl chr13:67,184,402...67,454,019

G

RAN binding protein 17

increases expression

ISO

leflunomide results in increased expression of RANBP17 mRNA

NCBI chr10:18,304,634...18,607,162
Ensembl chr10:18,305,227...18,607,047

G

Rap1 GTPase-activating protein

increases expression

ISO

leflunomide results in increased expression of RAP1GAP mRNA

NCBI chr 5:155,157,511...155,222,622
Ensembl chr 5:155,157,558...155,222,622

G

Rap guanine nucleotide exchange factor 1

increases expression

ISO

leflunomide results in increased expression of RAPGEF1 mRNA

NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119

G

Rap guanine nucleotide exchange factor 5

increases expression

ISO

leflunomide results in increased expression of RAPGEF5 mRNA

NCBI chr 6:144,588,162...144,822,908
Ensembl chr 6:144,580,976...144,822,908

G

Rap guanine nucleotide exchange factor like 1

decreases expression

ISO

leflunomide results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:84,289,980...84,306,614
Ensembl chr10:84,289,980...84,306,614

G

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

increases expression

ISO

leflunomide results in increased expression of RAPH1 mRNA

NCBI chr 9:69,397,272...69,484,174
Ensembl chr 9:69,401,517...69,484,019

G

ras related dexamethasone induced 1

increases expression

ISO

leflunomide results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RAS protein-specific guanine nucleotide-releasing factor 2

increases expression

ISO

leflunomide results in increased expression of RASGRF2 mRNA

NCBI chr 2:24,848,699...25,096,773
Ensembl chr 2:24,848,699...25,147,558

G

Ras association domain family member 2

increases expression

ISO

leflunomide results in increased expression of RASSF2 mRNA

NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:139,697,187...139,733,368

G

RB1-inducible coiled-coil 1

increases expression

ISO

leflunomide results in increased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

RB binding protein 6, ubiquitin ligase

decreases expression

ISO

leflunomide results in decreased expression of RBBP6 mRNA

NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852

G

RB binding protein 7, chromatin remodeling factor

decreases expression

ISO

leflunomide results in decreased expression of RBBP7 mRNA

NCBI chr X:35,544,873...35,563,030
Ensembl chr X:35,544,873...35,563,030

G

ribosome binding factor A

decreases expression

EXP

leflunomide results in decreased expression of RBFA mRNA

NCBI chr18:75,914,247...75,923,893
Ensembl chr18:75,914,145...75,939,219

G

ribosomal biogenesis factor

decreases expression

ISO

Leflunomide results in decreased expression of RBIS mRNA

NCBI chr 2:88,702,599...88,718,587
Ensembl chr 2:88,702,536...88,719,527

G

RB transcriptional corepressor like 2

decreases expression

ISO

leflunomide results in decreased expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411

G

RNA binding motif protein 12

decreases expression

ISO

leflunomide results in decreased expression of RBM12 mRNA

NCBI chr 3:165,069,744...165,089,994
Ensembl chr 3:165,042,878...165,090,021

G

RNA binding motif protein 12B

decreases expression

ISO

leflunomide results in decreased expression of RBM12B mRNA

NCBI chr 5:30,394,756...30,507,428
Ensembl chr 5:30,386,777...30,409,855

G

RNA binding motif protein 14

decreases expression

ISO

leflunomide results in decreased expression of RBM14 mRNA

NCBI chr 1:211,476,298...211,535,077
Ensembl chr 1:211,523,972...211,535,065

G

RNA binding motif protein 33

increases expression

ISO

leflunomide results in increased expression of RBM33 mRNA

NCBI chr 4:7,714,660...7,825,469
Ensembl chr 4:7,720,180...7,820,882

G

RNA binding motif protein 48

increases expression

ISO

leflunomide results in increased expression of RBM48 mRNA

NCBI chr 4:31,513,811...31,524,149
Ensembl chr 4:31,513,760...31,524,147

G

RNA binding motif protein 4B

decreases expression

ISO

leflunomide results in decreased expression of RBM4B mRNA

NCBI chr 1:211,477,337...211,487,428

G

ring-box 1

increases expression

EXP

leflunomide results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

ring finger and CCCH-type domains 1

decreases expression

ISO

leflunomide results in decreased expression of RC3H1 mRNA

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816

G

RCC1 domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of RCCD1 mRNA

NCBI chr 1:143,681,124...143,690,817
Ensembl chr 1:143,681,035...143,690,362

G

ring finger and CHY zinc finger domain containing 1

increases expression

EXP

leflunomide results in increased expression of RCHY1 mRNA

NCBI chr14:16,397,533...16,413,286
Ensembl chr14:16,397,494...16,413,451

G

reticulocalbin 2

decreases expression

ISO

leflunomide results in decreased expression of RCN2 mRNA

NCBI chr 8:65,345,247...65,362,290
Ensembl chr 8:65,345,273...65,364,632

G

REST corepressor 3

increases expression

ISO

leflunomide results in increased expression of RCOR3 mRNA

NCBI chr13:106,156,166...106,196,542
Ensembl chr13:106,157,232...106,196,575

G

RCSD domain containing 1

increases expression

ISO

leflunomide results in increased expression of RCSD1 mRNA

NCBI chr13:80,434,878...80,497,312
Ensembl chr13:80,434,878...80,498,931

G

retinol dehydrogenase 5

decreases expression

EXP

leflunomide results in decreased expression of RDH5 mRNA

NCBI chr 7:1,912,120...1,931,836
Ensembl chr 7:1,925,335...1,936,049

G

retinol dehydrogenase 9

increases expression

ISO

Leflunomide results in increased expression of RDH9 mRNA

NCBI chr 7:65,527,552...65,530,396

G

RecQ like helicase 5

decreases expression

ISO

leflunomide results in decreased expression of RECQL5 mRNA

NCBI chr10:101,625,477...101,664,582
Ensembl chr10:101,625,480...101,664,663

G

receptor accessory protein 4

decreases expression

EXP

leflunomide results in decreased expression of REEP4 mRNA

NCBI chr15:52,030,022...52,033,229
Ensembl chr15:52,029,646...52,033,231

G

receptor accessory protein 6

increases expression

EXP

leflunomide results in increased expression of REEP6 mRNA

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740

G

RE1-silencing transcription factor

increases expression

ISO

leflunomide results in increased expression of REST mRNA

NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662

G

reticulophagy regulator family member 3

increases expression

EXP

leflunomide results in increased expression of RETREG3 mRNA

NCBI chr10:86,529,048...86,552,873
Ensembl chr10:86,529,055...86,552,990

G

retinol saturase

increases expression

EXP

leflunomide results in increased expression of RETSAT mRNA

NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:106,211,436...106,229,552

G

required for excision 1-B domain containing

increases expression

EXP

leflunomide results in increased expression of REX1BD mRNA

NCBI chr16:18,956,023...18,958,494
Ensembl chr16:18,955,969...18,958,494

G

RNA exonuclease 5

decreases expression

ISO

leflunomide results in decreased expression of REXO5 mRNA

NCBI chr 1:183,599,954...183,698,433
Ensembl chr 1:183,600,037...183,672,850

G

replication factor C subunit 1

increases expression

EXP

leflunomide results in increased expression of RFC1 mRNA

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026

G

replication factor C subunit 4

decreases expression

ISO

leflunomide results in decreased expression of RFC4 mRNA

NCBI chr11:91,254,273...91,268,727
Ensembl chr11:91,254,243...91,268,730

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

increases expression

ISO

leflunomide results in increased expression of RFFL mRNA

NCBI chr10:68,238,273...68,301,225
Ensembl chr10:68,238,273...68,321,902

G

regulatory factor X5

decreases expression

EXP
ISO

leflunomide results in decreased expression of RFX5 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:185,210,206...185,217,735
Ensembl chr 2:185,210,217...185,217,743

G

regulatory factor X-associated protein

decreases expression

ISO

leflunomide results in decreased expression of RFXAP mRNA

NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:141,158,215...141,162,397

G

similar to RIKEN cDNA 3110043O21

increases expression

ISO

leflunomide results in increased expression of C9ORF72 mRNA

NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:54,562,570...54,587,637

G

RGD1559600

increases expression

EXP

leflunomide results in increased expression of RGD1559600 mRNA

NCBI chr 1:183,401,989...183,418,946
Ensembl chr 1:183,405,193...183,416,929

G

repulsive guidance molecule BMP co-receptor b

increases expression

ISO

leflunomide results in increased expression of RGMB mRNA

NCBI chr 1:65,439,748...65,465,149
Ensembl chr 1:65,441,410...65,465,098

G

regulator of G-protein signaling 10

increases expression

ISO

leflunomide results in increased expression of RGS10 mRNA

NCBI chr 1:192,376,772...192,422,640
Ensembl chr 1:192,376,774...192,418,904

G

regulator of G-protein signaling 16

decreases expression

ISO

leflunomide results in decreased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

RAD9-HUS1-RAD1 interacting nuclear orphan 1

decreases expression

ISO

leflunomide results in decreased expression of RHNO1 mRNA

NCBI chr 4:163,320,141...163,325,527
Ensembl chr 4:163,320,049...163,325,790

G

ras homolog family member B

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of RHOB mRNA
leflunomide results in increased expression of RHOB mRNA

PMID:24136188 PMID:28988120

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

Rho-related BTB domain containing 3

increases expression

EXP

leflunomide results in increased expression of RHOBTB3 mRNA

NCBI chr 2:7,094,972...7,201,507
Ensembl chr 2:7,095,253...7,150,906

G

rhophilin, Rho GTPase binding protein 2

increases expression

ISO

leflunomide results in increased expression of RHPN2 mRNA

NCBI chr 1:97,128,054...97,188,803
Ensembl chr 1:97,127,697...97,188,803

G

RIC8 guanine nucleotide exchange factor A

decreases expression

ISO

leflunomide results in decreased expression of RIC8A mRNA

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102

G

RIC8 guanine nucleotide exchange factor B

decreases expression

ISO

leflunomide results in decreased expression of RIC8B mRNA

NCBI chr 7:20,636,337...20,730,066
Ensembl chr 7:20,636,687...20,730,178

G

Rab interacting lysosomal protein-like 2

decreases expression

ISO

leflunomide results in decreased expression of RILPL2 mRNA

NCBI chr12:37,786,877...37,798,412
Ensembl chr12:37,786,825...37,798,412

G

RIO kinase 3

increases expression

ISO

leflunomide results in increased expression of RIOK3 mRNA

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,602,535...3,628,108

G

receptor interacting serine/threonine kinase 1

decreases expression

ISO

leflunomide results in decreased expression of RIPK1 mRNA

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 4

increases expression

ISO

leflunomide results in increased expression of RIPK4 mRNA

NCBI chr11:50,591,926...50,614,169
Ensembl chr11:50,591,936...50,614,169

G

RHO family interacting cell polarization regulator 1

increases expression

ISO

leflunomide results in increased expression of RIPOR1 mRNA

NCBI chr19:50,387,447...50,416,323
Ensembl chr19:50,387,523...50,416,319

G

RIPOR family member 3

increases expression

ISO

leflunomide results in increased expression of RIPOR3 mRNA

NCBI chr 3:177,106,436...177,179,423
Ensembl chr 3:177,106,892...177,179,095

G

ring finger protein, LIM domain interacting

increases expression

ISO

Leflunomide results in increased expression of RLIM mRNA

NCBI chr X:73,048,983...73,070,302
Ensembl chr X:73,054,098...73,069,992

G

RecQ mediated genome instability 2

decreases expression

ISO

leflunomide results in decreased expression of RMI2 mRNA

NCBI chr10:5,336,269...5,344,202
Ensembl chr10:5,338,060...5,344,235

G

Rho family GTPase 1

increases expression

ISO

leflunomide results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

Rho family GTPase 2

increases expression

EXP

leflunomide results in increased expression of RND2 mRNA

NCBI chr10:86,899,395...86,902,992
Ensembl chr10:86,899,395...86,902,992

G

ring finger protein 103

decreases expression

ISO

leflunomide results in decreased expression of RNF103 mRNA

NCBI chr 4:105,084,762...105,100,839
Ensembl chr 4:105,084,686...105,106,809

G

ring finger protein 141

decreases expression

ISO

leflunomide results in decreased expression of RNF141 mRNA

NCBI chr 1:174,365,789...174,391,848

G

ring finger protein 144B

increases expression

ISO

leflunomide results in increased expression of RNF144B mRNA

PMID:28988120 PMID:29427785

NCBI chr17:17,637,564...17,786,685
Ensembl chr17:17,639,079...17,769,037

G

ring finger protein 149

increases expression

EXP

leflunomide results in increased expression of RNF149 mRNA

NCBI chr 9:49,322,524...49,350,361
Ensembl chr 9:49,323,857...49,350,042

G

ring finger protein 150

increases expression

ISO

leflunomide results in increased expression of RNF150 mRNA

NCBI chr19:41,912,276...42,133,217
Ensembl chr19:41,912,276...42,133,217

G

ring finger protein 157

increases expression

ISO

leflunomide results in increased expression of RNF157 mRNA

NCBI chr10:102,070,842...102,138,738
Ensembl chr10:102,070,842...102,155,802

G

ring finger protein 169

increases expression

ISO

leflunomide results in increased expression of RNF169 mRNA

NCBI chr 1:163,662,582...163,724,154
Ensembl chr 1:163,666,592...163,723,897

G

ring finger protein 17

increases expression

ISO

leflunomide results in increased expression of RNF17 mRNA

NCBI chr15:34,603,448...34,741,658
Ensembl chr15:34,603,615...34,741,653

G

ring finger protein 19A, RBR E3 ubiquitin protein ligase

increases expression

ISO

leflunomide results in increased expression of RNF19A mRNA

NCBI chr 7:69,310,947...69,350,567
Ensembl chr 7:69,310,947...69,350,225

G

ring finger protein 217

increases expression

EXP

leflunomide results in increased expression of RNF217 mRNA

NCBI chr 1:27,835,741...27,927,805
Ensembl chr 1:27,835,148...27,928,044

G

ring finger protein 26

decreases expression

ISO

leflunomide results in decreased expression of RNF26 mRNA

NCBI chr 8:53,351,388...53,353,586
Ensembl chr 8:53,341,487...53,355,777

G

ring finger protein 32

decreases expression

ISO

leflunomide results in decreased expression of RNF32 mRNA

NCBI chr 4:6,822,700...6,884,411
Ensembl chr 4:6,824,970...6,883,976

G

ring finger protein 34

decreases expression

ISO

leflunomide results in decreased expression of RNF34 mRNA

NCBI chr12:39,364,461...39,385,391
Ensembl chr12:39,355,578...39,385,340

G

ring finger protein 43

increases expression

ISO

leflunomide results in increased expression of RNF43 mRNA

NCBI chr10:72,958,744...73,034,540
Ensembl chr10:72,961,641...73,034,551

G

RNA-binding region (RNP1, RRM) containing 3

decreases expression

ISO

leflunomide results in decreased expression of RNPC3 mRNA

NCBI chr 2:204,121,191...204,145,128
Ensembl chr 2:204,121,193...204,145,128

G

RNA, variant U1 small nuclear 7

increases expression

ISO

Leflunomide results in increased expression of RNVU1-7 mRNA

NCBI chr18:82,176,131...82,176,273
Ensembl chr18:82,176,131...82,176,273

G

roundabout guidance receptor 1

increases expression

ISO

leflunomide results in increased expression of ROBO1 mRNA

NCBI chr11:24,067,869...25,108,694
Ensembl chr11:24,067,878...25,108,694

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

ISO

leflunomide results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

reactive oxygen species modulator 1

increases expression

EXP

leflunomide results in increased expression of ROMO1 mRNA

NCBI chr 3:165,119,794...165,121,394
Ensembl chr 3:165,120,035...165,121,394

G

RAR-related orphan receptor A

increases expression

EXP

leflunomide results in increased expression of RORA mRNA

NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730

G

RAR-related orphan receptor C

multiple interactions

ISO

leflunomide inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

RP9, pre-mRNA splicing factor

increases expression

ISO

leflunomide results in increased expression of RP9 mRNA

NCBI chr 8:29,218,564...29,281,211
Ensembl chr 8:29,217,346...29,281,150

G

replication protein A1

decreases expression

ISO

leflunomide results in decreased expression of RPA1 mRNA

NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279

G

replication protein A2

decreases expression

ISO

leflunomide results in decreased expression of RPA2 mRNA

NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:150,260,723...150,271,546

G

ribosomal protein L3

decreases expression

ISO

leflunomide results in decreased expression of RPL3 mRNA

NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:113,501,960...113,507,990

G

ribosomal protein L36A like 1

decreases expression

ISO

leflunomide results in decreased expression of RPL36AL mRNA

NCBI chr 6:93,390,864...93,392,258
Ensembl chr 6:93,390,866...93,391,296
Ensembl chr20:93,390,866...93,391,296

G

ribosomal protein L41

decreases expression

ISO

leflunomide results in decreased expression of RPL41 mRNA

NCBI chr 7:1,562,417...1,563,497

G

ribosomal protein S10

decreases expression

ISO

leflunomide results in decreased expression of RPS10 mRNA

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S13

increases expression

ISO

leflunomide results in increased expression of RPS13 mRNA

NCBI chr 1:180,007,230...180,009,660
Ensembl chr 1:180,002,471...180,009,660

G

ribosomal protein S15a

increases expression

ISO

leflunomide results in increased expression of RPS15A mRNA

NCBI chr 1:181,854,396...181,861,330
Ensembl chr 1:181,854,396...181,861,201

G

ribosomal protein S17

decreases expression

ISO

leflunomide results in decreased expression of RPS17 mRNA

NCBI chr 1:144,705,150...144,707,736
Ensembl chr 1:144,705,149...144,707,734
Ensembl chr 8:144,705,149...144,707,734

G

ribosomal protein S26

decreases expression

ISO

Leflunomide results in decreased expression of RPS26 mRNA

NCBI chr 7:1,641,846...1,643,404
Ensembl chr 7:1,641,421...1,643,399

G

ribosomal protein S9

decreases expression

ISO

leflunomide results in decreased expression of RPS9 mRNA

NCBI chr 1:74,427,084...74,430,513
Ensembl chr 1:74,427,087...74,430,105

G

RNA pseudouridine synthase domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of RPUSD2 mRNA

NCBI chr 3:126,471,620...126,476,869
Ensembl chr 3:126,471,579...126,477,180

G

ribosome binding protein 1

increases expression

EXP

leflunomide results in increased expression of RRBP1 mRNA

NCBI chr 3:151,768,386...151,830,255
Ensembl chr 3:151,768,386...151,830,255

G

ras responsive element binding protein 1

increases expression

ISO

leflunomide results in increased expression of RREB1 mRNA

NCBI chr17:27,082,217...27,208,061
Ensembl chr17:27,082,227...27,208,061

G

ribonucleotide reductase M1, pseudogene 1

decreases expression

EXP

leflunomide results in decreased expression of RRM1-PS1 mRNA

NCBI chr14:76,389,709...76,392,646

G

ribonucleotide reductase regulatory subunit M2

decreases expression

EXP
ISO

leflunomide results in decreased expression of RRM2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

ribosomal RNA processing 8

increases expression

ISO

leflunomide results in increased expression of RRP8 mRNA

NCBI chr 1:169,489,829...169,500,551
Ensembl chr 1:169,465,397...169,501,164

G

round spermatid basic protein 1-like

increases expression

ISO

leflunomide results in increased expression of RSBN1L mRNA

NCBI chr 4:15,014,405...15,093,287
Ensembl chr 4:15,031,173...15,093,286

G

remodeling and spacing factor 1

increases expression

ISO

leflunomide results in increased expression of RSF1 mRNA

NCBI chr 1:161,303,596...161,426,326
Ensembl chr 1:161,303,660...161,420,290

G

ribosomal protein S6 kinase related

decreases expression

ISO

Leflunomide results in decreased expression of RSKR mRNA

NCBI chr10:63,683,387...63,690,032
Ensembl chr10:63,683,479...63,687,889

G

RT1 class I, locus CE16

affects expression

ISO

Leflunomide affects the expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548

