C4-dicarboxylic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	C4-dicarboxylic acid	go back to main search page
Accession:	CHEBI:66873	browse the term
Definition:	Any dicarboxylic acid that contains four carbon atoms.
Synonyms:	related_synonym:	C4-dicarboxylic acids
	cyclic_relationship:	is_conjugate_acid_of CHEBI:61336

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Rat (1361) Mouse (1360) Human (1451) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (24) Green Monkey (0) Naked Mole-rat (0) All
Genes (1361)

Ac-Asp-Glu

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

folate hydrolase 1

affects binding
multiple interactions

isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]

NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379

artesunate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

apoptosis inducing factor, mitochondria associated 1

affects localization

artesunate affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

androgen receptor

multiple interactions

artesunate binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

autophagy related 12

increases expression

Artesunate results in increased expression of ATG12 mRNA

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 3

increases expression

Artesunate results in increased expression of ATG3 mRNA

NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224

G

autophagy related 5

increases expression

Artesunate results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein

PMID:24704559 PMID:29031619 PMID:33002460

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein

PMID:24704559 PMID:29031619 PMID:33002460

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone marrow stromal cell antigen 1

increases response to substance

BST1 mRNA results in increased susceptibility to artesunate

NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180

G

caspase 3

increases activity
increases cleavage
multiple interactions

artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]

PMID:19513562 PMID:24704559 PMID:33002460

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

affects expression

artesunate affects the expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression
decreases response to substance

artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate

PMID:19513562 PMID:20144594

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

Artesunate results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

Artesunate results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

chaperonin containing TCP1 subunit 2

decreases response to substance

CCT2 mRNA results in decreased susceptibility to artesunate

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

cyclin dependent kinase 2

decreases expression

Artesunate results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression

Artesunate results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

checkpoint kinase 1

multiple interactions
increases phosphorylation

APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

multiple interactions
increases phosphorylation

APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein]

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

CAP-GLY domain containing linker protein family, member 4

increases response to substance

CLIP4 mRNA results in increased susceptibility to artesunate

NCBI chr 6:23,616,280...23,697,625
NCBI chr 6:23,718,580...23,729,231
NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874

G

coenzyme Q8A

decreases response to substance

COQ8A mRNA results in decreased susceptibility to artesunate

NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431

G

catenin beta 1

multiple interactions

artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

dopamine beta-hydroxylase

increases response to substance

DBH mRNA results in increased susceptibility to artesunate

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

desmin

multiple interactions
decreases expression

Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

estrogen receptor 1

multiple interactions

artesunate binds to and results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

Fas cell surface death receptor

increases expression

artesunate results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

filamin A

increases response to substance

FLNA mRNA results in increased susceptibility to artesunate

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

fibronectin 1

multiple interactions
decreases expression

Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

ferritin heavy chain 1

decreases expression
multiple interactions

Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

frizzled class receptor 7

increases response to substance

FZD7 mRNA results in increased susceptibility to artesunate

NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781

G

glutamate-cysteine ligase, catalytic subunit

affects response to substance
decreases response to substance

GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases response to substance

GCLM mRNA results in decreased susceptibility to artesunate

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione peroxidase 4

decreases activity
multiple interactions

Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione S-transferase mu 4

affects response to substance

GSTM4 mRNA affects the susceptibility to artesunate

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase pi 1

decreases expression

artesunate results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 2

affects response to substance

GSTT2 mRNA affects the susceptibility to artesunate

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

glutathione S-transferase zeta 1

affects response to substance

GSTZ1 mRNA affects the susceptibility to artesunate

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

H2A.X variant histone

multiple interactions
increases phosphorylation

APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

interleukin 1 beta

multiple interactions

Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein]

PMID:27474069 PMID:30031708

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein]

PMID:27474069 PMID:30031708

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 1

increases response to substance

ITGB1 mRNA results in increased susceptibility to artesunate

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microsomal glutathione S-transferase 3

affects response to substance

MGST3 mRNA affects the susceptibility to artesunate

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

marker of proliferation Ki-67

multiple interactions

artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 9

multiple interactions
decreases expression

artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]

PMID:29031619 PMID:30551460

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

decreases response to substance

MTHFD2 mRNA results in decreased susceptibility to artesunate

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

multiple interactions

artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

nascent polypeptide associated complex subunit alpha

decreases response to substance

NACA mRNA results in decreased susceptibility to artesunate

NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992

G

NCK-associated protein 1

increases response to substance

NCKAP1 mRNA results in increased susceptibility to artesunate

NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217

G

nuclear receptor coactivator 4

multiple interactions
decreases expression

Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

NFE2 like bZIP transcription factor 2

affects localization

artesunate affects the localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions

artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]

PMID:24704559 PMID:33002460

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

progesterone receptor

multiple interactions

artesunate binds to and results in increased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]

PMID:27474069 PMID:30031708

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

replication protein A2

increases phosphorylation

Artesunate results in increased phosphorylation of RPA2 protein

NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350

G

ribosomal protein L41

decreases response to substance

RPL41 mRNA results in decreased susceptibility to artesunate

NCBI chr 7:977,885...978,965

G

ribosomal protein L6

decreases response to substance

RPL6 mRNA results in decreased susceptibility to artesunate

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein L7

decreases response to substance

RPL7 mRNA results in decreased susceptibility to artesunate

NCBI chr 5:3,217,184...3,220,192

G

ribosomal protein S12

decreases response to substance

RPS12 mRNA results in decreased susceptibility to artesunate

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S15a

decreases response to substance

RPS15A mRNA results in decreased susceptibility to artesunate

NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995

G

ribosomal protein S6

decreases response to substance

RPS6 mRNA results in decreased susceptibility to artesunate

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

solute carrier family 25 member 19

decreases response to substance

SLC25A19 mRNA results in decreased susceptibility to artesunate

NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447

G

Sp1 transcription factor

decreases expression

artesunate results in decreased expression of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sequestosome 1

multiple interactions
decreases expression

Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

serine and arginine rich splicing factor 2

decreases response to substance

SRSF2 mRNA results in decreased susceptibility to artesunate

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

toll-like receptor 4

multiple interactions

artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein]

PMID:27474069 PMID:30031708

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
multiple interactions

Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein, translationally-controlled 1

affects response to substance
multiple interactions

TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]

PMID:15878303 PMID:33259807

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

Tu translation elongation factor, mitochondrial

decreases response to substance

TUFM mRNA results in decreased susceptibility to artesunate

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

unc-51 like autophagy activating kinase 1

increases phosphorylation
multiple interactions

Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

vascular endothelial growth factor A

multiple interactions

artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

YY1 transcription factor

decreases expression

artesunate results in decreased expression of YY1 protein

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

G

zinc finger and BTB domain containing 4

increases response to substance

ZBTB4 mRNA results in increased susceptibility to artesunate

NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492

aspartame

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 4

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily D member 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily D member 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

acetyl-CoA acyltransferase 1A

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-Coenzyme A acyltransferase 1B

