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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mephobarbital
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Accession:CHEBI:6758 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups.
Synonyms:exact_synonym: 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 1-methylphenobarbital;   5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione;   5-ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-1-methyl-5-phenylbarbituric acid;   Formula=C13H14N2O3;   InChI=1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18);   InChIKey=ALARQZQTBTVLJV-UHFFFAOYSA-N;   Mebaral;   Mephobarbitone;   N-methylphenobarbital;   SMILES=CCC1(C(=O)NC(=O)N(C)C1=O)c1ccccc1;   methylphenobarbital;   methylphenobarbitalum;   metilfenobarbital
 alt_id: CHEBI:165567
 xref: CAS:115-38-8;   DrugBank:DB00849;   Drug_Central:1696;   Gmelin:282754;   HMDB:HMDB0014987;   KEGG:C07829;   KEGG:D00700
 xref_mesh: MESH:D008618
 xref: PMID:12873507;   PMID:1455071;   PMID:2083148;   PMID:22342565;   PMID:2249375;   PMID:3298402;   PMID:3654008;   PMID:553327;   PMID:6094812;   Reaxys:256144;   Wikipedia:Methylphenobarbital


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mephobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Mephobarbital CTD PMID:12464242 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Mephobarbital binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biophysical role 14048
          membrane transport modulator 13884
            GABA modulator 5114
              barbiturates 4626
                mephobarbital 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteromonocyclic compound 17795
                                    diazines 13216
                                      pyrimidines 13086
                                        pyrimidone 10512
                                          barbiturates 4626
                                            mephobarbital 2
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