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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:o-toluidine
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Accession:CHEBI:66892 term browser browse the term
Definition:An aminotoluene in which the amino substituent is ortho to the methyl group.
Synonyms:related_synonym: 1-Amino-2-methylbenzene;   1-Methyl-2-aminobenzene;   2-Aminotoluene;   2-Methylbenzamine;   2-Methylbenzenamine;   2-Toluidine;   2-methylaniline;   o-Aminotoluene;   o-Methylaniline;   o-Methylbenzenamine;   o-Tolylamine
 xref: CAS:95-53-4;   HMDB:HMDB0041965
 xref_mesh: MESH:C023622
 xref: Reaxys:741981;   kegg.compound:C14403;   pubmed:21117897;   pubmed:21320752;   pubmed:21701861;   pubmed:22004833;   pubmed:22574454;   pubmed:22708702;   pubmed:22799188
 chemrof_formula: C7H9N
 chemrof_smiles: Cc1ccccc1N
 chemrof_inchi: InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3
 chemrof_inchikey: RNVCVTLRINQCPJ-UHFFFAOYSA-N


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o-toluidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO 2-toluidine results in increased expression of CYP2C29 mRNA CTD PMID:36870411 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO 2-toluidine results in increased expression of CYP3A4 mRNA; 2-toluidine results in increased expression of CYP3A4 protein CTD PMID:36870411 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-toluidine results in increased expression of H2AX protein CTD PMID:35279910 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine CTD PMID:20199096 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        aetiopathogenetic role 19572
          carcinogenic agent 18900
            o-toluidine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                carbocyclic compound 18739
                                  benzenoid aromatic compound 17899
                                    benzenes 17656
                                      anilines 6023
                                        substituted aniline 5996
                                          aminotoluene 608
                                            o-toluidine 4
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