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

acetyl-CoA carboxylase beta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

acetylcholinesterase

decreases activity

Aspartame metabolite results in decreased activity of ACHE protein

PMID:16129618 PMID:17580119 PMID:17673349

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aconitase 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA thioesterase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

adhesion G protein-coupled receptor E1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

angiotensinogen

decreases expression

Aspartame results in decreased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression

Aspartame results in decreased expression of AGTR1 mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

increases phosphorylation

Aspartame results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 15-lipoxygenase

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

apolipoprotein E

decreases expression

Aspartame results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
Aspartame results in increased expression of BAX mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA

PMID:23783067 PMID:25009784 PMID:32951320

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein
Aspartame results in decreased expression of BCL2 mRNA

PMID:25009784 PMID:32951320

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium binding protein 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA

NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 I

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA

NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268

G

calcium voltage-gated channel auxiliary subunit beta 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium voltage-gated channel auxiliary subunit gamma 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

calcium voltage-gated channel auxiliary subunit gamma 8

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA

NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089

G

calcium homeostasis modulator family member 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calreticulin 3

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

calcium activated nucleotidase 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA

NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109

G

caspase 3

multiple interactions
increases expression

[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form
Aspartame results in increased expression of CASP3 mRNA

PMID:25009784 PMID:32951320

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein
Aspartame results in decreased activity of CAT protein

PMID:25009784 PMID:32951320

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cadherin 1

decreases expression

Aspartame results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

affects localization
multiple interactions

Aspartame affects the localization of CDKN1A protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
decreases expression

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA
Aspartame results in decreased expression of CDKN1B protein

PMID:23783067 PMID:33992720

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

calcium homeostasis endoplasmic reticulum protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA

NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507

G

C-x(9)-C motif containing 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA

NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:117,798,945...117,900,462

G

cytochrome c oxidase copper chaperone COX11

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase subunit 7A1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

carnitine palmitoyltransferase 1B

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 1c

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

G

cAMP responsive element binding protein 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

colony stimulating factor 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Aspartame results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity

Aspartame results in increased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Aspartame results in increased expression of and results in increased activity of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases activity

Aspartame results in increased activity of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Aspartame results in increased expression of and results in increased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 62

increases activity

Aspartame results in increased activity of CYP3A62 protein

NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833

G

diablo, IAP-binding mitochondrial protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

DnaJ heat shock protein family (Hsp40) member C27

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA

NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:27,068,686...27,098,449

G

E2F transcription factor 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin 2

decreases expression

Aspartame results in decreased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

endothelin receptor type A

decreases expression

Aspartame results in decreased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

epoxide hydrolase 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

coagulation factor II, thrombin

decreases activity

Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor 1

increases expression

Aspartame results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

forkhead box O3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone subunit beta

decreases expression

Aspartame results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

GTP dependent ribosome recycling factor mitochondrial 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA

NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197

G

gastric inhibitory polypeptide

multiple interactions

Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]]

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

GLI family zinc finger 1

affects localization
multiple interactions

Aspartame affects the localization of GLI1 protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

decreases expression

Aspartame results in decreased expression of GLI2 protein

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

glycogen synthase kinase 3 beta

increases phosphorylation

Aspartame results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

[Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 5

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

hepatocyte growth factor

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HRas proto-oncogene, GTPase

increases expression

Aspartame results in increased expression of HRAS

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate proteoglycan 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interleukin 11

decreases expression

Aspartame results in decreased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 1 beta

increases expression

Aspartame results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 3

decreases expression

Aspartame results in decreased expression of IL3 mRNA

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 6

increases secretion

Aspartame results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inner membrane mitochondrial protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

insulin 2

increases expression
multiple interactions

Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]

PMID:1805284 PMID:23783067

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

kinase insert domain receptor

increases secretion

Aspartame results in increased secretion of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

leptin

decreases expression
multiple interactions

Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]

PMID:11890951 PMID:23783067

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone subunit beta

decreases expression

Aspartame results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipase G, endothelial type

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

LDL receptor related protein 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

LDL receptor related protein 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

LDL receptor related protein 4

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA

NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593

G

mitogen activated protein kinase 1

increases phosphorylation

Aspartame results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Aspartame results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitochondrial calcium uniporter

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA

NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110

G

MDM2 proto-oncogene

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mediator complex subunit 23

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA

NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463

G

myocyte enhancer factor 2D

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

G

mitochondrial contact site and cristae organizing system subunit 10

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA

NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485

G

mitochondrial calcium uptake 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

G

mitochondrial ribosomal protein L20

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA

NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L3

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA

NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544

G

mitochondrial ribosomal protein S12

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA

NCBI chr 1:84,025,896...84,028,896
Ensembl chr 1:84,025,899...84,028,780

G

mitochondrial ribosomal protein S24

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA

NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871

G

mitochondrial ribosomal protein S27

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA

NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577

G

mitochondrial ribosomal protein S7

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA

NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129

G

mitochondrial fission process 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA

NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Aspartame results in increased expression of MYC
Aspartame results in increased expression of MYC protein

PMID:17354619 PMID:33992720

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear receptor co-repressor 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

NADH:ubiquinone oxidoreductase subunit A12

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA

NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315

G

NADH:ubiquinone oxidoreductase subunit A5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase subunit B10

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA

NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442

G

NADH:ubiquinone oxidoreductase subunit B2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA

NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851

G

NADH:ubiquinone oxidoreductase subunit B6

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

NADH:ubiquinone oxidoreductase subunit S6

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NADH:ubiquinone oxidoreductase core subunit V1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA

NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466

G

neurofibromin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

notch receptor 1

multiple interactions
affects localization

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA
Aspartame affects the localization of NOTCH1 protein modified form
TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]

PMID:23783067 PMID:33992720

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

natriuretic peptide B

decreases expression

Aspartame results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neuropeptide Y

decreases expression

Aspartame results in decreased expression of NPY protein

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

one cut homeobox 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

pyruvate dehydrogenase E1 subunit alpha 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA

NCBI chr 2:229,872,300...229,873,848

G

pyruvate dehydrogenase E1 subunit beta

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

peroxisomal biogenesis factor 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA

NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:30,519,955...30,558,921

G

peroxisomal biogenesis factor 11 alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172

G

peroxisomal biogenesis factor 13

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA

NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262

G

peroxisomal biogenesis factor 5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA

NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431

G

peroxisomal biogenesis factor 7

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA

NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA

NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phospholipase D2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