G

rhotekin

decreases expression

ISO

leflunomide results in decreased expression of RTKN mRNA

NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660

G

rhotekin 2

decreases expression

ISO

leflunomide results in decreased expression of RTKN2 mRNA

NCBI chr20:20,535,553...20,608,863
Ensembl chr20:20,535,553...20,608,899

G

receptor (chemosensory) transporter protein 3

increases expression

ISO

leflunomide results in increased expression of RTP3 mRNA

NCBI chr 8:119,847,947...119,853,549
Ensembl chr 8:119,848,556...119,853,095

G

RUN and FYVE domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of RUFY2 mRNA

NCBI chr20:25,566,950...25,657,937
Ensembl chr20:25,621,646...25,656,844

G

RUNX family transcription factor 1

increases expression

ISO

Leflunomide results in increased expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

RUN and SH3 domain containing 2

increases expression

ISO

leflunomide results in increased expression of RUSC2 mRNA

NCBI chr 5:62,424,185...62,471,317
Ensembl chr 5:62,444,665...62,471,314

G

RWD domain containing 2A

decreases expression

ISO

leflunomide results in decreased expression of RWDD2A mRNA

NCBI chr 8:96,416,190...96,419,315
Ensembl chr 8:96,416,190...96,419,315

G

retinoid X receptor beta

decreases expression

ISO

leflunomide results in decreased expression of RXRB mRNA

NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359

G

RING1 and YY1 binding protein

increases expression

ISO

leflunomide results in increased expression of RYBP mRNA

NCBI chr 4:134,432,663...134,484,732
Ensembl chr 4:134,432,663...134,484,930

G

ryanodine receptor 1

decreases expression

ISO

leflunomide results in decreased expression of RYR1 mRNA

NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305

G

S100 calcium binding protein A10

decreases expression

EXP

leflunomide results in decreased expression of S100A10 mRNA

NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:181,904,261...181,913,103

G

S100 calcium binding protein A11

decreases expression

EXP

leflunomide results in decreased expression of S100A11 mRNA

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:181,875,130...181,880,541

G

sphingosine-1-phosphate receptor 2

increases expression

ISO

leflunomide results in increased expression of S1PR2 mRNA

NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:27,774,566...27,790,577

G

spalt-like transcription factor 2

decreases expression

ISO

leflunomide results in decreased expression of SALL2 mRNA

NCBI chr15:27,494,831...27,512,402
Ensembl chr15:27,494,589...27,512,402

G

sterile alpha motif domain containing 10

decreases expression

ISO

leflunomide results in decreased expression of SAMD10 mRNA

NCBI chr 3:189,077,795...189,082,069
Ensembl chr 3:189,078,513...189,082,582

G

sterile alpha motif domain containing 11

increases expression

ISO

leflunomide results in increased expression of SAMD11 mRNA

NCBI chr 5:172,113,900...172,142,026
Ensembl chr 5:172,113,654...172,131,927

G

sterile alpha motif domain containing 4A

increases expression

ISO

leflunomide results in increased expression of SAMD4A mRNA

NCBI chr15:22,616,200...22,831,872
Ensembl chr15:22,614,287...22,831,872

G

sterile alpha motif domain containing 8

increases expression

ISO

leflunomide results in increased expression of SAMD8 mRNA

NCBI chr15:2,561,435...2,611,702
Ensembl chr15:2,561,435...2,607,052

G

sterile alpha motif domain containing 9

decreases expression

ISO

leflunomide results in decreased expression of SAMD9 mRNA

NCBI chr 4:32,119,318...32,139,008
Ensembl chr 4:32,117,137...32,171,759

G

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

decreases expression

ISO

leflunomide results in decreased expression of SAMHD1 mRNA

NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:166,181,588...166,214,410

G

secretion associated, Ras related GTPase 1B

increases expression

EXP

leflunomide results in increased expression of SAR1B mRNA

NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,519,384...36,555,005

G

seryl-tRNA synthetase 1

increases expression

EXP
ISO

Leflunomide results in increased expression of SARS1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

SAS-6 centriolar assembly protein

decreases expression

ISO

leflunomide results in decreased expression of SASS6 mRNA

NCBI chr 2:207,231,896...207,263,840
Ensembl chr 2:207,231,333...207,263,851

G

spermidine/spermine N1-acetyl transferase 1

increases expression

ISO

leflunomide results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

spermidine/spermine N1-acetyltransferase family member 2

increases expression

EXP

leflunomide results in increased expression of SAT2 mRNA

NCBI chr10:54,839,531...54,841,651
Ensembl chr10:54,839,189...54,841,958

G

strawberry notch homolog 1

decreases expression

ISO

leflunomide results in decreased expression of SBNO1 mRNA

NCBI chr12:37,835,306...37,895,861
Ensembl chr12:37,846,514...37,891,231

G

SR-related CTD-associated factor 8

decreases expression

ISO

leflunomide results in decreased expression of SCAF8 mRNA

NCBI chr 1:46,132,972...46,321,162
Ensembl chr 1:46,132,873...46,261,174

G

SCAN domain-containing 1

increases expression

EXP

leflunomide results in increased expression of SCAND1 mRNA

NCBI chr 3:165,278,723...165,279,587
Ensembl chr 3:165,278,723...165,279,587

G

S-phase cyclin A-associated protein in the ER

increases expression

ISO

leflunomide results in increased expression of SCAPER mRNA

NCBI chr 8:64,828,789...65,228,240
Ensembl chr 8:64,828,789...65,228,453

G

scavenger receptor class B, member 1

increases expression

EXP

leflunomide results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

scavenger receptor class B, member 2

increases expression

EXP
ISO

leflunomide results in increased expression of SCARB2 mRNA

PMID:24136188 PMID:28988120

NCBI chr14:15,842,583...15,894,123
Ensembl chr14:15,842,515...15,896,671

G

small Cajal body-specific RNA 12

decreases expression

ISO

Leflunomide results in decreased expression of SCARNA12 mRNA

NCBI chr 4:159,206,825...159,207,085
Ensembl chr 4:159,206,825...159,207,085

G

Scm polycomb group protein like 2

decreases expression

ISO

leflunomide results in decreased expression of SCML2 mRNA

NCBI chr X:37,331,893...37,486,465
Ensembl chr X:37,334,841...37,439,276

G

sodium channel epithelial 1 subunit alpha

increases expression

ISO

leflunomide results in increased expression of SCNN1A mRNA

NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405

G

stimulator of chondrogenesis 1

increases expression

ISO

leflunomide results in increased expression of SCRG1 mRNA

NCBI chr16:37,770,739...37,799,010
Ensembl chr16:37,770,739...37,799,010

G

syndecan 4

increases expression

ISO

leflunomide results in increased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670

G

SDE2 telomere maintenance homolog

increases expression

ISO

leflunomide results in increased expression of SDE2 mRNA

NCBI chr13:95,110,598...95,126,929
Ensembl chr13:95,110,698...95,126,927

G

stromal cell derived factor 4

increases expression

EXP

leflunomide results in increased expression of SDF4 mRNA

NCBI chr 5:171,868,591...171,885,827
Ensembl chr 5:171,868,563...171,888,884

G

succinate dehydrogenase complex assembly factor 1

decreases expression

ISO

leflunomide results in decreased expression of SDHAF1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:94,703,662...94,704,611
Ensembl chr 1:94,702,409...94,706,092

G

succinate dehydrogenase complex assembly factor 2

decreases expression

ISO

leflunomide results in decreased expression of SDHAF2 mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:216,564,002...216,592,877
Ensembl chr 1:216,567,861...216,593,540

G

serine dehydratase-like

decreases expression

EXP

leflunomide results in decreased expression of SDSL mRNA

NCBI chr12:41,760,252...41,770,465
Ensembl chr12:41,760,252...41,770,465

G

SEC14-like lipid binding 4

increases expression

ISO

Leflunomide results in increased expression of SEC14L4 mRNA

NCBI chr14:83,136,335...83,152,382
Ensembl chr14:83,136,339...83,153,215

G

SEC16 homolog A, endoplasmic reticulum export factor

decreases expression

ISO

leflunomide results in decreased expression of SEC16A mRNA

NCBI chr 3:29,627,779...29,662,925
Ensembl chr 3:29,627,779...29,662,319

G

SEC24 homolog B, COPII coat complex component

increases expression

ISO

leflunomide results in increased expression of SEC24B mRNA

NCBI chr 2:221,236,897...221,306,986
Ensembl chr 2:221,236,898...221,306,919

G

secreted and transmembrane 1B

decreases expression

EXP

Leflunomide results in decreased expression of SECTM1B mRNA

NCBI chr10:106,822,397...106,832,105
Ensembl chr10:106,822,397...106,832,104

G

selenium binding protein 1

increases expression

EXP

leflunomide results in increased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295

G

semaphorin 3F

increases expression

ISO

leflunomide results in increased expression of SEMA3F mRNA

NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:117,236,269...117,265,206

G

semaphorin 3G

increases expression

ISO

leflunomide results in increased expression of SEMA3G mRNA

NCBI chr16:6,420,025...6,431,655
Ensembl chr16:6,420,012...6,432,553

G

semaphorin 7A (John Milton Hagen blood group)

decreases expression

ISO

leflunomide results in decreased expression of SEMA7A mRNA

NCBI chr 8:67,244,318...67,267,060
Ensembl chr 8:67,243,824...67,267,058

G

selenophosphate synthetase 1

increases expression

EXP

leflunomide results in increased expression of SEPHS1 mRNA

NCBI chr17:78,263,725...78,296,132
Ensembl chr17:78,263,725...78,292,082

G

Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

increases expression

ISO

leflunomide results in increased expression of SEPSECS mRNA

NCBI chr14:62,524,287...62,554,529
Ensembl chr14:62,524,313...62,554,533

G

serine incorporator 4

decreases expression

ISO

leflunomide results in decreased expression of SERINC4 mRNA

NCBI chr 3:128,882,617...128,888,376
Ensembl chr 3:128,882,617...128,888,376

G

serpin family A member 6

decreases expression

EXP

leflunomide results in decreased expression of SERPINA6 mRNA

NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:128,544,831...128,555,139

G

serpin family E member 1

increases expression

ISO

leflunomide results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

SERTA domain containing 2

increases expression

ISO

leflunomide results in increased expression of SERTAD2 mRNA

NCBI chr14:98,935,428...99,039,536
Ensembl chr14:98,934,769...99,041,468

G

SERTA domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of SERTAD3 mRNA

NCBI chr 1:91,891,141...91,894,861
Ensembl chr 1:91,893,616...91,897,110

G

sestrin 1

decreases expression

ISO

leflunomide results in decreased expression of SESN1 mRNA

NCBI chr20:46,876,918...46,970,010
Ensembl chr20:46,876,895...46,970,010

G

sestrin 2

increases expression

ISO

leflunomide results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

SET domain containing 3, actin N3(tau)-histidine methyltransferase

increases expression

EXP

leflunomide results in increased expression of SETD3 mRNA

NCBI chr 6:132,787,478...132,854,421
Ensembl chr 6:132,787,495...132,854,421

G

SET domain containing 4

increases expression

EXP

leflunomide results in increased expression of SETD4 mRNA

NCBI chr11:46,315,340...46,344,024
Ensembl chr11:46,323,895...46,344,024

G

seizure related 6 homolog

decreases expression

EXP

leflunomide results in decreased expression of SEZ6 mRNA

NCBI chr10:63,317,065...63,366,733
Ensembl chr10:63,316,953...63,366,723

G

splicing factor 3B subunit 4

decreases expression

ISO

leflunomide results in decreased expression of SF3B4 mRNA

NCBI chr 2:186,421,667...186,426,419
Ensembl chr 2:186,421,636...186,426,833

G

splicing factor 3b, subunit 5

increases expression

EXP

leflunomide results in increased expression of SF3B5 mRNA

NCBI chr 1:9,177,189...9,177,901
Ensembl chr 1:9,177,098...9,177,900

G

surfactant protein B

decreases expression

ISO

leflunomide results in decreased expression of SFTPB mRNA

NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646

G

sideroflexin 1

decreases expression

EXP

leflunomide results in decreased expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

sideroflexin 2

decreases expression

ISO

leflunomide results in decreased expression of SFXN2 mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:255,388,428...255,400,724
Ensembl chr 1:255,388,429...255,409,780

G

sideroflexin 3

decreases expression

ISO

leflunomide results in decreased expression of SFXN3 mRNA

PMID:28988120 PMID:29427785

NCBI chr 1:253,856,935...253,866,219
Ensembl chr 1:253,856,882...253,887,542

G

sideroflexin 5

decreases expression

ISO

leflunomide results in decreased expression of SFXN5 mRNA

PMID:28988120 PMID:29427785

NCBI chr 4:119,307,692...119,427,531
Ensembl chr 4:119,308,386...119,427,259

G

SAGA complex associated factor 29

increases expression

EXP

leflunomide results in increased expression of SGF29 mRNA

NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:190,669,028...190,717,906

G

sphingomyelin synthase 1

increases expression

EXP
ISO

leflunomide results in increased expression of SGMS1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:239,409,991...239,681,195
Ensembl chr 1:239,409,991...239,505,774

G

shugoshin 2

decreases expression

ISO

leflunomide results in decreased expression of SGO2 mRNA

NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:67,042,833...67,068,152

G

small glutamine rich tetratricopeptide repeat co-chaperone alpha

increases expression

EXP

leflunomide results in increased expression of SGTA mRNA

NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669

G

SH2B adaptor protein 1

decreases expression

ISO

leflunomide results in decreased expression of SH2B1 mRNA

NCBI chr 1:190,479,211...190,492,030
Ensembl chr 1:190,478,940...190,487,169

G

SH2B adaptor protein 3

increases expression

ISO

leflunomide results in increased expression of SH2B3 mRNA

NCBI chr12:40,391,755...40,414,336
Ensembl chr12:40,392,633...40,414,335

G

SH2 domain containing 4A

decreases expression

EXP
ISO

leflunomide results in decreased expression of SH2D4A mRNA

PMID:24136188 PMID:28988120

NCBI chr16:26,106,721...26,176,069
Ensembl chr16:26,106,730...26,175,974

G

SH3 domain binding glutamate-rich protein like 2

increases expression

ISO

leflunomide results in increased expression of SH3BGRL2 mRNA

NCBI chr 8:93,341,104...93,433,143
Ensembl chr 8:93,341,149...93,433,143

G

SH3-domain binding protein 2

increases expression

ISO

leflunomide results in increased expression of SH3BP2 mRNA

NCBI chr14:80,400,685...80,437,887
Ensembl chr14:80,400,685...80,437,906

G

SH3-domain binding protein 4

increases expression

ISO

leflunomide results in increased expression of SH3BP4 mRNA

NCBI chr 9:97,107,877...97,186,878
Ensembl chr 9:97,107,877...97,186,878

G

SH3-domain binding protein 5

increases expression

EXP

leflunomide results in increased expression of SH3BP5 mRNA

NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,589,877...6,655,211

G

SH3 binding domain protein 5 like

decreases expression

ISO

leflunomide results in decreased expression of SH3BP5L mRNA

NCBI chr10:43,012,902...43,027,319
Ensembl chr10:43,012,969...43,027,320

G

SH3 domain containing 19

increases expression

ISO

leflunomide results in increased expression of SH3D19 mRNA

NCBI chr 2:173,654,234...173,814,030
Ensembl chr 2:173,654,420...173,814,025

G

SH3 domain -containing GRB2-like endophilin B1

increases expression

ISO

leflunomide results in increased expression of SH3GLB1 mRNA

PMID:28988120 PMID:29427785

NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140

G

SH3 domain containing ring finger 1

increases expression

ISO

leflunomide results in increased expression of SH3RF1 mRNA

NCBI chr16:33,746,396...33,912,127
Ensembl chr16:33,746,396...33,912,153

G

SH3 domain and tetratricopeptide repeats 1

increases expression

ISO

leflunomide results in increased expression of SH3TC1 mRNA

NCBI chr14:79,230,322...79,274,622
Ensembl chr14:79,230,371...79,274,620

G

SH2 domain containing adaptor protein B

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of SHB mRNA
leflunomide results in increased expression of SHB mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072

G

Src homology 2 domain containing F

decreases expression

ISO

leflunomide results in decreased expression of SHF mRNA

NCBI chr 3:129,749,903...129,769,912
Ensembl chr 3:129,749,584...129,769,929

G

sonic hedgehog signaling molecule

increases expression

ISO

leflunomide results in increased expression of SHH mRNA

NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901

G

sedoheptulokinase

decreases expression

ISO

leflunomide results in decreased expression of SHPK mRNA

NCBI chr10:58,316,065...58,340,489
Ensembl chr10:58,316,111...58,340,490

G

siah E3 ubiquitin protein ligase 1

increases expression

ISO

leflunomide results in increased expression of SIAH1 mRNA

NCBI chr19:36,552,165...36,575,773
Ensembl chr19:36,540,947...36,581,541

G

siah E3 ubiquitin protein ligase 2

increases expression

ISO

leflunomide results in increased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

salt-inducible kinase 1

increases expression

ISO

leflunomide results in increased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

SIN3 transcription regulator family member B

increases expression

EXP

leflunomide results in increased expression of SIN3B mRNA

NCBI chr16:17,157,352...17,194,051
Ensembl chr16:17,157,352...17,270,664

G

SIN3-HDAC complex associated factor

increases expression

ISO

leflunomide results in increased expression of SINHCAF mRNA

NCBI chr 4:183,619,647...183,644,628
Ensembl chr 4:183,619,658...183,641,626

G

signal-induced proliferation-associated 1 like 2

increases expression

ISO

leflunomide results in increased expression of SIPA1L2 mRNA

NCBI chr19:70,287,134...70,437,810
Ensembl chr19:70,287,147...70,437,773

G

signal-regulatory protein alpha

decreases expression

ISO

leflunomide results in decreased expression of SIRPA mRNA

NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:137,273,042...137,311,279

G

sirtuin 4

increases expression

EXP

leflunomide results in increased expression of SIRT4 mRNA

NCBI chr12:46,785,852...46,800,179
Ensembl chr12:46,791,898...46,800,173

G

SIX homeobox 4

increases expression

ISO

leflunomide results in increased expression of SIX4 mRNA

NCBI chr 6:97,538,202...97,551,872
Ensembl chr 6:97,538,202...97,551,872

G

SKI-like proto-oncogene

increases expression

ISO

leflunomide results in increased expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:114,175,534...114,201,974

