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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:o-toluidine
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Accession:CHEBI:66892 term browser browse the term
Definition:An aminotoluene in which the amino substituent is ortho to the methyl group.
Synonyms:exact_synonym: 2-methylaniline
 related_synonym: 1-Amino-2-methylbenzene;   1-Methyl-2-aminobenzene;   2-Aminotoluene;   2-Methylbenzamine;   2-Methylbenzenamine;   2-Toluidine;   Formula=C7H9N;   InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3;   InChIKey=RNVCVTLRINQCPJ-UHFFFAOYSA-N;   SMILES=Cc1ccccc1N;   o-Aminotoluene;   o-Methylaniline;   o-Methylbenzenamine;   o-Tolylamine
 xref: CAS:95-53-4;   HMDB:HMDB0041965;   KEGG:C14403
 xref_mesh: MESH:C023622
 xref: PMID:21117897;   PMID:21320752;   PMID:21701861;   PMID:22004833;   PMID:22574454;   PMID:22708702;   PMID:22799188;   Reaxys:741981



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o-toluidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO 2-toluidine results in increased expression of CYP2C29 mRNA CTD PMID:36870411 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO 2-toluidine results in increased expression of CYP3A4 mRNA; 2-toluidine results in increased expression of CYP3A4 protein CTD PMID:36870411 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-toluidine results in increased expression of H2AX protein CTD PMID:35279910 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine CTD PMID:20199096 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        aetiopathogenetic role 19217
          carcinogenic agent 18525
            o-toluidine 4
              5-nitro-o-toluidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          anilines 14416
                                            substituted aniline 14046
                                              aminotoluene 597
                                                o-toluidine 4
                                                  5-nitro-o-toluidine 0
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