G

plasminogen

decreases expression

Aspartame results in decreased expression of PLG mRNA

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

plexin D1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

DNA polymerase gamma, catalytic subunit

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

proopiomelanocortin

increases expression

Aspartame results in increased expression of POMC protein alternative form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POU class 5 homeobox 1

affects localization

Aspartame affects the localization of POU5F1 protein

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peroxiredoxin 5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

S100 calcium binding protein A13

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein A8

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

sirtuin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

solute carrier family 15 member 1

decreases activity

Aspartame results in decreased activity of SLC15A1 protein

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 4 member 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

G

solute carrier family 8 member A1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

SRY-box transcription factor 2

affects localization

Aspartame affects the localization of SOX2 protein

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

sterol regulatory element binding transcription factor 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

SURF1, cytochrome c oxidase assembly factor

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA

NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315

G

taste 1 receptor member 1

increases expression
multiple interactions

Aspartame results in increased expression of TAS1R1 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]

NCBI chr 5:162,533,838...162,546,408
Ensembl chr 5:162,533,841...162,545,562

G

taste 1 receptor member 2

multiple interactions
affects binding

Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein

PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720

NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345

G

taste 1 receptor member 3

affects binding
decreases expression
multiple interactions

Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
Aspartame results in decreased expression of TAS1R3 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]

PMID:17168764 PMID:17935609 PMID:33992720

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

G

transcription factor A, mitochondrial

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

thrombospondin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

tumor necrosis factor

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
multiple interactions

Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA

PMID:17354619 PMID:23783067 PMID:32951320

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily V, member 1

increases activity

Aspartame results in increased activity of TRPV1 protein

PMID:17567713 PMID:18804451

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

Tu translation elongation factor, mitochondrial

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

uncoupling protein 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

ubiquinol-cytochrome c reductase, complex III subunit XI

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA

NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750

G

vascular endothelial growth factor A

increases secretion

Aspartame results in increased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression

Aspartame results in increased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xanthine dehydrogenase

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

citraconic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BTB domain and CNC homolog 1

affects localization

citraconic acid affects the localization of BACH1 protein

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

forkhead box M1

increases expression

citraconic acid results in increased expression of FOXM1 protein

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

ferritin heavy chain 1

increases expression

citraconic acid results in increased expression of FTH1 protein

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

multiple interactions
increases expression

citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glutamate-cysteine ligase, catalytic subunit

increases expression

citraconic acid results in increased expression of GCLC protein
citraconic acid results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

citraconic acid results in increased expression of GCLM protein
citraconic acid results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione-disulfide reductase

increases expression

citraconic acid results in increased expression of GSR mRNA
citraconic acid results in increased expression of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hydroxycarboxylic acid receptor 2

multiple interactions

citraconic acid binds to and results in increased activity of HCAR2 protein

NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504

G

heme oxygenase 1

increases expression

citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

mitochondrially encoded cytochrome b

multiple interactions
increases expression

NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

increases expression
multiple interactions

citraconic acid results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]

NCBI chr MT:2,740...3,694

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

increases expression
multiple interactions

citraconic acid results in increased expression of ND5 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]

NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

multiple interactions
increases expression

NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
citraconic acid affects the localization of NFE2L2 protein

PMID:27277809 PMID:28289076

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression

citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

RNA polymerase mitochondrial

increases expression
multiple interactions

citraconic acid results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]

NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791

D-aspartic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation

D-Aspartic Acid results in increased phosphorylation of AKT1 protein

PMID:26189884 PMID:31398714

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

androgen receptor

affects expression
increases expression

D-Aspartic Acid affects the expression of AR mRNA
D-Aspartic Acid results in increased expression of AR protein

PMID:24439162 PMID:26044185

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aurora kinase B

increases expression

D-Aspartic Acid results in increased expression of AURKB protein

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

caspase 3

multiple interactions

D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CLN8, transmembrane ER and ERGIC protein

multiple interactions
affects export

CLN8 protein affects the reaction [[Ionomycin co-treated with Calcium] results in increased transport of D-Aspartic Acid]; CLN8 protein affects the reaction [[Potassium Chloride co-treated with Calcium] results in increased transport of D-Aspartic Acid]
CLN8 protein affects the export of D-Aspartic Acid

NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

D-Aspartic Acid results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
decreases expression

D-Aspartic Acid results in increased expression of CYP19A1 mRNA; D-Aspartic Acid results in increased expression of CYP19A1 protein
D-Aspartic Acid results in decreased expression of CYP19A1 protein

PMID:24439162 PMID:26044185 PMID:26189884

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

D-aspartate oxidase

affects abundance
increases metabolic processing
increases degradation

DDO protein affects the abundance of D-Aspartic Acid
DDO protein results in increased metabolism of D-Aspartic Acid
DDO protein results in increased degradation of D-Aspartic Acid

PMID:16516413 PMID:16525061 PMID:16725213 PMID:18842900 PMID:26961959 More...

NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095

G

estrogen receptor 1

increases expression
decreases expression

D-Aspartic Acid results in increased expression of ESR1 mRNA
D-Aspartic Acid results in decreased expression of ESR1 protein

PMID:24439162 PMID:26044185

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression

D-Aspartic Acid results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

D-Aspartic Acid results in increased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

increases expression

D-Aspartic Acid results in increased expression of GRIN2A mRNA

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

inositol 1,4,5-trisphosphate receptor, type 3

affects metabolic processing

ITPR3 mutant form affects the metabolism of D-Aspartic Acid

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

luteinizing hormone subunit beta

increases expression

D-Aspartic Acid results in increased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen activated protein kinase 1

increases phosphorylation

D-Aspartic Acid results in increased phosphorylation of MAPK1 protein

PMID:24439162 PMID:26189884 PMID:31398714

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

D-Aspartic Acid results in increased phosphorylation of MAPK3 protein

PMID:24439162 PMID:26189884 PMID:31398714

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions
increases cleavage

D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

proliferating cell nuclear antigen

increases expression

D-Aspartic Acid results in increased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prolyl endopeptidase

increases expression

D-Aspartic Acid results in increased expression of PREP protein

NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466

G

superoxide dismutase 1

multiple interactions

SOD1 protein affects the reaction [Glycine results in increased secretion of D-Aspartic Acid]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroid 5 alpha-reductase 1

increases expression

D-Aspartic Acid results in increased expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

steroid 5 alpha-reductase 2

increases expression

D-Aspartic Acid results in increased expression of SRD5A2 mRNA

NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112

G

serine racemase

increases abundance
multiple interactions

SRR protein results in increased abundance of D-Aspartic Acid
[SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid; Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Adenosine Triphosphate promotes the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

steroidogenic acute regulatory protein

increases expression

D-Aspartic Acid results in increased expression of STAR mRNA; D-Aspartic Acid results in increased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

diethyl fumarate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases cleavage

diethyl fumarate results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

poly (ADP-ribose) polymerase 1

increases cleavage

diethyl fumarate results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

spectrin, alpha, non-erythrocytic 1

increases cleavage

diethyl fumarate results in increased cleavage of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

diethyl malate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

affects expression

diethyl malate affects the expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, alpha, cardiac muscle 1

affects expression

diethyl malate affects the expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

actinin alpha 3

affects expression

diethyl malate affects the expression of ACTN3 mRNA

NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012

G

adenylate cyclase 1

affects expression

diethyl malate affects the expression of ADCY1 mRNA

NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

diethyl malate affects the expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

angiotensinogen

affects expression

diethyl malate affects the expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiopoietin-like 4

increases expression

diethyl malate results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

anti-silencing function 1B histone chaperone

increases expression

diethyl malate results in increased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

