CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: enzalutamide
Accession: CHEBI:68534
browse the term
Definition: A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.
Synonyms: exact_synonym: 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
related_synonym: Formula=C21H16F4N4O2S; InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30); InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N; MDV 3100; MDV3100; SMILES=CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F; XTANDI
xref: CAS:915087-33-1; Drug_Central:4628; LINCS:LSM-6254
xref_mesh: MESH:C540278
xref: PMID:21986558; PMID:22101903; PMID:22113551; PMID:22162475; PMID:22229405; PMID:22258371; PMID:22258374; PMID:22266222; PMID:22310230; PMID:22373838; PMID:22393799; PMID:22411952; PMID:22429837; PMID:22472508; PMID:22516457; PMID:22710436; PMID:22815001; PMID:22845410; PMID:22852027; PMID:22894553; PMID:22956944; PMID:22985411; PMID:22987974; Patent:US2007254933; Patent:WO2006124118; Patent:WO2011106570; Reaxys:11718700; Wikipedia:Enzalutamide
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Aadat
aminoadipate aminotransferase
decreases expression
ISO
enzalutamide results in decreased expression of AADAT mRNA
CTD
PMID:29581250
NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
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Abcc4
ATP binding cassette subfamily C member 4
decreases expression
ISO
enzalutamide results in decreased expression of ABCC4 mRNA
CTD
PMID:29581250
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Acsm1
acyl-CoA synthetase medium-chain family member 1
decreases expression
ISO
enzalutamide results in decreased expression of ACSM1 mRNA
CTD
PMID:29581250
NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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Adam10
ADAM metallopeptidase domain 10
affects expression
ISO
enzalutamide affects the expression of ADAM10 mRNA
CTD
PMID:30940724
NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
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Adam17
ADAM metallopeptidase domain 17
affects expression
ISO
enzalutamide affects the expression of ADAM17 mRNA
CTD
PMID:30940724
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
decreases expression
ISO
enzalutamide results in decreased expression of ADPRM mRNA
CTD
PMID:29581250
NCBI chr10:51,732,073...51,744,635
Ensembl chr10:51,731,993...51,744,635
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Aff3
ALF transcription elongation factor 3
decreases expression
ISO
enzalutamide results in decreased expression of AFF3 mRNA
CTD
PMID:29581250
NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
decreases expression
ISO
enzalutamide results in decreased expression of ALDH1A3 mRNA
CTD
PMID:29581250
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Alpk2
alpha-kinase 2
decreases expression
ISO
enzalutamide results in decreased expression of ALPK2 mRNA
CTD
PMID:29581250
NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
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Anxa4
annexin A4
affects expression
ISO
enzalutamide affects the expression of ANXA4 mRNA
CTD
PMID:30940724
NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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Aph1a
aph-1 homolog A, gamma secretase subunit
affects expression
ISO
enzalutamide affects the expression of APH1A mRNA
CTD
PMID:30940724
NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
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Aph1b
aph-1 homolog B, gamma secretase subunit
affects expression
ISO
enzalutamide affects the expression of APH1B mRNA
CTD
PMID:30940724
NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
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App
amyloid beta precursor protein
affects expression
ISO
enzalutamide affects the expression of APP mRNA
CTD
PMID:30940724
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ar
androgen receptor
multiple interactions decreases expression decreases response to substance decreases activity
ISO
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA alternative form; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein alternative form; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of AR protein; enzalutamide binds to and results in decreased localization of and results in decreased activity of AR protein; enzalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide] enzalutamide results in decreased expression of AR protein; enzalutamide results in decreased expression of AR protein alternative form AR alternative form results in decreased susceptibility to enzalutamide; AR protein alternative form results in decreased susceptibility to enzalutamide; AR protein results in decreased susceptibility to enzalutamide enzalutamide results in decreased activity of AR protein
CTD
PMID:19359544 PMID:24740322 PMID:24759320 PMID:25908785 PMID:25970160 PMID:27994731 PMID:28757136 PMID:30940724 PMID:32184358 PMID:32805266 PMID:37019376 PMID:37777120 More...
