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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-marinopyrrole A
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Accession:CHEBI:66678 term browser browse the term
Definition:A member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities.
Synonyms:exact_synonym: (4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2'-diyl)bis[(2-hydroxyphenyl)methanone]
 related_synonym: Formula=C22H12Cl4N2O4;   InChI=1S/C22H12Cl4N2O4/c23-12-9-13(19(31)10-5-1-3-7-14(10)29)28(22(12)26)18-16(24)21(25)27-17(18)20(32)11-6-2-4-8-15(11)30/h1-9,27,29-30H;   InChIKey=QYPJBTMRYKRTFG-UHFFFAOYSA-N;   SMILES=Oc1ccccc1C(=O)c1cc(Cl)c(Cl)n1-c1c(Cl)c(Cl)[nH]c1C(=O)c1ccccc1O
 xref_mesh: MESH:C528298
 xref: PMID:18205372;   PMID:19673475;   PMID:21499535;   PMID:21502631;   PMID:22311987;   PMID:22690153;   Reaxys:11303256


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(-)-marinopyrrole A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 multiple interactions ISO [HUWE1 protein co-treated with marinopyrrole A] results in increased ubiquitination of MCL1 protein CTD PMID:36346691 NCBI chr  X:24,350,708...24,480,798
Ensembl chr  X:24,353,217...24,480,798 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [HUWE1 protein co-treated with marinopyrrole A] results in increased ubiquitination of MCL1 protein CTD PMID:36346691 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          (-)-marinopyrrole A 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  heteroarene 17448
                                    monocyclic heteroarene 15186
                                      azole 14620
                                        pyrroles 5940
                                          (-)-marinopyrrole A 2
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