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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(R)-mevalonolactone
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Accession:CHEBI:67849 term browser browse the term
Definition:A 4-hydroxy-4-methyloxan-2-one that has (R)-configuration. It is a natural product found in Phomopsis archeri.
Synonyms:related_synonym: (-)-(R)-mevalonic acid lactone;   (-)-mevalonolactone;   (4R)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one;   (4R)-4-hydroxy-4-methyloxan-2-one;   D-Mevalonolactone;   D-mevalonic acid lactone;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3/t6-/m1/s1;   InChIKey=JYVXNLLUYHCIIH-ZCFIWIBFSA-N;   SMILES=C[C@@]1(O)CCOC(=O)C1
 xref: CAS:19115-49-2;   LINCS:LSM-6716;   PMID:11667258;   PMID:20460804;   PMID:22905894;   PMID:23964677;   PMID:24431105;   PMID:32691474;   PMID:9208099
 cyclic_relationship: is_enantiomer_of CHEBI:194428


show annotations for term's descendants           Sort by:
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:86,707,690...86,710,073
Ensembl chr 1:86,707,503...86,711,874 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:104,003,744...104,004,234 JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:147,748,791...147,755,549 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            eukaryotic metabolite 19958
              plant metabolite 18270
                (R)-mevalonolactone 4
                  mevalonolactone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  ester 17805
                                    carboxylic ester 17260
                                      lactone 13419
                                        delta-lactone 4379
                                          2-pyranones 775
                                            4-hydroxy-4-methyloxan-2-one 4
                                              (R)-mevalonolactone 4
                                                mevalonolactone 4
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