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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:conduritol
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Accession:CHEBI:67218 term browser browse the term
Definition:A tetrol that is cyclohexene in which a hydrogen attached to each of the carbons at positions 3, 4, 5, and 6 is replaced by a hydroxy group. The group consists of six possible diastereoisomers, known as conduritols A to F, some of which can exist as two distinct enantiomers.
Synonyms:exact_synonym: cyclohex-5-ene-1,2,3,4-tetrol
 related_synonym: Formula=C6H10O4;   InChI=1S/C6H10O4/c7-3-1-2-4(8)6(10)5(3)9/h1-10H;   InChIKey=LRUBQXAKGXQBHA-UHFFFAOYSA-N;   SMILES=OC1C=CC(O)C(O)C1O
 xref: PMID:12003543;   PMID:16267592;   PMID:21630704;   Wikipedia:Conduritol


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conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 multiple interactions
decreases activity		 ISO
EXP		 [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA1 protein
[conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein		 CTD PMID:9101438 PMID:19576930 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        polyatomic entity 19824
          heteroatomic molecular entity 19781
            hydroxides 19341
              organic hydroxy compound 18951
                polyol 11690
                  cyclitol 7474
                    conduritol 2
                      (+)-conduritol B + 2
                      (-)-conduritol B + 2
                      conduritol A 0
                      conduritol epoxide + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  olefin 8918
                                    cyclic olefin 422
                                      monocyclic olefin 420
                                        cycloalkene 407
                                          cyclohexene 3
                                            conduritol 2
                                              (+)-conduritol B + 2
                                              (-)-conduritol B + 2
                                              conduritol A 0
                                              conduritol epoxide + 2
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