G

S-phase kinase associated protein 2

decreases expression

ISO

leflunomide results in decreased expression of SKP2 mRNA

NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438

G

solute carrier family 10 member 2

decreases expression

EXP

leflunomide results in decreased expression of SLC10A2 mRNA

NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025

G

solute carrier family 12 member 4

increases expression

ISO

leflunomide results in increased expression of SLC12A4 mRNA

NCBI chr19:50,748,268...50,770,217
Ensembl chr19:50,748,279...50,770,259

G

solute carrier family 12 member 7

increases expression

ISO

leflunomide results in increased expression of SLC12A7 mRNA

NCBI chr 1:31,301,243...31,382,825
Ensembl chr 1:31,301,243...31,382,957

G

solute carrier family 16, member 13

decreases expression

EXP

leflunomide results in decreased expression of SLC16A13 mRNA

NCBI chr10:55,424,633...55,436,555

G

solute carrier family 16, member 14

increases expression

ISO

leflunomide results in increased expression of SLC16A14 mRNA

NCBI chr 9:93,558,144...93,585,396
Ensembl chr 9:93,558,144...93,585,396

G

solute carrier family 16, member 6

increases expression

ISO

leflunomide results in increased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 16 member 7

increases expression

EXP

leflunomide results in increased expression of SLC16A7 mRNA

NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386

G

solute carrier family 16, member 9

increases expression

ISO

leflunomide results in increased expression of SLC16A9 mRNA

NCBI chr20:18,334,946...18,376,195
Ensembl chr20:18,334,946...18,376,195

G

solute carrier family 17 member 1

increases expression

EXP

leflunomide results in increased expression of SLC17A1 mRNA

NCBI chr17:41,647,332...41,683,078
Ensembl chr17:41,649,919...41,681,174

G

solute carrier family 17, member 2

increases expression

EXP

leflunomide results in increased expression of SLC17A2 mRNA

NCBI chr17:41,748,195...41,767,601
Ensembl chr17:41,748,195...41,764,180

G

solute carrier family 17 member 3

increases expression

EXP

leflunomide results in increased expression of SLC17A3 mRNA

NCBI chr17:41,698,679...41,729,057
Ensembl chr17:41,698,680...41,723,329

G

solute carrier family 18 member A2

decreases expression

ISO

leflunomide results in decreased expression of SLC18A2 mRNA

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 19 member 2

increases expression

ISO

leflunomide results in increased expression of SLC19A2 mRNA

PMID:19751817 PMID:28988120

NCBI chr13:79,135,118...79,149,316
Ensembl chr13:79,135,059...79,149,315

G

solute carrier family 20 member 1

increases expression

EXP
ISO

leflunomide results in increased expression of SLC20A1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:136,880,290...136,894,249

G

solute carrier family 20 member 2

increases expression

ISO

leflunomide results in increased expression of SLC20A2 mRNA

NCBI chr16:76,163,315...76,253,881
Ensembl chr16:76,162,922...76,253,881

G

solute carrier family 22 member 4

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of SLC22A4 mRNA
leflunomide results in decreased expression of SLC22A4 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 22 member 5

increases expression

EXP

leflunomide results in increased expression of SLC22A5 mRNA

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 23 member 2

increases expression

ISO

leflunomide results in increased expression of SLC23A2 mRNA

NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343

G

solute carrier family 25 member 14

decreases expression

ISO

leflunomide results in decreased expression of SLC25A14 mRNA

PMID:28988120 PMID:29427785

NCBI chr X:132,685,518...132,723,705
Ensembl chr X:132,676,818...132,723,703

G

solute carrier family 25 member 19

decreases expression

ISO

leflunomide results in decreased expression of SLC25A19 mRNA

PMID:28988120 PMID:29427785

NCBI chr10:101,353,426...101,366,551
Ensembl chr10:101,350,106...101,366,351

G

solute carrier family 25 member 20

increases expression

EXP

leflunomide results in increased expression of SLC25A20 mRNA

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 25 member 22

increases expression

EXP

leflunomide results in increased expression of SLC25A22 mRNA

NCBI chr 1:205,954,713...205,966,188
Ensembl chr 1:205,958,032...205,965,877

G

solute carrier family 25 member 25

increases expression

ISO

leflunomide results in increased expression of SLC25A25 mRNA

PMID:28988120 PMID:29427785

NCBI chr 3:36,106,448...36,139,812
Ensembl chr 3:36,106,449...36,140,011

G

solute carrier family 25 member 29

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of SLC25A29 mRNA
leflunomide results in decreased expression of SLC25A29 mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 6:133,506,403...133,517,322
Ensembl chr 6:133,506,331...133,517,827

G

solute carrier family 25 member 33

increases expression

EXP
ISO

leflunomide results in increased expression of SLC25A33 mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 5:165,478,070...165,518,186
Ensembl chr 5:165,478,072...165,502,973

G

solute carrier family 25 member 36

increases expression

ISO

leflunomide results in increased expression of SLC25A36 mRNA

PMID:28988120 PMID:29427785

NCBI chr 8:106,539,355...106,573,240

G

solute carrier family 25, member 46

increases expression

EXP

leflunomide results in increased expression of SLC25A46 mRNA

NCBI chr18:23,490,422...23,519,599
Ensembl chr18:23,490,425...23,518,730

G

solute carrier family 25, member 51

decreases expression

EXP

Leflunomide results in decreased expression of SLC25A51 mRNA

NCBI chr 5:64,445,610...64,459,172
Ensembl chr 5:64,443,616...64,459,462

G

solute carrier family 28 member 2

decreases expression

EXP

leflunomide results in decreased expression of SLC28A2 mRNA

NCBI chr 3:129,778,425...129,841,292
Ensembl chr 3:129,807,537...129,841,291

G

solute carrier family 2 member 1

increases expression

ISO

leflunomide results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 4

increases expression

ISO

leflunomide results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 2 member 8

increases expression

ISO

leflunomide results in increased expression of SLC2A8 mRNA

NCBI chr 3:36,672,589...36,682,206
Ensembl chr 3:36,672,591...36,682,194

G

solute carrier family 30 member 1

increases expression

ISO

leflunomide results in increased expression of SLC30A1 mRNA

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 30 member 2

increases expression

ISO

leflunomide results in increased expression of SLC30A2 mRNA

NCBI chr 5:151,843,451...151,855,674
Ensembl chr 5:151,843,389...151,855,670

G

solute carrier family 34 member 2

decreases expression

EXP

leflunomide results in decreased expression of SLC34A2 mRNA

NCBI chr14:62,123,313...62,153,020
Ensembl chr14:62,123,316...62,143,360

G

solute carrier family 35, member E2B

decreases expression

ISO

leflunomide results in decreased expression of SLC35E2B mRNA

NCBI chr 5:171,465,222...171,493,317
Ensembl chr 5:171,475,386...171,493,315

G

solute carrier family 35, member E3

increases expression

EXP

leflunomide results in increased expression of SLC35E3 mRNA

NCBI chr 7:55,222,962...55,236,022
Ensembl chr 7:55,219,998...55,236,035

G

solute carrier family 35, member G2

increases expression

ISO

leflunomide results in increased expression of SLC35G2 mRNA

NCBI chr 8:109,964,589...109,992,347
Ensembl chr 8:109,964,378...109,992,412

G

solute carrier family 37 member 4

decreases expression

EXP

leflunomide results in decreased expression of SLC37A4 mRNA

NCBI chr 8:53,619,952...53,626,110
Ensembl chr 8:53,620,141...53,626,110

G

solute carrier family 38, member 2

increases expression

ISO

leflunomide results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 3

increases expression

EXP

leflunomide results in increased expression of SLC39A3 mRNA

NCBI chr 7:9,327,541...9,333,542
Ensembl chr 7:9,327,455...9,335,845

G

solute carrier family 39 member 4

increases expression

EXP

leflunomide results in increased expression of SLC39A4 mRNA

NCBI chr 7:110,214,017...110,218,202
Ensembl chr 7:110,214,017...110,218,202

G

solute carrier family 3 member 2

increases expression

EXP
ISO

leflunomide results in increased expression of SLC3A2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 43 member 2

increases expression

ISO

leflunomide results in increased expression of SLC43A2 mRNA

NCBI chr10:60,873,721...60,919,113
Ensembl chr10:60,873,874...60,920,787

G

solute carrier family 44 member 2

increases expression

ISO

leflunomide results in increased expression of SLC44A2 mRNA

NCBI chr 8:28,147,023...28,181,496
Ensembl chr 8:28,147,030...28,181,495

G

solute carrier family 4 member 4

increases expression

EXP

leflunomide results in increased expression of SLC4A4 mRNA

NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435

G

solute carrier family 4 member 7

increases expression

ISO

leflunomide results in increased expression of SLC4A7 mRNA

NCBI chr15:13,015,854...13,095,485
Ensembl chr15:13,015,854...13,095,292

G

solute carrier family 51 member A

increases expression

ISO

leflunomide results in increased expression of SLC51A mRNA

NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539

G

SLC51 subunit beta

increases expression

ISO

leflunomide results in increased expression of SLC51B mRNA

NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109

G

solute carrier family 6 member 12

decreases expression

ISO

leflunomide results in decreased expression of SLC6A12 mRNA

NCBI chr 4:156,257,518...156,275,870
Ensembl chr 4:156,254,208...156,275,879

G

solute carrier family 6 member 13

increases expression

EXP

leflunomide results in increased expression of SLC6A13 mRNA

NCBI chr 4:156,211,381...156,248,491
Ensembl chr 4:156,211,462...156,248,489

G

solute carrier family 7 member 1

increases expression

ISO

leflunomide results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 7 member 11

increases expression

ISO

leflunomide results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier family 7 member 2

increases expression

ISO

leflunomide results in increased expression of SLC7A2 mRNA

NCBI chr16:58,115,991...58,174,256
Ensembl chr16:58,120,968...58,174,256

G

solute carrier family 7 member 5

increases expression

ISO

leflunomide results in increased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

solute carrier family 7 member 6

increases expression

ISO

leflunomide results in increased expression of SLC7A6 mRNA

NCBI chr19:50,982,459...51,010,140
Ensembl chr19:50,984,132...51,010,134

G

solute carrier family 9 member A6

decreases expression

ISO

leflunomide results in decreased expression of SLC9A6 mRNA

NCBI chr X:139,468,045...139,524,111
Ensembl chr X:139,458,127...139,524,109

G

SMAD family member 1

increases expression

ISO

leflunomide results in increased expression of SMAD1 mRNA

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957

G

SMAD family member 5

increases expression

ISO

leflunomide results in increased expression of SMAD5 mRNA

NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,871,984...7,890,992

G

SMAD family member 7

increases expression

ISO

leflunomide results in increased expression of SMAD7 mRNA

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849

G

SMAD family member 9

increases expression

ISO

leflunomide results in increased expression of SMAD9 mRNA

NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477

G

structural maintenance of chromosomes 4

decreases expression

ISO

leflunomide results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937

G

structural maintenance of chromosomes 5

decreases expression

ISO

leflunomide results in decreased expression of SMC5 mRNA

NCBI chr 1:230,195,894...230,265,677
Ensembl chr 1:230,195,894...230,265,621

G

SMG5 nonsense mediated mRNA decay factor

decreases expression

ISO

leflunomide results in decreased expression of SMG5 mRNA

NCBI chr 2:176,102,812...176,129,925
Ensembl chr 2:176,102,794...176,129,924

G

SMG9 nonsense mediated mRNA decay factor

decreases expression

ISO

leflunomide results in decreased expression of SMG9 mRNA

NCBI chr 1:89,116,459...89,139,182
Ensembl chr 1:89,116,482...89,139,182

G

small integral membrane protein 24

decreases expression

ISO

leflunomide results in decreased expression of SMIM24 mRNA

NCBI chr 7:8,964,107...8,967,234
Ensembl chr 7:8,964,107...8,967,234

G

smoothened, frizzled class receptor

decreases expression

ISO

leflunomide results in decreased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

sphingomyelin phosphodiesterase, acid-like 3A

increases expression

EXP

leflunomide results in increased expression of SMPDL3A mRNA

NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260

G

SET and MYND domain containing 2

decreases expression

EXP

leflunomide results in decreased expression of SMYD2 mRNA

NCBI chr13:103,956,470...103,997,774
Ensembl chr13:103,956,473...103,997,774

G

SET and MYND domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of SMYD4 mRNA

NCBI chr10:60,698,376...60,744,693
Ensembl chr10:60,698,388...60,744,711

G

snail family transcriptional repressor 1

increases expression

ISO

leflunomide results in increased expression of SNAI1 mRNA

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

increases expression

ISO

leflunomide results in increased expression of SNAI2 mRNA

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synaptosome associated protein 23

increases expression

EXP

leflunomide results in increased expression of SNAP23 mRNA

NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:127,967,886...127,998,067

G

synaptosome associated protein 47

decreases expression

ISO

leflunomide results in decreased expression of SNAP47 mRNA

NCBI chr10:44,692,430...44,733,986
Ensembl chr10:44,692,354...44,733,949

G

small nuclear RNA activating complex, polypeptide 1

increases expression

ISO

leflunomide results in increased expression of SNAPC1 mRNA

NCBI chr 6:98,420,588...98,442,065
Ensembl chr 6:98,420,340...98,442,489

G

stannin

decreases expression

ISO

leflunomide results in decreased expression of SNN mRNA

PMID:28988120 PMID:29427785

NCBI chr10:5,079,885...5,088,565
Ensembl chr 1:82,440,586...82,441,390
Ensembl chr10:82,440,586...82,441,390

G

small nucleolar RNA, H/ACA box 11

decreases expression

ISO

Leflunomide results in decreased expression of SNORA11 mRNA

NCBI chr X:23,162,365...23,162,479
Ensembl chr X:23,162,365...23,162,479

G

small nucleolar RNA, H/ACA box 21

increases expression

ISO

Leflunomide results in increased expression of SNORA21 mRNA

NCBI chr 5:164,341,679...164,341,814

G

small nucleolar RNA, H/ACA box 2B

decreases expression

ISO

Leflunomide results in decreased expression of SNORA2B mRNA

NCBI chr 7:131,555,365...131,555,501
Ensembl chr 7:131,555,365...131,555,501

G

small nucleolar RNA, H/ACA box 31

increases expression

ISO

Leflunomide results in increased expression of SNORA31 mRNA

NCBI chr15:57,568,564...57,568,693
Ensembl chr15:57,568,564...57,568,693

G

small nucleolar RNA, H/ACA box 65

decreases expression

ISO

Leflunomide results in decreased expression of SNORA65 mRNA

NCBI chr 3:36,663,472...36,663,601
Ensembl chr 3:36,663,472...36,663,601

G

small nucleolar RNA, H/ACA box 74A

decreases expression

ISO

Leflunomide results in decreased expression of SNORA74A mRNA

NCBI chr18:27,431,858...27,432,054
Ensembl chr18:27,431,858...27,432,054

G

small nucleolar RNA, H/ACA box 80B

increases expression

ISO

Leflunomide results in increased expression of SNORA80B mRNA

NCBI chr 6:46,059,847...46,059,980
Ensembl chr 6:46,059,847...46,059,980

G

small nucleolar RNA, H/ACA box 84

increases expression

ISO

Leflunomide results in increased expression of SNORA84 mRNA

NCBI chr11:70,315,418...70,315,551
Ensembl chr11:70,315,418...70,315,551

G

small nucleolar RNA, C/D box 121B

increases expression

ISO

Leflunomide results in increased expression of SNORD121B mRNA

NCBI chr 5:61,152,182...61,152,258
Ensembl chr 5:61,152,182...61,152,258

G

small nucleolar RNA, C/D box 18A

increases expression

ISO

Leflunomide results in increased expression of SNORD18A mRNA

NCBI chr 8:73,568,118...73,568,185
Ensembl chr 8:73,568,118...73,568,185

G

small nucleolar RNA, C/D box 22

decreases expression

ISO

Leflunomide results in decreased expression of SNORD22 mRNA

NCBI chr11:22,544,203...22,544,327
Ensembl chr11:22,544,203...22,544,327

G

small nucleolar RNA, C/D box 59A

increases expression

ISO

Leflunomide results in increased expression of SNORD59A mRNA

NCBI chr 7:1,100,895...1,100,970
Ensembl chr 7:1,100,895...1,100,970

G

small nuclear ribonucleoprotein U11/U12 subunit 35

decreases expression

ISO

leflunomide results in decreased expression of SNRNP35 mRNA

NCBI chr12:37,773,052...37,781,635
Ensembl chr12:37,771,759...37,783,908

G

small nuclear ribonucleoprotein polypeptide G

increases expression

EXP

leflunomide results in increased expression of SNRPG mRNA

NCBI chr 4:120,369,676...120,377,263
Ensembl chr 4:120,369,685...120,377,261
Ensembl chr X:120,369,685...120,377,261

G

syntrophin, beta 1

increases expression

ISO

leflunomide results in increased expression of SNTB1 mRNA

NCBI chr 7:88,950,642...89,219,017
Ensembl chr 7:88,950,642...89,219,017

G

sorting nexin 13

decreases expression

ISO

leflunomide results in decreased expression of SNX13 mRNA

NCBI chr 6:57,478,139...57,589,624
Ensembl chr 6:57,434,273...57,589,624

G

sorting nexin 16

increases expression

ISO

leflunomide results in increased expression of SNX16 mRNA

NCBI chr 2:93,242,779...93,265,048
Ensembl chr 2:93,243,494...93,265,050

G

suppressor of cytokine signaling 2

increases expression

ISO

leflunomide results in increased expression of SOCS2 mRNA

PMID:19751817 PMID:28988120

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423

G

suppressor of cytokine signaling 4

increases expression

ISO

leflunomide results in increased expression of SOCS4 mRNA

NCBI chr15:23,003,130...23,017,615
Ensembl chr15:23,002,883...23,022,499

G

suppressor of cytokine signaling 6

increases expression

ISO

leflunomide results in increased expression of SOCS6 mRNA

NCBI chr18:84,386,587...84,413,927
Ensembl chr18:84,384,573...84,414,053

G

superoxide dismutase 2

increases expression

EXP

leflunomide results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sortilin related receptor 1

increases expression

ISO

leflunomide results in increased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression
increases expression

ISO

leflunomide results in decreased expression of SOS1 mRNA
leflunomide results in increased expression of SOS1 mRNA

PMID:19751817 PMID:28988120

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

ISO

leflunomide results in decreased expression of SOS2 mRNA

NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811

G

sosondowah ankyrin repeat domain family member C

increases expression

ISO

leflunomide results in increased expression of SOWAHC mRNA

NCBI chr20:27,738,247...27,742,713
Ensembl chr20:27,736,326...27,752,912

G

SRY-box transcription factor 13

decreases expression

ISO

leflunomide results in decreased expression of SOX13 mRNA

NCBI chr13:47,383,145...47,427,572
Ensembl chr13:47,383,145...47,435,663

G

SRY-box transcription factor 4

increases expression

ISO

leflunomide results in increased expression of SOX4 mRNA

NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024

G

SRY-box transcription factor 5

decreases expression
increases expression

ISO

leflunomide results in decreased expression of SOX5 mRNA
leflunomide results in increased expression of SOX5 mRNA

