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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ryanodine receptor agonist
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Accession:CHEBI:67114 term browser browse the term
Definition:A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
Synonyms:related_synonym: RyR activator;   RyR activators;   RyR agonist;   RyR agonists;   RyRs activator;   RyRs agonist;   ryanodine receptor activator;   ryanodine receptor activators
 xref: PMID:30679133;   PMID:30684528;   PMID:31840405;   PMID:8597061;   Wikipedia:Ryanodine_receptor


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATM protein] CTD PMID:38104654 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552 		JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CCNB1 protein] CTD PMID:38104654 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDC25C protein] CTD PMID:38104654 NCBI chr 2:140,289,156...140,323,696
Ensembl chr 2:140,289,115...140,324,425 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDK1 protein] CTD PMID:38104654 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197 		JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of CHEK2 protein] CTD PMID:38104654 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G RYR1 ryanodine receptor 1 increases activity
multiple interactions		 EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 5152
    role 5119
      biological role 5119
        biophysical role 207
          membrane transport modulator 123
            calcium channel modulator 95
              ryanodine receptor modulator 8
                ryanodine receptor agonist 6
                  4-chloro-m-cresol 0
                  caffeine + 6
                  chlorantraniliprole 0
                  cyantraniliprole 0
                  cyclaniliprole 0
                  cyclic ADP-beta-D-ribose + 0
                  suramin 0
                  suramin sodium 0
                  tetraniliprole 0
paths to the root