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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methoxamine
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Accession:CHEBI:6839 term browser browse the term
Definition:An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine .
Synonyms:related_synonym: Formula=C11H17NO3;   InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3;   InChIKey=WJAJPNHVVFWKKL-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C(O)C(C)N)OC)OC;   methoxamedrine;   methoxamin
 xref: CAS:390-28-3;   KEGG:C07513;   KEGG:D08201;   LINCS:LSM-4423
 xref_mesh: MESH:D008729
 xref: PMID:24282936;   PMID:26914134;   PMID:28166217;   PMID:28599629


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methoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D affects binding ISO Methoxamine binds to ADRA1D protein CTD PMID:15493479 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion		 EXP Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein] CTD PMID:7816204 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of PTGS2 protein CTD PMID:12500202 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein CTD PMID:12500202 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            cardiovascular drug 8654
              antihypotensive agent 4
                methoxamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        amine 8307
                                          amphetamines 5814
                                            methoxamine 4
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