PMID:19751817 PMID:28988120

NCBI chr 4:178,512,272...179,467,686
Ensembl chr 4:178,512,272...178,938,495

G

SRY-box transcription factor 9

increases expression

ISO

leflunomide results in increased expression of SOX9 mRNA

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

Sp3 transcription factor

increases expression

ISO

leflunomide results in increased expression of SP3 mRNA

NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:78,219,426...78,264,517

G

Sp5 transcription factor

increases expression

ISO

leflunomide results in increased expression of SP5 mRNA

NCBI chr 3:75,682,677...75,685,479
Ensembl chr 3:75,682,677...75,685,479

G

sperm autoantigenic protein 17

decreases expression

ISO

leflunomide results in decreased expression of SPA17 mRNA

NCBI chr 8:45,496,175...45,507,262
Ensembl chr 8:45,496,175...45,507,262

G

SPARC like 1

increases expression

EXP

leflunomide results in increased expression of SPARCL1 mRNA

NCBI chr14:5,937,484...5,968,532
Ensembl chr14:5,914,535...5,969,120

G

spermatogenesis associated 2

decreases expression

ISO

leflunomide results in decreased expression of SPATA2 mRNA

NCBI chr 3:176,621,974...176,639,784
Ensembl chr 3:176,622,350...176,632,013

G

spermatogenesis associated, serine-rich 2-like

increases expression

ISO

leflunomide results in increased expression of SPATS2L mRNA

NCBI chr 9:66,814,217...66,988,084
Ensembl chr 9:66,814,228...66,988,578

G

SPC24 component of NDC80 kinetochore complex

decreases expression

EXP
ISO

leflunomide results in decreased expression of SPC24 mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:28,576,409...28,581,481
Ensembl chr 8:28,576,409...28,581,299

G

SPC25 component of NDC80 kinetochore complex

decreases expression

ISO

leflunomide results in decreased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:74,383,548...74,396,718

G

spindle apparatus coiled-coil protein 1

decreases expression

ISO

leflunomide results in decreased expression of SPDL1 mRNA

NCBI chr10:19,773,456...19,798,341
Ensembl chr10:19,773,457...19,798,297

G

spindlin 1

increases expression

EXP

leflunomide results in increased expression of SPIN1 mRNA

NCBI chr17:14,207,384...14,257,330
Ensembl chr17:14,207,384...14,257,190

G

spire-type actin nucleation factor 1

increases expression

ISO

leflunomide results in increased expression of SPIRE1 mRNA

NCBI chr18:63,311,800...63,441,545
Ensembl chr18:63,311,800...63,441,534

G

sperm microtubule inner protein 5

increases expression

ISO

Leflunomide results in increased expression of SPMIP5 mRNA

NCBI chr 1:267,912,696...267,919,413
Ensembl chr 1:267,910,932...267,920,557

G

sparc/osteonectin, cwcv and kazal like domains proteoglycan 1

increases expression

ISO

leflunomide results in increased expression of SPOCK1 mRNA

NCBI chr17:6,746,892...7,227,034
Ensembl chr17:6,747,646...7,230,282

G

spondin 2

decreases expression

EXP

leflunomide results in decreased expression of SPON2 mRNA

NCBI chr14:81,713,070...81,742,510
Ensembl chr14:81,731,188...81,742,609

G

speckle type BTB/POZ protein like

increases expression

ISO

leflunomide results in increased expression of SPOPL mRNA

NCBI chr 3:26,478,535...26,552,344
Ensembl chr 3:26,482,163...26,512,634

G

signal peptide peptidase-like 2A

increases expression

EXP

leflunomide results in increased expression of SPPL2A mRNA

NCBI chr 3:134,602,684...134,646,752
Ensembl chr 3:134,605,750...134,646,752

G

sprouty-related, EVH1 domain containing 1

increases expression

ISO

leflunomide results in increased expression of SPRED1 mRNA

NCBI chr 3:124,437,230...124,504,358
Ensembl chr 3:124,437,230...124,504,358

G

sprouty-related, EVH1 domain containing 2

increases expression

ISO

leflunomide results in increased expression of SPRED2 mRNA

NCBI chr14:98,350,577...98,452,143
Ensembl chr14:98,350,290...98,452,143

G

SREBF pathway regulator in golgi 1

increases expression

ISO

Leflunomide results in increased expression of SPRING1 mRNA

NCBI chr12:43,967,146...43,990,083
Ensembl chr12:43,967,146...43,990,213

G

SprT-like N-terminal domain

decreases expression

ISO

leflunomide results in decreased expression of SPRTN mRNA

NCBI chr19:69,754,989...69,762,240
Ensembl chr19:69,754,980...69,762,237

G

sprouty RTK signaling antagonist 1

increases expression

ISO

leflunomide results in increased expression of SPRY1 mRNA

NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956

G

sprouty RTK signaling antagonist 2

increases expression

ISO

leflunomide results in increased expression of SPRY2 mRNA

NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074

G

sprouty RTK signaling antagonist 4

increases expression

ISO

leflunomide results in increased expression of SPRY4 mRNA

NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,687,039...30,704,173

G

SPRY domain containing 4

decreases expression

ISO

leflunomide results in decreased expression of SPRYD4 mRNA

NCBI chr 7:1,217,984...1,222,231
Ensembl chr 7:1,218,122...1,219,942

G

spectrin, beta, non-erythrocytic 1

increases expression

ISO

leflunomide results in increased expression of SPTBN1 mRNA

NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836

G

serine palmitoyltransferase, long chain base subunit 3

decreases expression

ISO

leflunomide results in decreased expression of SPTLC3 mRNA

NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:147,301,801...147,434,044

G

squalene epoxidase

decreases expression

ISO

leflunomide results in decreased expression of SQLE mRNA

PMID:19751817 PMID:28988120

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050

G

sequestosome 1

increases expression

EXP
ISO

leflunomide results in increased expression of SQSTM1 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

steroid receptor associated and regulated protein

increases expression

ISO

leflunomide results in increased expression of SRARP mRNA

NCBI chr 5:159,023,949...159,028,053
Ensembl chr 5:159,023,949...159,028,053

G

steroid 5 alpha-reductase 1

decreases expression

EXP

leflunomide results in decreased expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

G

serum response factor

decreases expression
increases expression

ISO

leflunomide results in decreased expression of SRF mRNA
leflunomide results in increased expression of SRF mRNA

PMID:19751817 PMID:28988120

NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:21,924,076...21,933,337

G

serum response factor binding protein 1

increases expression

ISO

leflunomide results in increased expression of SRFBP1 mRNA

NCBI chr18:48,118,740...48,139,824
Ensembl chr18:48,117,375...48,140,864

G

sushi-repeat-containing protein, X-linked 2

increases expression

ISO

leflunomide results in increased expression of SRPX2 mRNA

NCBI chr X:101,399,748...101,425,486
Ensembl chr X:101,399,853...101,425,484

G

serine and arginine rich splicing factor 1

decreases expression

ISO

leflunomide results in decreased expression of SRSF1 mRNA

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:73,336,422...73,342,548

G

serine and arginine rich splicing factor 2

decreases expression

ISO

leflunomide results in decreased expression of SRSF2 mRNA

PMID:19751817 PMID:28988120

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

serine and arginine rich splicing factor 4

increases expression

EXP

leflunomide results in increased expression of SRSF4 mRNA

NCBI chr 5:149,345,538...149,373,309
Ensembl chr 5:149,345,422...149,374,609

G

serine and arginine rich splicing factor 5

decreases expression

ISO

leflunomide results in decreased expression of SRSF5 mRNA

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 6

decreases expression

ISO

leflunomide results in decreased expression of SRSF6 mRNA

NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:172,009,061...172,014,392

G

serine and arginine rich splicing factor 9

increases expression

EXP

leflunomide results in increased expression of SRSF9 mRNA

NCBI chr12:46,938,948...46,945,213
Ensembl chr12:46,938,950...46,945,283

G

sulfiredoxin 1

increases expression

EXP
ISO

leflunomide results in increased expression of SRXN1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

SS18 subunit of BAF chromatin remodeling complex

decreases expression

ISO

leflunomide results in decreased expression of SS18 mRNA

NCBI chr18:6,047,619...6,169,151
Ensembl chr18:6,047,619...6,109,913

G

SS18 like 2

decreases expression

ISO

leflunomide results in decreased expression of SS18L2 mRNA

NCBI chr 8:130,252,774...130,255,388
Ensembl chr 8:130,252,782...130,257,367

G

ST14 transmembrane serine protease matriptase

increases expression

ISO

leflunomide results in increased expression of ST14 mRNA

NCBI chr 8:37,798,994...37,839,881
Ensembl chr 8:37,798,995...37,855,652

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

increases expression

EXP

leflunomide results in increased expression of ST3GAL5 mRNA

NCBI chr 4:105,692,840...105,750,774
Ensembl chr 4:105,692,840...105,750,775

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

ISO

leflunomide results in increased expression of ST3GAL6 mRNA

NCBI chr11:55,530,120...55,590,950
Ensembl chr11:55,530,248...55,598,720

G

suppression of tumorigenicity 7-like

decreases expression

ISO

leflunomide results in decreased expression of ST7L mRNA

NCBI chr 2:195,052,939...195,122,755
Ensembl chr 2:195,052,922...195,175,857

G

SH3 and cysteine rich domain 3

decreases expression

EXP

leflunomide results in decreased expression of STAC3 mRNA

NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:65,228,352...65,235,878

G

StAR-related lipid transfer domain containing 13

increases expression

ISO

leflunomide results in increased expression of STARD13 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:5,401,878...5,797,937
Ensembl chr12:5,401,995...5,794,967

G

StAR-related lipid transfer domain containing 7

decreases expression

ISO

leflunomide results in decreased expression of STARD7 mRNA

NCBI chr 3:134,935,602...134,969,140
Ensembl chr 3:134,940,471...134,969,168

G

signal transducer and activator of transcription 3

increases expression

ISO

leflunomide results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 6

decreases phosphorylation
multiple interactions

ISO

leflunomide results in decreased phosphorylation of STAT6 protein
leflunomide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of STAT6 protein]; leflunomide inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795

G

starch binding domain 1

increases expression

EXP
ISO

leflunomide results in increased expression of STBD1 mRNA

PMID:24136188 PMID:28988120

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,754,644...15,761,659

G

stanniocalcin 2

increases expression

ISO

leflunomide results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

serine/threonine kinase 17b

increases expression

ISO

leflunomide results in increased expression of STK17B mRNA

NCBI chr 9:62,801,912...62,832,511
Ensembl chr 9:62,803,005...62,832,511

G

serine/threonine kinase 24

increases expression

EXP

leflunomide results in increased expression of STK24 mRNA

NCBI chr15:104,770,556...104,866,524
Ensembl chr15:104,773,569...104,865,975

G

serine/threonine kinase 38

decreases expression

ISO

leflunomide results in decreased expression of STK38 mRNA

NCBI chr20:7,035,923...7,070,657
Ensembl chr20:7,035,933...7,069,711

G

stathmin 1

decreases expression

EXP
ISO

leflunomide results in decreased expression of STMN1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

stonin 2

increases expression

ISO

leflunomide results in increased expression of STON2 mRNA

NCBI chr 6:116,291,898...116,441,391
Ensembl chr 6:116,298,198...116,407,092

G

STE20 related adaptor beta

decreases expression

ISO

leflunomide results in decreased expression of STRADB mRNA

NCBI chr 9:67,908,277...67,927,224
Ensembl chr 9:67,908,309...67,927,222

G

striatin 3

increases expression

ISO

leflunomide results in increased expression of STRN3 mRNA

NCBI chr 6:74,783,156...74,869,473
Ensembl chr 6:74,783,156...74,869,473

G

steroid sulfatase

increases expression

EXP

leflunomide results in increased expression of STS mRNA

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:46,102,548...46,111,104

G

STIP1 homology and U-box containing protein 1

increases expression

EXP

leflunomide results in increased expression of STUB1 mRNA

NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559

G

syntaxin 3

increases expression

ISO

leflunomide results in increased expression of STX3 mRNA

NCBI chr 1:217,940,697...218,114,865
Ensembl chr 1:217,909,169...218,110,466

G

SUN domain containing ossification factor

increases expression

ISO

leflunomide results in increased expression of SUCO mRNA

NCBI chr13:76,726,095...76,791,174
Ensembl chr13:76,726,859...76,791,174

G

SURP and G patch domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of SUGP1 mRNA

NCBI chr16:19,386,588...19,417,460
Ensembl chr16:19,386,589...19,417,460

G

SURP and G patch domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of SUGP2 mRNA

NCBI chr16:19,193,910...19,225,364
Ensembl chr16:19,198,831...19,225,292

G

sulfotransferase family 2A member 1

increases expression

ISO

leflunomide results in increased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

sulfatase modifying factor 1

increases expression

EXP

Leflunomide results in increased expression of SUMF1 mRNA

NCBI chr 4:142,634,766...142,716,726
Ensembl chr 4:142,634,767...142,716,712

G

sulfatase modifying factor 2

increases expression

EXP

leflunomide results in increased expression of SUMF2 mRNA

NCBI chr12:32,489,671...32,507,941
Ensembl chr12:32,489,671...32,507,928

G

Sad1 and UNC84 domain containing 2

increases expression

EXP

leflunomide results in increased expression of SUN2 mRNA

NCBI chr 7:113,155,766...113,172,950
Ensembl chr 7:113,155,766...113,172,940

G

sushi domain containing 6

increases expression

ISO

leflunomide results in increased expression of SUSD6 mRNA

NCBI chr 6:106,130,183...106,262,900
Ensembl chr 6:106,169,118...106,262,900

G

SUV39H1 histone lysine methyltransferase

decreases expression

ISO

Leflunomide results in decreased expression of SUV39H1 mRNA

NCBI chr X:17,093,059...17,105,942
Ensembl chr X:17,092,986...17,105,942

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

decreases expression

ISO

leflunomide results in decreased expression of SUV39H1 mRNA

NCBI chr X:146,828,818...146,831,485

G

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

decreases expression

ISO

leflunomide results in decreased expression of SVEP1 mRNA

NCBI chr 5:77,606,523...77,783,292
Ensembl chr 5:77,606,523...77,783,711

G

small VCP interacting protein

increases expression

EXP

leflunomide results in increased expression of SVIP mRNA

NCBI chr 1:110,723,051...110,728,741
Ensembl chr 1:110,723,051...110,729,075

G

SWI5 homologous recombination repair protein

decreases expression

ISO

leflunomide results in decreased expression of SWI5 mRNA

NCBI chr 3:35,972,436...35,981,658
Ensembl chr 3:35,972,436...35,981,554

G

synapse defective Rho GTPase homolog 1

decreases expression

ISO

leflunomide results in decreased expression of SYDE1 mRNA

NCBI chr 7:11,683,505...11,689,491
Ensembl chr 7:11,681,111...11,690,443

G

synapse defective Rho GTPase homolog 2

increases expression

ISO

leflunomide results in increased expression of SYDE2 mRNA

NCBI chr 2:237,557,395...237,591,290
Ensembl chr 2:237,558,274...237,591,290

G

synaptotagmin-like 2

decreases expression

EXP

leflunomide results in decreased expression of SYTL2 mRNA

NCBI chr 1:153,685,403...153,791,758
Ensembl chr 1:153,665,327...153,791,756

G

trace amine-associated receptor 6

decreases expression

ISO

leflunomide results in decreased expression of TAAR6 mRNA

NCBI chr 1:23,277,717...23,278,754
Ensembl chr 1:23,277,717...23,278,754

G

TGF-beta activated kinase 1/MAP3K7 binding protein 2

increases expression

ISO

leflunomide results in increased expression of TAB2 mRNA

NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485

G

TGF-beta activated kinase 1 (MAP3K7) binding protein 3

increases expression

ISO

leflunomide results in increased expression of TAB3 mRNA

NCBI chr X:53,923,473...53,995,777
Ensembl chr X:53,923,492...53,995,610

G

transforming, acidic coiled-coil containing protein 3

decreases expression

ISO

leflunomide results in decreased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:81,275,755...81,289,698

G

TATA-box binding protein associated factor 15

decreases expression

ISO

leflunomide results in decreased expression of TAF15 mRNA

NCBI chr10:68,770,408...68,802,458
Ensembl chr10:68,770,430...68,802,458

G

TATA-box binding protein associated factor, RNA polymerase I subunit D

decreases expression
increases expression

ISO

leflunomide results in decreased expression of TAF1D mRNA
leflunomide results in increased expression of TAF1D mRNA

PMID:19751817 PMID:28988120

NCBI chr 8:20,427,894...20,438,046
Ensembl chr 8:20,427,954...20,434,556

G

TATA-box binding protein associated factor 6 like

decreases expression

ISO

leflunomide results in decreased expression of TAF6L mRNA

NCBI chr 1:215,101,266...215,113,888
Ensembl chr 1:215,101,268...215,113,752

G

transgelin

increases expression

ISO

leflunomide results in increased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

increases expression

ISO

leflunomide results in increased expression of TANC2 mRNA

NCBI chr10:91,052,860...91,373,291
Ensembl chr10:91,053,067...91,368,570

G

transport and golgi organization 6 homolog

increases expression

ISO

leflunomide results in increased expression of TANGO6 mRNA

NCBI chr19:51,479,384...51,667,142
Ensembl chr19:51,479,391...51,687,621

G

TAO kinase 2

decreases expression

ISO

leflunomide results in decreased expression of TAOK2 mRNA

NCBI chr 1:190,906,236...190,925,359
Ensembl chr 1:190,906,239...190,925,140

G

TAR DNA binding protein

decreases expression

ISO

leflunomide results in decreased expression of TARDBP mRNA

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

threonyl-tRNA synthetase 1

increases expression

ISO

Leflunomide results in increased expression of TARS1 mRNA

NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802

G

tyrosine aminotransferase

increases expression

ISO

leflunomide results in increased expression of TAT mRNA

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

TBC1 domain family, member 13

decreases expression

ISO

leflunomide results in decreased expression of TBC1D13 mRNA

NCBI chr 3:33,806,772...33,823,346
Ensembl chr 3:33,795,746...33,823,345

G

TBC1 domain family, member 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of TBC1D2 mRNA
leflunomide results in decreased expression of TBC1D2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:65,679,670...65,727,978
Ensembl chr 5:65,679,680...65,726,996

G

TBC1 domain family, member 20

decreases expression

ISO

leflunomide results in decreased expression of TBC1D20 mRNA

NCBI chr 3:161,228,699...161,247,319
Ensembl chr 3:161,228,785...161,247,316

G

TBC1 domain family, member 8

increases expression

EXP

leflunomide results in increased expression of TBC1D8 mRNA

NCBI chr 9:49,147,109...49,257,140
Ensembl chr 9:49,147,109...49,257,118

G

TBC1 domain family member 9

increases expression

ISO

leflunomide results in increased expression of TBC1D9 mRNA

NCBI chr19:41,746,732...41,855,924
Ensembl chr19:41,746,732...41,856,092

G

tubulin folding cofactor C

decreases expression

ISO

leflunomide results in decreased expression of TBCC mRNA

NCBI chr 9:21,596,472...21,597,660
Ensembl chr 9:21,595,615...21,597,842

G

tubulin folding cofactor E-like

increases expression

ISO

leflunomide results in increased expression of TBCEL mRNA

NCBI chr 8:51,692,660...51,751,560
Ensembl chr 8:51,694,930...51,751,560

G

TBL1X/Y related 1

increases expression

EXP
ISO

leflunomide results in increased expression of TBL1XR1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:106,718,811...106,857,989
Ensembl chr 2:106,730,665...106,857,989

