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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-matairesinol
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Accession:CHEBI:6698 term browser browse the term
Definition:A lignan that is gamma-butyrolactone in which the 3 and 4 positions are substituted by 4-hydroxy-3-methoxybenzyl groups (the 3R,4R-diastereomer).
Synonyms:exact_synonym: (3R,4R)-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
 related_synonym: 3R,4R-Bis((4-hydroxy-3-methoxyphenyl)methyl)dihydro-2(3H)-furanone;   Artigenin congener;   Formula=C20H22O6;   InChI=1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1;   InChIKey=MATGKVZWFZHCLI-LSDHHAIUSA-N;   SMILES=COC1=CC(C[C@H]2COC(=O)[C@@H]2CC2=CC=C(O)C(OC)=C2)=CC=C1O
 alt_id: CHEBI:43819;   CHEBI:65005
 xref: CAS:580-72-3;   Chemspider:106491;   DrugBank:DB04200;   KEGG:C10682;   KNApSAcK:C00000606
 xref_mesh: MESH:C068935
 xref: MetaCyc:CPD-8912;   PDBeChem:MAX;   PMID:15653677;   PMID:19935713;   PMID:20734328;   PMID:21315909;   PMID:21522091;   PMID:21597179;   PMID:21736835;   PMID:22037685;   PMID:22113872;   PMID:22396124;   PMID:22483751;   PMID:22646817;   Reaxys:93883;   Wikipedia:Matairesinol


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(-)-matairesinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [matairesinol affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [matairesinol affects the activity of ABCC1 protein] which results in increased abundance of fluorexon CTD PMID:18204840 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO matairesinol results in decreased activity of ACP5 protein CTD PMID:24444335 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Adipor1 adiponectin receptor 1 multiple interactions ISO matairesinol binds to and results in increased activity of ADIPOR1 protein CTD PMID:23691032 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO matairesinol results in increased expression of BAX mRNA CTD PMID:25922263 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [matairesinol co-treated with TNFSF10 protein modified form] results in increased cleavage of BID CTD PMID:19935713 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [matairesinol co-treated with TNFSF10 protein modified form] results in increased activity of CASP3 protein CTD PMID:19935713 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO matairesinol results in increased expression of CASP9 mRNA CTD PMID:25922263 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:21048310 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO matairesinol results in decreased expression of CTNNB1 protein CTD PMID:20510325 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO CYP17A1 gene SNP affects the susceptibility to [Phytoestrogens results in increased abundance of matairesinol] CTD PMID:16702327 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO matairesinol binds to ESR1 protein CTD PMID:35631411 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ifng interferon gamma multiple interactions ISO matairesinol inhibits the reaction [Antigens, Dermatophagoides results in decreased expression of IFNG mRNA] CTD PMID:27085937 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO matairesinol inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL4 mRNA] CTD PMID:27085937 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO matairesinol inhibits the reaction [IL6 results in increased expression of STAT3 protein] CTD PMID:25100250 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21048310 PMID:28512713 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21048310 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:21048310 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO matairesinol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:24444335 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO matairesinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; matairesinol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21048310 PMID:28512713 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases phosphorylation ISO matairesinol results in decreased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO matairesinol results in increased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases phosphorylation ISO matairesinol results in increased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21048310 PMID:28512713 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of RELA protein] CTD PMID:28512713 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO matairesinol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of SRC protein] CTD PMID:28512713 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO matairesinol inhibits the reaction [IL6 results in increased expression of STAT3 protein] CTD PMID:25100250 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO matairesinol results in decreased secretion of TNF protein CTD PMID:29740324 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [matairesinol co-treated with TNFSF10 protein modified form] results in increased activity of CASP3 protein; [matairesinol co-treated with TNFSF10 protein modified form] results in increased cleavage of BID CTD PMID:19935713 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO matairesinol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:24444335 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        anti-asthmatic agent 9312
          (-)-matairesinol 30
            matairesinoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  ester 17455
                                    carboxylic ester 16741
                                      lactone 13297
                                        gamma-lactone 6854
                                          (-)-matairesinol 30
                                            matairesinoside 0
paths to the root