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G |
Adrb2 |
adrenoceptor beta 2 |
decreases response to substance |
ISO |
ADRB2 protein results in decreased susceptibility to Busulfan |
CTD |
PMID:7202579 |
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Busulfan results in increased expression of AHR mRNA |
CTD |
PMID:35641671 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Anp32b |
acidic nuclear phosphoprotein 32 family member B |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein |
CTD |
PMID:20933509 |
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NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
increases response to substance |
ISO |
APEX1 protein mutant form results in increased susceptibility to Busulfan |
CTD |
PMID:19470598 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:18324785 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
multiple interactions affects response to substance |
ISO |
ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] ARHGDIA mRNA affects the susceptibility to Busulfan |
CTD |
PMID:17264767 |
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NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of ATF4 protein] Busulfan results in increased expression of ATF4 mRNA |
CTD |
PMID:35533795 PMID:35641671 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein |
CTD |
PMID:20933509 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of BECN1 protein 3-methyladenine inhibits the reaction [Busulfan results in increased expression of BECN1 protein] |
CTD |
PMID:38220133 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bmp4 |
bone morphogenetic protein 4 |
decreases expression |
EXP |
Busulfan results in decreased expression of BMP4 mRNA |
CTD |
PMID:15786497 |
|
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] |
CTD |
PMID:17264767 PMID:18339423 PMID:19732952 PMID:20933509 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
ISO |
Busulfan results in increased activity of CASP8 protein [decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein] |
CTD |
PMID:18339423 PMID:19732952 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] |
CTD |
PMID:19732952 PMID:20933509 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cat |
catalase |
decreases expression |
ISO |
Busulfan results in decreased expression of CAT protein |
CTD |
PMID:38123000 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Cdc25b |
cell division cycle 25B |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein |
CTD |
PMID:20933509 |
|
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Busulfan results in decreased expression of CDK2 mRNA |
CTD |
PMID:15388331 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Busulfan results in decreased expression of CDK4 mRNA |
CTD |
PMID:15388331 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of CDKN1A protein [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein |
CTD |
PMID:16882877 PMID:20933509 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
Busulfan results in increased expression of CDKN2A mRNA |
CTD |
PMID:14500376 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Chek1 |
checkpoint kinase 1 |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:20933509 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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|
G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:20933509 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cldn11 |
claudin 11 |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of CLDN11 mRNA; Busulfan results in decreased expression of CLDN11 protein 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of CLDN11 protein] |
CTD |
PMID:35533795 |
|
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
Busulfan results in increased expression of COL1A1 mRNA |
CTD |
PMID:37597760 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression |
ISO |
Busulfan results in increased expression of COL3A1 mRNA |
CTD |
PMID:37597760 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a1 |
collagen type IV alpha 1 chain |
affects expression |
ISO |
Busulfan affects the expression of COL4A1 mRNA |
CTD |
PMID:15941629 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Busulfan results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of DDIT3 protein] |
CTD |
PMID:35533795 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:35533795 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
ISO |
Busulfan results in increased phosphorylation of EIF2S1 protein 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:35533795 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Faslg |
Fas ligand |
decreases expression |
ISO |
Busulfan results in decreased expression of FASL mRNA |
CTD |
PMID:15388331 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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|
G |
Fgf8 |
fibroblast growth factor 8 |
decreases expression |
EXP |
Busulfan results in decreased expression of FGF8 mRNA |
CTD |
PMID:15786497 |
|
NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
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G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
ISO |
Busulfan results in decreased expression of FSHB protein |
CTD |
PMID:38123000 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of FTH1 protein 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of FTH1 protein] |
CTD |
PMID:38220133 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gdnf |
glial cell derived neurotrophic factor |
affects expression increases expression |
ISO |
Busulfan affects the expression of GDNF mRNA Busulfan results in increased expression of GDNF mRNA |
CTD |
PMID:20684317 PMID:22082982 PMID:26524245 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of GJA1 mRNA; Busulfan results in decreased expression of GJA1 protein 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of GJA1 protein] |
CTD |
PMID:35533795 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions decreases expression |
ISO |
3-methyladenine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] Busulfan results in decreased expression of GPX4 mRNA; Busulfan results in decreased expression of GPX4 protein |
CTD |
PMID:32416107 PMID:38220133 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions affects response to substance affects metabolic processing affects abundance decreases response to substance |
ISO |
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione] GSTA1 polymorphism affects the susceptibility to Busulfan GSTA1 gene polymorphism affects the metabolism of Busulfan; GSTA1 protein affects the metabolism of Busulfan GSTA1 gene polymorphism affects the abundance of Busulfan GSTA1 protein results in decreased susceptibility to Busulfan |
CTD |
PMID:8886613 PMID:10437668 PMID:10570028 PMID:12429583 PMID:20672371 PMID:21135089 PMID:21215809 PMID:21441958 More...