G

T-box transcription factor 3

increases expression

ISO

leflunomide results in increased expression of TBX3 mRNA

NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171

G

T-box transcription factor 4

increases expression

ISO

leflunomide results in increased expression of TBX4 mRNA

NCBI chr10:71,228,145...71,258,222
Ensembl chr10:71,197,727...71,258,218

G

tandem C2 domains, nuclear

increases expression

EXP

leflunomide results in increased expression of TC2N mRNA

NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:126,526,009...126,614,215

G

transcription elongation factor A3

decreases expression

EXP

leflunomide results in decreased expression of TCEA3 mRNA

NCBI chr 5:153,760,401...153,792,934
Ensembl chr 5:153,760,407...153,792,930

G

transcription factor 12

increases expression

ISO

leflunomide results in increased expression of TCF12 mRNA

NCBI chr 8:81,371,201...81,682,337
Ensembl chr 8:81,373,321...81,679,922

G

transcription factor 19

decreases expression

ISO

leflunomide results in decreased expression of TCF19 mRNA

NCBI chr20:3,223,464...3,227,569
Ensembl chr20:3,223,324...3,230,060

G

transcription factor 7 like 2

increases expression

EXP
ISO

leflunomide results in increased expression of TCF7L2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225

G

trichoplein, keratin filament binding

decreases expression

ISO

leflunomide results in decreased expression of TCHP mRNA

NCBI chr12:47,538,520...47,553,895
Ensembl chr12:47,538,520...47,553,836

G

transcriptional and immune response regulator

increases expression

ISO

leflunomide results in increased expression of TCIM mRNA

NCBI chr16:74,298,344...74,299,637
Ensembl chr16:74,298,344...74,299,636

G

t-complex 11

increases expression

ISO

leflunomide results in increased expression of TCP11 mRNA

NCBI chr20:6,128,001...6,140,152
Ensembl chr20:6,128,003...6,174,578

G

t-complex 11 like 2

increases expression

ISO

leflunomide results in increased expression of TCP11L2 mRNA

NCBI chr 7:21,037,955...21,072,857
Ensembl chr 7:21,037,958...21,064,681

G

tectonic family member 2

decreases expression

ISO

leflunomide results in decreased expression of TCTN2 mRNA

NCBI chr12:37,643,711...37,668,035
Ensembl chr12:37,643,715...37,668,035

G

tyrosyl-DNA phosphodiesterase 1

decreases expression

ISO

leflunomide results in decreased expression of TDP1 mRNA

NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:124,881,574...124,960,642

G

TEA domain transcription factor 4

increases expression

ISO

leflunomide results in increased expression of TEAD4 mRNA

NCBI chr 4:163,180,192...163,258,342
Ensembl chr 4:163,180,192...163,258,479

G

terminal nucleotidyltransferase 5A

decreases expression

EXP
ISO

leflunomide results in decreased expression of TENT5A mRNA

PMID:24136188 PMID:28988120

NCBI chr 8:95,102,349...95,109,100
Ensembl chr 8:95,105,412...95,109,100

G

terminal nucleotidyltransferase 5B

increases expression

ISO

leflunomide results in increased expression of TENT5B mRNA

NCBI chr 5:150,979,238...150,986,548
Ensembl chr11:27,212,316...27,214,238
Ensembl chr 5:27,212,316...27,214,238

G

testis associated actin remodelling kinase 2

decreases expression

ISO

leflunomide results in decreased expression of TESK2 mRNA

NCBI chr 5:135,415,352...135,507,226
Ensembl chr 5:135,443,732...135,507,924

G

tet methylcytosine dioxygenase 2

increases expression

ISO

leflunomide results in increased expression of TET2 mRNA

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186

G

tet methylcytosine dioxygenase 3

increases expression

ISO

leflunomide results in increased expression of TET3 mRNA

NCBI chr 4:117,425,106...117,525,495
Ensembl chr 4:117,429,857...117,520,486

G

testis expressed gene 19.2

increases expression

ISO

leflunomide results in increased expression of TEX19 mRNA

NCBI chr10:106,878,083...106,880,671
Ensembl chr10:106,878,085...106,880,671

G

testis expressed 261

increases expression

EXP

leflunomide results in increased expression of TEX261 mRNA

NCBI chr 4:117,813,050...117,818,408
Ensembl chr 4:117,811,176...117,819,180

G

transcription factor B1, mitochondrial

decreases expression

EXP

leflunomide results in decreased expression of TFB1M mRNA

NCBI chr 1:46,520,510...46,567,004
Ensembl chr 1:46,524,435...46,566,948

G

transcription factor B2, mitochondrial

decreases expression

ISO

leflunomide results in decreased expression of TFB2M mRNA

PMID:28988120 PMID:29427785

NCBI chr13:93,810,859...93,828,678
Ensembl chr13:93,810,731...93,828,594

G

transcription factor CP2

increases expression

EXP

leflunomide results in increased expression of TFCP2 mRNA

NCBI chr 7:133,495,577...133,537,799
Ensembl chr 7:133,495,577...133,537,531

G

transferrin receptor 2

increases expression

EXP

leflunomide results in increased expression of TFR2 mRNA

NCBI chr12:24,744,450...24,761,413
Ensembl chr12:24,744,450...24,761,413

G

transforming growth factor alpha

increases expression

ISO

leflunomide results in increased expression of TGFA mRNA

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

transforming growth factor, beta receptor 2

decreases expression

ISO

leflunomide results in decreased expression of TGFBR2 mRNA

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transforming growth factor beta receptor 3

increases expression

ISO

leflunomide results in increased expression of TGFBR3 mRNA

NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,634,188...2,810,271

G

TGFB-induced factor homeobox 1

increases expression

ISO

leflunomide results in increased expression of TGIF1 mRNA

NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:118,194,444...118,204,442

G

transglutaminase 1

decreases expression

ISO

leflunomide results in decreased expression of TGM1 mRNA

NCBI chr15:33,160,985...33,175,632
Ensembl chr15:33,160,987...33,174,463

G

trans-golgi network protein 2

increases expression

EXP

leflunomide results in increased expression of TGOLN2 mRNA

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262

G

THAP domain containing 11

decreases expression

ISO

leflunomide results in decreased expression of THAP11 mRNA

NCBI chr19:50,656,839...50,658,656
Ensembl chr19:50,656,366...50,659,362

G

thrombospondin 1

increases expression

ISO

leflunomide results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thioesterase superfamily member 5

increases expression

EXP

leflunomide results in increased expression of THEM5 mRNA

NCBI chr 2:184,665,335...184,675,041
Ensembl chr 2:184,669,822...184,675,744

G

threonine synthase-like 1

decreases expression

ISO

leflunomide results in decreased expression of THNSL1 mRNA

NCBI chr17:88,623,054...88,630,681
Ensembl chr17:88,614,606...88,641,871

G

thyroid hormone receptor beta

increases expression

ISO

leflunomide results in increased expression of THRB mRNA

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

THUMP domain containing 2

increases expression

ISO

leflunomide results in increased expression of THUMPD2 mRNA

NCBI chr 6:19,677,039...19,728,947
Ensembl chr 6:19,677,025...19,739,317

G

TOPBP1-interacting checkpoint and replication regulator

decreases expression

ISO

leflunomide results in decreased expression of TICRR mRNA

NCBI chr 1:143,006,989...143,048,836
Ensembl chr 1:143,006,924...143,049,133

G

tigger transposable element derived 2

increases expression

ISO

leflunomide results in increased expression of TIGD2 mRNA

NCBI chr 4:89,744,516...89,747,608
Ensembl chr 4:89,744,510...89,747,940

G

tigger transposable element derived 3

decreases expression

ISO

leflunomide results in decreased expression of TIGD3 mRNA

NCBI chr 1:212,607,772...212,612,683
Ensembl chr 1:212,607,138...212,610,802

G

translocase of inner mitochondrial membrane 10B

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of TIMM10B mRNA
leflunomide results in decreased expression of TIMM10B mRNA

PMID:24136188 PMID:28988120 PMID:29427785

NCBI chr 1:169,392,355...169,395,201
Ensembl chr 1:169,392,177...169,395,205

G

translocase of inner mitochondrial membrane 21

decreases expression

ISO

leflunomide results in decreased expression of TIMM21 mRNA

PMID:28988120 PMID:29427785

NCBI chr18:80,589,775...80,594,237
Ensembl chr18:80,589,783...80,594,237

G

translocase of inner mitochondrial membrane 22

increases expression

EXP

leflunomide results in increased expression of TIMM22 mRNA

NCBI chr10:61,751,686...61,759,444
Ensembl chr10:61,751,666...61,760,850

G

translocase of inner mitochondrial membrane 29

increases expression

EXP

leflunomide results in increased expression of TIMM29 mRNA

NCBI chr 8:28,421,370...28,424,339
Ensembl chr 8:28,421,370...28,424,339

G

translocase of inner mitochondrial membrane 44

decreases expression

ISO

leflunomide results in decreased expression of TIMM44 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:7,410,424...7,428,179
Ensembl chr12:7,410,424...7,427,125

G

translocase of inner mitochondrial membrane 8A1

decreases expression

ISO

leflunomide results in decreased expression of TIMM8A mRNA

PMID:28988120 PMID:29427785

NCBI chr X:102,011,206...102,015,444
Ensembl chr X:102,011,206...102,015,444

G

TIMP metallopeptidase inhibitor 3

increases expression

ISO

leflunomide results in increased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

TERF1 interacting nuclear factor 2

increases expression

EXP

leflunomide results in increased expression of TINF2 mRNA

NCBI chr15:33,140,611...33,146,930
Ensembl chr15:33,140,714...33,146,930

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

ISO

leflunomide results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

thymidine kinase 1

decreases expression

EXP

leflunomide results in decreased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228

G

triokinase and FMN cyclase

decreases expression

EXP

leflunomide results in decreased expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

TLC domain containing 5

increases expression

ISO

Leflunomide results in increased expression of TLCD5 mRNA

NCBI chr 8:52,378,360...52,383,258
Ensembl chr 8:52,375,988...52,383,260

G

TLE family member 1, transcriptional corepressor

increases expression

ISO

leflunomide results in increased expression of TLE1 mRNA

NCBI chr 5:90,898,182...90,982,118
Ensembl chr 5:90,898,182...90,980,928

G

TLE family member 3, transcriptional corepressor

increases expression

ISO

leflunomide results in increased expression of TLE3 mRNA

NCBI chr 8:70,753,182...70,799,080
Ensembl chr 8:70,753,383...70,799,074

G

tousled-like kinase 2

increases expression

ISO

leflunomide results in increased expression of TLK2 mRNA

NCBI chr10:90,648,623...90,748,427
Ensembl chr10:90,653,851...90,748,428

G

TM2 domain containing 1

increases expression

EXP

leflunomide results in increased expression of TM2D1 mRNA

NCBI chr 5:118,136,299...118,177,639
Ensembl chr 5:118,136,299...118,170,283

G

TM2 domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of TM2D3 mRNA

NCBI chr 1:128,677,680...128,687,580
Ensembl chr 1:128,677,629...128,687,580

G

transmembrane 4 L six family member 1

increases expression

ISO

leflunomide results in increased expression of TM4SF1 mRNA

NCBI chr 2:143,606,980...143,616,176
Ensembl chr 2:143,603,271...143,616,176

G

transmembrane 4 L six family member 4

increases expression

EXP

leflunomide results in increased expression of TM4SF4 mRNA

NCBI chr 2:143,720,220...143,771,283
Ensembl chr 2:143,720,267...143,771,227

G

transmembrane 9 superfamily member 4

increases expression

EXP

leflunomide results in increased expression of TM9SF4 mRNA

NCBI chr 3:162,086,758...162,135,620
Ensembl chr 3:162,087,347...162,151,721

G

transmembrane BAX inhibitor motif containing 1

increases expression

ISO

leflunomide results in increased expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:83,320,979...83,338,657

G

transmembrane BAX inhibitor motif containing 4

decreases expression

ISO

leflunomide results in decreased expression of TMBIM4 mRNA

NCBI chr 7:57,604,275...57,618,861
Ensembl chr 7:57,604,275...57,621,056

G

transmembrane channel-like 7

increases expression

ISO

leflunomide results in increased expression of TMC7 mRNA

NCBI chr 1:182,287,742...182,340,000
Ensembl chr 1:182,287,742...182,339,947

G

transmembrane and coiled-coil domain family 1

increases expression

ISO

leflunomide results in increased expression of TMCC1 mRNA

NCBI chr 4:150,738,966...150,912,256
Ensembl chr 4:150,738,973...150,912,256

G

transmembrane p24 trafficking protein 6

decreases expression

ISO

leflunomide results in decreased expression of TMED6 mRNA

NCBI chr19:51,876,561...51,882,648
Ensembl chr19:51,876,561...51,882,648

G

transmembrane protein with EGF-like and two follistatin-like domains 1

increases expression

ISO

leflunomide results in increased expression of TMEFF1 mRNA

NCBI chr 5:67,706,269...67,792,022
Ensembl chr 5:67,706,269...67,792,021

G

transmembrane protein 115

decreases expression

ISO

leflunomide results in decreased expression of TMEM115 mRNA

NCBI chr 8:117,086,106...117,090,970
Ensembl chr 8:117,086,106...117,090,970

G

transmembrane protein 120B

increases expression

ISO

leflunomide results in increased expression of TMEM120B mRNA

NCBI chr12:39,108,280...39,148,090
Ensembl chr12:39,108,280...39,148,090

G

transmembrane protein 135

increases expression

ISO

leflunomide results in increased expression of TMEM135 mRNA

NCBI chr 1:152,418,929...152,692,405
Ensembl chr 1:152,418,930...152,633,717

G

transmembrane protein 138

decreases expression

ISO

leflunomide results in decreased expression of TMEM138 mRNA

NCBI chr 1:216,644,047...216,651,091

G

transmembrane protein 143

decreases expression

ISO

leflunomide results in decreased expression of TMEM143 mRNA

NCBI chr 1:105,508,370...105,524,419
Ensembl chr 1:105,508,459...105,524,424

G

transmembrane protein 14A

decreases expression

ISO

leflunomide results in decreased expression of TMEM14A mRNA

NCBI chr 9:31,137,011...31,148,794
Ensembl chr 9:31,136,963...31,148,800

G

transmembrane protein 14C

increases expression

EXP

leflunomide results in increased expression of TMEM14C mRNA

NCBI chr17:23,939,501...23,945,622
Ensembl chr17:23,939,509...23,959,055

G

transmembrane protein 150B

increases expression

ISO

leflunomide results in increased expression of TMEM150B mRNA

NCBI chr 1:78,153,729...78,164,149
Ensembl chr 1:78,153,961...78,169,810

G

transmembrane protein 154

increases expression

ISO

leflunomide results in increased expression of TMEM154 mRNA

NCBI chr 2:172,313,290...172,352,939
Ensembl chr 2:172,313,240...172,361,723

G

transmembrane protein 168

decreases expression

ISO

leflunomide results in decreased expression of TMEM168 mRNA

NCBI chr 4:42,796,714...42,824,854
Ensembl chr 4:42,796,720...42,824,854

G

transmembrane protein 169

increases expression

ISO

leflunomide results in increased expression of TMEM169 mRNA

NCBI chr 9:81,375,854...81,399,970

G

transmembrane protein 170B

decreases expression

ISO

leflunomide results in decreased expression of TMEM170B mRNA

NCBI chr17:23,336,914...23,375,707
Ensembl chr17:23,343,017...23,375,519

G

transmembrane protein 183A

increases expression

ISO

leflunomide results in increased expression of TMEM183A mRNA

NCBI chr13:48,355,664...48,372,437
Ensembl chr13:48,355,889...48,372,381

G

transmembrane protein 185A

increases expression

EXP

leflunomide results in increased expression of TMEM185A mRNA

NCBI chr X:154,187,833...154,212,557
Ensembl chr X:154,187,833...154,221,546

G

transmembrane protein 19

decreases expression

ISO

leflunomide results in decreased expression of TMEM19 mRNA

NCBI chr 7:52,844,985...52,871,708
Ensembl chr 7:52,844,985...52,872,012

G

transmembrane protein 217

decreases expression

ISO

leflunomide results in decreased expression of TMEM217 mRNA

NCBI chr20:7,594,223...7,620,628
Ensembl chr20:7,594,405...7,620,558

G

transmembrane protein 33

increases expression

EXP

leflunomide results in increased expression of TMEM33 mRNA

NCBI chr14:41,242,358...41,264,586
Ensembl chr14:41,242,358...41,264,586

G

transmembrane protein 37

increases expression

ISO

leflunomide results in increased expression of TMEM37 mRNA

NCBI chr13:33,737,096...33,743,602
Ensembl chr13:33,736,308...33,743,747

G

transmembrane protein 38B

increases expression

EXP

leflunomide results in increased expression of TMEM38B mRNA

NCBI chr 5:73,255,662...73,291,383
Ensembl chr 5:73,255,632...73,292,384

G

transmembrane protein 41B

decreases expression

ISO

leflunomide results in decreased expression of TMEM41B mRNA

NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:173,447,367...173,461,597

G

transmembrane protein 50B

increases expression

EXP

leflunomide results in increased expression of TMEM50B mRNA

NCBI chr11:44,290,805...44,323,650
Ensembl chr11:44,290,807...44,323,607

G

transmembrane protein 60

increases expression

EXP

leflunomide results in increased expression of TMEM60 mRNA

NCBI chr 4:15,102,168...15,107,023
Ensembl chr 4:15,100,348...15,107,139

G

transmembrane protein 62

increases expression

EXP

leflunomide results in increased expression of TMEM62 mRNA

NCBI chr 3:128,380,366...128,415,583
Ensembl chr 3:128,375,500...128,415,583

G

transmembrane protein 80

decreases expression

ISO

leflunomide results in decreased expression of TMEM80 mRNA

NCBI chr 1:205,865,564...205,873,933
Ensembl chr 1:205,864,852...205,873,933

G

transmembrane protein 82

increases expression

EXP

leflunomide results in increased expression of TMEM82 mRNA

NCBI chr 5:159,210,531...159,214,462

G

transmembrane protein 97

decreases expression

ISO

leflunomide results in decreased expression of TMEM97 mRNA

NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818

G

transmembrane and immunoglobulin domain containing 3

increases expression

ISO

leflunomide results in increased expression of TMIGD3 mRNA

NCBI chr 2:196,027,286...196,103,430
Ensembl chr 2:196,027,286...196,103,428

G

thymopoietin

decreases expression

ISO

leflunomide results in decreased expression of TMPO mRNA

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

thiol methyltransferase 1A

decreases expression
increases expression

ISO
EXP

Leflunomide results in decreased expression of TMT1A mRNA
Leflunomide results in increased expression of TMT1A mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959

G

thiol methyltransferase 1B

decreases expression
increases expression

ISO
EXP

Leflunomide results in decreased expression of TMT1B mRNA
Leflunomide results in increased expression of TMT1B mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:1,973,334...1,975,980
Ensembl chr 7:1,973,337...1,975,980

G

transmembrane O-mannosyltransferase targeting cadherins 1

increases expression

ISO

leflunomide results in increased expression of TMTC1 mRNA

NCBI chr 4:182,874,350...183,089,408
Ensembl chr 4:182,878,802...183,102,532

G

tumor necrosis factor

multiple interactions
increases expression

ISO

Leflunomide affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]; Leflunomide inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]; Leflunomide promotes the reaction [IL4 protein results in increased expression of TNF mRNA]
leflunomide results in increased expression of TNF mRNA

