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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pethidine
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Accession:CHEBI:6754 term browser browse the term
Definition:A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Synonyms:exact_synonym: ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
 related_synonym: 1-methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester;   1-methyl-4-phenylisonipecotic acid ethyl ester;   1-methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester;   Demerol;   Formula=C15H21NO2;   IDS-NP-001;   InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3;   InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N;   N-methyl-4-phenyl-4-carbethoxypiperidine;   Nemerol;   SMILES=C1(C(=O)OCC)(CCN(CC1)C)C2=CC=CC=C2;   ethyl 1-methyl-4-phenylisonipecotate;   isonipecaine;   meperidina;   meperidine;   meperidol;   methyl phenylpiperidine carbonic acid ethyl ester;   pethanol;   pethidin;   pethidineter;   pethidinum;   petidina;   petydyna;   phetidine
 xref: CAS:57-42-1;   DrugBank:DB00454;   Drug_Central:1690;   HMDB:HMDB0014597;   KEGG:C07128;   KEGG:D08343
 xref_mesh: MESH:D008614
 xref: PMID:27621675;   PMID:28666300;   PMID:29880084;   PMID:30115484;   PMID:30362203;   PMID:30386603;   PMID:30418234;   PMID:30487674;   PMID:30786304;   PMID:30902024;   PMID:30902579;   PMID:31001434;   PMID:31294134;   PMID:31319637;   PMID:31423145;   PMID:31486253;   PMID:31633090;   PMID:31874879;   PMID:32001961;   PMID:32214301;   Wikipedia:Pethidine
 cyclic_relationship: is_conjugate_base_of CHEBI:149471


show annotations for term's descendants           Sort by:
pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis		 ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine		 CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        pharmacological role 19101
          analgesic 14794
            opioid analgesic 743
              pethidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19366
                              organic hydroxy compound 18975
                                alcohol 15749
                                  primary alcohol 14706
                                    ethanols 8928
                                      ethanol 8928
                                        ethyl ester 4383
                                          pethidine 2
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