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstm1 |
glutathione S-transferase mu 1 |
affects metabolic processing affects abundance affects response to substance multiple interactions |
ISO |
GSTM1 protein affects the metabolism of Busulfan GSTM1 gene polymorphism affects the abundance of Busulfan GSTM1 gene polymorphism affects the susceptibility to Busulfan [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide] |
CTD |
PMID:8886613 PMID:15142875 PMID:19584821 PMID:20672371 PMID:21215809 PMID:28744217 More...
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstp1 |
glutathione S-transferase pi 1 |
affects metabolic processing affects abundance |
ISO |
GSTP1 protein affects the metabolism of Busulfan GSTP1 gene polymorphism affects the abundance of Busulfan |
CTD |
PMID:8886613 PMID:20672371 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt1 |
glutathione S-transferase theta 1 |
multiple interactions |
ISO |
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan |
CTD |
PMID:21215809 |
|
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation multiple interactions |
ISO |
Busulfan results in increased phosphorylation of H2AX protein [Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein |
CTD |
PMID:18339423 PMID:20933509 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
Busulfan results in increased expression of HIF1A mRNA |
CTD |
PMID:35641671 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of HSPA5 protein] |
CTD |
PMID:35533795 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Inhba |
inhibin subunit beta A |
multiple interactions increases expression |
ISO |
bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein] Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein |
CTD |
PMID:12966370 PMID:22286157 |
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NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
decreases expression |
ISO |
Busulfan results in decreased expression of KIT mRNA |
CTD |
PMID:15388331 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Lama1 |
laminin subunit alpha 1 |
affects expression |
ISO |
Busulfan affects the expression of LAMA1 mRNA |
CTD |
PMID:15941629 |
|
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
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G |
Lama4 |
laminin subunit alpha 4 |
affects expression |
ISO |
Busulfan affects the expression of LAMA4 mRNA |
CTD |
PMID:15941629 |
|
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Busulfan results in decreased expression of LHB protein |
CTD |
PMID:38123000 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of MAP1LC3B protein 3-methyladenine inhibits the reaction [Busulfan results in increased expression of MAP1LC3B protein] |
CTD |
PMID:38220133 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity |
ISO |
Busulfan results in increased activity of MAPK1 protein |
CTD |
PMID:16882877 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity |
ISO |
Busulfan results in increased activity of MAPK3 protein |
CTD |
PMID:16882877 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mgst2 |
microsomal glutathione S-transferase 2 |
decreases response to substance |
ISO |
MGST2 protein results in decreased susceptibility to Busulfan |
CTD |
PMID:15779864 |
|
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
decreases expression |
ISO |
Busulfan results in decreased expression of MTF1 mRNA |
CTD |
PMID:35641671 |
|
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein |
CTD |
PMID:20933509 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nanos2 |
nanos C2HC-type zinc finger 2 |
decreases expression |
ISO |
Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein |
CTD |
PMID:26524245 |
|
NCBI chr 1:78,635,668...78,637,128
Ensembl chr 1:78,635,668...78,637,128
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G |
Nanos3 |
nanos C2HC-type zinc finger 3 |
decreases expression |
ISO |
Busulfan results in decreased expression of NANOS3 mRNA |
CTD |
PMID:26524245 |
|
NCBI chr19:23,978,465...23,988,933
Ensembl chr19:23,985,504...23,988,932
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G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions increases expression |
ISO |
3-methyladenine inhibits the reaction [Busulfan results in increased expression of NCOA4 protein] |
CTD |
PMID:38220133 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression increases expression multiple interactions |
ISO |
Busulfan results in decreased expression of NFE2L2 protein Busulfan results in increased expression of NFE2L2 mRNA Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein] |
CTD |
PMID:32416107 PMID:35641671 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
increases expression |
ISO |
Busulfan results in increased expression of NFKB1 mRNA |
CTD |
PMID:35641671 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Npm1 |
nucleophosmin 1 |
multiple interactions |
ISO |
NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] |
CTD |
PMID:20172040 |
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NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
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G |
Ocln |
occludin |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of OCLN mRNA; Busulfan results in decreased expression of OCLN protein 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of OCLN protein] |
CTD |
PMID:35533795 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein] Busulfan results in increased cleavage of PARP1 protein |
CTD |
PMID:18339423 PMID:19732952 PMID:20933509 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Phb1 |
prohibitin 1 |
affects expression |
ISO |
Busulfan affects the expression of PHB1 mRNA |
CTD |
PMID:15388331 |
|
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects expression |
ISO |
Busulfan affects the expression of PPARG mRNA |
CTD |
PMID:35641671 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of PTGS2 mRNA ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA] |
CTD |
PMID:12966370 PMID:32416107 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pus7 |
pseudouridine synthase 7 |
increases expression |
ISO |
Busulfan results in increased expression of PUS7 mRNA |
CTD |
PMID:34097952 |
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NCBI chr 4:11,360,169...11,401,139
Ensembl chr 4:11,360,188...11,401,172
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Rad51 |
RAD51 recombinase |
decreases expression |
ISO |
Busulfan results in decreased expression of RAD51 mRNA |
CTD |
PMID:15388331 |