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Azgp1
alpha-2-glycoprotein 1, zinc-binding
decreases expression
ISO
enzalutamide results in decreased expression of AZGP1 mRNA
CTD
PMID:29581250
NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
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Birc5
baculoviral IAP repeat-containing 5
multiple interactions
ISO
enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]
CTD
PMID:25970160
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmpr1b
bone morphogenetic protein receptor type 1B
decreases expression
ISO
enzalutamide results in decreased expression of BMPR1B mRNA
CTD
PMID:29581250
NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368
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C13h1orf116
similar to human chromosome 1 open reading frame 116
decreases expression
ISO
enzalutamide results in decreased expression of C1ORF116 mRNA
CTD
PMID:29581250
NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426
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Casp3
caspase 3
multiple interactions decreases expression
ISO
enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of CASP3 protein] enzalutamide results in decreased expression of CASP3 protein
CTD
PMID:32184358 PMID:32805266
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
decreases expression
ISO
enzalutamide results in decreased expression of CASP8 protein
CTD
PMID:32805266
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccnb1
cyclin B1
decreases expression
ISO
enzalutamide results in decreased expression of CCNB1 protein
CTD
PMID:32805266
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cd46
CD46 molecule
increases expression
ISO
enzalutamide results in increased expression of CD46 protein
CTD
PMID:30185663
NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
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Cdc25c
cell division cycle 25C
multiple interactions
ISO
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C protein
CTD
PMID:32184358
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
affects expression
ISO
enzalutamide affects the expression of CDKN1B mRNA
CTD
PMID:30940724
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cebpa
CCAAT/enhancer binding protein alpha
affects expression
ISO
enzalutamide affects the expression of CEBPA mRNA
CTD
PMID:30940724
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cflar
CASP8 and FADD-like apoptosis regulator
decreases activity multiple interactions
ISO
enzalutamide results in decreased activity of CFLAR protein enzalutamide promotes the reaction [lupeol results in decreased activity of CFLAR protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of CFLAR protein]
CTD
PMID:37777120
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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Crebbp
CREB binding protein
affects expression
ISO
enzalutamide affects the expression of CREBBP mRNA
CTD
PMID:30940724
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Crisp3
cysteine-rich secretory protein 3
decreases expression
ISO
enzalutamide results in decreased expression of CRISP3 mRNA
CTD
PMID:29581250
NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
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Crym
crystallin, mu
multiple interactions decreases expression
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA]
CTD
PMID:29581250
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
decreases expression
ISO
enzalutamide results in decreased expression of CSGALNACT1 mRNA
CTD
PMID:29581250
NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
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Dpp4
dipeptidylpeptidase 4
decreases expression
ISO
enzalutamide results in decreased expression of DPP4 mRNA
CTD
PMID:29581250
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dtx2
deltex E3 ubiquitin ligase 2
affects expression
ISO
enzalutamide affects the expression of DTX2 mRNA
CTD
PMID:30940724
NCBI chr12:20,643,289...20,682,908
Ensembl chr12:20,643,297...20,682,885
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Dtx3
deltex E3 ubiquitin ligase 3
affects expression
ISO
enzalutamide affects the expression of DTX3 mRNA
CTD
PMID:30940724
NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522
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Dtx4
deltex E3 ubiquitin ligase 4
affects expression
ISO
enzalutamide affects the expression of DTX4 mRNA
CTD
PMID:30940724
NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
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Edem3
ER degradation enhancing alpha-mannosidase like protein 3
decreases expression
ISO
enzalutamide results in decreased expression of EDEM3 mRNA
CTD
PMID:29581250
NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523
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Eed
embryonic ectoderm development
multiple interactions decreases expression
ISO
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of EED protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of EED protein]
CTD
PMID:32805266
NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
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Efcab12
EF-hand calcium binding domain 12
decreases expression
ISO
enzalutamide results in decreased expression of EFCAB12 mRNA
CTD
PMID:29581250
NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560
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Ell2
elongation factor for RNA polymerase II 2
decreases expression
ISO
enzalutamide results in decreased expression of ELL2 mRNA
CTD
PMID:29581250
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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Elovl7
ELOVL fatty acid elongase 7
decreases expression
ISO
enzalutamide results in decreased expression of ELOVL7 mRNA
CTD
PMID:29581250
NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845
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Ep300
E1A binding protein p300
affects expression
ISO
enzalutamide affects the expression of EP300 mRNA
CTD
PMID:30940724
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Ephb4
EPH receptor B4
affects response to substance multiple interactions
ISO
EPHB4 protein affects the susceptibility to enzalutamide enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD
PMID:32184358
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
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Epn1
Epsin 1