PMID:26640276 PMID:26699812

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 2

increases expression

ISO

leflunomide results in increased expression of TNFAIP2 mRNA

NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106

G

TNF alpha induced protein 3

increases expression

ISO

leflunomide results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 8 like 1

decreases expression

ISO

leflunomide results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:1,055,801...1,092,803

G

TNF receptor superfamily member 11B

increases expression

ISO

leflunomide results in increased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 12A

increases expression

ISO

leflunomide results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF receptor superfamily member 13B

decreases expression

ISO

leflunomide results in decreased expression of TNFRSF13B mRNA

NCBI chr10:46,301,336...46,322,460
Ensembl chr10:46,301,316...46,324,408

G

TNF receptor superfamily member 1A

increases expression

ISO

leflunomide results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 21

increases expression

ISO

leflunomide results in increased expression of TNFRSF21 mRNA

NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:25,376,400...25,451,323

G

TNF superfamily member 10

decreases expression

ISO

leflunomide results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 13

decreases expression

ISO

leflunomide results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,898,805...54,901,815

G

TNF superfamily member 4

increases expression

ISO

leflunomide results in increased expression of TNFSF4 mRNA

NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133

G

tyrosine kinase, non-receptor, 1

decreases expression

ISO

leflunomide results in decreased expression of TNK1 mRNA

NCBI chr10:55,070,362...55,084,383
Ensembl chr10:55,069,837...55,078,710

G

tankyrase 1 binding protein 1

decreases expression

ISO

leflunomide results in decreased expression of TNKS1BP1 mRNA

NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:90,542,033...90,566,713

G

trinucleotide repeat containing adaptor 6A

decreases expression

ISO

leflunomide results in decreased expression of TNRC6A mRNA

NCBI chr 1:186,992,457...187,146,764
Ensembl chr 1:186,992,504...187,146,756

G

tensin 1

increases expression

ISO

leflunomide results in increased expression of TNS1 mRNA

NCBI chr 9:82,941,068...83,152,007
Ensembl chr 9:82,941,068...83,152,007

G

tensin 2

increases expression

ISO

leflunomide results in increased expression of TNS2 mRNA

NCBI chr 7:135,108,401...135,126,505
Ensembl chr 7:135,108,202...135,126,504

G

tensin 3

increases expression

ISO

leflunomide results in increased expression of TNS3 mRNA

NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712

G

transducer of ErbB-2.1

decreases expression

ISO

leflunomide results in decreased expression of TOB1 mRNA

NCBI chr10:79,659,993...79,662,031
Ensembl chr10:79,656,433...79,666,601

G

transducer of ERBB2, 2

decreases expression

ISO

leflunomide results in decreased expression of TOB2 mRNA

NCBI chr 7:115,242,843...115,251,563
Ensembl chr 7:115,239,895...115,258,155

G

target of EGR1, exonuclease

decreases expression

ISO

leflunomide results in decreased expression of TOE1 mRNA

NCBI chr 5:135,507,116...135,510,682
Ensembl chr 5:135,507,116...135,510,682

G

TOG array regulator of axonemal microtubules 1

increases expression

ISO

leflunomide results in increased expression of TOGARAM1 mRNA

NCBI chr 6:88,755,264...88,819,599
Ensembl chr 6:88,755,264...88,819,598

G

DNA topoisomerase II alpha

decreases expression

EXP
ISO

leflunomide results in decreased expression of TOP2A mRNA

PMID:24136188 PMID:28988120

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

TOX high mobility group box family member 3

increases expression

ISO

leflunomide results in increased expression of TOX3 mRNA

NCBI chr19:32,820,957...32,929,776
Ensembl chr19:32,820,977...32,929,776

G

two pore segment channel 2

increases expression

ISO

leflunomide results in increased expression of TPCN2 mRNA

NCBI chr 1:209,845,827...209,875,561
Ensembl chr 1:209,845,835...209,875,457

G

tropomyosin 4

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of TPM4 mRNA
leflunomide results in increased expression of TPM4 mRNA

PMID:24136188 PMID:28988120

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

tumor protein p63 regulated 1-like

decreases expression

ISO

leflunomide results in decreased expression of TPRG1L mRNA

NCBI chr 5:170,004,577...170,007,784
Ensembl chr 5:170,004,577...170,007,983

G

TPX2, microtubule nucleation factor

decreases expression

ISO

leflunomide results in decreased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:161,778,742...161,820,724

G

transformer 2 alpha

decreases expression

ISO

leflunomide results in decreased expression of TRA2A mRNA

NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619

G

transformer 2 beta

decreases expression

ISO

leflunomide results in decreased expression of TRA2B mRNA

NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781

G

TNFRSF1A-associated via death domain

decreases expression

ISO

leflunomide results in decreased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

Tnf receptor associated factor 4

increases expression

ISO

leflunomide results in increased expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

trafficking protein particle complex subunit 11

increases expression

ISO

leflunomide results in increased expression of TRAPPC11 mRNA

NCBI chr16:51,465,631...51,512,003
Ensembl chr16:51,465,524...51,512,004

G

trafficking protein particle complex subunit 13

decreases expression

ISO

leflunomide results in decreased expression of TRAPPC13 mRNA

NCBI chr 2:37,004,288...37,035,837
Ensembl chr 2:37,002,976...37,035,820

G

trafficking protein particle complex subunit 2L

increases expression

EXP

leflunomide results in increased expression of TRAPPC2L mRNA

NCBI chr19:67,570,954...67,574,722

G

trafficking protein particle complex subunit 4

decreases expression

ISO

leflunomide results in decreased expression of TRAPPC4 mRNA

NCBI chr 8:53,626,382...53,630,042
Ensembl chr 8:53,625,474...53,630,241

G

TP53 regulated inhibitor of apoptosis 1

decreases expression

ISO

leflunomide results in decreased expression of TRIAP1 mRNA

PMID:28988120 PMID:29427785

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766

G

tribbles pseudokinase 1

increases expression

ISO

leflunomide results in increased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tribbles pseudokinase 3

increases expression

EXP
ISO

leflunomide results in increased expression of TRIB3 mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 2

increases expression

EXP

leflunomide results in increased expression of TRIM2 mRNA

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468

G

tripartite motif-containing 23

increases expression

ISO

leflunomide results in increased expression of TRIM23 mRNA

NCBI chr 2:37,036,193...37,069,024
Ensembl chr 2:37,035,477...37,069,526

G

tripartite motif-containing 25

decreases expression

ISO

leflunomide results in decreased expression of TRIM25 mRNA

NCBI chr10:74,310,024...74,328,473
Ensembl chr10:74,310,022...74,331,716

G

tripartite motif-containing 27

decreases expression

ISO

leflunomide results in decreased expression of TRIM27 mRNA

NCBI chr17:48,233,999...48,246,348
Ensembl chr17:48,234,002...48,246,348

G

tripartite motif-containing 3

decreases expression

ISO

leflunomide results in decreased expression of TRIM3 mRNA

NCBI chr 1:169,362,751...169,385,430
Ensembl chr 1:169,356,738...169,385,430

G

tripartite motif-containing 32

decreases expression

ISO

leflunomide results in decreased expression of TRIM32 mRNA

NCBI chr 5:84,020,604...84,031,483
Ensembl chr 5:84,014,803...84,042,748

G

tripartite motif-containing 33

increases expression

ISO

leflunomide results in increased expression of TRIM33 mRNA

NCBI chr 2:193,495,743...193,588,595
Ensembl chr 2:193,500,755...193,581,156

G

tripartite motif containing 38

increases expression

ISO

leflunomide results in increased expression of TRIM38 mRNA

NCBI chr17:41,774,419...41,787,709

G

tripartite motif-containing 47

decreases expression

ISO

leflunomide results in decreased expression of TRIM47 mRNA

NCBI chr10:101,836,465...101,840,936
Ensembl chr10:101,836,465...101,840,936

G

tripartite motif-containing 52

decreases expression

ISO

leflunomide results in decreased expression of TRIM52 mRNA

NCBI chr15:89,300,495...89,324,140
Ensembl chr15:89,300,754...89,302,433

G

tripartite motif-containing 62

decreases expression

ISO

leflunomide results in decreased expression of TRIM62 mRNA

NCBI chr 5:146,516,349...146,545,015
Ensembl chr 5:146,515,090...146,545,015

G

tripartite motif-containing 65

decreases expression

ISO

leflunomide results in decreased expression of TRIM65 mRNA

NCBI chr10:101,847,822...101,863,052
Ensembl chr10:101,856,819...101,863,251

G

tripartite motif-containing 66

increases expression
decreases expression

ISO

leflunomide results in increased expression of TRIM66 mRNA
leflunomide results in decreased expression of TRIM66 mRNA

PMID:19751817 PMID:28988120

NCBI chr 1:172,903,771...172,974,475
Ensembl chr 1:172,799,348...172,974,801

G

TRIO and F-actin binding protein

decreases expression

ISO

leflunomide results in decreased expression of TRIOBP mRNA

NCBI chr 7:112,386,371...112,452,130
Ensembl chr 7:112,386,420...112,442,924

G

thyroid hormone receptor interactor 13

decreases expression

ISO

leflunomide results in decreased expression of TRIP13 mRNA

NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:31,185,594...31,230,634

G

triple QxxK/R motif containing

increases expression

ISO

leflunomide results in increased expression of TRIQK mRNA

NCBI chr 5:31,188,816...31,261,705
Ensembl chr 5:31,188,839...31,262,108

G

tRNA methyltransferase 2 homolog B

decreases expression

ISO

leflunomide results in decreased expression of TRMT2B mRNA

NCBI chr X:101,716,656...101,777,105

G

tRNA methyltransferase 44

increases expression

ISO

leflunomide results in increased expression of TRMT44 mRNA

NCBI chr14:79,399,943...79,424,761
Ensembl chr14:79,406,647...79,424,761

G

tRNA mitochondrial 2-thiouridylase

decreases expression

ISO

leflunomide results in decreased expression of TRMU mRNA

NCBI chr 7:118,849,586...118,866,190
Ensembl chr 7:118,849,600...118,867,539

G

tRNA selenocysteine 1 associated protein 1

decreases expression

ISO

leflunomide results in decreased expression of TRNAU1AP mRNA

NCBI chr 5:149,791,631...149,808,149
Ensembl chr 5:149,791,631...149,808,680

G

TMF1-regulated nuclear protein 1

increases expression

ISO

leflunomide results in increased expression of TRNP1 mRNA

NCBI chr 5:150,990,312...150,997,148
Ensembl chr 5:150,989,973...150,997,277

G

trophinin associated protein

decreases expression

EXP
ISO

leflunomide results in decreased expression of TROAP mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:132,111,892...132,121,296
Ensembl chr 7:132,113,433...132,121,294

G

transient receptor potential cation channel, subfamily M, member 4

increases expression

ISO

leflunomide results in increased expression of TRPM4 mRNA

NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653

G

transient receptor potential cation channel, subfamily V, member 1

decreases expression

ISO

leflunomide results in decreased expression of TRPV1 mRNA

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

transient receptor potential cation channel, subfamily V, member 4

increases expression

ISO

leflunomide results in increased expression of TRPV4 mRNA

NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143

G

TSC22 domain family, member 1

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of TSC22D1 mRNA
leflunomide results in increased expression of TSC22D1 mRNA

PMID:24136188 PMID:28988120

NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322

G

TSC22 domain family, member 2

increases expression

ISO

leflunomide results in increased expression of TSC22D2 mRNA

NCBI chr 2:144,796,760...144,847,930
Ensembl chr 2:144,796,841...144,843,559

G

tRNA splicing endonuclease subunit 2

decreases expression

ISO

leflunomide results in decreased expression of TSEN2 mRNA

NCBI chr 4:150,275,389...150,310,846
Ensembl chr 4:150,275,501...150,313,013

G

tsukushi, small leucine rich proteoglycan

increases expression

EXP
ISO

leflunomide results in increased expression of TSKU mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

tetraspanin 17

decreases expression

ISO

leflunomide results in decreased expression of TSPAN17 mRNA

NCBI chr17:9,824,353...9,831,985
Ensembl chr17:9,823,990...9,831,974

G

tetraspanin 33

increases expression

EXP

leflunomide results in increased expression of TSPAN33 mRNA

NCBI chr 4:59,270,713...59,294,249
Ensembl chr 4:59,270,703...59,294,249

G

tetraspanin 8

decreases expression

ISO

leflunomide results in decreased expression of TSPAN8 mRNA

NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401

G

TSPY-like 4

decreases expression

EXP
ISO

leflunomide results in decreased expression of TSPYL4 mRNA

PMID:24136188 PMID:28988120

NCBI chr20:39,653,788...39,655,784
Ensembl chr20:39,653,604...39,664,566

G

testis-specific serine kinase 4

increases expression

ISO

leflunomide results in increased expression of TSSK4 mRNA

NCBI chr15:33,108,248...33,114,083
Ensembl chr15:33,111,734...33,114,083

G

tetratricopeptide repeat domain 14

increases expression

ISO

leflunomide results in increased expression of TTC14 mRNA

NCBI chr 2:118,581,779...118,600,361
Ensembl chr 2:118,581,773...118,591,502

G

tetratricopeptide repeat domain 17

increases expression

EXP

leflunomide results in increased expression of TTC17 mRNA

NCBI chr 3:100,718,820...100,829,464
Ensembl chr 3:100,718,827...100,829,129

G

tetratricopeptide repeat domain 23

increases expression

EXP

leflunomide results in increased expression of TTC23 mRNA

NCBI chr 1:130,656,040...130,739,670
Ensembl chr 1:130,656,110...130,739,673

G

tetratricopeptide repeat domain 36

increases expression

EXP

leflunomide results in increased expression of TTC36 mRNA

NCBI chr 8:54,009,522...54,013,129
Ensembl chr 8:54,009,522...54,013,129

G

tetratricopeptide repeat domain 6

decreases expression

ISO

leflunomide results in decreased expression of TTC6 mRNA

NCBI chr 6:80,872,055...81,103,170
Ensembl chr 6:80,889,487...81,103,163

G

tetratricopeptide repeat domain 9C

decreases expression

ISO

leflunomide results in decreased expression of TTC9C mRNA

NCBI chr 1:215,130,887...215,142,384
Ensembl chr 1:215,130,888...215,141,585

G

Ttk protein kinase

decreases expression

ISO

leflunomide results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:93,634,319...93,672,664

G

alpha tocopherol transfer protein like

decreases expression

ISO

leflunomide results in decreased expression of TTPAL mRNA

NCBI chr 3:172,697,683...172,715,973
Ensembl chr 3:172,697,729...172,715,983

G

TUB bipartite transcription factor

decreases expression

ISO

leflunomide results in decreased expression of TUB mRNA

NCBI chr 1:172,386,772...172,465,791
Ensembl chr 1:172,382,197...172,465,790

G

tubulin, alpha 1A

decreases expression

ISO

leflunomide results in decreased expression of TUBA1A mRNA

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035

G

tubulin, alpha 1B

decreases expression

ISO

leflunomide results in decreased expression of TUBA1B mRNA

NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:131,968,770...131,996,035

G

tubulin, alpha 1C

decreases expression

ISO

leflunomide results in decreased expression of TUBA1C mRNA

NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:132,070,536...132,079,311

G

tubulin, alpha 4A

increases expression

EXP

leflunomide results in increased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584

G

tubulin, beta 2B class IIb

decreases expression

ISO

leflunomide results in decreased expression of TUBB2B mRNA

NCBI chr17:30,953,086...30,956,133
Ensembl chr17:30,952,923...30,955,990

G

tubulin, beta 4B class IVb

decreases expression

ISO

leflunomide results in decreased expression of TUBB4B mRNA

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719

G

tubulin, beta 5 class I

decreases expression

EXP
ISO

leflunomide results in decreased expression of TUBB5 mRNA
leflunomide results in decreased expression of TUBB mRNA

PMID:24136188 PMID:28988120

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

tubulin, beta 6 class V

decreases expression

EXP
ISO

leflunomide results in decreased expression of TUBB6 mRNA

PMID:24136188 PMID:28988120

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

tubulin, delta 1

decreases expression

ISO

leflunomide results in decreased expression of TUBD1 mRNA

NCBI chr10:71,865,446...71,888,731
Ensembl chr10:71,864,904...71,888,730

G

tuftelin 1

increases expression

ISO

leflunomide results in increased expression of TUFT1 mRNA

NCBI chr 2:184,949,437...184,995,321
Ensembl chr 2:184,949,437...184,995,383

G

TUB like protein 2

increases expression

ISO

leflunomide results in increased expression of TULP2 mRNA

NCBI chr 1:105,098,884...105,136,243
Ensembl chr 1:105,127,650...105,137,277

G

TUB like protein 4

increases expression

ISO

leflunomide results in increased expression of TULP4 mRNA

NCBI chr 1:49,082,492...49,218,262
Ensembl chr 1:49,087,886...49,218,250

G

tumor suppressor 2, mitochondrial calcium regulator

decreases expression

ISO

leflunomide results in decreased expression of TUSC2 mRNA

PMID:28988120 PMID:29427785

NCBI chr 8:117,115,479...117,118,697
Ensembl chr 8:117,115,479...117,118,697

G

taxilin alpha

decreases expression

ISO

leflunomide results in decreased expression of TXLNA mRNA

NCBI chr 5:147,253,694...147,269,410
Ensembl chr 5:147,255,649...147,269,273

G

thioredoxin-like 4B

decreases expression

ISO

leflunomide results in decreased expression of TXNL4B mRNA

NCBI chr19:54,439,686...54,449,777
Ensembl chr19:54,439,680...54,448,052

G

thioredoxin reductase 1

increases expression

EXP
ISO

leflunomide results in increased expression of TXNRD1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 3

decreases expression

ISO

leflunomide results in decreased expression of TXNRD3 mRNA

NCBI chr 4:123,629,768...123,669,713
Ensembl chr 4:123,648,750...123,668,552

G

trypsin like peroxisomal matrix peptidase 1

increases expression

EXP

leflunomide results in increased expression of TYSND1 mRNA

NCBI chr20:30,180,878...30,188,239
Ensembl chr20:30,181,090...30,188,236

G

tRNA-yW synthesizing protein 1 homolog

increases expression

EXP

leflunomide results in increased expression of TYW1 mRNA

NCBI chr12:31,968,198...32,054,454
Ensembl chr12:31,968,198...32,054,647

G

ubiquitin-associated protein 1

decreases expression

ISO

leflunomide results in decreased expression of UBAP1 mRNA

NCBI chr 5:61,316,650...61,357,077
Ensembl chr 5:61,316,643...61,357,076

G

ubiquitin associated and SH3 domain containing, B

increases expression

ISO

leflunomide results in increased expression of UBASH3B mRNA

NCBI chr 8:50,282,510...50,430,034
Ensembl chr 8:50,285,431...50,326,351

G

ubiquitin C

decreases expression

ISO

leflunomide results in decreased expression of UBC mRNA

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

ubiquitin D

decreases expression

EXP

leflunomide results in decreased expression of UBD mRNA

NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,390,600...1,413,965

G

ubiquitin-conjugating enzyme E2C

decreases expression

EXP
ISO

leflunomide results in decreased expression of UBE2C mRNA

PMID:24136188 PMID:28988120

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

ubiquitin-conjugating enzyme E2H

increases expression

ISO

leflunomide results in increased expression of UBE2H mRNA

NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:59,802,102...59,897,583

G

ubiquitin conjugating enzyme E2 Q2

decreases expression

ISO

leflunomide results in decreased expression of UBE2Q2 mRNA

NCBI chr 8:64,414,502...64,474,425
Ensembl chr 8:64,414,301...64,474,418

G

ubiquitin-conjugating enzyme E2W

increases expression

ISO

leflunomide results in increased expression of UBE2W mRNA

PMID:19751817 PMID:28988120

NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:7,474,003...7,598,245

G

ubiquitination factor E4B

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of UBE4B mRNA
leflunomide results in decreased expression of UBE4B mRNA