ATPase H+ transporting V1 subunit B2

increases expression

diethyl malate results in increased expression of ATP6V1B2 mRNA

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

BAG cochaperone 3

increases expression

diethyl malate results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCAS2, pre-mRNA processing factor

increases expression

diethyl malate results in increased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

Bcl2-like 11

increases expression

diethyl malate results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

bromodomain containing 2

increases expression

diethyl malate results in increased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

complement C3

affects expression

diethyl malate affects the expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

calcium voltage-gated channel auxiliary subunit beta 2

affects expression

diethyl malate affects the expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium voltage-gated channel auxiliary subunit beta 4

affects expression

diethyl malate affects the expression of CACNB4 mRNA

NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions
affects expression

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

caspase 3

increases expression

diethyl malate results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

carbonyl reductase 2

affects expression

diethyl malate affects the expression of CBR2 mRNA

NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001

G

C-C motif chemokine ligand 20

affects expression
increases expression

diethyl malate affects the expression of CCL20 mRNA
diethyl malate results in increased expression of CCL20 mRNA

PMID:24814887 PMID:38498338

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 7

affects expression

diethyl malate affects the expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

affects expression

diethyl malate affects the expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 2

increases expression

diethyl malate results in increased expression of CTGF mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin E2

increases expression

diethyl malate results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

diethyl malate results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

diethyl malate results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

cell death-inducing DFFA-like effector c

increases expression

diethyl malate results in increased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

CDC28 protein kinase regulatory subunit 2

increases expression

diethyl malate results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

CDC-like kinase 1

increases expression

diethyl malate results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

collagen type XI alpha 1 chain

affects expression

diethyl malate affects the expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type II alpha 1 chain

affects expression

diethyl malate affects the expression of COL2A1 mRNA

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type III alpha 1 chain

affects expression

diethyl malate affects the expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type VI alpha 1 chain

affects expression

diethyl malate affects the expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

cartilage oligomeric matrix protein

affects expression

diethyl malate affects the expression of COMP mRNA

NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845

G

cysteine and serine rich nuclear protein 1

increases expression

diethyl malate results in increased expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

C-X-C motif chemokine ligand 12

affects expression
multiple interactions

diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 3

affects expression

diethyl malate affects the expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

diethyl malate affects the expression of CYP2J9 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 4, subfamily f, polypeptide 18

increases expression

diethyl malate results in increased expression of CYP4F3 mRNA

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

death-associated protein kinase 2

affects expression

diethyl malate affects the expression of DAPK2 mRNA

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

DNA-damage inducible transcript 3

increases expression

diethyl malate results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dehydrogenase/reductase 3

affects expression

diethyl malate affects the expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DEXH-box helicase 58

affects expression

diethyl malate affects the expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

diethyl malate results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

ectodysplasin-A receptor

affects expression

diethyl malate affects the expression of EDAR mRNA

NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494

G

endothelin receptor type A

affects expression

diethyl malate affects the expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

EMG1 N1-specific pseudouridine methyltransferase

increases expression

diethyl malate results in increased expression of EMG1 mRNA

NCBI chr 4:157,509,258...157,517,540
Ensembl chr 4:157,509,277...157,517,540

G

enolase 2

increases expression

diethyl malate results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

endothelial PAS domain protein 1

affects expression

diethyl malate affects the expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor A7

affects expression

diethyl malate affects the expression of EPHA7 mRNA

NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112

G

Eph receptor B2

affects expression

diethyl malate affects the expression of EPHB2 mRNA

NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059

G

Eph receptor B6

affects expression

diethyl malate affects the expression of EPHB6 mRNA

NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230

G

family with sequence similarity 83, member D

increases expression

diethyl malate results in increased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

fibroblast growth factor 10

affects expression

diethyl malate affects the expression of FGF10 mRNA

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 18

multiple interactions
affects expression

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor receptor 2

affects expression

diethyl malate affects the expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

FOS like 1, AP-1 transcription factor subunit

increases expression

diethyl malate results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

follistatin

affects expression

diethyl malate affects the expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

frizzled class receptor 2

affects expression

diethyl malate affects the expression of FZD2 mRNA

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

frizzled class receptor 7

affects expression

diethyl malate affects the expression of FZD7 mRNA

NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781

G

glucose-6-phosphate dehydrogenase

increases expression

diethyl malate results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate-cysteine ligase, catalytic subunit

affects expression

diethyl malate affects the expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions
affects expression

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

diethyl malate results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

gamma-glutamyl transferase 6

affects expression

diethyl malate affects the expression of GGT6 mRNA

NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260

G

GLI family zinc finger 2

affects expression

diethyl malate affects the expression of GLI2 mRNA

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

G protein subunit alpha o1

affects expression

diethyl malate affects the expression of GNAO1 mRNA

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

G

G protein subunit gamma 7

affects expression

diethyl malate affects the expression of GNG7 mRNA

NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240

G

glucosamine-6-phosphate deaminase 1

increases expression

diethyl malate results in increased expression of GNPDA1 mRNA

NCBI chr18:30,165,435...30,177,462
Ensembl chr18:30,165,427...30,177,486

G

glycerol-3-phosphate acyltransferase 3

increases expression

diethyl malate results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glutathione-disulfide reductase

affects expression

diethyl malate affects the expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

multiple interactions
affects expression

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

guanylate cyclase 1 soluble subunit alpha 1

affects expression

diethyl malate affects the expression of GUCY1A1 mRNA

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

affects expression

diethyl malate affects the expression of GUCY1B1 mRNA

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

H2A clustered histone 4

increases expression

diethyl malate results in increased expression of HIST1H2AC mRNA

NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381

G

HCK proto-oncogene, Src family tyrosine kinase

affects expression

diethyl malate affects the expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

hepatocyte growth factor

affects expression

diethyl malate affects the expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

histone cluster 1 H2B family member D

increases expression

diethyl malate results in increased expression of HIST1H2BD mRNA

NCBI chr17:42,792,887...42,793,268

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

increases expression

diethyl malate results in increased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

hyaluronan-mediated motility receptor

increases expression

diethyl malate results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

diethyl malate results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein 90 alpha family class A member 1

increases expression

diethyl malate results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1A

increases expression

diethyl malate results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

diethyl malate results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

increases expression

diethyl malate results in increased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 8

increases expression

diethyl malate results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

interferon-related developmental regulator 1

increases expression

diethyl malate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1

affects expression

diethyl malate affects the expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

increases expression

diethyl malate results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 15

affects expression

diethyl malate affects the expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 18

affects expression

diethyl malate affects the expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

inositol 1,4,5-triphosphate receptor associated 1

affects expression

diethyl malate affects the expression of IRAG1 mRNA

NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176

G

interferon regulatory factor 7

affects expression

diethyl malate affects the expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