affects expression
ISO
enzalutamide affects the expression of EPN1 mRNA
CTD
PMID:30940724
NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
decreases expression multiple interactions
ISO
enzalutamide results in decreased expression of EZH2 protein [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]
CTD
PMID:32805266
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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Fkbp5
FKBP prolyl isomerase 5
multiple interactions decreases expression
ISO
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of FKBP5 mRNA; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of FKBP5 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of FKBP5 mRNA]
CTD
PMID:32184358
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Foxa1
forkhead box A1
affects expression
ISO
enzalutamide affects the expression of FOXA1 mRNA
CTD
PMID:30940724
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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Galnt11
polypeptide N-acetylgalactosaminyltransferase 11
affects expression
ISO
enzalutamide affects the expression of GALNT11 mRNA
CTD
PMID:30940724
NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140
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Gmds
GDP-mannose 4, 6-dehydratase
affects expression
ISO
enzalutamide affects the expression of GMDS mRNA
CTD
PMID:30940724
NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961
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Gnmt
glycine N-methyltransferase
decreases expression
ISO
enzalutamide results in decreased expression of GNMT mRNA
CTD
PMID:29581250
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
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Got1
glutamic-oxaloacetic transaminase 1
affects expression
ISO
enzalutamide affects the expression of GOT1 mRNA
CTD
PMID:30940724
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Greb1
growth regulating estrogen receptor binding 1
decreases expression
ISO
enzalutamide results in decreased expression of GREB1 mRNA
CTD
PMID:29581250
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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Hes1
hes family bHLH transcription factor 1
affects expression
ISO
enzalutamide affects the expression of HES1 mRNA
CTD
PMID:30940724
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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Hnf1b
HNF1 homeobox B
affects expression
ISO
enzalutamide affects the expression of HNF1B mRNA
CTD
PMID:30940724
NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
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Ift172
intraflagellar transport 172
affects expression
ISO
enzalutamide affects the expression of IFT172 mRNA
CTD
PMID:30940724
NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860
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Ift74
intraflagellar transport 74
affects expression
ISO
enzalutamide affects the expression of IFT74 mRNA
CTD
PMID:30940724
NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833
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Igf1
insulin-like growth factor 1
decreases expression
ISO
enzalutamide results in decreased expression of IGF1 mRNA
CTD
PMID:29581250
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igf1r
insulin-like growth factor 1 receptor
decreases expression
ISO
enzalutamide results in decreased expression of IGF1R mRNA
CTD
PMID:29581250
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Il6
interleukin 6
multiple interactions decreases response to substance
ISO
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]
CTD
PMID:25970160
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Iqgap2
IQ motif containing GTPase activating protein 2
decreases expression
ISO
enzalutamide results in decreased expression of IQGAP2 mRNA
CTD
PMID:29581250
NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
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Itch
itchy E3 ubiquitin protein ligase
affects expression
ISO
enzalutamide affects the expression of ITCH mRNA
CTD
PMID:30940724
NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
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Itgb1bp1
integrin subunit beta 1 binding protein 1
affects expression
ISO
enzalutamide affects the expression of ITGB1BP1 mRNA
CTD
PMID:30940724
NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
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Jag1
jagged canonical Notch ligand 1
affects expression
ISO
enzalutamide affects the expression of JAG1 mRNA
CTD
PMID:30940724
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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Jag2
jagged canonical Notch ligand 2
affects expression
ISO
enzalutamide affects the expression of JAG2 mRNA
CTD
PMID:30940724
NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818
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Kat2b
lysine acetyltransferase 2B
affects expression
ISO
enzalutamide affects the expression of KAT2B mRNA
CTD
PMID:30940724
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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Kdm1a
lysine demethylase 1A
multiple interactions
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA]
CTD
PMID:29581250
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
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Kif5c
kinesin family member 5C
decreases expression
ISO
enzalutamide results in decreased expression of KIF5C mRNA
CTD
PMID:29581250
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
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Klk1c10
kallikrein 1-related peptidase C10
increases expression multiple interactions decreases expression
ISO
enzalutamide results in increased expression of KLK3 mRNA [enzalutamide co-treated with NVP-BHG712] results in decreased expression of KLK3 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of KLK3 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of KLK3 protein; enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of KLK3 protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of KLK3 mRNA]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of KLK3 protein] enzalutamide results in decreased expression of KLK3 mRNA; enzalutamide results in decreased expression of KLK3 protein
CTD
PMID:19359544 PMID:23704919 PMID:25970160 PMID:29581250 PMID:30940724 PMID:32184358 PMID:32805266 PMID:33932781 PMID:37019376 More...