PMID:24136188 PMID:28988120

NCBI chr 5:165,049,897...165,153,572
Ensembl chr 5:165,049,897...165,153,572

G

ubiquitin family domain containing 1

increases expression

ISO

leflunomide results in increased expression of UBFD1 mRNA

NCBI chr 1:186,057,267...186,068,832
Ensembl chr 1:186,057,123...186,066,103

G

ubiquitin-like 4A

decreases expression

ISO

leflunomide results in decreased expression of UBL4A mRNA

NCBI chr X:157,302,528...157,305,380
Ensembl chr X:157,304,254...157,305,380

G

ubiquitin-like 7

increases expression

EXP

leflunomide results in increased expression of UBL7 mRNA

NCBI chr 8:67,217,151...67,236,224
Ensembl chr 8:67,216,527...67,236,224

G

U-box domain containing 5

increases expression

ISO

leflunomide results in increased expression of UBOX5 mRNA

NCBI chr 3:138,259,311...138,300,807
Ensembl chr 3:138,259,311...138,300,807

G

ubiquilin-like

decreases expression

ISO

leflunomide results in decreased expression of UBQLNL mRNA

NCBI chr 1:168,027,056...168,029,305
Ensembl chr 1:168,026,649...168,029,394

G

ubiquitin domain containing 2

decreases expression

ISO

leflunomide results in decreased expression of UBTD2 mRNA

NCBI chr10:17,542,008...17,604,548
Ensembl chr10:17,542,061...17,606,309

G

UBX domain protein 2A

increases expression

EXP

leflunomide results in increased expression of UBXN2A mRNA

NCBI chr 6:33,603,804...33,645,958
Ensembl chr 6:33,603,804...33,632,202
Ensembl chr20:33,603,804...33,632,202

G

uridine-cytidine kinase 1

decreases expression

ISO

leflunomide results in decreased expression of UCK1 mRNA

NCBI chr 3:35,936,328...35,942,213
Ensembl chr 3:35,936,339...35,954,311

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

EXP

leflunomide results in increased expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP-glucose ceramide glucosyltransferase

increases expression

ISO

leflunomide results in increased expression of UGCG mRNA

NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417

G

UDP-glucose 6-dehydrogenase

increases expression

EXP

leflunomide results in increased expression of UGDH mRNA

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

UDP glucuronosyltransferase family 1 member A1

increases expression

ISO

leflunomide results in increased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

increases expression

EXP

leflunomide results in increased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

U2AF homology motif kinase 1

decreases expression

ISO

leflunomide results in decreased expression of UHMK1 mRNA

NCBI chr13:84,929,418...84,949,194
Ensembl chr13:84,922,829...84,949,061

G

ubiquitin like with PHD and ring finger domains 2

increases expression

ISO

leflunomide results in increased expression of UHRF2 mRNA

NCBI chr 1:237,224,050...237,291,406
Ensembl chr 1:237,228,456...237,292,353

G

unc-119 lipid binding chaperone B

decreases expression

ISO

leflunomide results in decreased expression of UNC119B mRNA

NCBI chr12:47,139,492...47,152,115
Ensembl chr12:47,139,545...47,152,112

G

unc-5 family C-terminal like

decreases expression

EXP

leflunomide results in decreased expression of UNC5CL mRNA

NCBI chr 9:20,025,719...20,041,083
Ensembl chr 9:20,025,719...20,039,841

G

UPF2, regulator of nonsense mediated mRNA decay

decreases expression

ISO

leflunomide results in decreased expression of UPF2 mRNA

NCBI chr17:77,133,975...77,245,266
Ensembl chr17:77,134,716...77,245,704

G

UPF3B, regulator of nonsense mediated mRNA decay

decreases expression

ISO

leflunomide results in decreased expression of UPF3B mRNA

NCBI chr X:121,200,993...121,219,059
Ensembl chr X:121,200,993...121,218,921

G

ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

increases expression

EXP

leflunomide results in increased expression of URAD mRNA

NCBI chr12:12,745,388...12,755,034
Ensembl chr12:12,745,450...12,755,749

G

URI1, prefoldin-like chaperone

decreases expression

ISO

leflunomide results in decreased expression of URI1 mRNA

NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:99,783,158...99,853,906

G

upstream transcription factor 2, c-fos interacting

increases expression

EXP

leflunomide results in increased expression of USF2 mRNA

NCBI chr 1:95,302,109...95,321,334
Ensembl chr 1:95,302,105...95,313,119

G

ubiquitin specific peptidase 12

increases expression

ISO

leflunomide results in increased expression of USP12 mRNA

NCBI chr12:13,423,625...13,477,547
Ensembl chr12:13,422,427...13,477,547

G

ubiquitin specific peptidase 14

increases expression

EXP

leflunomide results in increased expression of USP14 mRNA

NCBI chr18:1,292,745...1,330,867
Ensembl chr18:1,292,745...1,330,336

G

ubiquitin specific peptidase 15

increases expression

EXP

leflunomide results in increased expression of USP15 mRNA

NCBI chr 7:60,643,611...60,805,137
Ensembl chr 7:60,643,613...60,734,099

G

ubiquitin specific peptidase 2

increases expression

EXP

leflunomide results in increased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

ubiquitin specific peptidase 20

decreases expression

ISO

leflunomide results in decreased expression of USP20 mRNA

NCBI chr 3:34,670,613...34,704,156
Ensembl chr 3:34,670,685...34,704,156

G

ubiquitin specific peptidase 28

decreases expression

ISO

leflunomide results in decreased expression of USP28 mRNA

NCBI chr 8:58,222,258...58,282,711
Ensembl chr 8:58,222,220...58,282,750

G

ubiquitin specific peptidase 31

increases expression

ISO

leflunomide results in increased expression of USP31 mRNA

NCBI chr 1:185,642,631...185,709,499
Ensembl chr 1:185,581,444...185,709,464

G

ubiquitin specific peptidase 35

decreases expression

ISO

leflunomide results in decreased expression of USP35 mRNA

NCBI chr 1:161,037,428...161,061,114
Ensembl chr 1:161,037,428...161,061,114

G

ubiquitin specific peptidase 36

increases expression

ISO

leflunomide results in increased expression of USP36 mRNA

NCBI chr10:103,995,970...104,027,492
Ensembl chr10:103,995,970...104,023,450

G

ubiquitin specific peptidase 37

increases expression

ISO

leflunomide results in increased expression of USP37 mRNA

NCBI chr 9:83,467,966...83,567,848
Ensembl chr 9:83,467,966...83,533,172

G

ubiquitin specific peptidase 38

increases expression

ISO

leflunomide results in increased expression of USP38 mRNA

NCBI chr19:43,910,459...43,941,875
Ensembl chr19:43,910,474...43,941,866

G

ubiquitin specific peptidase 40

decreases expression

ISO

leflunomide results in decreased expression of USP40 mRNA

NCBI chr 9:96,055,741...96,126,766
Ensembl chr 9:96,055,741...96,126,721

G

ubiquitin specific peptidase 43

increases expression

ISO

leflunomide results in increased expression of USP43 mRNA

NCBI chr10:53,047,368...53,110,099
Ensembl chr10:53,048,158...53,110,180

G

ubiquitin specific peptidase 50

decreases expression

ISO

leflunomide results in decreased expression of USP50 mRNA

NCBI chr 3:134,465,469...134,488,859
Ensembl chr 3:134,464,499...134,488,816

G

USP6 N-terminal like

increases expression

ISO

leflunomide results in increased expression of USP6NL mRNA

NCBI chr17:76,737,870...76,865,953
Ensembl chr17:76,739,906...76,865,373

G

UTP15, small subunit processome component

increases expression

ISO

leflunomide results in increased expression of UTP15 mRNA

NCBI chr 2:31,329,222...31,347,022
Ensembl chr 2:31,329,223...31,347,046

G

UTP25 small subunit processome component

increases expression

ISO

leflunomide results in increased expression of UTP25 mRNA

NCBI chr13:107,159,092...107,180,361
Ensembl chr13:107,149,183...107,180,361

G

utrophin

increases expression

ISO

leflunomide results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

G

UV radiation resistance associated

increases expression

EXP
ISO

leflunomide results in increased expression of UVRAG mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:162,596,515...162,854,348

G

vesicle-associated membrane protein 1

decreases expression

ISO

leflunomide results in decreased expression of VAMP1 mRNA

NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:159,698,629...159,713,608

G

vesicle-associated membrane protein 2

increases expression

ISO

leflunomide results in increased expression of VAMP2 mRNA

NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654

G

VANGL planar cell polarity protein 1

decreases expression

ISO

leflunomide results in decreased expression of VANGL1 mRNA

NCBI chr 2:192,277,762...192,326,151
Ensembl chr 2:192,280,422...192,326,186

G

vav guanine nucleotide exchange factor 3

decreases expression

ISO

leflunomide results in decreased expression of VAV3 mRNA

NCBI chr 2:199,699,861...200,042,344
Ensembl chr 2:199,700,445...200,042,343

G

vinculin

increases expression

ISO

leflunomide results in increased expression of VCL mRNA

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163

G

valosin-containing protein

decreases expression

ISO

leflunomide results in decreased expression of VCP mRNA

NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387

G

vascular endothelial growth factor A

decreases expression
increases expression

EXP
ISO

leflunomide results in decreased expression of VEGFA mRNA
leflunomide results in increased expression of VEGFA mRNA

PMID:26221077 PMID:28988120

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vascular endothelial growth factor B

increases expression

EXP

leflunomide results in increased expression of VEGFB mRNA

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152

G

vascular endothelial zinc finger 1

increases expression

ISO

leflunomide results in increased expression of VEZF1 mRNA

NCBI chr10:73,341,666...73,373,320
Ensembl chr10:73,356,985...73,373,320

G

vimentin

decreases expression

EXP

leflunomide results in decreased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vacuole membrane protein 1

increases expression

EXP
ISO

leflunomide results in increased expression of VMP1 mRNA

PMID:24136188 PMID:28988120

NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319

G

vanin 1

increases expression

EXP
ISO

leflunomide results in increased expression of VNN1 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

VPS18 core subunit of CORVET and HOPS complexes

decreases expression

ISO

leflunomide results in decreased expression of VPS18 mRNA

NCBI chr 3:126,733,276...126,744,130
Ensembl chr 3:126,733,232...126,744,129

G

VPS37A subunit of ESCRT-I

increases expression

ISO

leflunomide results in increased expression of VPS37A mRNA

NCBI chr16:58,434,802...58,478,777
Ensembl chr16:58,440,950...58,478,831

G

vacuolar protein sorting 45 homolog

decreases expression

ISO

leflunomide results in decreased expression of VPS45 mRNA

NCBI chr 2:186,244,839...186,305,177
Ensembl chr 2:186,244,842...186,305,177

G

vacuolar protein sorting 4 homolog B

decreases expression

ISO

leflunomide results in decreased expression of VPS4B mRNA

NCBI chr13:23,421,758...23,446,848
Ensembl chr13:23,421,758...23,446,973

G

V-set and immunoglobulin domain containing 10

decreases expression

ISO

leflunomide results in decreased expression of VSIG10 mRNA

NCBI chr12:44,902,172...44,940,112
Ensembl chr12:44,902,948...44,936,241

G

visinin-like 1

decreases expression

ISO

leflunomide results in decreased expression of VSNL1 mRNA

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556

G

von Willebrand factor A domain containing 8

increases expression

EXP

leflunomide results in increased expression of VWA8 mRNA

NCBI chr15:60,661,764...60,985,971
Ensembl chr15:60,661,877...60,985,971

G

WAPL cohesin release factor

increases expression

EXP

leflunomide results in increased expression of WAPL mRNA

NCBI chr16:10,011,741...10,081,472
Ensembl chr16:10,012,110...10,081,472

G

WD repeat and FYVE domain containing 2

increases expression

ISO

leflunomide results in increased expression of WDFY2 mRNA

NCBI chr15:41,259,840...41,385,549
Ensembl chr15:41,259,884...41,385,549

G

WD repeat domain 26

increases expression

EXP

leflunomide results in increased expression of WDR26 mRNA

NCBI chr13:95,462,017...95,503,826
Ensembl chr13:95,462,020...95,503,738

G

WD repeat domain 35

increases expression

ISO

leflunomide results in increased expression of WDR35 mRNA

NCBI chr 6:37,490,557...37,550,391
Ensembl chr 6:37,490,545...37,550,664

G

WD repeat domain 37

decreases expression

ISO

leflunomide results in decreased expression of WDR37 mRNA

NCBI chr17:66,547,425...66,613,841
Ensembl chr17:66,547,147...66,613,841

G

WD repeat domain 43

increases expression

ISO

leflunomide results in increased expression of WDR43 mRNA

NCBI chr 6:29,565,610...29,604,954
Ensembl chr 6:29,565,610...29,604,954

G

WD repeat domain 6

decreases expression

ISO

leflunomide results in decreased expression of WDR6 mRNA

NCBI chr 8:118,146,608...118,153,024
Ensembl chr 8:118,146,608...118,153,092

G

WEE1 G2 checkpoint kinase

increases expression

ISO

leflunomide results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

WEE2 oocyte meiosis inhibiting kinase

increases expression

ISO

leflunomide results in increased expression of WEE2 mRNA

NCBI chr 4:70,204,459...70,228,813
Ensembl chr 4:70,194,852...70,228,860

G

WASP homolog associated with actin, golgi membranes and microtubules

increases expression

EXP

leflunomide results in increased expression of WHAMM mRNA

NCBI chr 1:144,935,588...144,963,989
Ensembl chr 1:144,935,618...144,964,385

G

WNK lysine deficient protein kinase 4

increases expression

ISO

leflunomide results in increased expression of WNK4 mRNA

NCBI chr10:86,702,828...86,719,917
Ensembl chr10:86,702,865...86,720,198

G

Wnt family member 11

increases expression

ISO

leflunomide results in increased expression of WNT11 mRNA

NCBI chr 1:162,545,660...162,565,456
Ensembl chr 1:162,545,680...162,564,660

G

WD repeat containing, antisense to TP53

decreases expression

ISO

leflunomide results in decreased expression of WRAP53 mRNA

NCBI chr10:54,780,873...54,797,919
Ensembl chr10:54,773,282...54,797,651

G

WD repeat and SOCS box-containing 2

increases expression

EXP

leflunomide results in increased expression of WSB2 mRNA

NCBI chr12:44,878,483...44,899,474
Ensembl chr12:44,878,509...44,899,474

G

WW and C2 domain containing 1

increases expression

ISO

leflunomide results in increased expression of WWC1 mRNA

NCBI chr10:20,804,173...20,958,437
Ensembl chr10:20,799,237...20,958,437

G

X-box binding protein 1

increases expression

ISO

leflunomide results in increased expression of XBP1 mRNA; leflunomide results in increased expression of XBP1 protein alternative form

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

XK related 6

increases expression

ISO

leflunomide results in increased expression of XKR6 mRNA

NCBI chr15:42,032,411...42,269,300
Ensembl chr15:42,033,028...42,235,591

G

exportin 1

increases expression

EXP

leflunomide results in increased expression of XPO1 mRNA

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:101,434,517...101,476,714

G

xenotropic and polytropic retrovirus receptor 1

increases expression

EXP

leflunomide results in increased expression of XPR1 mRNA

NCBI chr13:69,991,517...70,136,249
Ensembl chr13:69,996,692...70,136,164

G

YAE1 maturation factor of ABCE1

decreases expression

ISO

leflunomide results in decreased expression of YAE1 mRNA

NCBI chr17:51,722,582...51,729,098
Ensembl chr17:51,722,570...51,729,095

G

tyrosyl-tRNA synthetase 1

increases expression

ISO

Leflunomide results in increased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377

G

Yip1 domain family, member 4

increases expression

ISO

leflunomide results in increased expression of YIPF4 mRNA

NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:26,682,488...26,714,066

G

YjeF N-terminal domain containing 3

decreases expression

ISO

leflunomide results in decreased expression of YJEFN3 mRNA

NCBI chr16:19,567,565...19,573,667
Ensembl chr16:19,558,947...19,573,956

G

yippee-like 2

increases expression

ISO

leflunomide results in increased expression of YPEL2 mRNA

NCBI chr10:72,243,591...72,301,124
Ensembl chr10:72,243,591...72,301,124

G

yrdC N(6)-threonylcarbamoyltransferase domain containing

increases expression

ISO

leflunomide results in increased expression of YRDC mRNA

NCBI chr 5:142,394,833...142,399,798
Ensembl chr 5:142,394,938...142,399,795

G

zinc finger and BTB domain containing 1

increases expression

ISO

leflunomide results in increased expression of ZBTB1 mRNA

NCBI chr 6:100,832,506...100,864,019
Ensembl chr 6:100,838,714...100,852,643

G

zinc finger and BTB domain containing 10

increases expression

ISO

leflunomide results in increased expression of ZBTB10 mRNA

NCBI chr 2:94,382,670...94,417,308
Ensembl chr 2:94,386,400...94,417,308

G

zinc finger and BTB domain containing 2

increases expression

ISO

leflunomide results in increased expression of ZBTB2 mRNA

NCBI chr 1:43,232,839...43,252,115
Ensembl chr 1:43,232,839...43,252,614

G

zinc finger and BTB domain containing 21

increases expression

ISO

leflunomide results in increased expression of ZBTB21 mRNA

NCBI chr11:50,781,697...50,796,399
Ensembl chr11:50,781,099...50,796,560

G

zinc finger and BTB domain containing 25

increases expression

ISO

leflunomide results in increased expression of ZBTB25 mRNA

NCBI chr 6:100,807,083...100,831,555
Ensembl chr 6:100,810,961...100,830,135

G

zinc finger and BTB domain containing 37

increases expression

ISO

leflunomide results in increased expression of ZBTB37 mRNA

NCBI chr13:75,805,272...75,836,702
Ensembl chr13:75,821,271...75,836,600

G

zinc finger and BTB domain containing 38

increases expression

ISO

leflunomide results in increased expression of ZBTB38 mRNA

NCBI chr 8:106,124,181...106,231,215
Ensembl chr 8:106,157,084...106,230,951

G

zinc finger and BTB domain containing 4

increases expression

ISO

leflunomide results in increased expression of ZBTB4 mRNA

NCBI chr10:54,979,421...55,000,215
Ensembl chr10:54,979,648...55,000,215

G

zinc finger and BTB domain containing 6

increases expression

ISO

leflunomide results in increased expression of ZBTB6 mRNA

NCBI chr 3:41,600,488...41,603,902
Ensembl chr 3:41,598,719...41,618,704

G

zinc finger and BTB domain containing 7A

decreases expression

ISO

leflunomide results in decreased expression of ZBTB7A mRNA

NCBI chr 7:9,211,733...9,229,273
Ensembl chr 7:9,214,496...9,227,252

G

zinc finger and BTB domain containing 9

decreases expression

ISO

leflunomide results in decreased expression of ZBTB9 mRNA

NCBI chr20:5,059,296...5,069,422
Ensembl chr20:5,059,297...5,067,144

G

zinc finger CCCH type containing 12C

increases expression

ISO

leflunomide results in increased expression of ZC3H12C mRNA

NCBI chr 8:61,340,446...61,404,932
Ensembl chr 8:61,345,271...61,400,610

G

zinc finger CCCH type containing 6

increases expression

ISO

leflunomide results in increased expression of ZC3H6 mRNA

NCBI chr 3:136,656,116...136,717,560
Ensembl chr 3:136,657,414...136,706,504

G

zinc finger CCCH-type containing, antiviral 1

decreases expression

ISO

leflunomide results in decreased expression of ZC3HAV1 mRNA

NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,979,055...68,029,353

G

zinc finger CCHC-type containing 17

decreases expression

ISO

leflunomide results in decreased expression of ZCCHC17 mRNA

NCBI chr 5:147,942,789...147,984,596
Ensembl chr 5:147,942,789...147,984,584

G

zinc finger CCHC-type containing 4

increases expression

ISO

leflunomide results in increased expression of ZCCHC4 mRNA

NCBI chr14:62,378,261...62,419,899
Ensembl chr14:62,378,269...62,419,544

G

zinc finger, DHHC-type containing 11

decreases expression

ISO

leflunomide results in decreased expression of ZDHHC11 mRNA

NCBI chr 1:31,124,900...31,156,075
Ensembl chr 1:31,124,900...31,155,498

G

zinc finger DHHC-type palmitoyltransferase 23

decreases expression

ISO

leflunomide results in decreased expression of ZDHHC23 mRNA

NCBI chr11:70,224,581...70,240,971
Ensembl chr11:70,225,045...70,240,102

G

zinc finger DHHC-type palmitoyltransferase 6

decreases expression

ISO

leflunomide results in decreased expression of ZDHHC6 mRNA

NCBI chr 1:264,340,883...264,361,435
Ensembl chr 1:264,317,494...264,361,435

G

zinc finger E-box binding homeobox 1

increases expression

ISO

leflunomide results in increased expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger AN1-type containing 1