ISG15 ubiquitin-like modifier

affects expression

diethyl malate affects the expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha 11

affects expression

diethyl malate affects the expression of ITGA11 mRNA

NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407

G

integrin subunit alpha 3

affects expression

diethyl malate affects the expression of ITGA3 mRNA

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

diethyl malate results in increased expression of JMJD6 mRNA

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

potassium calcium-activated channel subfamily M regulatory beta subunit 4

affects expression

diethyl malate affects the expression of KCNMB4 mRNA

NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278

G

laminin subunit alpha 1

affects expression

diethyl malate affects the expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

laminin subunit alpha 4

affects expression

diethyl malate affects the expression of LAMA4 mRNA

NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347

G

MAF bZIP transcription factor F

increases expression

diethyl malate results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor G

increases expression

diethyl malate results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

microtubule-associated protein 1 light chain 3 beta

increases expression

diethyl malate results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

affects phosphorylation
multiple interactions

diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

affects phosphorylation
multiple interactions

diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

increases expression

diethyl malate results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 3

increases expression

diethyl malate results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myosin, light chain 4

increases expression

diethyl malate results in increased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myosin light chain 9

affects expression

diethyl malate affects the expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

N-myc downstream regulated 1

increases expression

diethyl malate results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

ornithine decarboxylase 1

affects expression

diethyl malate affects the expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

oxidative stress induced growth inhibitor 1

increases expression

diethyl malate results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

platelet derived growth factor subunit B

affects expression
multiple interactions

diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor D

affects expression

diethyl malate affects the expression of PDGFD mRNA

NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395

G

platelet factor 4

affects expression

diethyl malate affects the expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

diethyl malate results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phosphoinositide-3-kinase interacting protein 1

affects expression

diethyl malate affects the expression of PIK3IP1 mRNA

NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608

G

perilipin 2

increases expression

diethyl malate results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

plexin C1

affects expression

diethyl malate affects the expression of PLXNC1 mRNA

NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779

G

protein phosphatase 1, regulatory subunit 15A

increases expression

diethyl malate results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein kinase cGMP-dependent 1

affects expression

diethyl malate affects the expression of PRKG1 mRNA

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

prostaglandin I2 synthase

affects expression

diethyl malate affects the expression of PTGIS mRNA

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

receptor activity modifying protein 2

affects expression

diethyl malate affects the expression of RAMP2 mRNA

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829

G

regulator of G-protein signaling 3

affects expression

diethyl malate affects the expression of RGS3 mRNA

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

RNA sensor RIG-1

affects expression

diethyl malate affects the expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

RT1 class II, locus DMb

affects expression

diethyl malate affects the expression of H2-DMB1 mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

RT1 class Ib, locus M3, gene 1

affects expression

diethyl malate affects the expression of H2-M3 mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

RUNX1 partner transcriptional co-repressor 1

affects expression

diethyl malate affects the expression of RUNX1T1 mRNA

NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592

G

semaphorin 3B

affects expression

diethyl malate affects the expression of SEMA3B mRNA

NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919

G

semaphorin 4G

affects expression

diethyl malate affects the expression of SEMA4G mRNA

NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341

G

semaphorin 5A

affects expression

diethyl malate affects the expression of SEMA5A mRNA

NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084

G

SERTA domain containing 1

increases expression

diethyl malate results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

solute carrier family 7 member 11

increases expression

diethyl malate results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

sulfiredoxin 1

increases expression

diethyl malate results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

signal transducer and activator of transcription 1

affects expression

diethyl malate affects the expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

transforming, acidic coiled-coil containing protein 3

increases expression

diethyl malate results in increased expression of TACC3 mRNA

NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219

G

testin LIM domain protein

increases expression

diethyl malate results in increased expression of TES mRNA

NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829

G

transforming growth factor, beta 2

affects expression
multiple interactions

diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

thrombospondin 1

affects expression

diethyl malate affects the expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

affects expression

diethyl malate affects the expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

tenascin C

affects expression

diethyl malate affects the expression of TNC mRNA

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

TNF receptor superfamily member 11B

affects expression

diethyl malate affects the expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

troponin T1, slow skeletal type

affects expression

diethyl malate affects the expression of TNNT1 mRNA

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

G

tribbles pseudokinase 3

increases expression

diethyl malate results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

thymic stromal lymphopoietin

affects expression

diethyl malate affects the expression of TSLP mRNA

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

vascular endothelial growth factor A

increases expression

diethyl malate results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

zinc finger and BTB domain containing 21

increases expression

diethyl malate results in increased expression of ZBTB21 mRNA

NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996

G

zinc finger protein 110

increases expression

diethyl malate results in increased expression of ZNF274 mRNA

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

G

zinc finger protein 367

increases expression

diethyl malate results in increased expression of ZNF367 mRNA

NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287

diethyl maleate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

diethyl maleate results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

diethyl maleate results in increased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

acetyl-CoA carboxylase alpha

decreases expression

diethyl maleate results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA oxidase 1

multiple interactions

diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

aminoacylase 3

decreases expression

diethyl maleate results in decreased expression of ACY3 mRNA

NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175

G

adrenomedullin

increases expression

diethyl maleate results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A3 receptor

decreases expression

diethyl maleate results in decreased expression of ADORA3 mRNA

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

apoptosis enhancing nuclease

increases expression

diethyl maleate results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

alpha-fetoprotein

increases expression

diethyl maleate results in increased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

adenosylhomocysteinase-like 1

increases expression

diethyl maleate results in increased expression of AHCYL1 mRNA

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

aldo-keto reductase family 1 member A1

increases expression

diethyl maleate results in increased expression of AKR1A1 protein

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1 member B10

increases expression

diethyl maleate results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

increases expression

diethyl maleate results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldehyde dehydrogenase 1 family, member A1

affects reduction

diethyl maleate affects the reduction of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