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Krt19
keratin 19
affects expression
ISO
enzalutamide affects the expression of KRT19 mRNA
CTD
PMID:30940724
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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Lck
LCK proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
enzalutamide results in decreased expression of LCK mRNA
CTD
PMID:29581250
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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Lcp1
lymphocyte cytosolic protein 1
multiple interactions decreases expression
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA]
CTD
PMID:29581250
NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
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Maf
MAF bZIP transcription factor
decreases expression
ISO
enzalutamide results in decreased expression of MAF mRNA
CTD
PMID:29581250
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
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Maml1
mastermind-like transcriptional coactivator 1
affects expression
ISO
enzalutamide affects the expression of MAML1 mRNA
CTD
PMID:30940724
NCBI chr10:34,588,639...34,623,024
Ensembl chr10:34,588,646...34,623,338
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Maml3
mastermind-like transcriptional coactivator 3
affects expression
ISO
enzalutamide affects the expression of MAML3 mRNA
CTD
PMID:30940724
NCBI chr 2:135,720,431...136,137,829
Ensembl chr 2:135,721,021...136,137,814
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
[enzalutamide co-treated with GSK-2816126] results in increased expression of MAP1LC3B protein modified form
CTD
PMID:32805266
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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Map2
microtubule-associated protein 2
multiple interactions decreases expression
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA]
CTD
PMID:29581250
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mdk
midkine
affects expression
ISO
enzalutamide affects the expression of MDK mRNA
CTD
PMID:30940724
NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
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Mib1
MIB E3 ubiquitin protein ligase 1
affects expression
ISO
enzalutamide affects the expression of MIB1 mRNA
CTD
PMID:30940724
NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689
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Mib2
MIB E3 ubiquitin protein ligase 2
affects expression
ISO
enzalutamide affects the expression of MIB2 mRNA
CTD
PMID:30940724
NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650
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Mki67
marker of proliferation Ki-67
multiple interactions
ISO
enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MKI67 protein]
CTD
PMID:32184358
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mpc2
mitochondrial pyruvate carrier 2
decreases expression
ISO
enzalutamide results in decreased expression of MPC2 mRNA
CTD
PMID:29581250
NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
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Msmb
microseminoprotein, beta
decreases expression
ISO
enzalutamide results in decreased expression of MSMB mRNA
CTD
PMID:33932781
NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression affects expression multiple interactions decreases activity
ISO
enzalutamide results in decreased expression of MYC protein enzalutamide affects the expression of MYC mRNA [enzalutamide co-treated with NVP-BHG712] results in decreased expression of MYC protein; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MYC protein] enzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein]
CTD
PMID:24759320 PMID:25970160 PMID:30940724 PMID:32184358 PMID:37777120
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myo1b
myosin Ib
multiple interactions decreases expression
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA]
CTD
PMID:29581250
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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Ncstn
nicastrin
affects expression
ISO
enzalutamide affects the expression of NCSTN mRNA
CTD
PMID:30940724
NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
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Neurl1b
neuralized E3 ubiquitin protein ligase 1B
affects expression
ISO
enzalutamide affects the expression of NEURL1B mRNA
CTD
PMID:30940724
NCBI chr10:16,754,002...16,785,049
Ensembl chr10:16,757,208...16,785,119
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Nkap
NFKB activating protein
affects expression
ISO
enzalutamide affects the expression of NKAP mRNA
CTD
PMID:30940724
NCBI chr X:116,373,031...116,392,677
Ensembl chr X:116,372,839...116,394,945
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Nkx3-1
NK3 homeobox 1
decreases expression multiple interactions
ISO
enzalutamide results in decreased expression of NKX3-1 mRNA enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of NKX3-1 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of NKX3-1 mRNA]
CTD
PMID:29581250 PMID:32184358
NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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Nle1
notchless homolog 1
affects expression
ISO
