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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:scalaradial
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Accession:CHEBI:67731 term browser browse the term
Definition:A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity.
Synonyms:exact_synonym: (4aS,4bR,6S,6aS,7R,10aS,10bR,12aS)-7,8-diformyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydrochrysen-6-yl acetate
 related_synonym: Formula=C27H40O4;   InChI=1S/C27H40O4/c1-17(30)31-23-14-22-25(4)12-7-11-24(2,3)20(25)10-13-26(22,5)21-9-8-18(15-28)19(16-29)27(21,23)6/h8,15-16,19-23H,7,9-14H2,1-6H3/t19-,20-,21-,22+,23-,25-,26-,27+/m0/s1;   InChIKey=ADWFEADZGIHPDE-QGERINELSA-N;   SMILES=[H]C(=O)[C@H]1C(=CC[C@@]2([H])[C@]3(C)CC[C@@]4([H])C(C)(C)CCC[C@]4(C)[C@@]3([H])C[C@H](OC(C)=O)[C@]12C)C([H])=O
 xref: CAS:53527-28-9;   Chemspider:10272825;   KNApSAcK:C00043907
 xref_mesh: MESH:C071197
 xref: PMID:15620263;   PMID:15645482;   PMID:17579085;   PMID:17691073;   PMID:18000710;   PMID:1930288;   PMID:21548580;   PMID:22509253;   PMID:23008213;   PMID:24769547;   PMID:29019677;   PMID:33665446;   PMID:7575673;   PMID:8185681;   PMID:8688196;   PMID:9060998


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scalaradial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:8113982 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        anti-inflammatory agent 16666
          scalaradial 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          formyl group 9051
                                            aldehyde 9051
                                              alpha,beta-unsaturated aldehyde 3109
                                                enal 3109
                                                  scalaradial 4
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