diethyl maleate results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 2 family member

decreases reduction
increases expression
decreases expression

diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein

PMID:19843705 PMID:21161181

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldolase, fructose-bisphosphate A

affects expression

diethyl maleate affects the expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

decreases expression

diethyl maleate results in decreased expression of ALDOB protein

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

adhesion molecule with Ig like domain 2

decreases expression

diethyl maleate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiopoietin-like 2

decreases expression

diethyl maleate results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin-like 4

increases expression

diethyl maleate results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat domain 46

decreases expression

diethyl maleate results in decreased expression of ANKRD46 mRNA

NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132

G

anillin, actin binding protein

increases expression

diethyl maleate results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

annexin A1

affects expression

diethyl maleate affects the expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A3

decreases expression

diethyl maleate results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

adaptor related protein complex 3 subunit mu 2

decreases expression

diethyl maleate results in decreased expression of AP3M2 mRNA

NCBI chr16:69,217,526...69,237,372
Ensembl chr16:69,217,633...69,235,431

G

apoptotic peptidase activating factor 1

increases expression

diethyl maleate results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor like protein 1

decreases expression

diethyl maleate results in decreased expression of APLP1 mRNA

NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155

G

apolipoprotein L9a

decreases expression

diethyl maleate results in decreased expression of APOL9A mRNA

NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649

G

Rho GTPase activating protein 9

increases expression

diethyl maleate results in increased expression of ARHGAP9 mRNA

NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524

G

arrestin domain containing 2

decreases expression

diethyl maleate results in decreased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

arrestin domain containing 4

decreases expression

diethyl maleate results in decreased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

anti-silencing function 1B histone chaperone

increases expression

diethyl maleate results in increased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

ASXL transcriptional regulator 1

decreases expression

diethyl maleate results in decreased expression of ASXL1 mRNA

NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538

G

ATM serine/threonine kinase

increases expression

diethyl maleate results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATP synthase F1 subunit beta

increases expression

diethyl maleate results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

aurora kinase A

increases expression
decreases expression

diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA

PMID:21161181 PMID:25270620

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

Bcl-2 binding component 3

increases expression

diethyl maleate results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA

PMID:22564015 PMID:33545341

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

decreases expression

diethyl maleate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

BCL3, transcription coactivator

decreases expression

diethyl maleate results in decreased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6B, transcription repressor

decreases expression

diethyl maleate results in decreased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

basic helix-loop-helix family, member e41

decreases expression

diethyl maleate results in decreased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

betaine-homocysteine S-methyltransferase

decreases expression

diethyl maleate results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

baculoviral IAP repeat-containing 3

multiple interactions

diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

biliverdin reductase B

increases expression

diethyl maleate results in increased expression of BLVRB mRNA

PMID:25270620 PMID:34626751

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

Bcl2 modifying factor

decreases expression

diethyl maleate results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BRCA1 interacting DNA helicase 1

increases expression

diethyl maleate results in increased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

BTB domain containing 2

decreases expression

diethyl maleate results in decreased expression of BTBD2 mRNA

NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344

G

BTG anti-proliferation factor 2

increases expression
decreases expression
multiple interactions

diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]

PMID:22003191 PMID:25270620 PMID:34626751

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C6

decreases expression

diethyl maleate results in decreased expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

caspase 2

increases expression

diethyl maleate results in increased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases expression
increases cleavage

diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein

PMID:11875189 PMID:21105742

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression

diethyl maleate results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

diethyl maleate results in decreased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

increases expression

diethyl maleate results in increased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

carbonyl reductase 3

increases expression
multiple interactions

diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]

PMID:20806931 PMID:25270620

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

chromobox 4

increases expression

diethyl maleate results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 50

decreases expression

diethyl maleate results in decreased expression of CCDC50 mRNA

NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150

G

cyclin A1

decreases expression

diethyl maleate results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

increases expression

diethyl maleate results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression
increases expression

diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA

PMID:11875189 PMID:21161181 PMID:25270620

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

increases expression

diethyl maleate results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin K

decreases expression

diethyl maleate results in decreased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

Cd80 molecule

multiple interactions
increases expression

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

multiple interactions
increases expression

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]

PMID:24136171 PMID:31958493

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 25A

increases expression

diethyl maleate results in increased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle associated 2

increases expression

diethyl maleate results in increased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 3

increases expression

diethyl maleate results in increased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 8

increases expression

diethyl maleate results in increased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 11

decreases expression

diethyl maleate results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]

PMID:11875189 PMID:27982581

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CDP-diacylglycerol synthase 2

increases expression

diethyl maleate results in increased expression of CDS2 mRNA

NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541

G

carboxylesterase 1D

decreases expression
increases reduction

diethyl maleate results in decreased expression of CES1D protein
diethyl maleate results in increased reduction of CES1D protein

PMID:19843705 PMID:21161181

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

CASP8 and FADD-like apoptosis regulator

decreases expression

diethyl maleate results in decreased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

cholinergic receptor nicotinic alpha 4 subunit

increases expression

diethyl maleate results in increased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cell death-inducing DFFA-like effector c

decreases expression

diethyl maleate results in decreased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

diethyl maleate results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

decreases expression

diethyl maleate results in decreased expression of CITED4 mRNA

NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135

G

creatine kinase B

decreases reduction

diethyl maleate results in decreased reduction of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CDC28 protein kinase regulatory subunit 2

increases expression

diethyl maleate results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

CDC-like kinase 1

increases expression

diethyl maleate results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

cytidine/uridine monophosphate kinase 2

decreases expression

diethyl maleate results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

contactin 1

increases expression

diethyl maleate results in increased expression of CNTN1 mRNA

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

collagen type I alpha 1 chain

decreases expression

diethyl maleate results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression

diethyl maleate results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 3

increases expression

diethyl maleate results in increased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