enzalutamide affects the expression of NLE1 mRNA
CTD
PMID:30940724
NCBI chr10:67,834,059...67,844,771
Ensembl chr10:67,834,062...67,842,658
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Notch1
notch receptor 1
affects response to substance multiple interactions affects expression
ISO
NOTCH1 protein affects the susceptibility to enzalutamide [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein enzalutamide affects the expression of NOTCH1 mRNA
CTD
PMID:30940724
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Notch2
notch receptor 2
affects expression
ISO
enzalutamide affects the expression of NOTCH2 mRNA
CTD
PMID:30940724
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Notch3
notch receptor 3
affects expression
ISO
enzalutamide affects the expression of NOTCH3 mRNA
CTD
PMID:30940724
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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Parp1
poly (ADP-ribose) polymerase 1
decreases cleavage multiple interactions
ISO
enzalutamide results in decreased cleavage of PARP1 protein [enzalutamide co-treated with GSK-2816126] results in increased cleavage of PARP1 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in increased cleavage of PARP1 protein; [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of PARP1 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD
PMID:30940724 PMID:32184358 PMID:32805266
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Perp
p53 apoptosis effector related to PMP22
affects expression
ISO
enzalutamide affects the expression of PERP mRNA
CTD
PMID:30940724
NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
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Pla2g5
phospholipase A2, group V
decreases expression
ISO
enzalutamide results in decreased expression of PLA2G5 mRNA
CTD
PMID:29581250
NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
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Plk1
polo-like kinase 1
multiple interactions
ISO
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of PLK1 mRNA]
CTD
PMID:32184358
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
decreases expression
ISO
enzalutamide results in decreased expression of PLOD2 mRNA
CTD
PMID:29581250
NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
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Pofut1
protein O-fucosyltransferase 1
affects expression
ISO
enzalutamide affects the expression of POFUT1 mRNA
CTD
PMID:30940724
NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786
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Psen1
presenilin 1
affects expression
ISO
enzalutamide affects the expression of PSEN1 mRNA
CTD
PMID:30940724
NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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Psen2
presenilin 2
affects expression
ISO
enzalutamide affects the expression of PSEN2 mRNA
CTD
PMID:30940724
NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
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Psenen
presenilin enhancer gamma secretase subunit
affects expression
ISO
enzalutamide affects the expression of PSENEN mRNA
CTD
PMID:30940724
NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
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Ptger4
prostaglandin E receptor 4
decreases expression
ISO
enzalutamide results in decreased expression of PTGER4 mRNA
CTD
PMID:29581250
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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Rbm15
RNA binding motif protein 15
affects expression
ISO
enzalutamide affects the expression of RBM15 mRNA
CTD
PMID:30940724
NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703
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Rbpj
recombination signal binding protein for immunoglobulin kappa J region
affects expression
ISO
enzalutamide affects the expression of RBPJ mRNA
CTD
PMID:30940724
NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
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Rgs2
regulator of G-protein signaling 2
decreases expression
ISO
enzalutamide results in decreased expression of RGS2 mRNA
CTD
PMID:29581250
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rhou
ras homolog family member U
decreases expression
ISO
enzalutamide results in decreased expression of RHOU mRNA
CTD
PMID:29581250
NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552
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Rps19
ribosomal protein S19
affects expression
ISO
enzalutamide affects the expression of RPS19 mRNA
CTD
PMID:30940724
NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508 Ensembl chr 7:80,480,951...80,486,508
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Rps27a
ribosomal protein S27a
affects expression
ISO
enzalutamide affects the expression of RPS27A mRNA
CTD
PMID:30940724
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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S1pr3
sphingosine-1-phosphate receptor 3
affects expression
ISO
enzalutamide affects the expression of S1PR3 mRNA
CTD
PMID:30940724
NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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Sel1l
SEL1L adaptor subunit of SYVN1 ubiquitin ligase
affects expression
ISO
