CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: metaproterenol
Accession: CHEBI:6792
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Definition: A phenylethanolamine that has formula C11H17NO3.
Synonyms: related_synonym: Formula=C11H17NO3; InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3; InChIKey=LMOINURANNBYCM-UHFFFAOYSA-N; Metaproterenol polistirex; Orciprenaline; SMILES=CC(C)NCC(O)c1cc(O)cc(O)c1
xref: CAS:586-06-1; HMDB:HMDB0014954; KEGG:C07144; KEGG:D08300
xref_mesh: MESH:D009921
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Adrb2
adrenoceptor beta 2
decreases expression multiple interactions increases phosphorylation affects expression increases activity
ISO
Metaproterenol results in decreased expression of ADRB2 protein [Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Metaproterenol binds to and results in increased activity of ADRB2 protein Metaproterenol results in increased phosphorylation of ADRB2 protein Metaproterenol affects the expression of ADRB2 mRNA Metaproterenol results in increased activity of ADRB2 protein
CTD
PMID:16980553 PMID:24705868 PMID:34601065
NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Metaproterenol results in increased expression of BAX protein
CTD
PMID:15052282
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcat1
branched chain amino acid transaminase 1
increases expression
EXP
Metaproterenol results in increased expression of BCAT1 mRNA
CTD
PMID:23558518
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Metaproterenol results in decreased expression of BCL2 protein
CTD
PMID:15052282
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bnip1
BCL2 interacting protein 1
increases expression
ISO
Metaproterenol results in increased expression of BNIP1 protein
CTD
PMID:15052282
NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,386,841...16,399,157
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Clu
clusterin
increases expression
ISO
Metaproterenol results in increased expression of CLU protein
CTD
PMID:15052282
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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Fabp3
fatty acid binding protein 3
increases expression
EXP
Metaproterenol results in increased expression of FABP3 protein
CTD
PMID:22878004
NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718
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Fhl1
four and a half LIM domains 1
increases expression
EXP
Metaproterenol results in increased expression of FHL1 mRNA
CTD
PMID:23558518
NCBI chr X:139,592,794...139,652,290
Ensembl chr X:134,555,479...134,614,928
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Il1a
interleukin 1 alpha
decreases expression
ISO
Metaproterenol results in decreased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
decreases expression
ISO
Metaproterenol results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Lmcd1
LIM and cysteine-rich domains 1
increases expression
EXP
Metaproterenol results in increased expression of LMCD1 mRNA
CTD
PMID:23558518
NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:145,393,145...145,452,046
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Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Metaproterenol results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:85,284,335...85,503,044
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Metaproterenol results in decreased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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Rnd1
Rho family GTPase 1
increases expression
EXP
Metaproterenol results in increased expression of RND1 mRNA
CTD
PMID:23558518
NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399
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Serpine1
serpin family E member 1
increases expression
EXP
Metaproterenol results in increased expression of SERPINE1 mRNA
CTD
PMID:23558518
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Metaproterenol results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453
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Spp1
secreted phosphoprotein 1
increases expression
EXP
Metaproterenol results in increased expression of SPP1 mRNA
CTD
PMID:23558518
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Tgfb2
transforming growth factor, beta 2
increases expression
EXP
Metaproterenol results in increased expression of TGFB2 mRNA
CTD
PMID:23558518
NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Metaproterenol results in increased expression of TIMP1 mRNA
CTD
PMID:23558518
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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Tnni3
troponin I3, cardiac type
increases expression
EXP
Metaproterenol results in increased expression of TNNI3 protein
CTD
PMID:22878004
NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580
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Tnnt2
troponin T2, cardiac type
increases expression
EXP
Metaproterenol results in increased expression of TNNT2 protein
CTD
PMID:22878004
NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388
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