G

catechol-O-methyltransferase

decreases expression

diethyl maleate results in decreased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

decreases expression

diethyl maleate results in decreased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cleavage and polyadenylation specific factor 4-like

increases expression

diethyl maleate results in increased expression of CPSF4L mRNA

NCBI chr10:98,741,816...98,756,069
Ensembl chr10:98,743,649...98,751,590

G

crystallin, mu

decreases expression

diethyl maleate results in decreased expression of CRYM mRNA

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

cysteine and glycine-rich protein 1

decreases expression

diethyl maleate results in decreased expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

cysteine and glycine rich protein 3

decreases reduction

diethyl maleate results in decreased reduction of CSRP3 protein

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

C-X-C motif chemokine ligand 10

decreases expression

diethyl maleate results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

diethyl maleate results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

decreases expression

diethyl maleate results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

cytochrome b5 type A

increases expression

diethyl maleate results in increased expression of CYB5A mRNA

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

diethyl maleate results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

D-box binding PAR bZIP transcription factor

decreases expression

diethyl maleate results in decreased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DNA-damage inducible transcript 3

increases expression

diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein

PMID:33545341 PMID:35724838

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

diethyl maleate results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA-damage-inducible transcript 4-like

increases expression

diethyl maleate results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DEXD/H-box helicase 60

decreases expression

diethyl maleate results in decreased expression of DDX60 mRNA

NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526

G

DEXH-box helicase 58

decreases expression

diethyl maleate results in decreased expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

diethyl maleate results in increased expression of DNAJB1 mRNA

PMID:33545341 PMID:34480604

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

diethyl maleate results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

dynamin binding protein

decreases expression

diethyl maleate results in decreased expression of DNMBP mRNA

NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604

G

dihydropyrimidinase-like 2

decreases reduction

diethyl maleate results in decreased reduction of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

deltex E3 ubiquitin ligase 3L

decreases expression

diethyl maleate results in decreased expression of DTX3L mRNA

NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538

G

dihydrouridine synthase 3-like

decreases expression

diethyl maleate results in decreased expression of DUS3L mRNA

NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655

G

dual specificity phosphatase 6

increases expression

diethyl maleate results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

eukaryotic elongation factor-2 kinase

decreases expression

diethyl maleate results in decreased expression of EEF2K mRNA

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

egl-9 family hypoxia-inducible factor 3

increases expression

diethyl maleate results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

diethyl maleate results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

diethyl maleate results in increased expression of ENTPD5 mRNA

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

ES cell expressed Ras

decreases expression

diethyl maleate results in decreased expression of ERAS mRNA

NCBI chr X:14,573,987...14,578,455
Ensembl chr X:14,573,987...14,578,374

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

increases expression

diethyl maleate results in increased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

exonuclease 1

increases expression

diethyl maleate results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

fatty acid binding protein 1

increases expression

diethyl maleate results in increased expression of FABP1 protein

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 7

decreases expression

diethyl maleate results in decreased expression of FABP7 mRNA

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

fumarylacetoacetate hydrolase

affects expression

diethyl maleate affects the expression of FAH mRNA

NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505

G

family with sequence similarity 83, member D

increases expression

diethyl maleate results in increased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

fatty acid synthase

decreases expression

diethyl maleate results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillin 1

decreases expression

diethyl maleate results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fructose-bisphosphatase 1

decreases expression

diethyl maleate results in decreased expression of FBP1 protein

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

fibroblast growth factor 17

decreases expression

diethyl maleate results in decreased expression of FGF17 mRNA

NCBI chr15:45,711,498...45,717,622
Ensembl chr15:45,711,998...45,717,063

G

fibrinogen gamma chain

decreases expression

diethyl maleate results in decreased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

diethyl maleate results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

fibronectin type III domain containing 3B

decreases expression

diethyl maleate results in decreased expression of FNDC3B mRNA

NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

diethyl maleate results in increased expression of FOS mRNA

PMID:10915739 PMID:33545341

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

increases expression

diethyl maleate results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follistatin like 3

increases expression

diethyl maleate results in increased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

diethyl maleate results in decreased expression of G6PC1 mRNA

PMID:25270620 PMID:30261343

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases activity
increases expression

diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA

PMID:3099627 PMID:30261343 PMID:33545341

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GRB2-associated binding protein 1

decreases expression

diethyl maleate results in decreased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

growth arrest and DNA-damage-inducible, alpha

increases expression

diethyl maleate results in increased expression of GADD45A mRNA

PMID:33545341 PMID:34480604

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

increases expression

diethyl maleate results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

glyceraldehyde-3-phosphate dehydrogenase

increases reduction

diethyl maleate results in increased reduction of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glucosylceramidase beta 2

decreases expression

diethyl maleate results in decreased expression of GBA2 mRNA

NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072

G

guanylate binding protein 2

decreases expression

diethyl maleate results in decreased expression of GBP2 mRNA

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

G

glutamate-cysteine ligase, catalytic subunit

increases activity
increases expression

diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein

PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More...

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein

PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 More...

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

diethyl maleate results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

diethyl maleate results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 9

increases expression

diethyl maleate results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

increases expression

diethyl maleate results in increased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

G

glutamate-ammonia ligase

decreases expression

diethyl maleate results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutamic-oxaloacetic transaminase 2

decreases expression

diethyl maleate results in decreased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

decreases expression

diethyl maleate results in decreased expression of GPIHBP1 mRNA

NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702

G

glutathione peroxidase 2

affects expression

diethyl maleate affects the expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

diethyl maleate results in decreased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

gelsolin

decreases reduction

diethyl maleate results in decreased reduction of GSN protein

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

increases expression

diethyl maleate results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

diethyl maleate results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

affects expression

diethyl maleate affects the expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

increases expression

diethyl maleate results in increased expression of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 5

increases expression

diethyl maleate results in increased expression of GSTA5 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase kappa 1

multiple interactions

[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

decreases expression

diethyl maleate results in decreased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase omega 1

increases expression

diethyl maleate results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

increases expression

diethyl maleate results in increased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases expression

diethyl maleate results in increased expression of GSTT1 protein

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

G-2 and S-phase expressed 1

increases expression

diethyl maleate results in increased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

H2A.Z variant histone 2

increases expression

diethyl maleate results in increased expression of H2AZ2 mRNA

NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144
Ensembl chr 4:81,293,299...81,312,144
Ensembl chr16:81,293,299...81,312,144

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

increases expression

diethyl maleate results in increased expression of H6PD mRNA

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hepcidin antimicrobial peptide

increases expression

diethyl maleate results in increased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

DNA helicase B

decreases expression

diethyl maleate results in decreased expression of HELB mRNA

NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585

G

hes family bHLH transcription factor 6

decreases expression

diethyl maleate results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

Holliday junction recognition protein

increases expression

diethyl maleate results in increased expression of HJURP mRNA

NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728

G

heme oxygenase 1

increases expression

diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein

PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein H1

decreases reduction

diethyl maleate results in decreased reduction of HNRNPH1 protein

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

hydroxysteroid (17-beta) dehydrogenase 10

increases expression

diethyl maleate results in increased expression of HSD17B10 mRNA

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

hydroxysteroid (17-beta) dehydrogenase 2

decreases expression

diethyl maleate results in decreased expression of HSD17B2 mRNA

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

heat shock protein family A (Hsp70) member 1B

increases expression

diethyl maleate results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

increases expression

diethyl maleate results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 5

decreases reduction

diethyl maleate results in decreased reduction of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

diethyl maleate results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

increases reduction

diethyl maleate results in increased reduction of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