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NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Busulfan results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15388331 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Sat2 |
spermidine/spermine N1-acetyltransferase family member 2 |
increases expression |
ISO |
Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein |
CTD |
PMID:28578006 |
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NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
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Serpinc1 |
serpin family C member 1 |
affects expression |
ISO |
Busulfan affects the expression of SERPINC1 protein |
CTD |
PMID:15580502 |
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NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1 |
serpin family E member 1 |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:22286157 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Slc40a1 |
solute carrier family 40 member 1 |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of SLC40A1 protein Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein] |
CTD |
PMID:32416107 |
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NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions decreases expression |
ISO |
3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC7A11 mRNA]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein] Busulfan results in decreased expression of SLC7A11 mRNA; Busulfan results in decreased expression of SLC7A11 protein |
CTD |
PMID:38220133 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Smc1a |
structural maintenance of chromosomes 1A |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein |
CTD |
PMID:20933509 |
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NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056
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G |
Smc3 |
structural maintenance of chromosomes 3 |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein |
CTD |
PMID:20933509 |
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NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SQSTM1 protein] |
CTD |
PMID:38220133 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Stat1 |
signal transducer and activator of transcription 1 |
affects expression |
ISO |
Busulfan affects the expression of STAT1 mRNA |
CTD |
PMID:35641671 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat2 |
signal transducer and activator of transcription 2 |
decreases expression |
ISO |
Busulfan results in decreased expression of STAT2 mRNA |
CTD |
PMID:35641671 |
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NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
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G |
Stra8 |
stimulated by retinoic acid 8 |
decreases expression |
ISO |
Busulfan results in decreased expression of STRA8 mRNA |
CTD |
PMID:15388331 |
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NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
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G |
Tf |
transferrin |
multiple interactions increases expression |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA] Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein |
CTD |
PMID:12966370 PMID:22286157 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tfpi |
tissue factor pathway inhibitor |
decreases expression |
ISO |
Busulfan results in decreased expression of TFPI mRNA |
CTD |
PMID:22286157 |
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NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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G |
Tfrc |
transferrin receptor |
decreases expression multiple interactions |
ISO |
Busulfan results in decreased expression of TFRC protein Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein] |
CTD |
PMID:32416107 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression multiple interactions |
ISO |
Busulfan results in increased expression of TGFB1 mRNA pirfenidone inhibits the reaction [Busulfan results in increased expression of TGFB1 mRNA] |
CTD |
PMID:22286157 PMID:37597760 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thbs1 |
thrombospondin 1 |
increases expression |
ISO |
Busulfan results in increased expression of THBS1 mRNA |
CTD |
PMID:22286157 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
Busulfan results in increased expression of TIMP1 mRNA |
CTD |
PMID:37597760 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
Busulfan results in increased expression of TNF mRNA |
CTD |
PMID:22286157 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Busulfan affects the phosphorylation of and affects the activity of TP53 protein Busulfan results in increased expression of TP53 mRNA |
CTD |
PMID:16882877 PMID:35641671 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txnrd1 |
thioredoxin reductase 1 |
decreases activity |
EXP |
Busulfan results in decreased activity of TXNRD1 protein |
CTD |
PMID:16085187 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Xbp1 |
X-box binding protein 1 |
affects expression |
ISO |
Busulfan affects the expression of XBP1 mRNA |
CTD |
PMID:35641671 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein |
CTD |
PMID:20933509 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Zbtb16 |
zinc finger and BTB domain containing 16 |
increases expression |
ISO |
Busulfan results in increased expression of ZBTB16 mRNA |
CTD |
PMID:26524245 |
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NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
Diflubenzuron results in increased expression of CYP1A1 protein |
CTD |
PMID:8812189 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects binding |
ISO |
Diflubenzuron binds to CYP1A2 protein |
CTD |
PMID:32278787 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects binding |
ISO |
Diflubenzuron binds to CYP3A4 protein |
CTD |
PMID:32278787 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Diflubenzuron results in increased expression of CYP3A23-3A1 protein |
CTD |
PMID:8812189 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
Diflubenzuron results in increased activity of NR1I2 protein |
CTD |
PMID:16565514 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
increases metabolic processing multiple interactions |
ISO |
CYP2A13 protein results in increased metabolism of Hempa CYP2A13 gene polymorphism inhibits the reaction [CYP2A13 protein results in increased metabolism of Hempa] |
CTD |
PMID:18669584 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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