enzalutamide affects the expression of SEL1L mRNA
CTD
PMID:30940724
NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
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Selenop
selenoprotein P
decreases expression
ISO
enzalutamide results in decreased expression of SELENOP mRNA
CTD
PMID:29581250
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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Slc22a3
solute carrier family 22 member 3
multiple interactions decreases expression
ISO
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA]
CTD
PMID:29581250
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Snw1
SNW domain containing 1
affects expression
ISO
enzalutamide affects the expression of SNW1 mRNA
CTD
PMID:30940724
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
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Socs2
suppressor of cytokine signaling 2
decreases expression
ISO
enzalutamide results in decreased expression of SOCS2 mRNA
CTD
PMID:29581250
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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Sox9
SRY-box transcription factor 9
affects expression
ISO
enzalutamide affects the expression of SOX9 mRNA
CTD
PMID:30940724
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Spen
spen family transcriptional repressor
affects expression
ISO
enzalutamide affects the expression of SPEN mRNA
CTD
PMID:30940724
NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811
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Spock1
sparc/osteonectin, cwcv and kazal like domains proteoglycan 1
decreases expression
ISO
enzalutamide results in decreased expression of SPOCK1 mRNA
CTD
PMID:29581250
NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935
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St6galnac1
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
decreases expression
ISO
enzalutamide results in decreased expression of ST6GALNAC1 mRNA
CTD
PMID:29581250
NCBI chr10:101,972,656...101,983,053
Ensembl chr10:101,972,668...101,983,053
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Stat3
signal transducer and activator of transcription 3
multiple interactions decreases response to substance
ISO
enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]
CTD
PMID:25970160
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Susd5
sushi domain containing 5
affects expression
ISO
enzalutamide affects the expression of SUSD5 mRNA
CTD
PMID:30940724
NCBI chr 8:113,996,771...114,036,133
Ensembl chr 8:113,997,362...114,035,861
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Suz12
SUZ12 polycomb repressive complex 2 subunit
multiple interactions decreases expression
ISO
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of SUZ12 protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of SUZ12 protein]
CTD
PMID:32805266
NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
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Tenm1
teneurin transmembrane protein 1
decreases expression
ISO
enzalutamide results in decreased expression of TENM1 mRNA
CTD
PMID:29581250
NCBI chr X:121,400,466...122,289,877
Ensembl chr X:121,403,649...122,290,207
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Tmcc3
transmembrane and coiled-coil domain family 3
decreases expression multiple interactions
ISO
enzalutamide results in decreased expression of TMCC3 mRNA KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA]
CTD
PMID:29581250
NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
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Tpd52
tumor protein D52
decreases expression
ISO
enzalutamide results in decreased expression of TPD52 mRNA
CTD
PMID:29581250
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
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Trpm8
transient receptor potential cation channel, subfamily M, member 8
decreases expression
ISO
enzalutamide results in decreased expression of TRPM8 mRNA
CTD
PMID:29581250
NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
affects expression
ISO
enzalutamide affects the expression of UBA52 mRNA
CTD
PMID:30940724
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ubb
ubiquitin B
affects expression
ISO
enzalutamide affects the expression of UBB mRNA
CTD
PMID:30940724
NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
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Ubc
ubiquitin C
affects expression
ISO
enzalutamide affects the expression of UBC mRNA
CTD
PMID:30940724
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
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Ube2c
ubiquitin-conjugating enzyme E2C
multiple interactions
ISO
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of UBE2C mRNA
CTD
PMID:32184358
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Wdr12
WD repeat domain 12
affects expression
ISO
enzalutamide affects the expression of WDR12 mRNA
CTD
PMID:30940724
NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469
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Wwtr1
WW domain containing transcription regulator 1
decreases expression
ISO
enzalutamide results in decreased expression of WWTR1 mRNA
CTD
PMID:29581250
NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
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