HIV-1 Tat interactive protein 2

increases expression

diethyl maleate results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

hyccin PI4KA lipid kinase complex subunit 2

decreases expression

diethyl maleate results in decreased expression of HYCC2 mRNA

NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

diethyl maleate results in decreased expression of ICAM1 mRNA
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]

PMID:25270620 PMID:35724838

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 3

decreases expression

diethyl maleate results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

inhibitor of DNA binding 4

decreases expression

diethyl maleate results in decreased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

diethyl maleate results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon-related developmental regulator 1

increases expression

diethyl maleate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

decreases expression

diethyl maleate results in decreased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

increases expression

diethyl maleate results in increased expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

increases secretion

diethyl maleate results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

increases expression

diethyl maleate results in increased expression of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

affects expression

diethyl maleate affects the expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 4

multiple interactions

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

inhibin subunit beta B

decreases expression

diethyl maleate results in decreased expression of INHBB mRNA

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

indolethylamine N-methyltransferase

decreases expression

diethyl maleate results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin 2

multiple interactions

diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

integrator complex subunit 7

decreases expression

diethyl maleate results in decreased expression of INTS7 mRNA

NCBI chr13:103,155,123...103,207,953
Ensembl chr13:103,155,090...103,208,592

G

interferon regulatory factor 7

decreases expression

diethyl maleate results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 9

decreases expression

diethyl maleate results in decreased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

immunity-related GTPase M

decreases expression

diethyl maleate results in decreased expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

integrin subunit alpha L

decreases expression

diethyl maleate results in decreased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

diethyl maleate results in decreased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

inter-alpha-trypsin inhibitor heavy chain 4

decreases expression

diethyl maleate results in decreased expression of ITIH4 mRNA

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

junctional adhesion molecule 3

decreases expression

diethyl maleate results in decreased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
increases phosphorylation

pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]
diethyl maleate results in increased expression of JUN mRNA

PMID:10915739 PMID:12774022 PMID:30261343

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily E regulatory subunit 3

decreases expression

diethyl maleate results in decreased expression of KCNE3 mRNA

NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020

G

Kelch-like ECH-associated protein 1

increases expression

diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein

PMID:27358234 PMID:33545341 PMID:34480604

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KH RNA binding domain containing, signal transduction associated 3

increases expression

diethyl maleate results in increased expression of KHDRBS3 mRNA

NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460

G

kinesin family member C1

increases expression

diethyl maleate results in increased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

G

KLF transcription factor 10

decreases expression

diethyl maleate results in decreased expression of KLF10 mRNA

PMID:21161181 PMID:25270620

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

keratin 75

increases reduction

diethyl maleate results in increased reduction of KRT75 protein

NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345

G

laminin subunit alpha 1

decreases expression

diethyl maleate results in decreased expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

LanC like glutathione S-transferase 2

decreases expression

diethyl maleate results in decreased expression of LANCL2 mRNA

NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800

G

low density lipoprotein receptor

decreases expression

diethyl maleate results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin receptor

decreases expression

diethyl maleate results in decreased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3 binding protein

decreases expression

diethyl maleate results in decreased expression of LGALS3BP mRNA

NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256

G

lamin B1

increases expression

diethyl maleate results in increased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LIM domain 7

decreases expression

diethyl maleate results in decreased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

leucine-rich repeats and immunoglobulin-like domains 3

decreases expression

diethyl maleate results in decreased expression of LRIG3 mRNA

NCBI chr 7:61,816,313...61,866,275
Ensembl chr 7:61,816,342...61,866,481

G

leucine rich repeat neuronal 4

increases expression

diethyl maleate results in increased expression of LRRN4 mRNA

NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831

G

leucine-rich repeats and transmembrane domains 2

decreases expression

diethyl maleate results in decreased expression of LRTM2 mRNA

NCBI chr 4:152,485,863...152,508,248
Ensembl chr 4:152,485,866...152,500,377

G

leukotriene C4 synthase

decreases expression

diethyl maleate results in decreased expression of LTC4S mRNA

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

lumican

decreases expression

diethyl maleate results in decreased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

Ly6-C antigen

decreases expression

diethyl maleate results in decreased expression of LY6C mRNA

NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329

G

MAF bZIP transcription factor F

increases expression

diethyl maleate results in increased expression of MAFF mRNA

PMID:20491607 PMID:33545341

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor G

increases expression

diethyl maleate results in increased expression of MAFG mRNA

PMID:33545341 PMID:34480604

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

monoamine oxidase A

increases expression

diethyl maleate results in increased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen-activated protein kinase 1 interacting protein 1-like

increases expression

diethyl maleate results in increased expression of MAPK1IP1L mRNA

NCBI chr15:20,545,043...20,571,466
Ensembl chr15:20,545,059...20,569,674

G

mitogen-activated protein kinase 8

increases expression
multiple interactions

diethyl maleate results in increased expression of MAPK8 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MARVEL domain containing 1

decreases expression

diethyl maleate results in decreased expression of MARVELD1 mRNA

NCBI chr 1:240,954,050...240,958,101
Ensembl chr 1:240,954,452...240,958,384

G

membrane bound O-acyltransferase domain containing 7

increases expression

diethyl maleate results in increased expression of MBOAT7 mRNA

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

G

minichromosome maintenance 10 replication initiation factor

increases expression

diethyl maleate results in increased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 4

increases expression

diethyl maleate results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

malic enzyme 1

increases expression

diethyl maleate results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

microfibril associated protein 4

decreases expression

diethyl maleate results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

O-6-methylguanine-DNA methyltransferase

decreases activity

diethyl maleate results in decreased activity of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

increases expression

diethyl maleate results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

decreases expression

diethyl maleate results in decreased expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

matrix metallopeptidase 1

increases expression

diethyl maleate results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 12

increases expression

diethyl maleate results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 2

decreases expression

diethyl maleate results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

increases expression

diethyl maleate results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myelin protein zero-like 1

decreases expression

diethyl maleate results in decreased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

moesin

increases reduction

diethyl maleate results in increased reduction of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

metallothionein 1

increases expression

diethyl maleate results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

increases expression

diethyl maleate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MX dynamin like GTPase 1

decreases expression

diethyl maleate results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MX dynamin like GTPase 2

decreases expression

diethyl maleate results in decreased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYB proto-oncogene like 2

increases expression

diethyl maleate results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYCN proto-oncogene, bHLH transcription factor

decreases expression

diethyl maleate results in decreased expression of MYCN mRNA

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

N-acetyltransferase 8

decreases expression

diethyl maleate results in decreased expression of NAT8 mRNA

NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763

G

non-SMC condensin I complex, subunit H

increases expression

diethyl maleate results in increased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

N-myc downstream regulated 1

increases expression

diethyl maleate results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NFE2 like bZIP transcription factor 2

affects localization
increases activity
increases expression
multiple interactions
decreases response to substance

diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]

PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726