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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Meclizine
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Accession:CHEBI:6709 term browser browse the term
Definition:A diarylmethane that has formula C25H27ClN2.
Synonyms:related_synonym: Formula=C25H27ClN2;   InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3;   InChIKey=OCJYIGYOJCODJL-UHFFFAOYSA-N;   Meclozine;   SMILES=Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1;   meclizine HCl;   meclizine hydrochloride;   meclozine dihydrochloride
 xref: CAS:569-65-3;   Drug_Central:1649;   HMDB:HMDB0014875;   KEGG:C07116;   KEGG:D08163;   LINCS:LSM-1607
 xref_mesh: MESH:D008468


show annotations for term's descendants           Sort by:
Meclizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of ABCC2 mRNA CTD PMID:15272053 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO Meclizine results in increased expression of ABCC3 mRNA
Meclizine promotes the reaction [Ethanol results in increased expression of ABCC3 mRNA]		 CTD PMID:34217791 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Clu clusterin affects expression ISO Meclizine affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA
Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]		 CTD PMID:15272053 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA]
[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA		 CTD PMID:15272053 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression		 ISO [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone; [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Testosterone
Meclizine results in increased expression of CYP3A4 mRNA		 CTD PMID:26239802 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Meclizine inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Meclizine inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] CTD PMID:26239802 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Meclizine affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Meclizine affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions ISO [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA CTD PMID:15272053 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Meclizine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Meclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein]
Meclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein]		 CTD PMID:15272053 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 ISO
EXP		 Meclizine binds to and results in decreased activity of NR1I3 protein; Meclizine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA]; Meclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein]
[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of ABCC2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA; Meclizine binds to and results in increased activity of NR1I3 protein; Meclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Meclizine results in increased activity of NR1I3 protein alternative form
Meclizine results in increased activity of NR1I3 protein alternative form; Meclizine results in increased activity of NR1I3 protein mutant form		 CTD PMID:15272053 PMID:21778469 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Meclizine affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression
multiple interactions		 ISO Meclizine results in increased expression of SLCO2B1 mRNA
Meclizine promotes the reaction [Ethanol results in increased expression of SLCO2B1 mRNA]		 CTD PMID:34217791 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Meclizine affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA CTD PMID:15272053 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      group 19863
        polyatomic entity 19862
          molecule 19752
            cyclic compound 19523
              organic cyclic compound 19526
                organic aromatic compound 19390
                  diarylmethane 9440
                    Meclizine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      p-block molecular entity 19826
                        carbon group molecular entity 19766
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  diarylmethane 9440
                                    Meclizine 16
paths to the root