increases expression

ISO

leflunomide results in increased expression of ZFAND1 mRNA

NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:93,351,917...93,360,665

G

zinc finger AN1-type containing 3

increases expression

EXP
ISO

leflunomide results in increased expression of ZFAND3 mRNA

PMID:24136188 PMID:28988120

NCBI chr20:8,084,898...8,281,093
Ensembl chr20:8,084,299...8,281,094

G

zinc finger AN1-type containing 5

increases expression

EXP
ISO

leflunomide results in increased expression of ZFAND5 mRNA

PMID:24136188 PMID:28988120

NCBI chr 1:228,191,064...228,206,947
Ensembl chr 1:228,192,311...228,206,947

G

zinc finger homeobox 3

increases expression

ISO

leflunomide results in increased expression of ZFHX3 mRNA

NCBI chr19:52,789,146...53,795,664
Ensembl chr19:53,551,488...53,795,664

G

zinc finger protein 112

decreases expression

ISO

leflunomide results in decreased expression of ZNF112 mRNA

NCBI chr 1:88,804,833...88,819,889
Ensembl chr 1:88,813,821...88,819,761

G

zinc finger protein 3

decreases expression
increases expression

ISO

leflunomide results in decreased expression of ZFP113 mRNA
leflunomide results in increased expression of ZNF3 mRNA

PMID:19751817 PMID:28988120

NCBI chr12:22,135,812...22,147,427
Ensembl chr12:22,137,159...22,147,455

G

zinc finger protein 133

increases expression

ISO

leflunomide results in increased expression of ZNF133 mRNA

NCBI chr 3:152,282,744...152,300,892
Ensembl chr 3:152,282,735...152,300,889

G

zinc finger protein 174

decreases expression

ISO

leflunomide results in decreased expression of ZNF174 mRNA

NCBI chr10:12,169,012...12,182,775
Ensembl chr10:12,174,540...12,182,689

G

zinc finger protein 182

decreases expression

ISO

leflunomide results in decreased expression of ZNF182 mRNA

NCBI chr X:3,480,991...3,555,009
Ensembl chr X:3,472,127...3,555,013

G

zinc finger protein 184

increases expression

ISO

leflunomide results in increased expression of ZNF184 mRNA

NCBI chr17:47,262,566...47,299,675
Ensembl chr17:47,262,568...47,299,004

G

zinc finger protein 202

increases expression

ISO

leflunomide results in increased expression of ZNF202 mRNA

NCBI chr 8:49,439,849...49,460,117
Ensembl chr 8:49,447,840...49,459,900

G

zinc finger protein 207

decreases expression

ISO

leflunomide results in decreased expression of ZNF207 mRNA

NCBI chr10:65,883,630...65,895,895
Ensembl chr10:65,883,599...65,895,895

G

zinc finger protein 248

decreases expression

ISO

leflunomide results in decreased expression of ZNF248 mRNA

NCBI chr 4:153,277,735...153,302,545
Ensembl chr 4:153,277,736...153,301,941

G

zinc finger protein 251

increases expression

ISO

leflunomide results in increased expression of ZNF251 mRNA

NCBI chr 7:110,449,194...110,479,218
Ensembl chr 7:110,449,194...110,479,218

G

zinc finger protein 280C

increases expression

ISO

leflunomide results in increased expression of ZNF280C mRNA

NCBI chr X:132,594,279...132,685,548
Ensembl chr X:132,594,292...132,685,841

G

zinc finger protein 280D

increases expression

ISO

leflunomide results in increased expression of ZNF280D mRNA

NCBI chr 8:81,872,108...81,961,194
Ensembl chr 8:81,873,335...81,961,201

G

zinc finger protein 292

increases expression

ISO

leflunomide results in increased expression of ZNF292 mRNA

NCBI chr 5:54,184,174...54,264,454
Ensembl chr 5:54,184,174...54,304,147

G

zinc finger protein 318

decreases expression

ISO

leflunomide results in decreased expression of ZNF318 mRNA

NCBI chr 9:22,060,899...22,100,174
Ensembl chr 9:22,060,916...22,099,551

G

zinc finger protein 34

increases expression

ISO

Leflunomide results in increased expression of ZNF34 mRNA

NCBI chr 5:162,776,433...162,797,153

G

zinc finger protein 35

increases expression

ISO

Leflunomide results in increased expression of ZNF79 mRNA

NCBI chr18:15,543,604...15,559,084
Ensembl chr18:15,543,516...15,559,837

G

zinc finger protein 36

increases expression

ISO

leflunomide results in increased expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 367

decreases expression

ISO

leflunomide results in decreased expression of ZNF367 mRNA

NCBI chr17:970,896...990,025
Ensembl chr17:970,741...990,029

G

zinc finger protein 36, C3H type-like 1

increases expression

ISO

leflunomide results in increased expression of ZFP36L1 mRNA

NCBI chr 6:104,663,396...104,669,815
Ensembl chr 6:104,663,399...104,687,979

G

zinc finger protein 36, C3H type-like 2

increases expression

ISO

leflunomide results in increased expression of ZFP36L2 mRNA

NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:16,242,610...16,246,653

G

zinc finger protein 398

increases expression

ISO

leflunomide results in increased expression of ZNF398 mRNA

NCBI chr 4:78,180,620...78,214,367
Ensembl chr 4:78,180,561...78,207,187

G

zinc finger protein 451

increases expression

ISO

leflunomide results in increased expression of ZNF451 mRNA

NCBI chr 9:43,481,395...43,546,103
Ensembl chr 9:43,481,401...43,516,706

G

zinc finger protein 458

increases expression

ISO

leflunomide results in increased expression of ZNF43 mRNA

NCBI chr 2:86,369,495...86,410,904
Ensembl chr 2:86,401,448...86,410,900

G

zinc finger protein 46

decreases expression

ISO

leflunomide results in decreased expression of ZNF436 mRNA

NCBI chr 5:153,802,887...153,813,388
Ensembl chr 5:153,802,834...153,812,941

G

zinc finger protein 503

increases expression

ISO

leflunomide results in increased expression of ZNF503 mRNA

NCBI chr15:2,362,450...2,366,238
Ensembl chr15:2,362,427...2,366,238

G

zinc finger protein 507

increases expression

ISO

leflunomide results in increased expression of ZNF507 mRNA

NCBI chr 1:97,572,675...97,605,449
Ensembl chr 1:97,575,133...97,605,405

G

zinc finger protein 512

decreases expression

ISO

leflunomide results in decreased expression of ZNF512 mRNA

NCBI chr 6:30,696,889...30,727,895
Ensembl chr 6:30,697,426...30,727,966

G

zinc finger protein 516

increases expression

ISO

leflunomide results in increased expression of ZNF516 mRNA

NCBI chr18:78,561,069...78,661,263
Ensembl chr18:78,573,562...78,674,419

G

zinc finger protein 551

decreases expression

ISO

leflunomide results in decreased expression of ZNF551 mRNA

NCBI chr 1:81,615,977...81,626,233
Ensembl chr 1:81,617,869...81,626,234

G

zinc finger protein 560

increases expression

ISO

Leflunomide results in increased expression of ZNF121 mRNA

NCBI chr 8:27,176,392...27,190,689
Ensembl chr 8:27,176,778...27,190,608

G

zinc finger protein 599

increases expression

ISO

Leflunomide results in increased expression of ZNF577 mRNA

NCBI chr 8:29,032,266...29,048,658
Ensembl chr 8:29,034,127...29,048,870

G

zinc finger protein 605

decreases expression

ISO

leflunomide results in decreased expression of ZNF605 mRNA

NCBI chr12:52,202,487...52,234,782
Ensembl chr12:52,205,132...52,234,512

G

zinc finger protein 609

increases expression

ISO

leflunomide results in increased expression of ZNF609 mRNA

NCBI chr 8:75,109,676...75,243,045
Ensembl chr 8:75,109,676...75,213,086

G

zinc finger protein 62

decreases expression

ISO

leflunomide results in decreased expression of ZFP62 mRNA

NCBI chr10:34,019,367...34,040,564
Ensembl chr10:33,971,943...34,054,637

G

zinc finger protein 629

decreases expression

ISO

Leflunomide results in decreased expression of ZNF629 mRNA

NCBI chr 1:191,648,753...191,689,082
Ensembl chr 1:191,639,332...191,663,832

G

zinc finger protein 637

decreases expression

ISO

leflunomide results in decreased expression of ZNF32 mRNA

NCBI chr 4:152,656,937...152,682,499
Ensembl chr 4:152,656,973...152,685,097

G

zinc finger protein 641

increases expression

ISO

leflunomide results in increased expression of ZNF641 mRNA

NCBI chr 7:131,313,620...131,324,149
Ensembl chr 7:131,313,624...131,323,691

G

zinc finger protein 644

increases expression

ISO

leflunomide results in increased expression of ZNF644 mRNA

NCBI chr14:3,248,350...3,324,820
Ensembl chr14:3,249,888...3,324,820

G

zinc finger protein 652

decreases expression

ISO

leflunomide results in decreased expression of ZNF652 mRNA

NCBI chr10:81,123,326...81,203,153
Ensembl chr10:81,146,507...81,198,827

G

zinc finger protein 69

decreases expression

ISO

leflunomide results in decreased expression of ZFP69 mRNA

NCBI chr 5:139,783,735...139,801,650
Ensembl chr 5:139,787,526...139,799,422

G

zinc finger protein 703

increases expression

ISO

leflunomide results in increased expression of ZNF703 mRNA

NCBI chr16:71,779,340...71,783,510
Ensembl chr16:71,779,340...71,783,510

G

zinc finger protein 770

increases expression

ISO

leflunomide results in increased expression of ZNF770 mRNA

NCBI chr 3:121,417,723...121,425,956
Ensembl chr 3:121,417,250...121,422,153

G

zinc finger protein 771

increases expression

EXP

leflunomide results in increased expression of ZFP771 mRNA

NCBI chr 1:191,294,530...191,305,629
Ensembl chr 1:191,294,530...191,306,215

G

zinc finger protein 799

increases expression

ISO

leflunomide results in increased expression of ZNF799 mRNA

NCBI chr 7:12,548,586...12,561,317
Ensembl chr 7:12,550,400...12,561,507

G

zinc finger protein 839

increases expression

ISO

leflunomide results in increased expression of ZNF839 mRNA

NCBI chr 6:135,686,132...135,711,856
Ensembl chr 6:135,687,100...135,704,299

G

zinc finger protein 866

increases expression

ISO

Leflunomide results in increased expression of ZNF700 mRNA

NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330

G

zinc finger protein 873

increases expression

ISO

Leflunomide results in increased expression of ZNF441 mRNA

NCBI chr 7:8,577,725...8,602,577
Ensembl chr 7:8,577,999...8,602,710

G

zinc finger protein 94

decreases expression

ISO

Leflunomide results in decreased expression of ZNF45 mRNA

NCBI chr 1:88,986,094...89,007,584
Ensembl chr 1:88,992,642...88,999,155

G

zinc finger protein 951

increases expression

ISO

Leflunomide results in increased expression of ZNF844 mRNA

NCBI chr14:5,332,634...5,353,458
Ensembl chr14:5,338,008...5,353,478

G

zinc finger protein X-linked

decreases expression

ISO

leflunomide results in decreased expression of ZFX mRNA

NCBI chr X:62,798,483...62,847,068
Ensembl chr X:62,798,483...62,875,309

G

zinc finger FYVE-type containing 21

decreases expression

ISO

leflunomide results in decreased expression of ZFYVE21 mRNA

NCBI chr 6:136,695,132...136,715,601
Ensembl chr 6:136,694,908...136,715,601

G

zinc finger FYVE-type containing 26

decreases expression

ISO

leflunomide results in decreased expression of ZFYVE26 mRNA

NCBI chr 6:103,764,864...103,828,520
Ensembl chr 6:103,765,510...103,828,463

G

zinc finger with KRAB and SCAN domains 5

decreases expression

ISO

leflunomide results in decreased expression of ZKSCAN5 mRNA

NCBI chr12:14,498,342...14,519,537
Ensembl chr12:14,498,342...14,519,537

G

zinc finger, matrin type 3

increases expression

ISO

leflunomide results in increased expression of ZMAT3 mRNA

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:117,034,517...117,065,294

G

zinc finger, MIZ-type containing 1

increases expression

ISO

leflunomide results in increased expression of ZMIZ1 mRNA

NCBI chr16:1,033,983...1,239,425
Ensembl chr16:1,034,020...1,239,406

G

zinc finger MYM-type containing 3

decreases expression

ISO

leflunomide results in decreased expression of ZMYM3 mRNA

NCBI chr X:70,568,573...70,584,221
Ensembl chr X:70,568,573...70,584,768

G

zinc finger, MYND-type containing 8

increases expression

EXP

leflunomide results in increased expression of ZMYND8 mRNA

NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:174,948,537...175,061,571

G

Zinc finger protein 16 like, pseudogene 1

increases expression

ISO

leflunomide results in increased expression of ZNF16 mRNA

NCBI chr 7:110,531,504...110,550,857

G

zinc finger protein 235

decreases expression

ISO

Leflunomide results in decreased expression of ZNF235 mRNA

NCBI chr 1:88,826,910...88,836,360
Ensembl chr 1:88,827,737...88,836,359

G

zinc finger protein 48

increases expression

EXP

Leflunomide results in increased expression of ZFP553 mRNA

NCBI chr 1:191,284,976...191,289,482
Ensembl chr 1:191,263,224...191,291,307

G

zinc finger protein 599 like, pseudogene 1

decreases expression

ISO

leflunomide results in decreased expression of ZNF599 mRNA

NCBI chr 1:95,580,833...95,611,375

G

zinc finger protein 624 like

increases expression

ISO

leflunomide results in increased expression of ZNF624 mRNA

NCBI chr 7:8,504,136...8,550,137
Ensembl chr 7:8,503,571...8,541,778

G

zinc finger protein 740

decreases expression

ISO

leflunomide results in decreased expression of ZNF740 mRNA

NCBI chr 7:135,215,413...135,226,189
Ensembl chr 7:135,215,642...135,226,144

G

zinc finger protein 783

decreases expression

ISO

Leflunomide results in decreased expression of ZNF783 mRNA

NCBI chr 4:78,277,038...78,283,563

G

zinc finger protein 8

increases expression

ISO

Leflunomide results in increased expression of ZNF8 mRNA

NCBI chr 1:82,570,719...82,584,121
Ensembl chr 1:82,570,687...82,584,119

G

zinc finger, HIT-type containing 6

increases expression

ISO

leflunomide results in increased expression of ZNHIT6 mRNA

NCBI chr 2:237,147,014...237,178,279
Ensembl chr 2:237,146,992...237,178,334

G

zinc and ring finger 3

increases expression

ISO

leflunomide results in increased expression of ZNRF3 mRNA

NCBI chr14:84,375,668...84,527,465
Ensembl chr14:84,374,412...84,527,448

G

zinc finger RANBP2-type containing 2

increases expression
decreases expression

EXP
ISO

leflunomide results in increased expression of ZRANB2 mRNA
leflunomide results in decreased expression of ZRANB2 mRNA

PMID:24136188 PMID:28988120

NCBI chr 2:249,232,010...249,245,786
Ensembl chr 2:249,232,010...249,245,780

G

zinc finger and SCAN domain containing 12

increases expression

ISO

leflunomide results in increased expression of ZSCAN12 mRNA

NCBI chr17:47,942,976...47,948,930
Ensembl chr17:47,942,977...47,964,605

G

zinc finger and SCAN domain containing 21

increases expression

ISO

leflunomide results in increased expression of ZSCAN21 mRNA

NCBI chr12:22,112,204...22,142,506
Ensembl chr12:22,117,311...22,128,783

G

zinc finger and SCAN domain containing 25

decreases expression

ISO

leflunomide results in decreased expression of ZSCAN25 mRNA

NCBI chr12:14,441,458...14,451,919
Ensembl chr12:14,441,458...14,451,985

G

zinc finger, SWIM-type containing 3

decreases expression

ISO

leflunomide results in decreased expression of ZSWIM3 mRNA

NCBI chr 3:173,962,078...173,977,360
Ensembl chr 3:173,941,801...173,977,692

G

zinc finger, SWIM-type containing 4

increases expression

ISO

leflunomide results in increased expression of ZSWIM4 mRNA

NCBI chr19:40,832,608...40,857,742
Ensembl chr19:40,832,635...40,857,742

G

zinc finger, SWIM-type containing 6

increases expression

ISO

leflunomide results in increased expression of ZSWIM6 mRNA

NCBI chr 2:40,944,617...41,112,340
Ensembl chr 2:40,946,435...41,112,519

G

ZW10 interacting kinetochore protein

increases expression

EXP

leflunomide results in increased expression of ZWINT mRNA

NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,937,396...15,953,203

G

zyxin

increases expression

ISO

leflunomide results in increased expression of ZYX mRNA

NCBI chr 4:72,203,991...72,213,181
Ensembl chr 4:72,204,007...72,213,181

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
biochemical role	19888
enzyme inhibitor	18710
pathway inhibitor	12137
pyrimidine synthesis inhibitor	2714
brequinar	146
brequinar sodium	0
leflunomide	2631
tetflupyrolimet	0

paths to the root